A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices

Nature Materials

Volumn 14, Issue 10, 2015, Pages 1065-1071

  Zhang, Shiyi ^a   Bellinger, Andrew M ^a,b   Glettig, Dean L ^a   Barman, Ross ^a,c   Lee, Young Ah Lucy ^a   Zhu, Jiahua ^d   Cleveland, Cody ^a   Montgomery, Veronica A ^a   Gu, Li ^a   Nash, Landon D ^e   Maitland, Duncan J ^e   Langer, Robert ^a,f   Traverso, Giovanni ^a,c  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d OAK RIDGE NATIONAL LABORATORY   (United States)

^e TEXAS A AND M UNIVERSITY   (United States)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIGESTIVE SYSTEM; DRUG DOSAGE; ELASTOMERS; SUPRAMOLECULAR CHEMISTRY;

ACIDIC ENVIRONMENT; ANIMAL MODEL; CLINICAL APPLICATION; DOSAGE FORMS; LARGE INTESTINE; PH-RESPONSIVE; PROTOTYPE DEVICES; SUPRAMOLECULAR POLYMERS;

POLYMERS;

ELASTOMER; GEL; POLYMER; TABLET;

ANIMAL; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; ELECTRONICS; ESOPHAGUS; GASTROINTESTINAL TRANSIT; GEL; HUMAN; PH; PHARMACEUTICS; PHYSIOLOGY; PIG; STOMACH; TABLET;

ANIMALS; DRUG DELIVERY SYSTEMS; ELASTOMERS; ELECTRONICS; ESOPHAGUS; GASTROINTESTINAL TRANSIT; GELS; HUMANS; HYDROGEN-ION CONCENTRATION; POLYMERS; STOMACH; SWINE; TABLETS; TECHNOLOGY, PHARMACEUTICAL;

EID: 84942234781     PISSN: 14761122     EISSN: 14764660     Source Type: Journal    
DOI: 10.1038/nmat4355     Document Type: Article

References (44)

1. Kethu, S. R. et al. Endoluminal bariatric techniques. Gastrointest. Endosc. 76, 1-7 (2012).
2. Genco, A. et al. BioEnterics intragastric balloon: The Italian experience with 2,515 patients. Obes. Surg. 15, 1161-1164 (2005).
3. Won, Y.W. et al. Oligopeptide complex for targeted non-viral gene delivery to adipocytes. Nature Mater. 13, 1157-1164 (2014).
4. Tao, H. et al. Silk-based conformal, adhesive, edible food sensors. Adv. Mater. 24, 1067-1072 (2012).
5. Kim, Y. J.,Wu,W., Chun, S. E.,Whitacre, J. F. & Bettinger, C. J. Biologically derived melanin electrodes in aqueous sodium-ion energy storage devices. Proc. Natl Acad. Sci. USA 110, 20912-20917 (2013).
6. Byrne, C. & Lim, C. L. The ingestible telemetric body core temperature sensor: A review of validity and exercise applications. Br. J. Sports. Med. 41, 126-133 (2007).
7. Belknap, R. et al. Feasibility of an ingestible sensor-based system for monitoring adherence to tuberculosis therapy. PLoS ONE 8, e53373 (2013).
8. Moes, A. J. Gastroretentive dosage forms. Crit. Rev. Ther. Drug 10, 143-195 (1993).
9. Hwang, S. J., Park, H. & Park, K. Gastric retentive drug-delivery systems. Crit. Rev. Ther. Drug 15, 243-284 (1998).
10. Singh, B. N. & Kim, K. H. Floating drug delivery systems: An approach to oral controlled drug delivery via gastric retention. J. Control Release 63, 235-259 (2000).
11. Fuhrmann, G. et al. Sustained gastrointestinal activity of dendronized polymerffenzyme conjugates. Nature Chem. 5, 582-589 (2013).
12. Laulicht, B., Gidmark, N. J., Tripathi, A. & Mathiowitz, E. Localization of magnetic pills. Proc. Natl Acad. Sci. USA 108, 2252-2257 (2011).
13. Salessiotis, N. Measurement of the diameter of the pylorus in man: Part I. Experimental project for clinical application. Am. J. Surgery 124, 331-333 (1972).
14. Munk, J. F., Gannaway, R. M., Hoare, M. & Johnson, A. G. in Gastrointestinal Motility in Health and Disease (ed. Duthie, H. L.) Ch. 38, 349-359 (Springer, 1978).
15. Sultan, M. & Norton, R. Esophageal diameter and the treatment of achalasia. Digest Dis. Sci. 14, 611-618 (1969).
16. Vanstiegmann, G., Cambre, T. & Sun, J. H. A new endoscopic elastic band ligating device. Gastrointest. Endosc. 32, 230-233 (1986).
17. Dumonceau, J. M. Evidence-based review of the bioenterics intragastric balloon for weight loss. Obes. Surg. 18, 1611-1617 (2008).
18. Cheifetz, A. S. et al. The risk of retention of the capsule endoscope in patients with known or suspected Crohn's disease. Am. J. Gastroenterol. 101, 2218-2222 (2006).
19. McGovern, R., Barkin, J. S., Goldberg, R. I. & Phillips, R. S. Duodenal obstruction: A complication of percutaneous endoscopic gastrostomy tube migration. Am. J. Gastroenterol. 85, 1037-1038 (1990).
20. Trande, P. et al. Effcacy, tolerance and safety of new intragastric air-filled balloon (Heliosphere BAG) for obesity: The experience of 17 cases. Obes. Surg. 20, 1227-1230 (2010).
21. Roman, S. et al. Intragastric balloon for non-morbid'' obesity: A retrospective evaluation of tolerance and effcacy. Obes. Surg. 14, 539-544 (2004).
22. Traverso, G. & Langer, R. Perspective: Special delivery for the gut. Nature 519, S19 (2015).
23. Lappas, L. C. & Mckeehan,W. Synthetic polymers as potential enteric and sustained-release coatings. J. Pharm. Sci. 51, 808 (1962).
24. Siepmann, F., Siepmann, J.,Walther, M., MacRae, R. J. & Bodmeier, R. Polymer blends for controlled release coatings. J. Control Release 125, 1-15 (2008).
25. Yan, X. Z.,Wang, F., Zheng, B. & Huang, F. H. Stimuli-responsive supramolecular polymeric materials. Chem. Soc. Rev. 41, 6042-6065 (2012).
26. Wojtecki, R. J., Meador, M. A. & Rowan, S. J. Using the dynamic bond to access macroscopically responsive structurally dynamic polymers. Nature Mater. 10, 14-27 (2011).
27. Li, J. H., Viveros, J. A.,Wrue, M. H. & Anthamatten, M. Shape-memory effects in polymer networks containing reversibly associating side-groups. Adv. Mater. 19, 2851-2855 (2007).
28. Yan, X. Z. et al. A multiresponsive, shape-persistent, and elastic supramolecular polymer network gel constructed by orthogonal self-assembly. Adv. Mater. 24, 362-369 (2012).
29. Jang, S. G., Kramer, E. J. & Hawker, C. J. Controlled supramolecular assembly of micelle-like gold nanoparticles in PS-b-P2VP diblock copolymers via hydrogen bonding. J. Am. Chem. Soc. 133, 16986-16996 (2011).
30. Tee, B. C. K.,Wang, C., Allen, R. & Bao, Z. N. An electrically and mechanically self-healing composite with pressure- and flexion-sensitive properties for electronic skin applications. Nature Nanotech. 7, 825-832 (2012).
31. Chen, Y. L., Kushner, A. M.,Williams, G. A. & Guan, Z. B.Multiphase design of autonomic self-healing thermoplastic elastomers. Nature Chem. 4, 467-472 (2012).
32. Schaaf, P. & Schleno-, J. B. Saloplastics: Processing compact polyelectrolyte complexes. Adv. Mater. 27, 2420-2432 (2015).
33. Lendlein, A., Neffe, A. T. & Jerme, C. Advanced functional polymers for medicine. Adv. Healthc. Mater. 3, 1939-1940 (2014).
34. Stuart, M. A. C. et al. Emerging applications of stimuli-responsive polymer materials. Nature Mater. 9, 101-113 (2010).
35. Sathish, D., Himabindu, S., Kumar, Y. S. & Shayeda Rao, Y. M. Floating drug delivery systems for prolonging gastric residence time: A review. Curr. Drug Deliv. 8, 494-510 (2011).
36. Phadke, A. et al. Rapid self-healing hydrogels. Proc. Natl Acad. Sci. USA 109, 4383-4388 (2012).
37. Luzar, A. & Chandler, D. Structure and hydrogen bond dynamics of waterffdimethyl sulfoxide mixtures by computer simulations. J. Chem. Phys. 98, 8160-8173 (1993).
38. Woodru-, M. A. & Hutmacher, D.W. The return of a forgotten polymerffpolycaprolactone in the 21st century. Prog. Polym. Sci. 35, 1217-1256 (2010).
39. Kearney, C. J. & Mooney, D. J. Macroscale delivery systems for molecular and cellular payloads. Nature Mater. 12, 1004-1017 (2013).
40. Khosla, R. & Davis, S. S. The effect of tablet size on the gastric emptying of non-disintegrating tablets. Int. J. Pharm. 62, R9-R11 (1990).
41. Cargill, R. et al. Controlled gastric emptying. 1. effects of physical properties on gastric residence times of nondisintegrating geometric shapes in beagle dogs. Pharm. Res. 5, 533-536 (1988).
42. Martinez, M. N. & Papich, M. G. Factors influencing the gastric residence of dosage forms in dogs. J. Pharm. Sci. 98, 844-860 (2009).
43. Swindle, M. M., Makin, A., Herron, A. J., Clubb, F. J. & Frazier, K. S. Swine as models in biomedical research and toxicology testing. Vet. Pathol. 49, 344-356 (2012)
44. Cooper, A. R. & Matzinger, D. P. Aqueous gel permeation chromatography: The effect of solvent ionic strength. J. Appl. Polym. Sci. 23, 419-427 (1979).