Proapoptotic Activity of a Monomeric Smac Mimetic on Human Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis

Inflammation

Volumn 38, Issue 1, 2015, Pages 102-109

  Lattuada, D ^a   Casnici, C ^a   Crotta, K ^a   Seneci, P F ^a   Corradini, C ^b   Truzzi, M ^b   Ingegnoli, F ^c   Marelli, O ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Institute of General Pathology   (Italy)

^c ISTITUTO ORTOPEDICO GAETANO PINI   (Italy)

Author keywords

fibroblast like synoviocytes; IAP proteins; osteoarthritis; rheumatoid arthritis; Smac mimetics; synovium

Indexed keywords

CASPASE 3; CASPASE 8; RECOMBINANT PROTEIN; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE 066; SOMATOMEDIN BINDING PROTEIN 5; UNCLASSIFIED DRUG; ANTIRHEUMATIC AGENT; BIOMIMETIC MATERIAL; DIABLO PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; SIGNAL PEPTIDE;

APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST LIKE SYNOVIOCYTE; HUMAN; HUMAN CELL; OSTEOARTHRITIS; OSTEOBLAST; PROTEIN CLEAVAGE; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; SYNOVIUM; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; PATHOLOGY; PHYSIOLOGY; SYNOVIAL FLUID;

INTRACISTERNAL A-PARTICLES;

ANTIRHEUMATIC AGENTS; APOPTOSIS; ARTHRITIS, RHEUMATOID; BIOMIMETIC MATERIALS; CELLS, CULTURED; FIBROBLASTS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOCHONDRIAL PROTEINS; SYNOVIAL FLUID;

EID: 84922112723     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-014-0012-1     Document Type: Article

References (28)

1. Vaux, D.L., and J. Silke. 2003. Mammalian mitochondrial IAP binding proteins. Biochemical and Biophysical Research Communications 304: 499–504.
2. Miller, L.K. 1999. An exegesis of IAPs: salvation and surprises from BIR motifs. Trends in Cell Biology 9: 323–328.
3. Du, C., M. Fang, and Y. Li. 2000. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102: 33–42.
4. Verhagen, A.M., P.G. Ekert, and M. Pakusch. 2000. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102: 43–53.
5. Hunter, A.M., E.C. Lacasse, and R.G. Korneluk. 2007. The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis 12: 1543–1568.
6. Gyrd-Hansen, M., and P. Meier. 2010. IAPs: from caspase inhibitors to modulators NF-kappaB, inflammation and cancer. Nature Reviews Cancer 10: 561–574.
7. van Vollenhoven, R.F. 2013. Small molecular compounds in development for rheumatoid arthritis. Current Opinion in Rheumatology 25: 391–397.
8. Navarro-Millán, I., and J.R. Curtis. 2013. Newest clinical trial results with antitumor necrosis factor and nonantitumor necrosis factor biologics for rheumatoid arthritis. Current Opinion in Rheumatology 25: 384–390.
9. McInnes, I.B., and G. Schett. 2011. The pathogenesis of rheumatoid arthritis. New England Journal of Medicine 365: 2205–2219.
10. Bottini, N., and G.S. Firestein. 2013. Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nature Reviews. Rheumatology 9: 24–33.
11. Cha H.S., S. Rosengren, D. Boyle 2006. PUMA regulation and proapoptotic effects in fibroblast-like synoviocytes. Arthritis and Rheumatism 54:587–92.
12. Shi, J., Z. Diao, and J. Zhou. 2012. Epirubicin potentiates recombinant adeno-associated virus type 2/5-mediated TRAIL expression in fibroblast-like synoviocytes and augments the antiarthritic effects of rAAV2/5-TRAIL. Arthritis and Rheumatism 64: 1345–1354.
13. Martinez-Ruiz, G., V. Maldonado, G. Ceballos-Cancino, et al. 2008. Role of Smac/DIABLO in cancer progression. Journal of Experimental & Clinical Cancer Research 27: 48–54.
14. Thompson, C.B. 1995. Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456–1462.
15. Seneci, P., A. Bianchi, and C. Battaglia. 2009. Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy. Bioorganic and Medicinal Chemistry 17: 5834–5856.
16. Bianchi, A., M. Ugazzi, L. Ferrante, et al. 2012. Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents. Bioorganic and Medicinal Chemistry Letters 22: 2204–2208.
17. Schneider, M.R., E. Wolf, A. Hoeflich, and H. Lahm. 2002. IGF-binding protein-5: flexible player in the IGF system and effector on its own. Journal of Endocrinology 17: 423–440.
18. Bartok G. S. Firestein. 2010. Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunological Reviews 233:233–255.
19. Korb, H. Pavenstadt, T. Pap. 2009. Cell death in rheumatoid arthritis. Apoptosis 14:447–454.
20. Pope, R.M. 2002. Apoptosis as a therapeutic tool in rheumatoid arthritis. Nature Reviews Immunology 2: 527–535.
21. Goldring, S.R., and M.B. Goldring. 2004. The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clinical Orthopaedics and Related Research 23: S27–36.
22. Maneiro, E., M.A. Martin, M.C. de Andres, M.J. Lopes-Armada, J.L. Fernandes-Sueiro, P. del Hoyo, et al. 2003. Mitochondrial respiratory activity is altered in osteoarthritic human articular cartilage. Arthritis and Rheumatism 48(700): 700–708.
23. Riedl, S.J., and Y. Shi. 2004. Molecular mechanisms of caspase regulation during apoptosis. Nature Reviews Molecular Cell Biology 5: 897–907.
24. Firth, S.M., and R.C. Baxter. 2002. Cellular actions of the insulin-like growth factor binding proteins. Endocrine Reviews 23: 824–885.
25. Lochrie, J.D., K. Phillips, and E. Tonner. 2006. Insulin-like growth factor binding protein (IGFBP)-5 is upregulated during both differentiation and apoptosis in primary cultures of mouse mammary epithelial cells. Journal of Cellular Physiology 207: 471–479.
26. Petersen, S.L., L. Wang, and A. Yalcin–Chi. 2007. Autocrine TNF alpha signalling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell 12: 445–456.
27. Uren, A.G., M. Pakusch, C.J. Hawkins, K.L.D. Puls, and L. Vaux. 1996. Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. Proceedings of the National Academy of Science of the USA 93: 4974–4978.
28. Rothe, M., M.G. Pan, W.J. Henzel, T.M. Ayres, and D.V. Goeddel. 1995. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 83: 1243–1252.