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Volumn 60, Issue 10, 2008, Pages 1153-1166

Microbubbles in ultrasound-triggered drug and gene delivery

Author keywords

Acoustic; Echo; Microbubbles; Molecular imaging; Triggered release; Ultrasound; Ultrasound contrast agent

Indexed keywords

BIOCOMPATIBILITY; DNA SEQUENCES; DRUG DELIVERY; GENES;

EID: 44249105593     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2008.03.005     Document Type: Review
Times cited : (847)

References (146)
  • 1
    • 0029887902 scopus 로고    scopus 로고
    • Physical enhancement of dermatologic drug delivery: iontophoresis and phonophoresis
    • Kassan D.G., Lynch A.M., and Stiller M.J. Physical enhancement of dermatologic drug delivery: iontophoresis and phonophoresis. J. Am. Acad. Dermatol. 34 (1996) 657-666
    • (1996) J. Am. Acad. Dermatol. , vol.34 , pp. 657-666
    • Kassan, D.G.1    Lynch, A.M.2    Stiller, M.J.3
  • 2
    • 0014327602 scopus 로고
    • Echocardiography of the aortic root
    • Gramiak R., and Shah P.M. Echocardiography of the aortic root. Invest. Radiol. 3 (1968) 356-366
    • (1968) Invest. Radiol. , vol.3 , pp. 356-366
    • Gramiak, R.1    Shah, P.M.2
  • 5
    • 0032100726 scopus 로고    scopus 로고
    • Dissolution of multicomponent microbubbles in the bloodstream: 1. Theory
    • Kabalnov A., Klein D., Pelura T., Schutt E., and Weers J. Dissolution of multicomponent microbubbles in the bloodstream: 1. Theory. Ultrasound. Med. Biol. 24 (1998) 739-749
    • (1998) Ultrasound. Med. Biol. , vol.24 , pp. 739-749
    • Kabalnov, A.1    Klein, D.2    Pelura, T.3    Schutt, E.4    Weers, J.5
  • 6
    • 0035807141 scopus 로고    scopus 로고
    • Equilibrium and dynamic interfacial tension measurements at microscopic interfaces using a micropipet technique. 2. Dynamics of phospholipid monolayer formation and equilibrium tensions at the water-air interface
    • Lee S., Kim D.H., and Needham D. Equilibrium and dynamic interfacial tension measurements at microscopic interfaces using a micropipet technique. 2. Dynamics of phospholipid monolayer formation and equilibrium tensions at the water-air interface. Langmuir 17 (2001) 5544-5550
    • (2001) Langmuir , vol.17 , pp. 5544-5550
    • Lee, S.1    Kim, D.H.2    Needham, D.3
  • 8
    • 0026830293 scopus 로고
    • Absorption and scatter of encapsulated gas filled microspheres: theoretical considerations and some measurements
    • de Jong N., Hoff L., Skotland T., and Bom N. Absorption and scatter of encapsulated gas filled microspheres: theoretical considerations and some measurements. Ultrasonics 30 (1992) 95-103
    • (1992) Ultrasonics , vol.30 , pp. 95-103
    • de Jong, N.1    Hoff, L.2    Skotland, T.3    Bom, N.4
  • 9
    • 0036105740 scopus 로고    scopus 로고
    • Basic acoustic properties of microbubbles
    • de Jong N., Bouakaz A., and Frinking P. Basic acoustic properties of microbubbles. Echocardiography 19 (2002) 229-240
    • (2002) Echocardiography , vol.19 , pp. 229-240
    • de Jong, N.1    Bouakaz, A.2    Frinking, P.3
  • 10
    • 1642601722 scopus 로고    scopus 로고
    • Development and characterization of a nano-scale contrast agent
    • Oeffinger B.E., and Wheatley M.A. Development and characterization of a nano-scale contrast agent. Ultrasonics 42 (2004) 343-347
    • (2004) Ultrasonics , vol.42 , pp. 343-347
    • Oeffinger, B.E.1    Wheatley, M.A.2
  • 12
    • 0031670557 scopus 로고    scopus 로고
    • Improved left ventricular endocardial border delineation and opacification with Optison (fs069), a new echocardiographic contrast agent. Results of a phase III multicenter trial
    • Cohen J.L., Cheirif J., Segar D.S., Gillam L.D., Gottdiener J.S., Hausnerova E., and Bruns D.E. Improved left ventricular endocardial border delineation and opacification with Optison (fs069), a new echocardiographic contrast agent. Results of a phase III multicenter trial. J. Am. Coll. Cardiol. 32 (1998) 746-752
    • (1998) J. Am. Coll. Cardiol. , vol.32 , pp. 746-752
    • Cohen, J.L.1    Cheirif, J.2    Segar, D.S.3    Gillam, L.D.4    Gottdiener, J.S.5    Hausnerova, E.6    Bruns, D.E.7
  • 16
    • 0027742893 scopus 로고
    • Quantifying myocardial blood flow with contrast echocardiography
    • Jayaweera A.R., and Kaul S. Quantifying myocardial blood flow with contrast echocardiography. Am. J. Card. Imaging 7 (1993) 317-335
    • (1993) Am. J. Card. Imaging , vol.7 , pp. 317-335
    • Jayaweera, A.R.1    Kaul, S.2
  • 17
    • 0028308410 scopus 로고
    • In vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography. Comparison with radiolabeled red blood cells
    • Jayaweera A.R., Edwards N., Glasheen W.P., Villanueva F.S., Abbott R.D., and Kaul S. In vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography. Comparison with radiolabeled red blood cells. Circ. Res. 74 (1994) 1157-1165
    • (1994) Circ. Res. , vol.74 , pp. 1157-1165
    • Jayaweera, A.R.1    Edwards, N.2    Glasheen, W.P.3    Villanueva, F.S.4    Abbott, R.D.5    Kaul, S.6
  • 18
    • 0024392826 scopus 로고
    • The behavior of sonicated albumin microbubbles within the microcirculation: a basis for their use during myocardial contrast echocardiography
    • Keller M.W., Segal S.S., Kaul S., and Duling B. The behavior of sonicated albumin microbubbles within the microcirculation: a basis for their use during myocardial contrast echocardiography. Circ. Res. 65 (1989) 458-467
    • (1989) Circ. Res. , vol.65 , pp. 458-467
    • Keller, M.W.1    Segal, S.S.2    Kaul, S.3    Duling, B.4
  • 19
    • 0035869313 scopus 로고    scopus 로고
    • Quantification of renal blood flow with contrast-enhanced ultrasound
    • Wei K., Le E., Bin J.P., Coggins M., Thorpe J., and Kaul S. Quantification of renal blood flow with contrast-enhanced ultrasound. J. Am. Coll. Cardiol. 37 (2001) 1135-1140
    • (2001) J. Am. Coll. Cardiol. , vol.37 , pp. 1135-1140
    • Wei, K.1    Le, E.2    Bin, J.P.3    Coggins, M.4    Thorpe, J.5    Kaul, S.6
  • 24
    • 1242329827 scopus 로고    scopus 로고
    • Optical observation of lipid- and polymer-shelled ultrasound microbubble contrast agents
    • Bloch S.H., Dayton P.A., Wan M., and Ferrara K.W. Optical observation of lipid- and polymer-shelled ultrasound microbubble contrast agents. Appl. Phys. Lett. 84 (2004) 631-633
    • (2004) Appl. Phys. Lett. , vol.84 , pp. 631-633
    • Bloch, S.H.1    Dayton, P.A.2    Wan, M.3    Ferrara, K.W.4
  • 27
    • 0038108601 scopus 로고    scopus 로고
    • Ultrasound imaging of acute cardiac transplant rejection with microbubbles targeted to intercellular adhesion molecule-1
    • Weller G.E., Lu E., Csikari M.M., Klibanov A.L., Fischer D., Wagner W.R., and Villanueva F.S. Ultrasound imaging of acute cardiac transplant rejection with microbubbles targeted to intercellular adhesion molecule-1. Circulation 108 (2003) 218-224
    • (2003) Circulation , vol.108 , pp. 218-224
    • Weller, G.E.1    Lu, E.2    Csikari, M.M.3    Klibanov, A.L.4    Fischer, D.5    Wagner, W.R.6    Villanueva, F.S.7
  • 29
    • 18844382464 scopus 로고    scopus 로고
    • Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression
    • Leong-Poi H., Christiansen J., Heppner P., Lewis C.W., Klibanov A.L., Kaul S., and Lindner J.R. Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression. Circulation 111 (2005) 3248-3254
    • (2005) Circulation , vol.111 , pp. 3248-3254
    • Leong-Poi, H.1    Christiansen, J.2    Heppner, P.3    Lewis, C.W.4    Klibanov, A.L.5    Kaul, S.6    Lindner, J.R.7
  • 30
    • 12544258353 scopus 로고    scopus 로고
    • Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the tumor-binding peptide arginine-arginine-leucine
    • Weller G.E., Wong M.K., Modzelewski R.A., Lu E., Klibanov A.L., Wagner W.R., and Villanueva F.S. Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the tumor-binding peptide arginine-arginine-leucine. Cancer Res. 65 (2005) 533-539
    • (2005) Cancer Res. , vol.65 , pp. 533-539
    • Weller, G.E.1    Wong, M.K.2    Modzelewski, R.A.3    Lu, E.4    Klibanov, A.L.5    Wagner, W.R.6    Villanueva, F.S.7
  • 31
    • 33847253010 scopus 로고    scopus 로고
    • Polymeric ultrasound contrast agents targeted to integrins: importance of process methods and surface density of ligands
    • Wheatley M.A., Lathia J.D., and Oum K.L. Polymeric ultrasound contrast agents targeted to integrins: importance of process methods and surface density of ligands. Biomacromolecules 8 (2007) 516-522
    • (2007) Biomacromolecules , vol.8 , pp. 516-522
    • Wheatley, M.A.1    Lathia, J.D.2    Oum, K.L.3
  • 32
    • 2442662932 scopus 로고    scopus 로고
    • Molecular targeting of lymph nodes with l-selectin ligand-specific us contrast agent: a feasibility study in mice and dogs
    • Hauff P., Reinhardt M., Briel A., Debus N., and Schirner M. Molecular targeting of lymph nodes with l-selectin ligand-specific us contrast agent: a feasibility study in mice and dogs. Radiology 231 (2004) 667-673
    • (2004) Radiology , vol.231 , pp. 667-673
    • Hauff, P.1    Reinhardt, M.2    Briel, A.3    Debus, N.4    Schirner, M.5
  • 35
    • 0033893616 scopus 로고    scopus 로고
    • The influence of tiered layers of surface-grafted poly(ethylene glycol) on receptor-ligand-mediated adhesion between phospholipid monolayer-stabilized microbubbles and coated glass beads
    • Kim D.H., Klibanov A.L., and Needham D. The influence of tiered layers of surface-grafted poly(ethylene glycol) on receptor-ligand-mediated adhesion between phospholipid monolayer-stabilized microbubbles and coated glass beads. Langmuir 16 (2000) 2808-2817
    • (2000) Langmuir , vol.16 , pp. 2808-2817
    • Kim, D.H.1    Klibanov, A.L.2    Needham, D.3
  • 38
    • 1842869919 scopus 로고    scopus 로고
    • Modulating targeted adhesion of an ultrasound contrast agent to dysfunctional endothelium
    • Weller G.E., Villanueva F.S., Klibanov A.L., and Wagner W.R. Modulating targeted adhesion of an ultrasound contrast agent to dysfunctional endothelium. Ann. Biomed. Eng. 30 (2002) 1012-1019
    • (2002) Ann. Biomed. Eng. , vol.30 , pp. 1012-1019
    • Weller, G.E.1    Villanueva, F.S.2    Klibanov, A.L.3    Wagner, W.R.4
  • 40
    • 17044386185 scopus 로고    scopus 로고
    • Acoustic radiation force enhances targeted delivery of ultrasound contrast microbubbles: in vitro verification
    • Rychak J.J., Klibanov A.L., and Hossack J.A. Acoustic radiation force enhances targeted delivery of ultrasound contrast microbubbles: in vitro verification. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 52 (2005) 421-433
    • (2005) IEEE Trans. Ultrason. Ferroelectr. Freq. Control , vol.52 , pp. 421-433
    • Rychak, J.J.1    Klibanov, A.L.2    Hossack, J.A.3
  • 41
    • 0036841216 scopus 로고    scopus 로고
    • The magnitude of radiation force on ultrasound contrast agents
    • Dayton P.A., Allen J.S., and Ferrara K.W. The magnitude of radiation force on ultrasound contrast agents. J. Acoust. Soc. Am. 112 (2002) 2183-2192
    • (2002) J. Acoust. Soc. Am. , vol.112 , pp. 2183-2192
    • Dayton, P.A.1    Allen, J.S.2    Ferrara, K.W.3
  • 43
    • 9144246262 scopus 로고    scopus 로고
    • Radiation-force assisted targeting facilitates ultrasonic molecular imaging
    • Zhao S., Borden M., Bloch S.H., Kruse D., Ferrara K.W., and Dayton P.A. Radiation-force assisted targeting facilitates ultrasonic molecular imaging. Mol. Imaging 3 (2004) 135-148
    • (2004) Mol. Imaging , vol.3 , pp. 135-148
    • Zhao, S.1    Borden, M.2    Bloch, S.H.3    Kruse, D.4    Ferrara, K.W.5    Dayton, P.A.6
  • 44
    • 0032855567 scopus 로고    scopus 로고
    • Acoustic radiation force in vivo: a mechanism to assist targeting of microbubbles
    • Dayton P., Klibanov A., Brandenburger G., and Ferrara K. Acoustic radiation force in vivo: a mechanism to assist targeting of microbubbles. Ultrasound Med. Biol. 25 (1999) 1195-1201
    • (1999) Ultrasound Med. Biol. , vol.25 , pp. 1195-1201
    • Dayton, P.1    Klibanov, A.2    Brandenburger, G.3    Ferrara, K.4
  • 46
    • 0141750513 scopus 로고    scopus 로고
    • Impact of myocardial contrast echocardiography on vascular permeability: an in vivo dose response study of delivery mode, pressure amplitude and contrast dose
    • Li P., Cao L.Q., Dou C.Y., Armstrong W.F., and Miller D. Impact of myocardial contrast echocardiography on vascular permeability: an in vivo dose response study of delivery mode, pressure amplitude and contrast dose. Ultrasound Med. Biol. 29 (2003) 1341-1349
    • (2003) Ultrasound Med. Biol. , vol.29 , pp. 1341-1349
    • Li, P.1    Cao, L.Q.2    Dou, C.Y.3    Armstrong, W.F.4    Miller, D.5
  • 47
    • 0032575349 scopus 로고    scopus 로고
    • Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue
    • Skyba D.M., Price R.J., Linka A.Z., Skalak T.C., and Kaul S. Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue. Circulation 98 (1998) 290-293
    • (1998) Circulation , vol.98 , pp. 290-293
    • Skyba, D.M.1    Price, R.J.2    Linka, A.Z.3    Skalak, T.C.4    Kaul, S.5
  • 48
    • 0034730121 scopus 로고    scopus 로고
    • Diagnostic ultrasound activation of contrast agent gas bodies induces capillary rupture in mice
    • Miller D.L., and Quddus J. Diagnostic ultrasound activation of contrast agent gas bodies induces capillary rupture in mice. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 10179-10184
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 10179-10184
    • Miller, D.L.1    Quddus, J.2
  • 49
    • 0035943072 scopus 로고    scopus 로고
    • Destruction of contrast microbubbles by ultrasound: effects on myocardial function, coronary perfusion pressure, and microvascular integrity
    • Ay T., Havaux X., Van Camp G., Campanelli B., Gisellu G., Pasquet A., Denef J.F., Melin J.A., and Vanoverschelde J.L. Destruction of contrast microbubbles by ultrasound: effects on myocardial function, coronary perfusion pressure, and microvascular integrity. Circulation 104 (2001) 461-466
    • (2001) Circulation , vol.104 , pp. 461-466
    • Ay, T.1    Havaux, X.2    Van Camp, G.3    Campanelli, B.4    Gisellu, G.5    Pasquet, A.6    Denef, J.F.7    Melin, J.A.8    Vanoverschelde, J.L.9
  • 50
    • 0032191834 scopus 로고    scopus 로고
    • Gas-body-based contrast agent enhances vascular bioeffects of 1.09 MHz ultrasound on mouse intestine
    • Miller D.L., and Gies R.A. Gas-body-based contrast agent enhances vascular bioeffects of 1.09 MHz ultrasound on mouse intestine. Ultrasound Med. Biol. 24 (1998) 1201-1208
    • (1998) Ultrasound Med. Biol. , vol.24 , pp. 1201-1208
    • Miller, D.L.1    Gies, R.A.2
  • 51
    • 1042298887 scopus 로고    scopus 로고
    • Impact of myocardial contrast echocardiography on vascular permeability: comparison of three different contrast agents
    • Li P., Armstrong W.F., and Miller D.L. Impact of myocardial contrast echocardiography on vascular permeability: comparison of three different contrast agents. Ultrasound Med. Biol. 30 (2004) 83-91
    • (2004) Ultrasound Med. Biol. , vol.30 , pp. 83-91
    • Li, P.1    Armstrong, W.F.2    Miller, D.L.3
  • 53
    • 13244273880 scopus 로고    scopus 로고
    • Histological characterization of microlesions induced by myocardial contrast echocardiography
    • Miller D.L., Li P., Gordon D., and Armstrong W.F. Histological characterization of microlesions induced by myocardial contrast echocardiography. Echocardiography 22 (2005) 25-34
    • (2005) Echocardiography , vol.22 , pp. 25-34
    • Miller, D.L.1    Li, P.2    Gordon, D.3    Armstrong, W.F.4
  • 54
    • 24944508083 scopus 로고    scopus 로고
    • Influence of contrast agent dose and ultrasound exposure on cardiomyocyte injury induced by myocardial contrast echocardiography in rats
    • Miller D.L., Li P., Dou C., Gordon D., Edwards C.A., and Armstrong W.F. Influence of contrast agent dose and ultrasound exposure on cardiomyocyte injury induced by myocardial contrast echocardiography in rats. Radiology 237 (2005) 137-143
    • (2005) Radiology , vol.237 , pp. 137-143
    • Miller, D.L.1    Li, P.2    Dou, C.3    Gordon, D.4    Edwards, C.A.5    Armstrong, W.F.6
  • 55
    • 24944478188 scopus 로고    scopus 로고
    • The influence of agent delivery mode on cardiomyocyte injury induced by myocardial contrast echocardiography in rats
    • Miller D.L., Dou C., and Armstrong W.F. The influence of agent delivery mode on cardiomyocyte injury induced by myocardial contrast echocardiography in rats. Ultrasound Med. Biol. 31 (2005) 1257-1263
    • (2005) Ultrasound Med. Biol. , vol.31 , pp. 1257-1263
    • Miller, D.L.1    Dou, C.2    Armstrong, W.F.3
  • 56
    • 33645422453 scopus 로고    scopus 로고
    • Microvascular permeabilization and cardiomyocyte injury provoked by myocardial contrast echocardiography in a canine model
    • Miller D.L., Driscoll E.M., Dou C., Armstrong W.F., and Lucchesi B.R. Microvascular permeabilization and cardiomyocyte injury provoked by myocardial contrast echocardiography in a canine model. J. Am. Coll. Cardiol. 47 (2006) 1464-1468
    • (2006) J. Am. Coll. Cardiol. , vol.47 , pp. 1464-1468
    • Miller, D.L.1    Driscoll, E.M.2    Dou, C.3    Armstrong, W.F.4    Lucchesi, B.R.5
  • 58
    • 2242482891 scopus 로고    scopus 로고
    • Arrhythmias in rat hearts exposed to pulsed ultrasound after intravenous injection of a contrast agent
    • discussion 1343-45
    • Zachary J.F., Hartleben S.A., Frizzell L.A., and O'Brien Jr. W.D. Arrhythmias in rat hearts exposed to pulsed ultrasound after intravenous injection of a contrast agent. J. Ultrasound Med. 21 (2002) 1347-1356 discussion 1343-45
    • (2002) J. Ultrasound Med. , vol.21 , pp. 1347-1356
    • Zachary, J.F.1    Hartleben, S.A.2    Frizzell, L.A.3    O'Brien Jr., W.D.4
  • 60
    • 33751325866 scopus 로고    scopus 로고
    • Overview of experimental studies of biological effects of medical ultrasound caused by gas body activation and inertial cavitation
    • Miller D.L. Overview of experimental studies of biological effects of medical ultrasound caused by gas body activation and inertial cavitation. Prog. Biophys. Mol. Biol. 93 (2007) 314-330
    • (2007) Prog. Biophys. Mol. Biol. , vol.93 , pp. 314-330
    • Miller, D.L.1
  • 62
    • 0018136191 scopus 로고
    • [Removal of intravascular thrombi by means of ultrasonics. Experimental study with a new method and its clinical use]
    • Trubestein G. [Removal of intravascular thrombi by means of ultrasonics. Experimental study with a new method and its clinical use]. Fortschr. Med. 96 (1978) 755-760
    • (1978) Fortschr. Med. , vol.96 , pp. 755-760
    • Trubestein, G.1
  • 63
    • 0029154850 scopus 로고
    • Albumin microbubble echo-contrast material as an enhancer for ultrasound accelerated thrombolysis
    • Tachibana K., and Tachibana S. Albumin microbubble echo-contrast material as an enhancer for ultrasound accelerated thrombolysis. Circulation 92 (1995) 1148-1150
    • (1995) Circulation , vol.92 , pp. 1148-1150
    • Tachibana, K.1    Tachibana, S.2
  • 64
    • 0029807006 scopus 로고    scopus 로고
    • Thrombolytic enhancement with perfluorocarbon-exposed sonicated dextrose albumin microbubbles
    • Porter T.R., LeVeen R.F., Fox R., Kricsfeld A., and Xie F. Thrombolytic enhancement with perfluorocarbon-exposed sonicated dextrose albumin microbubbles. Am. Heart J. 132 (1996) 964-968
    • (1996) Am. Heart J. , vol.132 , pp. 964-968
    • Porter, T.R.1    LeVeen, R.F.2    Fox, R.3    Kricsfeld, A.4    Xie, F.5
  • 68
    • 35648979467 scopus 로고    scopus 로고
    • Timing of recanalization after microbubble-enhanced intravenous thrombolysis in basilar artery occlusion
    • Pagola J., Ribo M., Alvarez-Sabin J., Lange M., Rubiera M., and Molina C.A. Timing of recanalization after microbubble-enhanced intravenous thrombolysis in basilar artery occlusion. Stroke 38 (2007) 2931-2934
    • (2007) Stroke , vol.38 , pp. 2931-2934
    • Pagola, J.1    Ribo, M.2    Alvarez-Sabin, J.3    Lange, M.4    Rubiera, M.5    Molina, C.A.6
  • 70
    • 9344224597 scopus 로고    scopus 로고
    • Microvascular remodeling and accelerated hyperemia blood flow restoration in arterially occluded skeletal muscle exposed to ultrasonic microbubble destruction
    • Song J., Cottler P.S., Klibanov A.L., Kaul S., and Price R.J. Microvascular remodeling and accelerated hyperemia blood flow restoration in arterially occluded skeletal muscle exposed to ultrasonic microbubble destruction. Am. J. Physiol. Heart Circ. Physiol. 287 (2004) H2754-H2761
    • (2004) Am. J. Physiol. Heart Circ. Physiol. , vol.287
    • Song, J.1    Cottler, P.S.2    Klibanov, A.L.3    Kaul, S.4    Price, R.J.5
  • 71
    • 0032578520 scopus 로고    scopus 로고
    • Delivery of colloidal particles and red blood cells to tissue through microvessel ruptures created by targeted microbubble destruction with ultrasound
    • Price R.J., Skyba D.M., Kaul S., and Skalak T.C. Delivery of colloidal particles and red blood cells to tissue through microvessel ruptures created by targeted microbubble destruction with ultrasound. Circulation 98 (1998) 1264-1267
    • (1998) Circulation , vol.98 , pp. 1264-1267
    • Price, R.J.1    Skyba, D.M.2    Kaul, S.3    Skalak, T.C.4
  • 72
    • 0037138499 scopus 로고    scopus 로고
    • Influence of injection site, microvascular pressure and ultrasound variables on microbubble-mediated delivery of microspheres to muscle
    • Song J., Chappell J.C., Qi M., VanGieson E.J., Kaul S., and Price R.J. Influence of injection site, microvascular pressure and ultrasound variables on microbubble-mediated delivery of microspheres to muscle. J. Am. Coll. Cardiol. 39 (2002) 726-731
    • (2002) J. Am. Coll. Cardiol. , vol.39 , pp. 726-731
    • Song, J.1    Chappell, J.C.2    Qi, M.3    VanGieson, E.J.4    Kaul, S.5    Price, R.J.6
  • 73
    • 24044509564 scopus 로고    scopus 로고
    • Treatment of ischemic limbs based on local recruitment of vascular endothelial growth factor-producing inflammatory cells with ultrasonic microbubble destruction
    • Yoshida J., Ohmori K., Takeuchi H., Shinomiya K., Namba T., Kondo I., Kiyomoto H., and Kohno M. Treatment of ischemic limbs based on local recruitment of vascular endothelial growth factor-producing inflammatory cells with ultrasonic microbubble destruction. J. Am. Coll. Cardiol. 46 (2005) 899-905
    • (2005) J. Am. Coll. Cardiol. , vol.46 , pp. 899-905
    • Yoshida, J.1    Ohmori, K.2    Takeuchi, H.3    Shinomiya, K.4    Namba, T.5    Kondo, I.6    Kiyomoto, H.7    Kohno, M.8
  • 74
    • 0037126042 scopus 로고    scopus 로고
    • Stimulation of arteriogenesis in skeletal muscle by microbubble destruction with ultrasound
    • Song J., Qi M., Kaul S., and Price R.J. Stimulation of arteriogenesis in skeletal muscle by microbubble destruction with ultrasound. Circulation 106 (2002) 1550-1555
    • (2002) Circulation , vol.106 , pp. 1550-1555
    • Song, J.1    Qi, M.2    Kaul, S.3    Price, R.J.4
  • 77
    • 35448999745 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor facilitates the angiogenesis induced by ultrasonic microbubble destruction
    • Miyake Y., Ohmori K., Yoshida J., Ishizawa M., Mizukawa M., Yukiiri K., and Kohno M. Granulocyte colony-stimulating factor facilitates the angiogenesis induced by ultrasonic microbubble destruction. Ultrasound Med. Biol. 33 (2007) 1796-1804
    • (2007) Ultrasound Med. Biol. , vol.33 , pp. 1796-1804
    • Miyake, Y.1    Ohmori, K.2    Yoshida, J.3    Ishizawa, M.4    Mizukawa, M.5    Yukiiri, K.6    Kohno, M.7
  • 78
    • 27744441243 scopus 로고    scopus 로고
    • MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits
    • McDannold N., Vykhodtseva N., Raymond S., Jolesz F.A., and Hynynen K. MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits. Ultrasound Med. Biol. 31 (2005) 1527-1537
    • (2005) Ultrasound Med. Biol. , vol.31 , pp. 1527-1537
    • McDannold, N.1    Vykhodtseva, N.2    Raymond, S.3    Jolesz, F.A.4    Hynynen, K.5
  • 79
    • 34547121440 scopus 로고    scopus 로고
    • Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound
    • Treat L.H., McDannold N., Vykhodtseva N., Zhang Y., Tam K., and Hynynen K. Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound. Int. J. Cancer 121 (2007) 901-907
    • (2007) Int. J. Cancer , vol.121 , pp. 901-907
    • Treat, L.H.1    McDannold, N.2    Vykhodtseva, N.3    Zhang, Y.4    Tam, K.5    Hynynen, K.6
  • 80
    • 33846299555 scopus 로고    scopus 로고
    • Focused ultrasound for blood-brain disruption and delivery of therapeutic molecules into the brain
    • Hynynen K. Focused ultrasound for blood-brain disruption and delivery of therapeutic molecules into the brain. Expert Opin. Drug. Deliv. 4 (2007) 27-35
    • (2007) Expert Opin. Drug. Deliv. , vol.4 , pp. 27-35
    • Hynynen, K.1
  • 81
    • 0036202671 scopus 로고    scopus 로고
    • Observation on the integrity of the blood-brain barrier after microbubble destruction by diagnostic transcranial color-coded sonography
    • Schlachetzki F., Holscher T., Koch H.J., Draganski B., May A., Schuierer G., and Bogdahn U. Observation on the integrity of the blood-brain barrier after microbubble destruction by diagnostic transcranial color-coded sonography. J. Ultrasound Med. 21 (2002) 419-429
    • (2002) J. Ultrasound Med. , vol.21 , pp. 419-429
    • Schlachetzki, F.1    Holscher, T.2    Koch, H.J.3    Draganski, B.4    May, A.5    Schuierer, G.6    Bogdahn, U.7
  • 83
    • 0032918935 scopus 로고    scopus 로고
    • Ultrasound-induced cell lysis and sonoporation enhanced by contrast agents
    • Ward M., Wu J., and Chiu J.F. Ultrasound-induced cell lysis and sonoporation enhanced by contrast agents. J. Acoust. Soc. Am. 105 (1999) 2951-2957
    • (1999) J. Acoust. Soc. Am. , vol.105 , pp. 2951-2957
    • Ward, M.1    Wu, J.2    Chiu, J.F.3
  • 84
    • 0036195641 scopus 로고    scopus 로고
    • Reparable sonoporation generated by microstreaming
    • Wu J., Ross J.P., and Chiu J.F. Reparable sonoporation generated by microstreaming. J. Acoust. Soc. Am. 111 (2002) 1460-1464
    • (2002) J. Acoust. Soc. Am. , vol.111 , pp. 1460-1464
    • Wu, J.1    Ross, J.P.2    Chiu, J.F.3
  • 87
    • 8844228263 scopus 로고    scopus 로고
    • Micromanipulation of endothelial cells: ultrasound-microbubble-cell interaction
    • van Wamel A., Bouakaz A., Versluis M., and de Jong N. Micromanipulation of endothelial cells: ultrasound-microbubble-cell interaction. Ultrasound Med. Biol. 30 (2004) 1255-1258
    • (2004) Ultrasound Med. Biol. , vol.30 , pp. 1255-1258
    • van Wamel, A.1    Bouakaz, A.2    Versluis, M.3    de Jong, N.4
  • 89
    • 33749316457 scopus 로고    scopus 로고
    • Transient permeabilization of cell membranes by ultrasound-exposed microbubbles is related to formation of hydrogen peroxide
    • Juffermans L.J., Dijkmans P.A., Musters R.J., Visser C.A., and Kamp O. Transient permeabilization of cell membranes by ultrasound-exposed microbubbles is related to formation of hydrogen peroxide. Am. J. Physiol. Heart Circ. Physiol. 291 (2006) H1595-H1601
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.291
    • Juffermans, L.J.1    Dijkmans, P.A.2    Musters, R.J.3    Visser, C.A.4    Kamp, O.5
  • 90
    • 0032171442 scopus 로고    scopus 로고
    • Effect of gas-containing microspheres and echo contrast agents on free radical formation by ultrasound
    • Kondo T., Misik V., and Riesz P. Effect of gas-containing microspheres and echo contrast agents on free radical formation by ultrasound. Free Radic. Biol. Med. 25 (1998) 605-612
    • (1998) Free Radic. Biol. Med. , vol.25 , pp. 605-612
    • Kondo, T.1    Misik, V.2    Riesz, P.3
  • 91
    • 0031962427 scopus 로고    scopus 로고
    • The interaction of ultrasonic heating and cavitation in vascular bioeffects on mouse intestine
    • Miller D.L., and Gies R.A. The interaction of ultrasonic heating and cavitation in vascular bioeffects on mouse intestine. Ultrasound Med. Biol. 24 (1998) 123-128
    • (1998) Ultrasound Med. Biol. , vol.24 , pp. 123-128
    • Miller, D.L.1    Gies, R.A.2
  • 93
    • 0034749976 scopus 로고    scopus 로고
    • Intracellular drug delivery using low-frequency ultrasound: quantification of molecular uptake and cell viability
    • Keyhani K., Guzman H.R., Parsons A., Lewis T.N., and Prausnitz M.R. Intracellular drug delivery using low-frequency ultrasound: quantification of molecular uptake and cell viability. Pharm. Res. 18 (2001) 1514-1520
    • (2001) Pharm. Res. , vol.18 , pp. 1514-1520
    • Keyhani, K.1    Guzman, H.R.2    Parsons, A.3    Lewis, T.N.4    Prausnitz, M.R.5
  • 94
    • 33845879855 scopus 로고    scopus 로고
    • Microbubble-enhanced ultrasound exposure improves gene transfer in vascular endothelial cells
    • Nie F., Xu H.X., Tang Q., and Lu M.D. Microbubble-enhanced ultrasound exposure improves gene transfer in vascular endothelial cells. World J. Gastroenterol. 12 (2006) 7508-7513
    • (2006) World J. Gastroenterol. , vol.12 , pp. 7508-7513
    • Nie, F.1    Xu, H.X.2    Tang, Q.3    Lu, M.D.4
  • 95
    • 33947306105 scopus 로고    scopus 로고
    • Ultrasonically targeted delivery into endothelial and smooth muscle cells in ex vivo arteries
    • Hallow D.M., Mahajan A.D., and Prausnitz M.R. Ultrasonically targeted delivery into endothelial and smooth muscle cells in ex vivo arteries. J. Control. Release 118 (2007) 285-293
    • (2007) J. Control. Release , vol.118 , pp. 285-293
    • Hallow, D.M.1    Mahajan, A.D.2    Prausnitz, M.R.3
  • 98
  • 99
    • 36349003379 scopus 로고    scopus 로고
    • Hydrodynamic gene delivery: its principles and applications
    • Suda T., and Liu D. Hydrodynamic gene delivery: its principles and applications. Mol. Ther. 15 (2007) 2063-2069
    • (2007) Mol. Ther. , vol.15 , pp. 2063-2069
    • Suda, T.1    Liu, D.2
  • 100
    • 0030453791 scopus 로고    scopus 로고
    • Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion
    • Tsurumi Y., Takeshita S., Chen D., Kearney M., Rossow S.T., Passeri J., Horowitz J.R., Symes J.F., and Isner J.M. Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion. Circulation 94 (1996) 3281-3290
    • (1996) Circulation , vol.94 , pp. 3281-3290
    • Tsurumi, Y.1    Takeshita, S.2    Chen, D.3    Kearney, M.4    Rossow, S.T.5    Passeri, J.6    Horowitz, J.R.7    Symes, J.F.8    Isner, J.M.9
  • 102
    • 0036227368 scopus 로고    scopus 로고
    • Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle
    • Taniyama Y., Tachibana K., Hiraoka K., Aoki M., Yamamoto S., Matsumoto K., Nakamura T., Ogihara T., Kaneda Y., and Morishita R. Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle. Gene Ther. 9 (2002) 372-380
    • (2002) Gene Ther. , vol.9 , pp. 372-380
    • Taniyama, Y.1    Tachibana, K.2    Hiraoka, K.3    Aoki, M.4    Yamamoto, S.5    Matsumoto, K.6    Nakamura, T.7    Ogihara, T.8    Kaneda, Y.9    Morishita, R.10
  • 104
    • 0242441584 scopus 로고    scopus 로고
    • Microbubble-enhanced sonoporation: efficient gene transduction technique for chick embryos
    • Ohta S., Suzuki K., Tachibana K., and Yamada G. Microbubble-enhanced sonoporation: efficient gene transduction technique for chick embryos. Genesis 37 (2003) 91-101
    • (2003) Genesis , vol.37 , pp. 91-101
    • Ohta, S.1    Suzuki, K.2    Tachibana, K.3    Yamada, G.4
  • 107
    • 33745111263 scopus 로고    scopus 로고
    • Sustained transgene expression in intervertebral disc cells in vivo mediated by microbubble-enhanced ultrasound gene therapy
    • Nishida K., Doita M., Takada T., Kakutani K., Miyamoto H., Shimomura T., Maeno K., and Kurosaka M. Sustained transgene expression in intervertebral disc cells in vivo mediated by microbubble-enhanced ultrasound gene therapy. Spine 31 (2006) 1415-1419
    • (2006) Spine , vol.31 , pp. 1415-1419
    • Nishida, K.1    Doita, M.2    Takada, T.3    Kakutani, K.4    Miyamoto, H.5    Shimomura, T.6    Maeno, K.7    Kurosaka, M.8
  • 109
    • 28844435295 scopus 로고    scopus 로고
    • Delivery of oligodeoxynucleotides into human saphenous veins and the adjunct effect of ultrasound and microbubbles
    • Kodama T., Tan P.H., Offiah I., Partridge T., Cook T., George A.J., and Blomley M.J. Delivery of oligodeoxynucleotides into human saphenous veins and the adjunct effect of ultrasound and microbubbles. Ultrasound Med. Biol. 31 (2005) 1683-1691
    • (2005) Ultrasound Med. Biol. , vol.31 , pp. 1683-1691
    • Kodama, T.1    Tan, P.H.2    Offiah, I.3    Partridge, T.4    Cook, T.5    George, A.J.6    Blomley, M.J.7
  • 110
    • 0345862002 scopus 로고    scopus 로고
    • Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubbles
    • Christiansen J.P., French B.A., Klibanov A.L., Kaul S., and Lindner J.R. Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubbles. Ultrasound Med. Biol. 29 (2003) 1759-1767
    • (2003) Ultrasound Med. Biol. , vol.29 , pp. 1759-1767
    • Christiansen, J.P.1    French, B.A.2    Klibanov, A.L.3    Kaul, S.4    Lindner, J.R.5
  • 114
    • 0037022843 scopus 로고    scopus 로고
    • Vascular gene transfer of phosphomimetic endothelial nitric oxide synthase (s1177d) using ultrasound-enhanced destruction of plasmid-loaded microbubbles improves vasoreactivity
    • Teupe C., Richter S., Fisslthaler B., Randriamboavonjy V., Ihling C., Fleming I., Busse R., Zeiher A.M., and Dimmeler S. Vascular gene transfer of phosphomimetic endothelial nitric oxide synthase (s1177d) using ultrasound-enhanced destruction of plasmid-loaded microbubbles improves vasoreactivity. Circulation 105 (2002) 1104-1109
    • (2002) Circulation , vol.105 , pp. 1104-1109
    • Teupe, C.1    Richter, S.2    Fisslthaler, B.3    Randriamboavonjy, V.4    Ihling, C.5    Fleming, I.6    Busse, R.7    Zeiher, A.M.8    Dimmeler, S.9
  • 115
    • 0041857832 scopus 로고    scopus 로고
    • Ultrasound-targeted microbubble destruction can repeatedly direct highly specific plasmid expression to the heart
    • Bekeredjian R., Chen S., Frenkel P.A., Grayburn P.A., and Shohet R.V. Ultrasound-targeted microbubble destruction can repeatedly direct highly specific plasmid expression to the heart. Circulation 108 (2003) 1022-1026
    • (2003) Circulation , vol.108 , pp. 1022-1026
    • Bekeredjian, R.1    Chen, S.2    Frenkel, P.A.3    Grayburn, P.A.4    Shohet, R.V.5
  • 116
    • 0034612205 scopus 로고    scopus 로고
    • Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium
    • Shohet R.V., Chen S., Zhou Y.T., Wang Z., Meidell R.S., Unger R.H., and Grayburn P.A. Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium. Circulation 101 (2000) 2554-2556
    • (2000) Circulation , vol.101 , pp. 2554-2556
    • Shohet, R.V.1    Chen, S.2    Zhou, Y.T.3    Wang, Z.4    Meidell, R.S.5    Unger, R.H.6    Grayburn, P.A.7
  • 117
    • 0036518709 scopus 로고    scopus 로고
    • Ultrasound-mediated transfection of canine myocardium by intravenous administration of cationic microbubble-linked plasmid DNA
    • Vannan M., McCreery T., Li P., Han Z., Unger E., Kuersten B., Nabel E., and Rajagopalan S. Ultrasound-mediated transfection of canine myocardium by intravenous administration of cationic microbubble-linked plasmid DNA. J. Am. Soc. Echocardiogr. 15 (2002) 214-218
    • (2002) J. Am. Soc. Echocardiogr. , vol.15 , pp. 214-218
    • Vannan, M.1    McCreery, T.2    Li, P.3    Han, Z.4    Unger, E.5    Kuersten, B.6    Nabel, E.7    Rajagopalan, S.8
  • 118
    • 0036020090 scopus 로고    scopus 로고
    • DNA-loaded albumin microbubbles enhance ultrasound-mediated transfection in vitro
    • Frenkel P.A., Chen S., Thai T., Shohet R.V., and Grayburn P.A. DNA-loaded albumin microbubbles enhance ultrasound-mediated transfection in vitro. Ultrasound Med. Biol. 28 (2002) 817-822
    • (2002) Ultrasound Med. Biol. , vol.28 , pp. 817-822
    • Frenkel, P.A.1    Chen, S.2    Thai, T.3    Shohet, R.V.4    Grayburn, P.A.5
  • 120
    • 0038826285 scopus 로고    scopus 로고
    • Optimization of ultrasound parameters for cardiac gene delivery of adenoviral or plasmid deoxyribonucleic acid by ultrasound-targeted microbubble destruction
    • Chen S., Shohet R.V., Bekeredjian R., Frenkel P., and Grayburn P.A. Optimization of ultrasound parameters for cardiac gene delivery of adenoviral or plasmid deoxyribonucleic acid by ultrasound-targeted microbubble destruction. J. Am. Coll. Cardiol. 42 (2003) 301-308
    • (2003) J. Am. Coll. Cardiol. , vol.42 , pp. 301-308
    • Chen, S.1    Shohet, R.V.2    Bekeredjian, R.3    Frenkel, P.4    Grayburn, P.A.5
  • 121
    • 13244274387 scopus 로고    scopus 로고
    • Augmentation of cardiac protein delivery using ultrasound targeted microbubble destruction
    • Bekeredjian R., Chen S., Grayburn P.A., and Shohet R.V. Augmentation of cardiac protein delivery using ultrasound targeted microbubble destruction. Ultrasound Med. Biol. 31 (2005) 687-691
    • (2005) Ultrasound Med. Biol. , vol.31 , pp. 687-691
    • Bekeredjian, R.1    Chen, S.2    Grayburn, P.A.3    Shohet, R.V.4
  • 122
    • 0037215799 scopus 로고    scopus 로고
    • Ultrasound-targeted antisense oligonucleotide attenuates ischemia/reperfusion-induced myocardial tumor necrosis factor-alpha
    • Erikson J.M., Freeman G.L., and Chandrasekar B. Ultrasound-targeted antisense oligonucleotide attenuates ischemia/reperfusion-induced myocardial tumor necrosis factor-alpha. J. Mol. Cell. Cardiol. 35 (2003) 119-130
    • (2003) J. Mol. Cell. Cardiol. , vol.35 , pp. 119-130
    • Erikson, J.M.1    Freeman, G.L.2    Chandrasekar, B.3
  • 124
    • 11144356848 scopus 로고    scopus 로고
    • Local delivery of E2F decoy oligodeoxynucleotides using ultrasound with microbubble agent (Optison) inhibits intimal hyperplasia after balloon injury in rat carotid artery model
    • Hashiya N., Aoki M., Tachibana K., Taniyama Y., Yamasaki K., Hiraoka K., Makino H., Yasufumi K., Ogihara T., and Morishita R. Local delivery of E2F decoy oligodeoxynucleotides using ultrasound with microbubble agent (Optison) inhibits intimal hyperplasia after balloon injury in rat carotid artery model. Biochem. Biophys. Res. Commun. 317 (2004) 508-514
    • (2004) Biochem. Biophys. Res. Commun. , vol.317 , pp. 508-514
    • Hashiya, N.1    Aoki, M.2    Tachibana, K.3    Taniyama, Y.4    Yamasaki, K.5    Hiraoka, K.6    Makino, H.7    Yasufumi, K.8    Ogihara, T.9    Morishita, R.10
  • 127
    • 0032044082 scopus 로고    scopus 로고
    • MRX-501: a novel ultrasound contrast agent with therapeutic properties
    • Unger E.C., McCreery T.P., and Sweitzer R.H. MRX-501: a novel ultrasound contrast agent with therapeutic properties. Acad. Radiol. 5 suppl.1 (1998) S247-S249
    • (1998) Acad. Radiol. , vol.5 , Issue.SUPPL.1
    • Unger, E.C.1    McCreery, T.P.2    Sweitzer, R.H.3
  • 128
    • 0032470386 scopus 로고    scopus 로고
    • Acoustically active lipospheres containing paclitaxel: a new therapeutic ultrasound contrast agent
    • Unger E.C., McCreery T.P., Sweitzer R.H., Caldwell V.E., and Wu Y. Acoustically active lipospheres containing paclitaxel: a new therapeutic ultrasound contrast agent. Invest. Radiol. 33 (1998) 886-892
    • (1998) Invest. Radiol. , vol.33 , pp. 886-892
    • Unger, E.C.1    McCreery, T.P.2    Sweitzer, R.H.3    Caldwell, V.E.4    Wu, Y.5
  • 130
    • 0032078351 scopus 로고    scopus 로고
    • Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: effect of the protein and polymer properties and of the co-encapsulation of surfactants
    • Blanco D., and Alonso M.J. Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: effect of the protein and polymer properties and of the co-encapsulation of surfactants. Eur. J. Pharm. Biopharm. 45 (1998) 285-294
    • (1998) Eur. J. Pharm. Biopharm. , vol.45 , pp. 285-294
    • Blanco, D.1    Alonso, M.J.2
  • 131
    • 0034602127 scopus 로고    scopus 로고
    • Influence of the co-encapsulation of different non-ionic surfactants on the properties of PLGA insulin-loaded microspheres
    • Rosa G.D., Iommelli R., La Rotonda M.I., Miro A., and Quaglia F. Influence of the co-encapsulation of different non-ionic surfactants on the properties of PLGA insulin-loaded microspheres. J. Control. Release 69 (2000) 283-295
    • (2000) J. Control. Release , vol.69 , pp. 283-295
    • Rosa, G.D.1    Iommelli, R.2    La Rotonda, M.I.3    Miro, A.4    Quaglia, F.5
  • 132
    • 0032994945 scopus 로고    scopus 로고
    • Optimization of preparative conditions for poly-dl-lactide-polyethylene glycol microspheres with entrapped vibrio cholera antigens
    • Deng X.M., Li X.H., Yuan M.L., Xiong C.D., Huang Z.T., Jia W.X., and Zhang Y.H. Optimization of preparative conditions for poly-dl-lactide-polyethylene glycol microspheres with entrapped vibrio cholera antigens. J. Control. Release 58 (1999) 123-131
    • (1999) J. Control. Release , vol.58 , pp. 123-131
    • Deng, X.M.1    Li, X.H.2    Yuan, M.L.3    Xiong, C.D.4    Huang, Z.T.5    Jia, W.X.6    Zhang, Y.H.7
  • 133
    • 0034738791 scopus 로고    scopus 로고
    • Influence of process parameters on the protein stability encapsulated in poly-dl-lactide-poly(ethylene glycol) microspheres
    • Li X., Zhang Y., Yan R., Jia W., Yuan M., Deng X., and Huang Z. Influence of process parameters on the protein stability encapsulated in poly-dl-lactide-poly(ethylene glycol) microspheres. J. Control. Release 68 (2000) 41-52
    • (2000) J. Control. Release , vol.68 , pp. 41-52
    • Li, X.1    Zhang, Y.2    Yan, R.3    Jia, W.4    Yuan, M.5    Deng, X.6    Huang, Z.7
  • 134
    • 0035053516 scopus 로고    scopus 로고
    • In vitro protein release and degradation of poly-dl-lactide-poly(ethylene glycol) microspheres with entrapped human serum albumin: quantitative evaluation of the factors involved in protein release phases
    • Li X., Deng X., and Huang Z. In vitro protein release and degradation of poly-dl-lactide-poly(ethylene glycol) microspheres with entrapped human serum albumin: quantitative evaluation of the factors involved in protein release phases. Pharm. Res. 18 (2001) 117-124
    • (2001) Pharm. Res. , vol.18 , pp. 117-124
    • Li, X.1    Deng, X.2    Huang, Z.3
  • 135
    • 0033919959 scopus 로고    scopus 로고
    • Effects of salt addition on the microencapsulation of proteins using w/o/w double emulsion technique
    • Pistel K.F., and Kissel T. Effects of salt addition on the microencapsulation of proteins using w/o/w double emulsion technique. J. Microencapsul. 17 (2000) 467-483
    • (2000) J. Microencapsul. , vol.17 , pp. 467-483
    • Pistel, K.F.1    Kissel, T.2
  • 136
    • 0035907172 scopus 로고    scopus 로고
    • Brush-like branched biodegradable polyesters, part III. Protein release from microspheres of poly(vinyl alcohol)-graft-poly(d,l-lactic-co-glycolic acid)
    • Frauke Pistel K., Breitenbach A., Zange-Volland R., and Kissel T. Brush-like branched biodegradable polyesters, part III. Protein release from microspheres of poly(vinyl alcohol)-graft-poly(d,l-lactic-co-glycolic acid). J. Control. Release 73 (2001) 7-20
    • (2001) J. Control. Release , vol.73 , pp. 7-20
    • Frauke Pistel, K.1    Breitenbach, A.2    Zange-Volland, R.3    Kissel, T.4
  • 137
    • 0034601882 scopus 로고    scopus 로고
    • Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method
    • Yang Y.Y., Chia H.H., and Chung T.S. Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method. J. Control. Release 69 (2000) 81-96
    • (2000) J. Control. Release , vol.69 , pp. 81-96
    • Yang, Y.Y.1    Chia, H.H.2    Chung, T.S.3
  • 139
    • 34547813763 scopus 로고    scopus 로고
    • Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy
    • Rapoport N., Gao Z., and Kennedy A. Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy. J. Natl. Cancer Inst. 99 (2007) 1095-1106
    • (2007) J. Natl. Cancer Inst. , vol.99 , pp. 1095-1106
    • Rapoport, N.1    Gao, Z.2    Kennedy, A.3
  • 141
    • 33344477285 scopus 로고    scopus 로고
    • Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubbles
    • Lum A.F., Borden M.A., Dayton P.A., Kruse D.E., Simon S.I., and Ferrara K.W. Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubbles. J. Control. Release 111 (2006) 128-134
    • (2006) J. Control. Release , vol.111 , pp. 128-134
    • Lum, A.F.1    Borden, M.A.2    Dayton, P.A.3    Kruse, D.E.4    Simon, S.I.5    Ferrara, K.W.6
  • 142
    • 33947302582 scopus 로고    scopus 로고
    • Acoustically-active microbubbles conjugated to liposomes: characterization of a proposed drug delivery vehicle
    • Kheirolomoom A., Dayton P.A., Lum A.F., Little E., Paoli E.E., Zheng H., and Ferrara K.W. Acoustically-active microbubbles conjugated to liposomes: characterization of a proposed drug delivery vehicle. J. Control. Release 118 (2007) 275-284
    • (2007) J. Control. Release , vol.118 , pp. 275-284
    • Kheirolomoom, A.1    Dayton, P.A.2    Lum, A.F.3    Little, E.4    Paoli, E.E.5    Zheng, H.6    Ferrara, K.W.7
  • 144
    • 33748782179 scopus 로고    scopus 로고
    • Development of a novel microbubble agent for ultrasound-mediated targeted drug delivery
    • Lewis C.W., McConaughy J., Rinkevich D., Klibanov A.L., and Lindner J.R. Development of a novel microbubble agent for ultrasound-mediated targeted drug delivery. Circulation 110 suppl 5 (2004) 511
    • (2004) Circulation , vol.110 , Issue.SUPPL. 5 , pp. 511
    • Lewis, C.W.1    McConaughy, J.2    Rinkevich, D.3    Klibanov, A.L.4    Lindner, J.R.5
  • 145
    • 0038329331 scopus 로고    scopus 로고
    • Controlled vesicle deformation and lysis by single oscillating bubbles
    • Marmottant P., and Hilgenfeldt S. Controlled vesicle deformation and lysis by single oscillating bubbles. Nature 423 (2003) 153-156
    • (2003) Nature , vol.423 , pp. 153-156
    • Marmottant, P.1    Hilgenfeldt, S.2
  • 146
    • 14744278053 scopus 로고    scopus 로고
    • High-speed optical observations of contrast agent destruction
    • Bouakaz A., Versluis M., and de Jong N. High-speed optical observations of contrast agent destruction. Ultrasound Med. Biol. 31 (2005) 391-399
    • (2005) Ultrasound Med. Biol. , vol.31 , pp. 391-399
    • Bouakaz, A.1    Versluis, M.2    de Jong, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.