Transdermal delivery of heparin and low-molecular weight heparin using low-frequency ultrasound

Pharmaceutical Research

Volumn 18, Issue 8, 2001, Pages 1151-1156

  Mitragotri, S ^a   Kost, J ^b,c  

^a University of California at Santa Barbara   (United States)

^b Sontra Medical Inc   (United States)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Heparin; Low molecular weight heparin; Sonophoresis; Thrombosis; Ultrasound

Indexed keywords

ANTICOAGULANT AGENT; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING TIME; CONTROLLED STUDY; DRUG PENETRATION; FEMALE; GEL ELECTROPHORESIS; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN PERMEABILITY; SWINE; ULTRASOUND;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION; ELECTRIC CONDUCTIVITY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HEPARIN; HEPARIN, LOW-MOLECULAR-WEIGHT; INULIN; MALE; RATS; RATS, SPRAGUE-DAWLEY; SKIN ABSORPTION; SWINE; ULTRASONICS;

EID: 0034813451     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010979010907     Document Type: Article

References (15)

1. Low-molecular weight heparins: An overview of their pharmacodynamics, pharmacokinetics and metabolism in humans
2. Transdermal delivery of heparin by skin electroporation
3. Ultrasound-mediated transdermal protein delivery
4. A mechanistic study of ultrasonically enhanced transdermal drug delivery
5. Sonophoresis. I. The use of high-frequency ultrasound to enhance transdermal drug delivery
6. Sonophoresis. II. Examination of the mechanism(s) of ultrasound-enhanced transdermal drug delivery
7. Transdermal delivery of insulin to alloxan-diabetc rabbits by ultrasound exposure
8. Synergistic effect of ultrasound and sodium lauryl sulfate on transdermal drug delivery
9. Low-frequency sonophoresis: A non-invasive method for drug delivery and diagnostics
10. Determination of the threshold energy dose for ultrasound-induced transdermal drug delivery
11. Gradient polyacrylamide gel electrophoresis for determination of molecular weights of heparin preparations and low-molecular weight heparin derivatives
12. Transdermal extraction of glucose and other analytes using ultrasound
13. Comparison of the pharmacodynamic and pharmacokinetic profiles of two low-molecular-mass heparins in rats