Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation

Journal of Biological Chemistry

Volumn 286, Issue 38, 2011, Pages 33037-33044

  Sears, Nathaniel ^a   Sen, Ganes C ^a   Stark, George R ^a   Chattopadhyay, Saurabh ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLEAVAGE SITES; CYTOSOLIC; GENE INDUCTION; IN-VITRO ASSAYS; INNATE IMMUNE RESPONSE; INTERFERON REGULATORY FACTOR 3; PATTERN RECOGNITION RECEPTORS; UBIQUITINATION;

ANTIBIOTICS; GENE EXPRESSION; GLYCOPROTEINS; PATTERN RECOGNITION;

DEGRADATION;

CASPASE 8; DOUBLE STRANDED RNA; INTERFERON REGULATORY FACTOR 3; PROTEASOME;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UBIQUITINATION;

CASPASE 8; CELL LINE, TUMOR; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; INTERFERON REGULATORY FACTOR-3; MODELS, BIOLOGICAL; MUTANT PROTEINS; MUTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA HELICASES; RNA, DOUBLE-STRANDED; SENDAI VIRUS; SIGNAL TRANSDUCTION; UBIQUITINATION;

EID: 80052989433     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.257022     Document Type: Article

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