RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

Nature Communications

Volumn 6, Issue , 2015, Pages

  Lawlor, Kate E ^a,b   Khan, Nufail ^a,b   Mildenhall, Alison ^a,b   Gerlic, Motti ^c   Croker, Ben A ^d   D'Cruz, Akshay A ^d   Hall, Cathrine ^a,b   Kaur Spall, Sukhdeep ^a,b   Anderton, Holly ^a,b   Masters, Seth L ^a,b   Rashidi, Maryam ^a,b   Wicks, Ian P ^a,b   Alexander, Warren S ^a,b   Mitsuuchi, Yasuhiro ^e   Benetatos, Christopher A ^e   Condon, Stephen M ^e   Wong, W Wei Lynn ^f   Silke, John ^a,b   Vaux, David L ^a,b   Vince, James E ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c TEL AVIV UNIVERSITY   (Israel)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e TetraLogic Pharmaceuticals   (United States)

^f UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CASPASE 8; CELLULAR IAP1 PROTEIN; CELLULAR IAP2 PROTEIN; CRYOPYRIN; INFLAMMASOME; INHIBITOR OF APOPTOSIS PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MIXED LINEAGE KINASE; MIXED LINEAGE KINASE DOMAIN LIKE; PROTEIN KINASE; RECEPTOR INTERACTING PROTEIN KINASE 3; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; BIRC4 PROTEIN, MOUSE; CARRIER PROTEIN; CASP8 PROTEIN, MOUSE; LIPOPOLYSACCHARIDE; MLKL PROTEIN, MOUSE; NLRP3 PROTEIN, MOUSE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK3 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR;

ANTIBODY; APOPTOSIS; CELLS AND CELL COMPONENTS; ENZYME ACTIVITY; EXPERIMENTAL STUDY; GENE EXPRESSION; MUTATION; PROTEIN; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE EXACERBATION; GENE DELETION; IN VITRO STUDY; MALE; MOUSE; NECROPTOSIS; NONHUMAN; RHEUMATOID ARTHRITIS; UBIQUITINATION; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CHEMISTRY; CYTOLOGY; EMBRYOLOGY; ENZYME ACTIVATION; FEMALE; INFLAMMATION; LIVER; METABOLISM; NECROSIS;

INTRACISTERNAL A-PARTICLES; MUS;

ANIMALS; APOPTOSIS; AUTOANTIBODIES; BONE MARROW CELLS; CARRIER PROTEINS; CASPASE 8; ENZYME ACTIVATION; FEMALE; INFLAMMASOMES; INFLAMMATION; INHIBITOR OF APOPTOSIS PROTEINS; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; LIVER; MALE; MICE; MICE, INBRED C57BL; NECROSIS; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PROTEIN KINASES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; TUMOR NECROSIS FACTOR-ALPHA; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84923674191     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7282     Document Type: Article

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