Ultrasound-triggered release of materials entrapped in microbubble-liposome constructs: A tool for targeted drug delivery

Journal of Controlled Release

Volumn 148, Issue 1, 2010, Pages 13-17

  Klibanov, Alexander L ^a   Shevchenko, Talent I ^a   Raju, Balasundar I ^b   Seip, Ralf ^b   Chin, Chien T ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b PHILIPS RESEARCH LABORATORIES   (Netherlands)

Author keywords

Calcein; Clotting; Liposomes; Microbubbles; Thrombin; Triggered release; Ultrasound

Indexed keywords

CALCEIN; CLOTTING; MICROBUBBLES; THROMBIN; TRIGGERED RELEASE; ULTRASOUND;

DRUG DELIVERY; LIPOSOMES; PHOSPHOLIPIDS;

ULTRASONICS;

CALCEIN; LIPOSOME; THROMBIN;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG RELEASE; FLUORESCENCE ANALYSIS; IN VITRO STUDY; MICROBUBBLE; PRIORITY JOURNAL; ULTRASOUND;

ANIMALS; DOGS; DRUG DELIVERY SYSTEMS; FLUORESCEINS; FLUORESCENCE; LIPOSOMES; MICROBUBBLES; THROMBIN; ULTRASONICS;

EID: 78649375767     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.07.115     Document Type: Article

References (27)

1. Unger E.C., McCreery T.P., Sweitzer R.H., Caldwell V.E., Wu Y. Acoustically active lipospheres containing paclitaxel: a new therapeutic ultrasound contrast agent. Invest. Radiol. 1998, 33:886-892.
2. Tartis M.S., McCallan J., Lum A.F., LaBell R., Stieger S.M., Matsunaga T.O., Ferrara K.W. Therapeutic effects of paclitaxel-containing ultrasound contrast agents. Ultrasound Med. Biol. 2006, 32:1771-1780.
3. McCreery T.P., Sweitzer R.H., Unger E.C., Sullivan S. DNA delivery to cells in vivo by ultrasound. Methods Mol. Biol. 2004, 245:293-298.
4. Christiansen J.P., French B.A., Klibanov A.L., Kaul S., Lindner J.R. Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubbles. Ultrasound Med. Biol. 2003, 29:1759-1767.
5. Leong-Poi H., Kuliszewski M.A., Lekas M., Sibbald M., Teichert-Kuliszewska K., Klibanov A.L., Stewart D.J., Lindner J.R. Therapeutic arteriogenesis by ultrasound-mediated VEGF165 plasmid gene delivery to chronically ischemic skeletal muscle. Circ. Res. 2007, 101:295-303.
6. Klibanov A.L., Rinkevich D., McConaughy J., Lewis C.W., Lindner J.R., Kaul S. Triggered release of microbubble-associated material: site-targeted drug release and deposition. Controlled Release Society 31st Annual Meeting Transactions, Honolulu 2004, 735.
7. Lewis C.W., McConaughy J., Rinkevich D., Klibanov A.L., Lindner J.R. Development of a novel microbubble agent for ultrasound-mediated targeted drug delivery. Circulation 2004, 110:511.
8. Marmottant P., Hilgenfeldt S. Controlled vesicle deformation and lysis by single oscillating bubbles. Nature 2003, 423:153-156.
9. Lentacker I., Geers B., Demeester J., De Smedt S.C., Sanders N.N. Design and evaluation of doxorubicin-containing microbubbles for ultrasound-triggered doxorubicin delivery: cytotoxicity and mechanisms involved. Mol. Ther. 2010, 18:101-108.
10. Klibanov A.L., Rychak J.J., Yang W.C., Alikhani S., Li B., Acton S., Lindner J.R., Ley K., Kaul S. Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow. Contrast Media Mol. Imaging 2006, 1:259-266.
11. Rengel R.G., Barisic K., Pavelic Z., Grubisic T.Z., Cepelak I., Filipovic-Grcic J. High efficiency entrapment of superoxide dismutase into mucoadhesive chitosan-coated liposomes. Eur. J. Pharm. Sci. 2002, 15:441-448.
12. Szoka F., Papahadjopoulos D. Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proc. Natl Acad. Sci. U.S.A. 1978, 75:4194-4198.
13. Maruyama K., Suzuki R., Takizawa T., Utoguchi N., Negishi Y. Drug and gene delivery by "bubble liposomes" and ultrasound. Yakugaku Zasshi 2007, 127:781-787.
14. Hauck M.L., LaRue S.M., Petros W.P., Poulson J.M., Yu D., Spasojevic I., Pruitt A.F., Klein A., Case B., Thrall D.E., Needham D., Dewhirst M.W. Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors. Clin. Cancer Res. 2006, 12:4004-4010.
15. Dromi S., Frenkel V., Luk A., Traughber B., Angstadt M., Bur M., Poff J., Xie J.W., Libutti S.K., Li K.C.P., Wood B.J. Pulsed-high intensity focused ultrasound and low temperature sensitive liposomes for enhanced targeted drug delivery and antitumor effect. Clin. Cancer Res. 2007, 13:2722-2727.
16. McDannold N., Clement G.T., Black P., Jolesz F., Hynynen K. Transcranial magnetic resonance imaging-guided focused ultrasound surgery of brain tumors: initial findings in 3 patients. Neurosurgery 2010, 66:323-332.
17. Yuh E.L., Shulman S.G., Mehta S.A., Xie J., Chen L., Frenkel V., Bednarski M.D., Li K.C. Delivery of systemic chemotherapeutic agent to tumors by using focused ultrasound: study in a murine model. Radiology 2005, 234:431-437.
18. Monsky W.L., Kruskal J.B., Lukyanov A.N., Girnun G.D., Ahmed M., Gazelle G.S., Huertas J.C., Stuart K.E., Torchilin V.P., Goldberg S.N. Radio-frequency ablation increases intratumoral liposomal doxorubicin accumulation in a rat breast tumor model. Radiology 2002, 224:823-829.
19. Rapoport N., Gao Z., Kennedy A. Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy. J. Natl. Cancer Inst. 2007, 99:1095-1106.
20. Lentacker I., Wang N., Vandenbroucke R.E., Demeester J., De Smedt S.C., Sanders N.N. Ultrasound exposure of lipoplex loaded microbubbles facilitates direct cytoplasmic entry of the lipoplexes. Mol. Pharm. 2009, 6:457-467.
21. Chomas J.E., Dayton P.A., May D., Allen J., Klibanov A., Ferrara K. Optical observation of contrast agent destruction. Appl. Phys. Lett. 2000, 77:1056-1058.
22. Meijering B.D., Juffermans L.J., van Wamel A., Henning R.H., Zuhorn I.S., Emmer M., Versteilen A.M., Paulus W.J., van Gilst W.H., Kooiman K., de Jong N., Musters R.J., Deelman L.E., Kamp O. Ultrasound and microbubble-targeted delivery of macromolecules is regulated by induction of endocytosis and pore formation. Circ. Res. 2009, 104:679-687.
23. Klibanov A.L., Maruyama K., Torchilin V.P., Huang L. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett. 1990, 268:235-237.
24. Klibanov A.L., Maruyama K., Beckerleg A.M., Torchilin V.P., Huang L. Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target. Biochim. Biophys. Acta 1991, 1062:142-148.
25. Tartis M.S., Kruse D.E., Zheng H., Zhang H., Kheirolomoom A., Marik J., Ferrara K.W. Dynamic microPET imaging of ultrasound contrast agents and lipid delivery. J. Controlled Release 2008, 131:160-166.
26. Dienst A., Grunow A., Unruh M., Rabausch B., Nor J.E., Fries J.W., Gottstein C. Specific occlusion of murine and human tumor vasculature by VCAM-1-targeted recombinant fusion proteins. J. Natl. Cancer Inst. 2005, 97:733-747.
27. Ran S., Downes A., Thorpe P.E. Increased exposure of anionic phospholipids on the surface of tumor blood vessels. Cancer Res. 2002, 62:6132-6140.