메뉴 건너뛰기




Volumn 12, Issue 9, 2016, Pages 543-558

The inflammatory role of phagocyte apoptotic pathways in rheumatic diseases

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; CHEMOKINE; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR5; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INFLAMMASOME; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TRANSFORMING GROWTH FACTOR BETA; APOPTOSIS REGULATORY PROTEIN; FADD PROTEIN, MOUSE; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS PROTEIN, MOUSE; FLICE INHIBITORY PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6;

EID: 84983436115     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2016.132     Document Type: Review
Times cited : (54)

References (199)
  • 1
    • 38149138096 scopus 로고    scopus 로고
    • Estimates of the prevalence of arthritis and other rheumatic conditions in the United States
    • Helmick, C. G., et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum. 58, 15-25 (2008
    • (2008) Part I. Arthritis Rheum , vol.58 , pp. 15-25
    • Helmick, C.G.1
  • 2
    • 34247570854 scopus 로고    scopus 로고
    • Cells of the synovium in rheumatoid arthritis T lymphocytes
    • Lundy, S. K., Sarkar, S., Tesmer, L. A., & Fox, D. A. Cells of the synovium in rheumatoid arthritis. T lymphocytes. Arthritis Res. Ther. 9, 202 (2007
    • (2007) Arthritis Res. Ther , vol.9 , pp. 202
    • Lundy, S.K.1    Sarkar, S.2    Tesmer, L.A.3    Fox, D.A.4
  • 3
    • 76249095169 scopus 로고    scopus 로고
    • Development of monocytes, macrophages, and dendritic cells
    • Geissmann, F., et al. Development of monocytes, macrophages, and dendritic cells. Science 327, 656-661 (2010
    • (2010) Science , vol.327 , pp. 656-661
    • Geissmann, F.1
  • 4
    • 84875225901 scopus 로고    scopus 로고
    • Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense
    • Farache, J., Zigmond, E., Shakhar, G., & Jung, S. Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense. Immunol. Cell Biol. 91, 232-239 (2013
    • (2013) Immunol. Cell Biol , vol.91 , pp. 232-239
    • Farache, J.1    Zigmond, E.2    Shakhar, G.3    Jung, S.4
  • 5
    • 80054899779 scopus 로고    scopus 로고
    • Phenotypic and functional plasticity of cells of innate immunity: Macrophages, mast cells and neutrophils
    • Galli, S. J., Borregaard, N., & Wynn, T. A. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat. Immunol. 12, 1035-1044 (2011
    • (2011) Nat. Immunol , vol.12 , pp. 1035-1044
    • Galli, S.J.1    Borregaard, N.2    Wynn, T.A.3
  • 6
    • 0029810201 scopus 로고    scopus 로고
    • The role of macrophages in chronic arthritis
    • van den Berg, W. B., & van Lent, P. L. E. M. The role of macrophages in chronic arthritis. Immunbiol. 195, 614-623 (1996
    • (1996) Immunbiol , vol.195 , pp. 614-623
    • Van Den Berg, W.B.1    Van Lent, P.L.E.M.2
  • 7
    • 77958185103 scopus 로고    scopus 로고
    • Nomenclature of monocytes and dendritic cells in blood
    • Ziegler-Heitbrock, L., et al. Nomenclature of monocytes and dendritic cells in blood. Blood 116, e74-80 (2010
    • (2010) Blood , vol.116 , pp. e74-80
    • Ziegler-Heitbrock, L.1
  • 8
    • 0030066502 scopus 로고    scopus 로고
    • Synovial tissue macrophage populations and articular damage in rheumatoid arthritis
    • Mulherin, D., Fitzgerald, O., & Bresnihan, B. Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum. 39, 115-124 (1996
    • (1996) Arthritis Rheum , vol.39 , pp. 115-124
    • Mulherin, D.1    Fitzgerald, O.2    Bresnihan, B.3
  • 9
    • 0028158689 scopus 로고
    • Synovial tissue macrophages and joint erosion in rheumatoid arthritis
    • Yanni, G., Whelan, A., Feighery, C., & Bresnihan, B. Synovial tissue macrophages and joint erosion in rheumatoid arthritis. Ann. Rheum. Dis. 53, 39-44 (1994
    • (1994) Ann. Rheum. Dis , vol.53 , pp. 39-44
    • Yanni, G.1    Whelan, A.2    Feighery, C.3    Bresnihan, B.4
  • 10
    • 0035932519 scopus 로고    scopus 로고
    • Cytokine pathways and joint inflammation in rheumatoid arthritis
    • Choy, E. H., & Panayi, G. S. Cytokine pathways and joint inflammation in rheumatoid arthritis. N. Engl. J. Med. 344, 907-916 (2001
    • (2001) N. Engl. J. Med , vol.344 , pp. 907-916
    • Choy, E.H.1    Panayi, G.S.2
  • 11
    • 34547450707 scopus 로고    scopus 로고
    • Increased macrophage activation mediated through toll-like receptors in rheumatoid arthritis
    • Huang, Q., Ma, Y., Adebayo, A., & Pope, R. M. Increased macrophage activation mediated through toll-like receptors in rheumatoid arthritis. Arthritis Rheum. 56, 2192-2201 (2007
    • (2007) Arthritis Rheum , vol.56 , pp. 2192-2201
    • Huang, Q.1    Ma, Y.2    Adebayo, A.3    Pope, R.M.4
  • 12
    • 84873739004 scopus 로고    scopus 로고
    • Ligation of TLR7 by rheumatoid arthritis synovial fluid single strand RNA induces transcription of TNFα in monocytes
    • Chamberlain, N. D., et al. Ligation of TLR7 by rheumatoid arthritis synovial fluid single strand RNA induces transcription of TNFα in monocytes. Ann. Rheum. Dis. 72, 418-426 (2013
    • (2013) Ann. Rheum. Dis , vol.72 , pp. 418-426
    • Chamberlain, N.D.1
  • 13
    • 77956416903 scopus 로고    scopus 로고
    • Toll-like receptor signaling: A potential link among rheumatoid arthritis, systemic lupus, and atherosclerosis
    • Huang, Q., & Pope, R. M. Toll-like receptor signaling: a potential link among rheumatoid arthritis, systemic lupus, and atherosclerosis. J. Leukocyte Biol. 88, 253-262 (2010
    • (2010) J. Leukocyte Biol , vol.88 , pp. 253-262
    • Huang, Q.1    Pope, R.M.2
  • 14
    • 0036845130 scopus 로고    scopus 로고
    • Long-Term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin 1 receptor antagonist) in patients with rheumatoid arthritis: Extension phase of a randomized, double-blind, placebo-controlled trial
    • Nuki, G., Bresnihan, B., Bear, M. B., & McCabe, D. Long-Term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin 1 receptor antagonist) in patients with rheumatoid arthritis: extension phase of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 46, 2838-2846 (2002
    • (2002) Arthritis Rheum , vol.46 , pp. 2838-2846
    • Nuki, G.1    Bresnihan, B.2    Bear, M.B.3    McCabe, D.4
  • 15
    • 0036274944 scopus 로고    scopus 로고
    • Etanercept versus methotrexate in patients with early rheumatoid arthritis: Two-year radiographic and clinical outcomes
    • Genovese, M. C., et al. Etanercept versus methotrexate in patients with early rheumatoid arthritis: two-year radiographic and clinical outcomes. Arthritis Rheum. 46, 1443-1450 (2002
    • (2002) Arthritis Rheum , vol.46 , pp. 1443-1450
    • Genovese, M.C.1
  • 16
    • 18144407623 scopus 로고    scopus 로고
    • Differential expression and response to anti-TNFα treatment of infiltrating versus resident tissue macrophage subsets in autoimmune arthritis
    • De Rycke, L., et al. Differential expression and response to anti-TNFα treatment of infiltrating versus resident tissue macrophage subsets in autoimmune arthritis. J. Pathol. 206, 17-27 (2005
    • (2005) J. Pathol , vol.206 , pp. 17-27
    • De Rycke, L.1
  • 17
    • 33847632067 scopus 로고    scopus 로고
    • Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: Standardization and consistency across centers
    • Bresnihan, B., et al. Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: standardization and consistency across centers. J. Rheumatol. 34, 620-622 (2007
    • (2007) J. Rheumatol , vol.34 , pp. 620-622
    • Bresnihan, B.1
  • 18
    • 36048940661 scopus 로고    scopus 로고
    • Absence of changes in the number of synovial sublining macrophages after ineffective treatment for rheumatoid arthritis: Implications for use of synovial sublining macrophages as a biomarker
    • Wijbrandts, C. A., et al. Absence of changes in the number of synovial sublining macrophages after ineffective treatment for rheumatoid arthritis: implications for use of synovial sublining macrophages as a biomarker. Arthritis Rheum. 56, 3869-3871 (2007
    • (2007) Arthritis Rheum , vol.56 , pp. 3869-3871
    • Wijbrandts, C.A.1
  • 19
    • 84939625807 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic cells in homeostasis
    • Arandjelovic, S., & Ravichandran, K. S. Phagocytosis of apoptotic cells in homeostasis. Nat. Immunol. 16, 907-917 (2015
    • (2015) Nat. Immunol , vol.16 , pp. 907-917
    • Arandjelovic, S.1    Ravichandran, K.S.2
  • 20
    • 51649130783 scopus 로고    scopus 로고
    • Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells
    • Gatza, E., et al. Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells. Blood 112, 1515-1521 (2008
    • (2008) Blood , vol.112 , pp. 1515-1521
    • Gatza, E.1
  • 21
    • 80053156515 scopus 로고    scopus 로고
    • Dendritic cell and macrophage heterogeneity in vivo
    • Hashimoto, D., Miller, J., & Merad, M. Dendritic cell and macrophage heterogeneity in vivo. Immunity 35, 323-335 (2011
    • (2011) Immunity , vol.35 , pp. 323-335
    • Hashimoto, D.1    Miller, J.2    Merad, M.3
  • 22
    • 84930958641 scopus 로고    scopus 로고
    • Understanding the mysterious M2 macrophage through activation markers and effector mechanisms
    • Roszer, T. Understanding the mysterious M2 macrophage through activation markers and effector mechanisms. Mediators Inflamm. 2015, 816460 (2015
    • (2015) Mediators Inflamm , vol.2015 , pp. 816460
    • Roszer, T.1
  • 23
    • 77953268611 scopus 로고    scopus 로고
    • Alternative activation of macrophages: Mechanism and functions
    • Gordon, S., & Martinez, F. O. Alternative activation of macrophages: mechanism and functions. Immunity 32, 593-604 (2010
    • (2010) Immunity , vol.32 , pp. 593-604
    • Gordon, S.1    Martinez, F.O.2
  • 24
    • 79751496064 scopus 로고    scopus 로고
    • Alternative macrophage activation and metabolism
    • Odegaard, J. I., & Chawla, A. Alternative macrophage activation and metabolism. Annu. Rev. Pathol. 6, 275-297 (2011
    • (2011) Annu. Rev. Pathol , vol.6 , pp. 275-297
    • Odegaard, J.I.1    Chawla, A.2
  • 25
    • 84897556094 scopus 로고    scopus 로고
    • The M1 and M2 paradigm of macrophage activation: Time for reassessment
    • Martinez, F. O., & Gordon, S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep. 6, 13 (2014
    • (2014) F1000Prime Rep , vol.6 , pp. 13
    • Martinez, F.O.1    Gordon, S.2
  • 26
    • 84904394690 scopus 로고    scopus 로고
    • Macrophage activation and polarization: Nomenclature and experimental guidelines
    • Murray, P. J., et al. Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines. Immunity 41, 14-20 (2014
    • (2014) Immunity , vol.41 , pp. 14-20
    • Murray, P.J.1
  • 27
    • 84894102230 scopus 로고    scopus 로고
    • Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
    • Xue, J., et al. Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity 40, 274-288 (2014
    • (2014) Immunity , vol.40 , pp. 274-288
    • Xue, J.1
  • 28
    • 0014325451 scopus 로고
    • The origin and kinetics of mononuclear phagocytes
    • van Furth, R., & Cohn, Z. A. The origin and kinetics of mononuclear phagocytes. J. Exp. Med. 128, 415-435 (1968
    • (1968) J. Exp. Med , vol.128 , pp. 415-435
    • Van Furth, R.1    Cohn, Z.A.2
  • 29
    • 0020048105 scopus 로고
    • Demonstration of bone marrow derived cells in synovial lining by means of giant intracellular granules as genetic markers
    • Edwards, J. C., & Willoughby, D. A. Demonstration of bone marrow derived cells in synovial lining by means of giant intracellular granules as genetic markers. Ann. Rheum. Dis. 41, 177-182 (1982
    • (1982) Ann. Rheum. Dis , vol.41 , pp. 177-182
    • Edwards, J.C.1    Willoughby, D.A.2
  • 30
    • 0028339814 scopus 로고
    • The nature and origins of synovium: Experimental approaches to the study of synoviocyte differentiation
    • Edwards, J. C. The nature and origins of synovium: experimental approaches to the study of synoviocyte differentiation. J. Anat. 184, 493-501 (1994
    • (1994) J. Anat , vol.184 , pp. 493-501
    • Edwards, J.C.1
  • 31
    • 84872765982 scopus 로고    scopus 로고
    • Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
    • Yona, S., et al. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity 38, 79-91 (2013
    • (2013) Immunity , vol.38 , pp. 79-91
    • Yona, S.1
  • 32
    • 84859508307 scopus 로고    scopus 로고
    • A lineage of myeloid cells independent of Myb and hematopoietic stem cells
    • Schulz, C., et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 336, 86-90 (2012
    • (2012) Science , vol.336 , pp. 86-90
    • Schulz, C.1
  • 33
    • 78149360132 scopus 로고    scopus 로고
    • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    • Ginhoux, F., et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330, 841-845 (2010
    • (2010) Science , vol.330 , pp. 841-845
    • Ginhoux, F.1
  • 34
    • 84951304572 scopus 로고    scopus 로고
    • The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis
    • Amit, I., Winter, D. R., & Jung, S. The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis. Nat. Immunol. 17, 18-25 (2015
    • (2015) Nat. Immunol , vol.17 , pp. 18-25
    • Amit, I.1    Winter, D.R.2    Jung, S.3
  • 35
    • 84925465211 scopus 로고    scopus 로고
    • Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
    • Gomez Perdiguero, E., et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature 518, 547-551 (2015
    • (2015) Nature , vol.518 , pp. 547-551
    • Gomez Perdiguero, E.1
  • 36
    • 84963490949 scopus 로고    scopus 로고
    • The origin of tissue-resident macrophages: When an erythro-myeloid progenitor is an erythro-myeloid progenitor
    • Gomez Perdiguero, E., et al. The origin of tissue-resident macrophages: when an erythro-myeloid progenitor is an erythro-myeloid progenitor. Immunity 43, 1023-1024 (2015
    • (2015) Immunity , vol.43 , pp. 1023-1024
    • Gomez Perdiguero, E.1
  • 37
    • 84946564588 scopus 로고    scopus 로고
    • Ontogeny of tissue-resident macrophages
    • Hoeffel, G., & Ginhoux, F. Ontogeny of tissue-resident macrophages. Front. Immunol. 6, 486 (2015
    • (2015) Front. Immunol , vol.6 , pp. 486
    • Hoeffel, G.1    Ginhoux, F.2
  • 38
    • 84928189502 scopus 로고    scopus 로고
    • C Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages
    • Hoeffel, G., et al C Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. Immunity 42, 665-678 (2015
    • (2015) Immunity , vol.42 , pp. 665-678
    • Hoeffel, G.1
  • 39
    • 84951284076 scopus 로고    scopus 로고
    • The development and maintenance of resident macrophages
    • Perdiguero, E. G., & Geissmann, F. The development and maintenance of resident macrophages. Nat. Immunol. 17, 2-8 (2015
    • (2015) Nat. Immunol , vol.17 , pp. 2-8
    • Perdiguero, E.G.1    Geissmann, F.2
  • 40
    • 84927613295 scopus 로고    scopus 로고
    • Macrophages: Development and tissue specialization
    • Varol, C., Mildner, A., & Jung, S. Macrophages: development and tissue specialization. Annu. Rev. Immunol. 33, 643-675 (2015
    • (2015) Annu. Rev. Immunol , vol.33 , pp. 643-675
    • Varol, C.1    Mildner, A.2    Jung, S.3
  • 41
    • 84876775203 scopus 로고    scopus 로고
    • Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes
    • Hashimoto, D., et al. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity 38, 792-804 (2013
    • (2013) Immunity , vol.38 , pp. 792-804
    • Hashimoto, D.1
  • 42
    • 79958715229 scopus 로고    scopus 로고
    • Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation
    • Jenkins, S. J., et al. Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science 332, 1284-1288 (2011
    • (2011) Science , vol.332 , pp. 1284-1288
    • Jenkins, S.J.1
  • 43
    • 79960706327 scopus 로고    scopus 로고
    • A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation
    • Davies, L. C., et al. A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation. Eur. J. Immunol. 41, 2155-2164 (2011
    • (2011) Eur. J. Immunol , vol.41 , pp. 2155-2164
    • Davies, L.C.1
  • 44
    • 84878738380 scopus 로고    scopus 로고
    • Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation
    • Davies, L. C., et al. Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nat. Commun. 4, 1886 (2013
    • (2013) Nat. Commun , vol.4 , pp. 1886
    • Davies, L.C.1
  • 45
    • 84919688020 scopus 로고    scopus 로고
    • Nonclassical Ly6C-monocytes drive the development of inflammatory arthritis in mice
    • Misharin, A. V., et al. Nonclassical Ly6C-monocytes drive the development of inflammatory arthritis in mice. Cell Rep. 9, 591-604 (2014
    • (2014) Cell Rep , vol.9 , pp. 591-604
    • Misharin, A.V.1
  • 47
    • 42049089122 scopus 로고    scopus 로고
    • Rheumatoid arthritis synovium contains two subsets of cd83-dc lamp-dendritic cells with distinct cytokine profiles
    • Lebre, M. C., et al. Rheumatoid arthritis synovium contains two subsets of CD83-DC LAMP-dendritic Cells with Distinct Cytokine Profiles. Am. J. Pathol. 172, 940-950 (2008
    • (2008) Am. J. Pathol , vol.172 , pp. 940-950
    • Lebre, M.C.1
  • 48
    • 0030584785 scopus 로고    scopus 로고
    • Functional differentiation of dendritic cells in rheumatoid arthritis: Role of CD86 in the synovium
    • Thomas, R., & Quinn, C. Functional differentiation of dendritic cells in rheumatoid arthritis: role of CD86 in the synovium. J. Immunol. 156, 3074-3086 (1996
    • (1996) J. Immunol , vol.156 , pp. 3074-3086
    • Thomas, R.1    Quinn, C.2
  • 49
    • 0029738136 scopus 로고    scopus 로고
    • Expression and function of CD80 and CD86 costimulator molecules on synovial dendritic cells in chronic arthritis
    • Summers, K. L., O?Donnell, J. L., Williams, L. A., & Hart, D. N. Expression and function of CD80 and CD86 costimulator molecules on synovial dendritic cells in chronic arthritis. Arthritis Rheum. 39, 1287-1291 (1996
    • (1996) Arthritis Rheum , vol.39 , pp. 1287-1291
    • Summers, K.L.1    O'Donnell, J.L.2    Williams, L.A.3    Hart, D.N.4
  • 50
    • 0037093852 scopus 로고    scopus 로고
    • Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: Correlation with selective chemokine expression in rheumatoid synovium
    • Page, G., Lebecque, S., & Miossec, P. Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium. J. Immunol. 168, 5333-5341 (2002
    • (2002) J. Immunol , vol.168 , pp. 5333-5341
    • Page, G.1    Lebecque, S.2    Miossec, P.3
  • 51
    • 9644279660 scopus 로고    scopus 로고
    • Increased FcγRII expression and aberrant tumour necrosis factor α production by mature dendritic cells from patients with active rheumatoid arthritis
    • Radstake, T. R., et al. Increased FcγRII expression and aberrant tumour necrosis factor α production by mature dendritic cells from patients with active rheumatoid arthritis. Ann. Rheum. Dis. 63, 1556-1563 (2004
    • (2004) Ann. Rheum. Dis , vol.63 , pp. 1556-1563
    • Radstake, T.R.1
  • 52
    • 10444278132 scopus 로고    scopus 로고
    • Expression of Toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin 12 and interleukin 18 via interferon-γ
    • Radstake, T. R., et al. Expression of Toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin 12 and interleukin 18 via interferon-γ. Arthritis Rheum. 50, 3856-3865 (2004
    • (2004) Arthritis Rheum , vol.50 , pp. 3856-3865
    • Radstake, T.R.1
  • 53
    • 0036927108 scopus 로고    scopus 로고
    • The natural interferon-α producing cells in systemic lupus erythematosus
    • Ronnblom, L., & Alm, G. V. The natural interferon-α producing cells in systemic lupus erythematosus. Hum. Immunol. 63, 1181-1193 (2002
    • (2002) Hum. Immunol , vol.63 , pp. 1181-1193
    • Ronnblom, L.1    Alm, G.V.2
  • 54
    • 34249712937 scopus 로고    scopus 로고
    • Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: Assignment of a type i interferon signature in a subpopulation of patients
    • van der Pouw Kraan, T. C., et al. Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: assignment of a type I interferon signature in a subpopulation of patients. Ann. Rheum. Dis. 66, 1008-1014 (2007
    • (2007) Ann. Rheum. Dis , vol.66 , pp. 1008-1014
    • Van Der Pouw Kraan, T.C.1
  • 55
    • 67650924246 scopus 로고    scopus 로고
    • Myeloid dendritic cells correlate with clinical response whereas plasmacytoid dendritic cells impact autoantibody development in rheumatoid arthritis patients treated with infliximab
    • Richez, C., et al. Myeloid dendritic cells correlate with clinical response whereas plasmacytoid dendritic cells impact autoantibody development in rheumatoid arthritis patients treated with infliximab. Arthritis Res. Ther. 11, R100 (2009
    • (2009) Arthritis Res. Ther , vol.11 , pp. R100
    • Richez, C.1
  • 56
    • 0028267610 scopus 로고
    • Rheumatoid synovium is enriched in mature antigen-presenting dendritic cells
    • Thomas, R., Davis, L. S., & Lipsky, P. E. Rheumatoid synovium is enriched in mature antigen-presenting dendritic cells. J. Immunol. 152, 2613-2623 (1994
    • (1994) J. Immunol , vol.152 , pp. 2613-2623
    • Thomas, R.1    Davis, L.S.2    Lipsky, P.E.3
  • 57
    • 0033866750 scopus 로고    scopus 로고
    • Differentiated dendritic cells expressing nuclear RelB are predominantly located in rheumatoid synovial tissue perivascular mononuclear cell aggregates
    • Pettit, A. R., MacDonald, K. P., O?Sullivan, B., & Thomas, R. Differentiated dendritic cells expressing nuclear RelB are predominantly located in rheumatoid synovial tissue perivascular mononuclear cell aggregates. Arthritis Rheum. 43, 791-800 (2000
    • (2000) Arthritis Rheum , vol.43 , pp. 791-800
    • Pettit, A.R.1    MacDonald, K.P.2    O'Sullivan, B.3    Thomas, R.4
  • 58
    • 0000785070 scopus 로고
    • Evidence in support of a self-perpetuating HLA DR dependent delayed-Type cell reaction in rheumatoid arthritis
    • Klareskog, L., Forsum, U., Scheynius, A., Kabelitz, D., & Wigzell, H. Evidence in support of a self-perpetuating HLA DR dependent delayed-Type cell reaction in rheumatoid arthritis. Proc. Natl Acad. Sci. USA 79, 3632-3636 (1982
    • (1982) Proc. Natl Acad. Sci. USA , vol.79 , pp. 3632-3636
    • Klareskog, L.1    Forsum, U.2    Scheynius, A.3    Kabelitz, D.4    Wigzell, H.5
  • 59
    • 70350513152 scopus 로고    scopus 로고
    • Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis
    • Jongbloed, S. L., et al. Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis. Arthritis Res. Ther. 8, R15 (2006
    • (2006) Arthritis Res. Ther , vol.8 , pp. R15
    • Jongbloed, S.L.1
  • 60
    • 79952622190 scopus 로고    scopus 로고
    • Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality
    • Remijsen, Q., et al. Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality. Cell Death Differ. 18, 581-588 (2011
    • (2011) Cell Death Differ , vol.18 , pp. 581-588
    • Remijsen, Q.1
  • 61
    • 84902968079 scopus 로고    scopus 로고
    • Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines
    • Schauer, C., et al. Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nat. Med. 20, 511-517 (2014
    • (2014) Nat. Med , vol.20 , pp. 511-517
    • Schauer, C.1
  • 62
    • 0036636094 scopus 로고    scopus 로고
    • Apoptosis as a therapeutic tool in rheumatoid arthritis
    • Pope, R. M. Apoptosis as a therapeutic tool in rheumatoid arthritis. Nat. Rev. Immunol. 2, 527-535 (2002
    • (2002) Nat. Rev. Immunol , vol.2 , pp. 527-535
    • Pope, R.M.1
  • 63
    • 62449202978 scopus 로고    scopus 로고
    • Cell death in rheumatoid arthritis
    • Korb, A., Pavenstadt, H., & Pap, T. Cell death in rheumatoid arthritis. Apoptosis 14, 447-454 (2009
    • (2009) Apoptosis , vol.14 , pp. 447-454
    • Korb, A.1    Pavenstadt, H.2    Pap, T.3
  • 64
    • 34247536682 scopus 로고    scopus 로고
    • The CD95 receptor: Apoptosis revisited
    • Peter, M. E., et al. The CD95 receptor: apoptosis revisited. Cell 129, 447-450 (2007
    • (2007) Cell , vol.129 , pp. 447-450
    • Peter, M.E.1
  • 65
    • 0032544268 scopus 로고    scopus 로고
    • Apoptotic pathways: The roads to ruin
    • Green, D. R. Apoptotic pathways: the roads to ruin. Cell 94, 695-698 (1998
    • (1998) Cell , vol.94 , pp. 695-698
    • Green, D.R.1
  • 67
    • 0037160117 scopus 로고    scopus 로고
    • The long form of FLIP is an activator of caspase 8 at the Fas death-inducing signaling complex
    • Micheau, O., et al. The long form of FLIP is an activator of caspase 8 at the Fas death-inducing signaling complex. J. Biol. Chem. 277, 45162-45171 (2002
    • (2002) J. Biol. Chem , vol.277 , pp. 45162-45171
    • Micheau, O.1
  • 68
    • 0032555716 scopus 로고    scopus 로고
    • Bid, a Bcl 2 interacting protein mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
    • Luo, X., Budihardjo, I., Zou, H., Slaughter, C., & Wang, X. Bid, a Bcl 2 interacting protein mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94, 481-490 (1998
    • (1998) Cell , vol.94 , pp. 481-490
    • Luo, X.1    Budihardjo, I.2    Zou, H.3    Slaughter, C.4    Wang, X.5
  • 69
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf 1/caspase 9 complex initiates an apoptotic protease cascade
    • Li, P., et al. Cytochrome c and dATP-dependent formation of Apaf 1/caspase 9 complex initiates an apoptotic protease cascade. Cell 91, 479-489 (1997
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1
  • 71
    • 0029126857 scopus 로고
    • Apoptosis in rheumatoid arthritis synovium
    • Firestein, G. S. Apoptosis in rheumatoid arthritis synovium. J. Clin. Invest. 96, 1631-1638 (1995
    • (1995) J. Clin. Invest , vol.96 , pp. 1631-1638
    • Firestein, G.S.1
  • 72
    • 0028916863 scopus 로고
    • Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes
    • Nakajima, T., et al. Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes. Arthritis Rheum. 38, 485-491 (1995
    • (1995) Arthritis Rheum , vol.38 , pp. 485-491
    • Nakajima, T.1
  • 73
    • 0031900570 scopus 로고    scopus 로고
    • Soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis
    • Hashmioto, H., et al. Soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum. 41, 657-662 (1998
    • (1998) Arthritis Rheum , vol.41 , pp. 657-662
    • Hashmioto, H.1
  • 74
    • 62849096248 scopus 로고    scopus 로고
    • Susceptibility of rheumatoid arthritis synovial fibroblasts to FasL-And TRAIL-induced apoptosis is cell cycle-dependent
    • Pundt, N., et al. Susceptibility of rheumatoid arthritis synovial fibroblasts to FasL-And TRAIL-induced apoptosis is cell cycle-dependent. Arthritis Res. Ther. 11, R16 (2009
    • (2009) Arthritis Res. Ther , vol.11 , pp. R16
    • Pundt, N.1
  • 75
    • 0030851731 scopus 로고    scopus 로고
    • Deficient Fas ligand expression by synovial lymphocytes from patients with rheumatoid arthritis
    • Cantwell, M. J., Hua, T., Zvaifler, N. J., & Kipps, T. J. Deficient Fas ligand expression by synovial lymphocytes from patients with rheumatoid arthritis. Arthritis Rheum. 40, 1644-1652 (1997
    • (1997) Arthritis Rheum , vol.40 , pp. 1644-1652
    • Cantwell, M.J.1    Hua, T.2    Zvaifler, N.J.3    Kipps, T.J.4
  • 76
    • 14444282195 scopus 로고    scopus 로고
    • Modulation by proinflammatory cytokines of Fas/Fas ligand-mediated apoptotic cell death of synovial cells in patients with rheumatoid arthritis
    • Wakisaka, S., et al. Modulation by proinflammatory cytokines of Fas/Fas ligand-mediated apoptotic cell death of synovial cells in patients with rheumatoid arthritis. Clin. Exp. Immunol. 114, 119-128 (1998
    • (1998) Clin. Exp. Immunol , vol.114 , pp. 119-128
    • Wakisaka, S.1
  • 77
    • 0034083131 scopus 로고    scopus 로고
    • Differential regulation of Fas-mediated apoptosis of rheumatoid synoviocytes by tumor necrosis factor alpha and basic fibroblast growth factor is associated with the expression of apoptosis-related molecules
    • Kobayashi, T., et al. Differential regulation of Fas-mediated apoptosis of rheumatoid synoviocytes by tumor necrosis factor alpha and basic fibroblast growth factor is associated with the expression of apoptosis-related molecules. Arthritis Rheum. 43, 1106-1114 (2000
    • (2000) Arthritis Rheum , vol.43 , pp. 1106-1114
    • Kobayashi, T.1
  • 78
    • 0030777295 scopus 로고    scopus 로고
    • Inhibition of T cell apoptosis in the rheumatoid synovium
    • Salmon, M., et al. Inhibition of T cell apoptosis in the rheumatoid synovium. J. Clin. Invest. 99, 439-446 (1997
    • (1997) J. Clin. Invest , vol.99 , pp. 439-446
    • Salmon, M.1
  • 79
    • 0034938198 scopus 로고    scopus 로고
    • Nitric oxide protects cultured rheumatoid synovial cells from Fas-induced apoptosis by inhibiting caspase 3
    • Migita, K., et al. Nitric oxide protects cultured rheumatoid synovial cells from Fas-induced apoptosis by inhibiting caspase 3. Immunology 103, 362-367 (2001
    • (2001) Immunology , vol.103 , pp. 362-367
    • Migita, K.1
  • 80
    • 0025875259 scopus 로고
    • Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease
    • Cohen, P. L., & Eisenberg, R. A. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9, 243-269 (1991
    • (1991) Annu. Rev. Immunol , vol.9 , pp. 243-269
    • Cohen, P.L.1    Eisenberg, R.A.2
  • 81
    • 0031004645 scopus 로고    scopus 로고
    • Rheumatic diseases in an MRL strain of mice with a deficit in the functional Fas ligand
    • Ito, M. R., et al. Rheumatic diseases in an MRL strain of mice with a deficit in the functional Fas ligand. Arthritis Rheum. 40, 1054-1063 (1997
    • (1997) Arthritis Rheum , vol.40 , pp. 1054-1063
    • Ito, M.R.1
  • 82
    • 84857733516 scopus 로고    scopus 로고
    • Requirement of myeloid cell-specific Fas expression for prevention of systemic autoimmunity in mice
    • Cuda, C. M., et al. Requirement of myeloid cell-specific Fas expression for prevention of systemic autoimmunity in mice. Arthritis Rheum. 64, 808-820 (2012
    • (2012) Arthritis Rheum , vol.64 , pp. 808-820
    • Cuda, C.M.1
  • 83
    • 79952245823 scopus 로고    scopus 로고
    • Role for toll-like receptors in autoimmune disease: The example of systemic lupus erythematosus
    • Richez, C., Blanco, P., Rifkin, I., Moreau, J. F., & Schaeverbeke, T. Role for toll-like receptors in autoimmune disease: the example of systemic lupus erythematosus. Joint Bone Spine 78, 124-130 (2010
    • (2010) Joint Bone Spine , vol.78 , pp. 124-130
    • Richez, C.1    Blanco, P.2    Rifkin, I.3    Moreau, J.F.4    Schaeverbeke, T.5
  • 84
    • 10344262904 scopus 로고    scopus 로고
    • Fas death receptor signaling represses monocyte numbers and macrophage activation in vivo
    • Brown, N. J., et al. Fas death receptor signaling represses monocyte numbers and macrophage activation in vivo. J. Immunol. 173, 7584-7593 (2004
    • (2004) J. Immunol , vol.173 , pp. 7584-7593
    • Brown, N.J.1
  • 85
    • 5044228305 scopus 로고    scopus 로고
    • Fas ligation on macrophages enhances IL 1R1 Toll-like receptor 4 signaling and promotes chronic inflammation
    • Ma Y., et al. Fas ligation on macrophages enhances IL 1R1 Toll-like receptor 4 signaling and promotes chronic inflammation. Nat. Immunol. 380-387 2004
    • (2004) Nat. Immunol , pp. 380-387
    • Ma, Y.1
  • 86
    • 84897018315 scopus 로고    scopus 로고
    • Fas signaling in macrophages promotes chronicity in K/BxN serum-induced arthritis
    • Huang, Q. Q., et al. Fas signaling in macrophages promotes chronicity in K/BxN serum-induced arthritis. Arthritis Rheumatol. 66, 68-77 (2014
    • (2014) Arthritis Rheumatol , vol.66 , pp. 68-77
    • Huang, Q.Q.1
  • 87
    • 34248577055 scopus 로고    scopus 로고
    • Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity
    • Stranges, P. B., et al. Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity 26, 629-641 (2007
    • (2007) Immunity , vol.26 , pp. 629-641
    • Stranges, P.B.1
  • 88
    • 0034103590 scopus 로고    scopus 로고
    • Novel gene therapy for rheumatoid arthritis by FADD gene transfer: Induction of apoptosis of rheumatoid synoviocytes but not chondrocytes
    • Kobayashi, T., et al. Novel gene therapy for rheumatoid arthritis by FADD gene transfer: induction of apoptosis of rheumatoid synoviocytes but not chondrocytes. Gene Ther. 7, 527-533 (2000
    • (2000) Gene Ther , vol.7 , pp. 527-533
    • Kobayashi, T.1
  • 89
    • 49649098390 scopus 로고    scopus 로고
    • Adenosine receptors control a new pathway of Fas-Associated death domain protein expression regulation by secretion
    • Tourneur, L., Mistou, S., Schmitt, A., & Chiocchia, G. Adenosine receptors control a new pathway of Fas-Associated death domain protein expression regulation by secretion. J. Biol. Chem. 283, 17929-17938 (2008
    • (2008) J. Biol. Chem , vol.283 , pp. 17929-17938
    • Tourneur, L.1    Mistou, S.2    Schmitt, A.3    Chiocchia, G.4
  • 90
    • 27744456525 scopus 로고    scopus 로고
    • Synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes
    • Berckmans, R. J., et al. Synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes. Arthritis Res. Ther. 7, R536-544 (2005
    • (2005) Arthritis Res. Ther , vol.7 , pp. R536-544
    • Berckmans, R.J.1
  • 91
    • 84861469413 scopus 로고    scopus 로고
    • Fas-Associated death domain protein and adenosine partnership: Fad in RA
    • Vilmont, V., Tourneur, L., & Chiocchia, G. Fas-Associated death domain protein and adenosine partnership: fad in RA. Rheumatology (Oxford) 51, 964-975 (2012
    • (2012) Rheumatology (Oxford , vol.51 , pp. 964-975
    • Vilmont, V.1    Tourneur, L.2    Chiocchia, G.3
  • 92
    • 84929485512 scopus 로고    scopus 로고
    • Deletion of FADD in macrophages and granulocytes results in RIP3-And MyD88 dependent systemic inflammation
    • Schock, S. N., Young, J. A., He, T. H., Sun, Y., & Winoto, A. Deletion of FADD in macrophages and granulocytes results in RIP3-And MyD88 dependent systemic inflammation. PLoS ONE 10, e0124391 (2015
    • (2015) PLoS ONE , vol.10 , pp. e0124391
    • Schock, S.N.1    Young, J.A.2    He, T.H.3    Sun, Y.4    Winoto, A.5
  • 93
    • 84879799191 scopus 로고    scopus 로고
    • Commensal microbiota are required for systemic inflammation triggered by necrotic dendritic cells
    • Young, J. A., He, T. H., Reizis, B., & Winoto, A. Commensal microbiota are required for systemic inflammation triggered by necrotic dendritic cells. Cell Rep. 3, 1932-1944 (2013
    • (2013) Cell Rep , vol.3 , pp. 1932-1944
    • Young, J.A.1    He, T.H.2    Reizis, B.3    Winoto, A.4
  • 94
    • 0035147059 scopus 로고    scopus 로고
    • Rheumatoid arthritis synovial macrophages express the Fas-Associated death domain-like interleukin 1β converting enzyme-inhibitory protein and are refractory to Fas-mediated apoptosis
    • Perlman, H., et al. Rheumatoid arthritis synovial macrophages express the Fas-Associated death domain-like interleukin 1β converting enzyme-inhibitory protein and are refractory to Fas-mediated apoptosis. Arthritis Rheum. 44, 21-30 (2001
    • (2001) Arthritis Rheum , vol.44 , pp. 21-30
    • Perlman, H.1
  • 95
    • 0036786268 scopus 로고    scopus 로고
    • Low levels of apoptosis and high FLIP expression in early rheumatoid arthritis synovium
    • Catrina, A. I., Ulfgren, A. K., Lindblad, S., Grondal, L., & Klareskog, L. Low levels of apoptosis and high FLIP expression in early rheumatoid arthritis synovium. Ann. Rheum. Dis. 61, 934-936 (2002
    • (2002) Ann. Rheum. Dis , vol.61 , pp. 934-936
    • Catrina, A.I.1    Ulfgren, A.K.2    Lindblad, S.3    Grondal, L.4    Klareskog, L.5
  • 96
    • 0036269587 scopus 로고    scopus 로고
    • FLICE-inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis
    • Schedel, J., et al. FLICE-inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis. Arthritis Rheum. 46, 1512-1518 (2002
    • (2002) Arthritis Rheum , vol.46 , pp. 1512-1518
    • Schedel, J.1
  • 97
    • 0033456158 scopus 로고    scopus 로고
    • FLICE-inhibitory protein expression during macrophage differentiation confers resistance to fas-mediated apoptosis
    • Perlman, H., et al. FLICE-inhibitory protein expression during macrophage differentiation confers resistance to fas-mediated apoptosis. J. Exp. Med. 190, 1679-1688 (1999
    • (1999) J. Exp. Med , vol.190 , pp. 1679-1688
    • Perlman, H.1
  • 98
    • 78649731663 scopus 로고    scopus 로고
    • FLIP: A novel regulator of macrophage differentiation and granulocyte homeostasis
    • Huang, Q. Q., et al. FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis. Blood 116, 4968-4977 (2010
    • (2010) Blood , vol.116 , pp. 4968-4977
    • Huang, Q.Q.1
  • 99
    • 78751508599 scopus 로고    scopus 로고
    • Regulation of steady-state neutrophil homeostasis by macrophages
    • Gordy, C., Pua, H., Sempowski, G. D., & He, Y. W. Regulation of steady-state neutrophil homeostasis by macrophages. Blood 117, 618-629 (2011
    • (2011) Blood , vol.117 , pp. 618-629
    • Gordy, C.1    Pua, H.2    Sempowski, G.D.3    He, Y.W.4
  • 100
    • 84929224752 scopus 로고    scopus 로고
    • CD11c mediated deletion of Flip promotes autoreactivity and inflammatory arthritis
    • Huang, Q. Q., et al. CD11c mediated deletion of Flip promotes autoreactivity and inflammatory arthritis. Nat. Commun. 6, 7086 (2015
    • (2015) Nat. Commun , vol.6 , pp. 7086
    • Huang, Q.Q.1
  • 101
    • 84941791388 scopus 로고    scopus 로고
    • Cellular FLIP inhibits myeloid cell activation by suppressing selective innate signaling
    • Wu, Y. J., et al. Cellular FLIP inhibits myeloid cell activation by suppressing selective innate signaling. J. Immunol. 195, 2612-2623 (2015
    • (2015) J. Immunol , vol.195 , pp. 2612-2623
    • Wu, Y.J.1
  • 102
    • 84898789502 scopus 로고    scopus 로고
    • Regulation of the immune system by the resident intestinal bacteria
    • Kamada, N., & Nunez, G. Regulation of the immune system by the resident intestinal bacteria. Gastroenterology 146, 1477-1488 (2014
    • (2014) Gastroenterology , vol.146 , pp. 1477-1488
    • Kamada, N.1    Nunez, G.2
  • 103
    • 84921367265 scopus 로고    scopus 로고
    • Modulation of immune development and function by intestinal microbiota
    • Kabat, A. M., Srinivasan, N., & Maloy, K. J. Modulation of immune development and function by intestinal microbiota. Trends Immunol. 35, 507-517 (2014
    • (2014) Trends Immunol , vol.35 , pp. 507-517
    • Kabat, A.M.1    Srinivasan, N.2    Maloy, K.J.3
  • 104
    • 84923207808 scopus 로고    scopus 로고
    • Dietary modulation of the microbiome affects autoinflammatory disease
    • Lukens, J. R., et al. Dietary modulation of the microbiome affects autoinflammatory disease. Nature 516, 246-249 (2014
    • (2014) Nature , vol.516 , pp. 246-249
    • Lukens, J.R.1
  • 105
    • 84894288992 scopus 로고    scopus 로고
    • Genetics of rheumatoid arthritis contributes to biology and drug discovery
    • Okada, Y., et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506, 376-381 (2014
    • (2014) Nature , vol.506 , pp. 376-381
    • Okada, Y.1
  • 106
    • 33646264300 scopus 로고    scopus 로고
    • Caspase 8 promotes cell motility and calpain activity under nonapoptotic conditions
    • Helfer, B., et al. Caspase 8 promotes cell motility and calpain activity under nonapoptotic conditions. Cancer Res. 66, 4273-4278 (2006
    • (2006) Cancer Res , vol.66 , pp. 4273-4278
    • Helfer, B.1
  • 107
    • 17844361968 scopus 로고    scopus 로고
    • Cellular FLIP (long form) regulates CD8+ T cell activation through caspase 8 dependent NF kappa B activation
    • Dohrman, A., et al. Cellular FLIP (long form) regulates CD8+ T cell activation through caspase 8 dependent NF kappa B activation. J. Immunol. 174, 5270-5278 (2005
    • (2005) J. Immunol , vol.174 , pp. 5270-5278
    • Dohrman, A.1
  • 108
    • 79952770123 scopus 로고    scopus 로고
    • RIG i RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase 8 mediated cleavage of the RIP1 protein
    • Rajput, A., et al. RIG I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase 8 mediated cleavage of the RIP1 protein. Immunity 34, 340-351(2011
    • (2011) Immunity , vol.34 , pp. 340-351
    • Rajput, A.1
  • 109
    • 70350484946 scopus 로고    scopus 로고
    • Caspase 8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease
    • Kovalenko, A., et al. Caspase 8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J. Exp. Med. 206, 2161-2177 (2009
    • (2009) J. Exp. Med , vol.206 , pp. 2161-2177
    • Kovalenko, A.1
  • 110
    • 0034646478 scopus 로고    scopus 로고
    • Activation of NF kappaB by FADD, Casper, and caspase 8
    • Hu, W. H., Johnson, H., & Shu, H. B. Activation of NF kappaB by FADD, Casper, and caspase 8. J. Biol. Chem. 275, 10838-10844 (2000
    • (2000) J. Biol. Chem , vol.275 , pp. 10838-10844
    • Hu, W.H.1    Johnson, H.2    Shu, H.B.3
  • 111
    • 80052989433 scopus 로고    scopus 로고
    • Caspase 8 mediated cleavage inhibits IRF 3 protein by facilitating its proteasome-mediated degradation
    • Sears, N., Sen, G. C., Stark, G. R., & Chattopadhyay, S. Caspase 8 mediated cleavage inhibits IRF 3 protein by facilitating its proteasome-mediated degradation. J. Biol. Chem. 286, 33037-33044 (2011
    • (2011) J. Biol. Chem , vol.286 , pp. 33037-33044
    • Sears, N.1    Sen, G.C.2    Stark, G.R.3    Chattopadhyay, S.4
  • 112
    • 84944877351 scopus 로고    scopus 로고
    • Conditional deletion of caspase 8 in macrophages alters macrophage activation in a RIPK-dependent manner
    • Cuda, C. M., et al. Conditional deletion of caspase 8 in macrophages alters macrophage activation in a RIPK-dependent manner. Arthritis Res. Ther. 17, 291 (2015
    • (2015) Arthritis Res. Ther , vol.17 , pp. 291
    • Cuda, C.M.1
  • 113
    • 4344560197 scopus 로고    scopus 로고
    • Caspase 8 serves both apoptotic and nonapoptotic roles
    • Kang, T. B., et al. Caspase 8 serves both apoptotic and nonapoptotic roles. J. Immunol. 173, 2976-2984 (2004
    • (2004) J. Immunol , vol.173 , pp. 2976-2984
    • Kang, T.B.1
  • 114
    • 84902127968 scopus 로고    scopus 로고
    • Caspase 8 acts as a molecular rheostat to limit RIPK1-And MyD88 mediated dendritic cell activation
    • Cuda, C. M., et al. Caspase 8 acts as a molecular rheostat to limit RIPK1-And MyD88 mediated dendritic cell activation. J. Immunol. 192, 5548-5560 (2014
    • (2014) J. Immunol , vol.192 , pp. 5548-5560
    • Cuda, C.M.1
  • 115
    • 84872764927 scopus 로고    scopus 로고
    • Caspase 8 blocks kinase RIPK3 mediated activation of the NLRP3 inflammasome
    • Kang, T. B., Yang, S. H., Toth, B., Kovalenko, A., & Wallach, D. Caspase 8 blocks kinase RIPK3 mediated activation of the NLRP3 inflammasome. Immunity 38, 27-40 (2013
    • (2013) Immunity , vol.38 , pp. 27-40
    • Kang, T.B.1    Yang, S.H.2    Toth, B.3    Kovalenko, A.4    Wallach, D.5
  • 116
    • 0032575688 scopus 로고    scopus 로고
    • The Bcl 2 protein family: Arbiters of cell survival
    • Adams, J. M., & Cory, S. The Bcl 2 protein family: arbiters of cell survival. Science 281, 1322-1326 (1998
    • (1998) Science , vol.281 , pp. 1322-1326
    • Adams, J.M.1    Cory, S.2
  • 117
    • 84930758648 scopus 로고    scopus 로고
    • The BCL 2 protein family, BH3 mimetics and cancer therapy
    • Delbridge, A. R., & Strasser, A. The BCL 2 protein family, BH3 mimetics and cancer therapy. Cell Death Differ. 22, 1071-1080 (2015
    • (2015) Cell Death Differ , vol.22 , pp. 1071-1080
    • Delbridge, A.R.1    Strasser, A.2
  • 118
    • 84978929546 scopus 로고    scopus 로고
    • Attacking cancer?s Achilles heel: Antagonism of anti-Apoptotic BCL 2 family members
    • Opferman, J. T. Attacking cancer?s Achilles heel: antagonism of anti-Apoptotic BCL 2 family members. FEBS J. http://dx.doi.org/10.1111/febs.13472 (2015
    • (2015) FEBS J
    • Opferman, J.T.1
  • 119
    • 0343091223 scopus 로고    scopus 로고
    • Bcl 2 expression in synovial fibroblasts is essential for maintaining mitochondrial homeostasis and cell viability
    • Perlman, H., et al. Bcl 2 expression in synovial fibroblasts is essential for maintaining mitochondrial homeostasis and cell viability. J. Immunol. 164, 5227-5235 (2000
    • (2000) J. Immunol , vol.164 , pp. 5227-5235
    • Perlman, H.1
  • 120
    • 33749181440 scopus 로고    scopus 로고
    • Bcl x(L) expression in vivo in rheumatoid synovium
    • Busteed S., et al. Bcl x(L) expression in vivo in rheumatoid synovium. Clin. Rheumatol 25 789-793 2006
    • (2006) Clin. Rheumatol , vol.25 , pp. 789-793
    • Busteed, S.1
  • 121
    • 33750347729 scopus 로고    scopus 로고
    • Regulation of Mcl 1 expression in rheumatoid arthritis synovial macrophages
    • Liu, H., et al. Regulation of Mcl 1 expression in rheumatoid arthritis synovial macrophages. Arthritis Rheum. 54, 3174-3181 (2006
    • (2006) Arthritis Rheum , vol.54 , pp. 3174-3181
    • Liu, H.1
  • 122
    • 29144526644 scopus 로고    scopus 로고
    • Mcl 1 is essential for the survival of synovial fibroblasts in rheumatoid arthritis
    • Liu, H., et al. Mcl 1 is essential for the survival of synovial fibroblasts in rheumatoid arthritis. J. Immunol. 175, 8337-8345 (2005
    • (2005) J. Immunol , vol.175 , pp. 8337-8345
    • Liu, H.1
  • 123
    • 32444439657 scopus 로고    scopus 로고
    • PUMA regulation and proapoptotic effects in fibroblast-like synoviocytes
    • Cha, H. S., Rosengren, S., Boyle, D. L., & Firestein, G. S. PUMA regulation and proapoptotic effects in fibroblast-like synoviocytes. Arthritis Rheum. 54, 587-592 (2006
    • (2006) Arthritis Rheum , vol.54 , pp. 587-592
    • Cha, H.S.1    Rosengren, S.2    Boyle, D.L.3    Firestein, G.S.4
  • 124
    • 0037353415 scopus 로고    scopus 로고
    • Expression of the apoptosis accelerator Bax in rheumatoid arthritis synovium
    • Hilbers, I., et al. Expression of the apoptosis accelerator Bax in rheumatoid arthritis synovium. Rheumatol Int. 23, 75-81 (2003
    • (2003) Rheumatol Int , vol.23 , pp. 75-81
    • Hilbers, I.1
  • 125
    • 75749091858 scopus 로고    scopus 로고
    • Bim-Bcl 2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis
    • Scatizzi, J. C., et al. Bim-Bcl 2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis. Arthritis Rheum. 62, 441-451 (2010
    • (2010) Arthritis Rheum , vol.62 , pp. 441-451
    • Scatizzi, J.C.1
  • 126
    • 38449085339 scopus 로고    scopus 로고
    • Overexpression of Bcl(XL) in B cells promotes TH1 response and exacerbates collagen-induced arthritis
    • Zheng, B., et al. Overexpression of Bcl(XL) in B cells promotes TH1 response and exacerbates collagen-induced arthritis. J. Immunol. 179, 7087-7092 (2007
    • (2007) J. Immunol , vol.179 , pp. 7087-7092
    • Zheng, B.1
  • 127
    • 0036173058 scopus 로고    scopus 로고
    • Constitutive expression of BCL X(L) in the T lineage attenuates collagen-induced arthritis in Bcl X(L) transgenic mice
    • Chen, Y., Rosloniec, E., Price, J., Boothby, M., & Chen, J. Constitutive expression of BCL X(L) in the T lineage attenuates collagen-induced arthritis in Bcl X(L) transgenic mice. Arthritis Rheum. 46, 514-521 (2002
    • (2002) Arthritis Rheum , vol.46 , pp. 514-521
    • Chen, Y.1    Rosloniec, E.2    Price, J.3    Boothby, M.4    Chen, J.5
  • 128
    • 84875642818 scopus 로고    scopus 로고
    • Bcl 2 overexpression ameliorates immune complex-mediated arthritis by altering FcγRIIb expression and monocyte homeostasis
    • Lawlor, K. E., et al. Bcl 2 overexpression ameliorates immune complex-mediated arthritis by altering FcγRIIb expression and monocyte homeostasis. J. Leukocyte Biol. 93, 585-597 (2013
    • (2013) J. Leukocyte Biol , vol.93 , pp. 585-597
    • Lawlor, K.E.1
  • 129
    • 67649198526 scopus 로고    scopus 로고
    • The Bcl 2 family antagonist ABT 737 significantly inhibits multiple animal models of autoimmunity
    • Bardwell, P. D., et al. The Bcl 2 family antagonist ABT 737 significantly inhibits multiple animal models of autoimmunity. J. Immunol. 182, 7482-7489 (2009
    • (2009) J. Immunol , vol.182 , pp. 7482-7489
    • Bardwell, P.D.1
  • 131
    • 33750302629 scopus 로고    scopus 로고
    • Bim deficiency leads to exacerbation and prolongation of joint inflammation in experimental arthritis
    • Scatizzi, J. C., et al. Bim deficiency leads to exacerbation and prolongation of joint inflammation in experimental arthritis. Arthritis Rheum. 54, 3182-3193 (2006
    • (2006) Arthritis Rheum , vol.54 , pp. 3182-3193
    • Scatizzi, J.C.1
  • 132
    • 34347219754 scopus 로고    scopus 로고
    • Pro-Apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis
    • Scatizzi, J. C., et al. Pro-Apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis. Arthritis Res. Ther. 9, R49 (2007
    • (2007) Arthritis Res. Ther , vol.9 , pp. R49
    • Scatizzi, J.C.1
  • 133
    • 0033607506 scopus 로고    scopus 로고
    • Proapoptotic Bcl 2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    • Bouillet, P., et al. Proapoptotic Bcl 2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286, 1735-1738 (1999
    • (1999) Science , vol.286 , pp. 1735-1738
    • Bouillet, P.1
  • 134
    • 38949209522 scopus 로고    scopus 로고
    • Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity
    • Hutcheson, J., et al. Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity. Immunity 28, 206-217 (2008
    • (2008) Immunity , vol.28 , pp. 206-217
    • Hutcheson, J.1
  • 135
    • 68149139457 scopus 로고    scopus 로고
    • BH3 only proteins in rheumatoid arthritis: Potential targets for therapeutic intervention
    • Hutcheson, J., & Perlman, H. BH3 only proteins in rheumatoid arthritis: potential targets for therapeutic intervention. Oncogene 27 (Suppl. 1), S168-S175 (2008
    • (2008) Oncogene , vol.27 , pp. S168-S175
    • Hutcheson, J.1    Perlman, H.2
  • 136
    • 1542283724 scopus 로고    scopus 로고
    • VavP Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia
    • pii 2004
    • Egle, A., Harris, A. W., Bath, M. L., O?Reilly, L., & Cory, S. VavP Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia. Blood 103, 2276-2283 (2003). pii] (2004
    • (2003) Blood , vol.103 , pp. 2276-2283
    • Egle, A.1    Harris, A.W.2    Bath, M.L.3    O'Reilly, L.4    Cory, S.5
  • 137
    • 0035877981 scopus 로고    scopus 로고
    • MCL1 transgenic mice exhibit a high incidence of B cell lymphoma manifested as a spectrum of histologic subtypes
    • Zhou, P., et al. MCL1 transgenic mice exhibit a high incidence of B cell lymphoma manifested as a spectrum of histologic subtypes. Blood 97, 3902-3909 (2001
    • (2001) Blood , vol.97 , pp. 3902-3909
    • Zhou, P.1
  • 138
    • 0032211158 scopus 로고    scopus 로고
    • Mcl 1 in transgenic mice promotes survival in a spectrum of hematopoietic cell types and immortalization in the myeloid lineage
    • Zhou, P., et al. Mcl 1 in transgenic mice promotes survival in a spectrum of hematopoietic cell types and immortalization in the myeloid lineage. Blood 92, 3226-3239 (1998
    • (1998) Blood , vol.92 , pp. 3226-3239
    • Zhou, P.1
  • 139
    • 34248340997 scopus 로고    scopus 로고
    • Deficiency of Bim in dendritic cells contributes to over-Activation of lymphocytes and autoimmunity
    • Chen, M., Huang, L., & Wang, J. Deficiency of Bim in dendritic cells contributes to over-Activation of lymphocytes and autoimmunity. Blood 109, 4360-4367 (2007
    • (2007) Blood , vol.109 , pp. 4360-4367
    • Chen, M.1    Huang, L.2    Wang, J.3
  • 140
    • 45549089713 scopus 로고    scopus 로고
    • Enhanced dendritic cell survival attenuates lipopolysaccharide-induced immunosuppression and increases resistance to lethal endotoxic shock
    • Gautier, E. L., et al. Enhanced dendritic cell survival attenuates lipopolysaccharide-induced immunosuppression and increases resistance to lethal endotoxic shock. J. Immunol. 180, 6941-6946 (2008
    • (2008) J. Immunol , vol.180 , pp. 6941-6946
    • Gautier, E.L.1
  • 141
    • 0037105559 scopus 로고    scopus 로고
    • Bcl 2 controls dendritic cell longevity in vivo
    • Nopora, A., & Brocker, T. Bcl 2 controls dendritic cell longevity in vivo. J. Immunol. 169, 3006-3014 (2002
    • (2002) J. Immunol , vol.169 , pp. 3006-3014
    • Nopora, A.1    Brocker, T.2
  • 142
    • 2942679279 scopus 로고    scopus 로고
    • Bcl 2 dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells
    • Hou, W. S., & Van Parijs, L. A. Bcl 2 dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells. Nat. Immunol. 5, 583-589 (2004
    • (2004) Nat. Immunol , vol.5 , pp. 583-589
    • Hou, W.S.1    Van Parijs, L.A.2
  • 143
    • 79957962932 scopus 로고    scopus 로고
    • Non-Apoptotic role of BID in inflammation and innate immunity
    • Yeretssian, G., et al. Non-Apoptotic role of BID in inflammation and innate immunity. Nature 474, 96-99 (2011
    • (2011) Nature , vol.474 , pp. 96-99
    • Yeretssian, G.1
  • 144
    • 84922602504 scopus 로고    scopus 로고
    • Necroptosis and its role in inflammation
    • Pasparakis, M., & Vandenabeele, P. Necroptosis and its role in inflammation. Nature 517, 311-320 (2015
    • (2015) Nature , vol.517 , pp. 311-320
    • Pasparakis, M.1    Vandenabeele, P.2
  • 145
    • 79952810024 scopus 로고    scopus 로고
    • Catalytic activity of the caspase 8 FLIP(L) complex inhibits RIPK3 dependent necrosis
    • Oberst, A., et al. Catalytic activity of the caspase 8 FLIP(L) complex inhibits RIPK3 dependent necrosis. Nature 471, 363-367 (2011
    • (2011) Nature , vol.471 , pp. 363-367
    • Oberst, A.1
  • 146
    • 79960922705 scopus 로고    scopus 로고
    • CIAPs block Ripoptosome formation, a RIP1/caspase 8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
    • Feoktistova, M., et al. cIAPs block Ripoptosome formation, a RIP1/caspase 8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol. Cell 43, 449-463 (2011
    • (2011) Mol. Cell , vol.43 , pp. 449-463
    • Feoktistova, M.1
  • 147
    • 84857404572 scopus 로고    scopus 로고
    • Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin 1 activation
    • Vince, J. E., et al. Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin 1 activation. Immunity 36, 215-227 (2012
    • (2012) Immunity , vol.36 , pp. 215-227
    • Vince, J.E.1
  • 148
    • 84894271641 scopus 로고    scopus 로고
    • Fadd and caspase 8 mediate priming and activation of the canonical and noncanonical nlrp3 inflammasomes
    • Gurung, P., et al. FADD and Caspase 8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes. J. Immunol. 192, 1835-1846 (2014
    • (2014) J. Immunol , vol.192 , pp. 1835-1846
    • Gurung, P.1
  • 149
    • 84896500701 scopus 로고    scopus 로고
    • Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL 1β in response to TLR4 stimulation through a caspase 8-And TRIF-dependent pathway
    • Shenderov, K., et al. Cutting edge: endoplasmic reticulum stress licenses macrophages to produce mature IL 1β in response to TLR4 stimulation through a caspase 8-And TRIF-dependent pathway. J. Immunol. 192, 2029-2033 (2014
    • (2014) J. Immunol , vol.192 , pp. 2029-2033
    • Shenderov, K.1
  • 150
    • 79952780505 scopus 로고    scopus 로고
    • Functional complementation between FADD and RIP1 in embryos and lymphocytes
    • Zhang, H., et al. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 471, 373-376 (2011
    • (2011) Nature , vol.471 , pp. 373-376
    • Zhang, H.1
  • 151
    • 0842304221 scopus 로고    scopus 로고
    • Kinase RIP3 is dispensable for normal NF kappa Bs, signaling by the B cell and T cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4
    • Newton, K., Sun, X., & Dixit, V. M. Kinase RIP3 is dispensable for normal NF kappa Bs, signaling by the B cell and T cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Mol. Cell. Biol. 24, 1464-1469 (2004
    • (2004) Mol. Cell. Biol , vol.24 , pp. 1464-1469
    • Newton, K.1    Sun, X.2    Dixit, V.M.3
  • 152
    • 79952811804 scopus 로고    scopus 로고
    • RIP3 mediates the embryonic lethality of caspase 8 deficient mice
    • Kaiser, W. J., et al. RIP3 mediates the embryonic lethality of caspase 8 deficient mice. Nature 471, 368-372 (2011
    • (2011) Nature , vol.471 , pp. 368-372
    • Kaiser, W.J.1
  • 153
    • 84861712290 scopus 로고    scopus 로고
    • Survival function of the FADD-CASPASE 8 cFLIP(L) complex
    • Dillon, C. P., et al. Survival function of the FADD-CASPASE 8 cFLIP(L) complex. Cell Rep. 1, 401-407 (2012
    • (2012) Cell Rep , vol.1 , pp. 401-407
    • Dillon, C.P.1
  • 154
    • 84923674191 scopus 로고    scopus 로고
    • RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
    • Lawlor, K. E., et al. RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL. Nat. Commun. 6, 6282 (2015
    • (2015) Nat. Commun , vol.6 , pp. 6282
    • Lawlor, K.E.1
  • 155
    • 84922112723 scopus 로고    scopus 로고
    • Proapoptotic activity of a monomeric smac mimetic on human fibroblast-like synoviocytes from patients with rheumatoid arthritis
    • Lattuada, D., et al. Proapoptotic activity of a monomeric smac mimetic on human fibroblast-like synoviocytes from patients with rheumatoid arthritis. Inflammation 38, 102-109 (2015
    • (2015) Inflammation , vol.38 , pp. 102-109
    • Lattuada, D.1
  • 156
    • 0032522738 scopus 로고    scopus 로고
    • IAPs block apoptotic events induced by caspase 8 and cytochrome c by direct inhibition of distinct caspases
    • Deveraux, Q. L., et al. IAPs block apoptotic events induced by caspase 8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 17, 2215-2223 (1998
    • (1998) EMBO J. , vol.17 , pp. 2215-2223
    • Deveraux, Q.L.1
  • 157
    • 0034616945 scopus 로고    scopus 로고
    • Smac, a mitochondrial protein that promotes cytochrome c dependent caspase activation by eliminating IAP inhibition
    • Du, C., Fang, M., Li, Y., Li, L., & Wang, X. Smac, a mitochondrial protein that promotes cytochrome c dependent caspase activation by eliminating IAP inhibition. Cell 102, 33-42 (2000
    • (2000) Cell , vol.102 , pp. 33-42
    • Du, C.1    Fang, M.2    Li, Y.3    Li, L.4    Wang, X.5
  • 158
    • 0034616942 scopus 로고    scopus 로고
    • Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
    • Verhagen, A. M., et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102, 43-53 (2000
    • (2000) Cell , vol.102 , pp. 43-53
    • Verhagen, A.M.1
  • 159
    • 77955486657 scopus 로고    scopus 로고
    • Autophagy induction and CHOP under-expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress
    • Shin, Y. J., et al. Autophagy induction and CHOP under-expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress. Arthritis Res. Ther. 12, R19 (2010
    • (2010) Arthritis Res. Ther , vol.12 , pp. R19
    • Shin, Y.J.1
  • 160
    • 84873738247 scopus 로고    scopus 로고
    • Reduced apoptosis correlates with enhanced autophagy in synovial tissues of rheumatoid arthritis
    • Xu, K., et al. Reduced apoptosis correlates with enhanced autophagy in synovial tissues of rheumatoid arthritis. Inflamm Res. 62, 229-237 (2013
    • (2013) Inflamm Res , vol.62 , pp. 229-237
    • Xu, K.1
  • 161
    • 84897018493 scopus 로고    scopus 로고
    • Dual role of autophagy in stress-induced cell death in rheumatoid arthritis synovial fibroblasts
    • Kato, M., Ospelt, C., Gay, R. E., Gay, S., & Klein, K. Dual role of autophagy in stress-induced cell death in rheumatoid arthritis synovial fibroblasts. Arthritis Rheumatol. 66, 40-48 (2014
    • (2014) Arthritis Rheumatol , vol.66 , pp. 40-48
    • Kato, M.1    Ospelt, C.2    Gay, R.E.3    Gay, S.4    Klein, K.5
  • 162
    • 84887173781 scopus 로고    scopus 로고
    • Rheumatoid arthritis: Autophagy: A dual role in the life and death of RASFs
    • Buckland, J. Rheumatoid arthritis: Autophagy: a dual role in the life and death of RASFs. Nat. Rev. Rheumatol 9, 637 (2013
    • (2013) Nat. Rev. Rheumatol , vol.9 , pp. 637
    • Buckland, J.1
  • 163
    • 70349956567 scopus 로고    scopus 로고
    • Apoptosis and autophagy: Regulation of caspase 9 by phosphorylation
    • Allan, L. A., & Clarke, P. R. Apoptosis and autophagy: Regulation of caspase 9 by phosphorylation. FEBS J. 276, 6063-6073 (2009
    • (2009) FEBS J. , vol.276 , pp. 6063-6073
    • Allan, L.A.1    Clarke, P.R.2
  • 164
    • 22944470530 scopus 로고    scopus 로고
    • Low-dose methotrexate: A mainstay in the treatment of rheumatoid arthritis
    • Cronstein, B. N. Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis. Pharmacol. Rev. 57, 163-172 (2005
    • (2005) Pharmacol. Rev , vol.57 , pp. 163-172
    • Cronstein, B.N.1
  • 165
    • 0034897803 scopus 로고    scopus 로고
    • Methotrexate inhibits rheumatoid synovitis by inducing apoptosis
    • Nakazawa, F., et al. Methotrexate inhibits rheumatoid synovitis by inducing apoptosis. J. Rheumatol 28, 1800-1808 (2001
    • (2001) J. Rheumatol , vol.28 , pp. 1800-1808
    • Nakazawa, F.1
  • 166
    • 77954936289 scopus 로고    scopus 로고
    • Apoptosis in the rheumatoid arthritis synovial membrane: Modulation by disease-modifying anti-rheumatic drug treatment
    • Smith, M. D., et al. Apoptosis in the rheumatoid arthritis synovial membrane: modulation by disease-modifying anti-rheumatic drug treatment. Rheumatology (Oxford) 49, 862-875 (2010
    • (2010) Rheumatology (Oxford , vol.49 , pp. 862-875
    • Smith, M.D.1
  • 167
    • 84951807395 scopus 로고    scopus 로고
    • Autophagy induction contributes to the resistance to methotrexate treatment in rheumatoid arthritis fibroblast-like synovial cells through high mobility group box chromosomal protein 1
    • Xu, K., et al. Autophagy induction contributes to the resistance to methotrexate treatment in rheumatoid arthritis fibroblast-like synovial cells through high mobility group box chromosomal protein 1. Arthritis Res. Ther. 17, 374 (2015
    • (2015) Arthritis Res. Ther , vol.17 , pp. 374
    • Xu, K.1
  • 168
    • 84885448124 scopus 로고    scopus 로고
    • Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells
    • Yang, Z., Fujii, H., Mohan, S. V., Goronzy, J. J., & Weyand, C. M. Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells. J. Exp. Med. 210, 2119-2134 (2013
    • (2013) J. Exp. Med , vol.210 , pp. 2119-2134
    • Yang, Z.1    Fujii, H.2    Mohan, S.V.3    Goronzy, J.J.4    Weyand, C.M.5
  • 169
    • 84855516226 scopus 로고    scopus 로고
    • Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells
    • Ireland, J. M., & Unanue, E. R. Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells. J. Exp. Med. 208, 2625-2632 (2011
    • (2011) J. Exp. Med , vol.208 , pp. 2625-2632
    • Ireland, J.M.1    Unanue, E.R.2
  • 170
    • 73249145617 scopus 로고    scopus 로고
    • Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
    • Wegner, N., et al. Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. Immunol. Rev. 233, 34-54 (2010
    • (2010) Immunol. Rev , vol.233 , pp. 34-54
    • Wegner, N.1
  • 171
    • 84875915764 scopus 로고    scopus 로고
    • Autophagy regulates TNFalpha-mediated joint destruction in experimental arthritis
    • Lin, N. Y., et al. Autophagy regulates TNFalpha-mediated joint destruction in experimental arthritis. Ann. Rheum. Dis. 72, 761-768 (2013
    • (2013) Ann. Rheum. Dis , vol.72 , pp. 761-768
    • Lin, N.Y.1
  • 172
    • 84868478863 scopus 로고    scopus 로고
    • Bone research: Autophagy is central to joint destruction in arthritis
    • Onuora, S. Bone research: Autophagy is central to joint destruction in arthritis. Nat. Rev. Rheumatol 8, 633 (2012
    • (2012) Nat. Rev. Rheumatol , vol.8 , pp. 633
    • Onuora, S.1
  • 173
    • 84983410554 scopus 로고    scopus 로고
    • Suppression of experimental arthritis through AMP-Activated protein kinase activation and autophagy modulation
    • Yan, H., Zhou, H. F., Hu, Y., & Pham, C. T. Suppression of experimental arthritis through AMP-Activated protein kinase activation and autophagy modulation. J. Rheum. Dis. Treat. 1, 5 (2015
    • (2015) J. Rheum. Dis. Treat , vol.1 , pp. 5
    • Yan, H.1    Zhou, H.F.2    Hu, Y.3    Pham, C.T.4
  • 174
    • 79951513121 scopus 로고    scopus 로고
    • Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus
    • Orozco, G., et al. Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus. Ann. Rheum. Dis. 70, 463-468 (2011
    • (2011) Ann. Rheum. Dis , vol.70 , pp. 463-468
    • Orozco, G.1
  • 175
    • 33846627302 scopus 로고    scopus 로고
    • A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    • Hampe, J., et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat. Genet. 39, 207-211 (2007
    • (2007) Nat. Genet , vol.39 , pp. 207-211
    • Hampe, J.1
  • 176
    • 66749106217 scopus 로고    scopus 로고
    • Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: A meta-Analysis approach
    • Palomino-Morales, R. J., et al. Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-Analysis approach. Genes Immun. 10, 356-364 (2009
    • (2009) Genes Immun , vol.10 , pp. 356-364
    • Palomino-Morales, R.J.1
  • 177
    • 13444256307 scopus 로고    scopus 로고
    • The role of T cell interleukin 17 in conducting destructive arthritis: Lessons from animal models
    • Lubberts, E., Koenders, M. I., & van den Berg, W. B. The role of T cell interleukin 17 in conducting destructive arthritis: lessons from animal models. Arthritis Res. Ther. 7, 29-37 (2005
    • (2005) Arthritis Res. Ther , vol.7 , pp. 29-37
    • Lubberts, E.1    Koenders, M.I.2    Van Den Berg, W.B.3
  • 178
    • 0344585384 scopus 로고    scopus 로고
    • Suppression of immune induction of collagen-induced arthritis in IL 17 deficient mice
    • Nakae, S., Nambu, A., Sudo, K., & Iwakura, Y. Suppression of immune induction of collagen-induced arthritis in IL 17 deficient mice. J. Immunol. 171, 6173-6177 (2003
    • (2003) J. Immunol , vol.171 , pp. 6173-6177
    • Nakae, S.1    Nambu, A.2    Sudo, K.3    Iwakura, Y.4
  • 179
    • 0034888885 scopus 로고    scopus 로고
    • The genetic and immunopathological processes underlying collagen-induced arthritis
    • Luross, J. A., & Williams, N. A. The genetic and immunopathological processes underlying collagen-induced arthritis. Immunology 103, 407-416 (2001
    • (2001) Immunology , vol.103 , pp. 407-416
    • Luross, J.A.1    Williams, N.A.2
  • 180
    • 60549095495 scopus 로고    scopus 로고
    • Dendritic cells and their potential implication in pathology and treatment of rheumatoid arthritis
    • Wenink, M. H., Han, W., Toes, R. E., & Radstake, T. R. Dendritic cells and their potential implication in pathology and treatment of rheumatoid arthritis. Handb Exp. Pharmacol. 188, 81-98 (2009
    • (2009) Handb Exp. Pharmacol , vol.188 , pp. 81-98
    • Wenink, M.H.1    Han, W.2    Toes, R.E.3    Radstake, T.R.4
  • 181
    • 69849090650 scopus 로고    scopus 로고
    • Effector mechanisms of interleukin 17 in collagen-induced arthritis in the absence of interferon-gamma and counteraction by interferon-gamma
    • Kelchtermans, H., et al. Effector mechanisms of interleukin 17 in collagen-induced arthritis in the absence of interferon-gamma and counteraction by interferon-gamma. Arthritis Res. Ther. 11, R122 (2009
    • (2009) Arthritis Res. Ther , vol.11 , pp. R122
    • Kelchtermans, H.1
  • 182
    • 82955233192 scopus 로고    scopus 로고
    • Collagen-induced arthritis and related animal models: How much of their pathogenesis is auto-immune, how much is auto-inflammatory?
    • Billiau, A., & Matthys, P. Collagen-induced arthritis and related animal models: how much of their pathogenesis is auto-immune, how much is auto-inflammatory? Cytokine Growth Factor Rev. 22, 339-344 (2011
    • (2011) Cytokine Growth Factor Rev , vol.22 , pp. 339-344
    • Billiau, A.1    Matthys, P.2
  • 183
    • 84877603562 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab in patients with rheumatoid arthritis: A phase II, dose-finding, double-blind, randomised, placebo controlled study
    • Genovese, M. C., et al. Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study. Ann. Rheum. Dis. 72, 863-869 (2013
    • (2013) Ann. Rheum. Dis , vol.72 , pp. 863-869
    • Genovese, M.C.1
  • 184
    • 0033607499 scopus 로고    scopus 로고
    • Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme
    • Matsumoto, I., Staub, A., Benoist, C., & Mathis, D. Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science 286, 1732-1735 (1999
    • (1999) Science , vol.286 , pp. 1732-1735
    • Matsumoto, I.1    Staub, A.2    Benoist, C.3    Mathis, D.4
  • 185
    • 77955363222 scopus 로고    scopus 로고
    • Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?
    • Bevaart, L., Vervoordeldonk, M. J., & Tak, P. P. Evaluation of therapeutic targets in animal models of arthritis: how does it relate to rheumatoid arthritis? Arthritis Rheum. 62, 2192-2205 (2010
    • (2010) Arthritis Rheum , vol.62 , pp. 2192-2205
    • Bevaart, L.1    Vervoordeldonk, M.J.2    Tak, P.P.3
  • 186
    • 18344365948 scopus 로고    scopus 로고
    • Arthritis critically dependent on innate immune system players
    • Ji, H., et al. Arthritis critically dependent on innate immune system players. Immunity 16, 157-168 (2002
    • (2002) Immunity , vol.16 , pp. 157-168
    • Ji, H.1
  • 187
    • 0033118675 scopus 로고    scopus 로고
    • From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins
    • Korganow, A. S., et al. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity 10, 451-461 (1999
    • (1999) Immunity , vol.10 , pp. 451-461
    • Korganow, A.S.1
  • 188
    • 0037089664 scopus 로고    scopus 로고
    • Arthritogenic monoclonal antibodies from K/BxN mice
    • Maccioni, M., et al. Arthritogenic monoclonal antibodies from K/BxN mice. J. Exp. Med. 195, 1071-1077 (2002
    • (2002) J. Exp. Med , vol.195 , pp. 1071-1077
    • Maccioni, M.1
  • 189
    • 0036884551 scopus 로고    scopus 로고
    • The role of FcγR signaling in the K/B x N serum transfer model of arthritis
    • Corr, M., & Crain, B. The role of FcγR signaling in the K/B x N serum transfer model of arthritis. J. Immunol. 169, 6604-6609 (2002
    • (2002) J. Immunol , vol.169 , pp. 6604-6609
    • Corr, M.1    Crain, B.2
  • 190
    • 0036645277 scopus 로고    scopus 로고
    • Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis
    • Ji, H., et al. Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J. Exp. Med. 196, 77-85 (2002
    • (2002) J. Exp. Med , vol.196 , pp. 77-85
    • Ji, H.1
  • 192
    • 84959100242 scopus 로고    scopus 로고
    • Fas/FasL, Bcl2 and Caspase 8 gene polymorphisms in Chinese patients with rheumatoid arthritis
    • Zhu, A., et al. Fas/FasL, Bcl2 and Caspase 8 gene polymorphisms in Chinese patients with rheumatoid arthritis. Rheumatol. Int. 36, 807-818 (2016
    • (2016) Rheumatol. Int , vol.36 , pp. 807-818
    • Zhu, A.1
  • 193
    • 17044389715 scopus 로고    scopus 로고
    • Immunogenetics of primary Sjogren?s syndrome in Colombians
    • Anaya, J. M., Mantilla, R. D., & Correa, P. A. Immunogenetics of primary Sjogren?s syndrome in Colombians. Semin. Arthritis Rheum. 34, 735-743 (2005
    • (2005) Semin. Arthritis Rheum , vol.34 , pp. 735-743
    • Anaya, J.M.1    Mantilla, R.D.2    Correa, P.A.3
  • 194
    • 75749146276 scopus 로고    scopus 로고
    • Bcl 2 antagonist killer 1 (BAK1) polymorphisms influence the risk of developing autoimmune rheumatic diseases in women
    • Delgado-Vega, A. M., et al. Bcl 2 antagonist killer 1 (BAK1) polymorphisms influence the risk of developing autoimmune rheumatic diseases in women. Ann. Rheum. Dis. 69, 462-465 (2010
    • (2010) Ann. Rheum. Dis , vol.69 , pp. 462-465
    • Delgado-Vega, A.M.1
  • 195
    • 84982980919 scopus 로고    scopus 로고
    • Bcl 2 proteins in development, health and disease of the hematopoietic system
    • Kollek, M., Muller, A., Egle, A., & Erlacher, M. Bcl 2 proteins in development health and disease of the hematopoietic system. FEBS J. http://dx.doi.org/10.1111/febs.13683 2016
    • (2016) FEBS J.
    • Kollek, M.1    Muller, A.2    Egle, A.3    Erlacher, M.4
  • 196
    • 0033593038 scopus 로고    scopus 로고
    • Constitutive Bcl 2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival
    • Ogilvy, S., et al. Constitutive Bcl 2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival. Proc. Natl Acad. Sci. USA 96, 14943-14948 (1999
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 14943-14948
    • Ogilvy, S.1
  • 197
    • 0029924630 scopus 로고    scopus 로고
    • Frequent aberrant immunoglobulin gene rearrangements in pro B cells revealed by a Bcl xL transgene
    • Fang, W., et al. Frequent aberrant immunoglobulin gene rearrangements in pro B cells revealed by a Bcl xL transgene. Immunity 4, 291-299 (1996
    • (1996) Immunity , vol.4 , pp. 291-299
    • Fang, W.1
  • 198
    • 0030610288 scopus 로고    scopus 로고
    • BCL XL regulated apoptosis in T cell development
    • Chao, D. T., & Korsmeyer, S. J. BCL XL regulated apoptosis in T cell development. Int. Immunol. 9, 1375-1384 (1997
    • (1997) Int. Immunol , vol.9 , pp. 1375-1384
    • Chao, D.T.1    Korsmeyer, S.J.2
  • 199
    • 84884340814 scopus 로고    scopus 로고
    • Autophagy regulates phagocytosis by modulating the expression of scavenger receptors
    • Bonilla, D. L., et al. Autophagy regulates phagocytosis by modulating the expression of scavenger receptors. Immunity 39, 537-547 (2013
    • (2013) Immunity , vol.39 , pp. 537-547
    • Bonilla, D.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.