Function of an implanted tissue glucose sensor for more than 1 year in animals

Science Translational Medicine

Volumn 2, Issue 42, 2010, Pages

  Gough, David A ^a   Kumosa, Lucas S ^a   Routh, Timothy L ^b   Lin, Joe T ^b   Lucisano, Joseph Y ^b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b GlySens Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; OXYGEN;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALIBRATION; CONTROLLED STUDY; ELECTROCHEMICAL DETECTION; ELECTRONIC SENSOR; ENCAPSULATION; ENZYME ELECTRODE; GLUCOSE BLOOD LEVEL; IMPLANTATION; INSULIN DEPENDENT DIABETES MELLITUS; INTRAVENOUS GLUCOSE TOLERANCE TEST; MICROVASCULATURE; MONITORING; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SIGNAL PROCESSING; STREPTOZOCIN DIABETES; SUBCUTANEOUS TISSUE; SWINE; TELEMETRY; TISSUE GLUCOSE SENSOR; TISSUE LEVEL; TISSUE PERFUSION; ANIMAL; GENETIC PROCEDURES; METABOLISM; METHODOLOGY; PROSTHESES AND ORTHOSES;

ANIMALS; BIOSENSING TECHNIQUES; GLUCOSE; PROSTHESES AND IMPLANTS; SWINE;

EID: 77955600560     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3001148     Document Type: Article

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38. Funding: This work was supported by grants DK64570 and DK77101 [University of California San Diego (UCSD)] and DK77254 (GlySens) from the NIH. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Diabetes and Digestive and Kidney Diseases or the NIH. Early research was supported by grants from the Juvenile Diabetes Research Foundation. Author contributions: Sensor design was done by D.A.G., J.Y.L., J.T.L., and T.L.R.; animal studies were conducted by J.T.L., T.L.R., and J.Y.L.; histology samples were processed and images were prepared by L.S.K.; device fabrication was carried out by T.L.R., J.T.L., and J.Y.L.; all authors participated in data analysis and manuscript preparation. Competing interests: D.A.G. is founder and consultant to GlySens Incorporated, an arrangement approved by UCSD in accordance with its conflict of interest policies. He is a co-inventor of patents related to the device reported here. J.Y.L. is the president and CEO of GlySens Incorporated and a co-inventor of patents related to the device. D.A.G., J.T.L., J.Y.L., and T.L.R. have equity interests in GlySens. GlySens is the owner and developer of the device and licensee of intellectual property for some aspects of the technology from UCSD. UCSD holds three patents related to this work.