Dendritic cells and their potential implication in pathology and treatment of rheumatoid arthritis

Handbook of Experimental Pharmacology

Volumn 188, Issue , 2009, Pages 81-98

  Radstake, T R D J ^a   Wenink, M H ^b   Han, W ^b   Toes, R E M ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FC RECEPTOR; INTERFERON; INTERLEUKIN 12; INTERLEUKIN 23; INTERLEUKIN 6; LECTIN; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VACCINE; IMMUNOGLOBULIN RECEPTOR;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELL MATURATION; COLLAGEN INDUCED ARTHRITIS; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; HELPER CELL; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIUM; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; TREATMENT PLANNING; ANIMAL; DISEASE MODEL; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; METABOLISM; METHODOLOGY;

ANIMALS; ANTIGEN PRESENTATION; ARTHRITIS, RHEUMATOID; AUTOIMMUNITY; CYTOKINES; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; HUMANS; IMMUNE TOLERANCE; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; RECEPTORS, IMMUNOLOGIC; T-LYMPHOCYTES;

EID: 60549095495     PISSN: 01712004     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-540-71029-5-4     Document Type: Review

References (121)

1. Abdollahi-Roodsaz S, Joosten LA, Koenders MI, Devesa I, Roelofs MF, Radstake TR, Heuvelmans-Jacobs M, Akira S, Nicklin MJ, Ribeiro-Dias F, van den Berg WB (2007a) Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest 118:205-216
2. Abdollahi-Roodsaz S, Joosten LA, RoelofsMF, Radstake TR,Matera G, Popa C, van der Meer JW, NeteaMG, van den BergWB(2007b) Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis. Arthritis Rheum 56:2957-2967
3. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413:732-738
4. Annunziato F, Cosmi L, Santarlasci V, Maggi L, Liotta F, Mazzinghi B, Parente E, Fili L, Ferri S, Frosali F, Giudici F, Romagnani P, Parronchi P, Tonelli F, Maggi E, Romagnani S (2007) Phenotypic and functional features of human Th17 cells. J Exp Med 204:1849-1861
5. Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392: 245-252
6. Banchereau J, Fay J, Pascual V, Palucka AK (2003) Dendritic cells: controllers of the immune system and a new promise for immunotherapy. Novartis Found Symp 252:226-235; discussion 235-8, 257-67
7. Barrat FJ, Cua DJ, Boonstra A, Richards DF, Crain C, Savelkoul HF, de Waal-Malefyt R, Coffman RL, Hawrylowicz CM, O'Garra A (2002) In vitro generation of interleukin 10- producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med 195:603-616
8. Bates EE, Fournier N, Garcia E, Valladeau J, Durand I, Pin JJ, Zurawski SM, Patel S, Abrams JS, Lebecque S, Garrone P, Saeland S (1999) APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. J Immunol 163: 1973-1983
9. Bave U, Magnusson M, Eloranta ML, Perers A, Alm GV, Ronnblom L (2003) Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG. J Immunol 171:3296-3302
10. BaxM, Garcia-Vallejo JJ, Jang-Lee J, North SJ, Gilmartin TJ, Hernandez G, Crocker PR, Leffler H, Head SR, Haslam SM, Dell A, van Kooyk Y (2007) Dendritic cell maturation results in pronounced changes in glycan expression affecting recognition by siglecs and galectins. J Immunol 179:8216-8224
11. Bellone S, Pecorelli S, Cannon MJ, Santin AD (2007) Advances in dendritic-cell-based therapeutic vaccines for cervical cancer. Expert Rev Anticancer Ther 7:1473-1486
12. Bianco NR, Kim SH, Morelli AE, Robbins PD (2007) Modulation of the immune response using dendritic cell-derived exosomes. Methods Mol Biol 380:443-456
13. Biragyn A, Ruffini PA, Leifer CA, Klyushnenkova E, Shakhov A, Chertov O, Shirakawa AK, Farber JM, Segal DM, Oppenheim JJ, Kwak LW (2002) Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science 298:1025-1029
14. Bonifaz L, Bonnyay D, Mahnke K, Rivera M, Nussenzweig MC, Steinman RM (2002) Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med 196:1627-1638
15. Boruchov AM, Heller G, Veri MC, Bonvini E, Ravetch JV, Young JW (2005) Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions. J Clin Invest 115:2914-2923
16. Brentano F, Schorr O, Gay RE, Gay S, Kyburz D (2005) RNA released from necrotic synovialfluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3. ArthritisRheum 52:2656-2665
17. Brown GD (2006) Dectin-1: a signalling non-TLR pattern-recognition receptor. Nat Rev Immuno l6:33-43
18. Charbonnier LM, van Duivenvoorde LM, Apparailly F, Cantos C, Han WG, Noel D, Duperray C,
19. Huizinga TW, Toes RE, Jorgensen C, Louis-Plence P (2006) Immature dendritic cells suppress collagen-induced arthritis by in vivo expansion of CD49b+ regulatory T cells. J Immunol 177:3806-3813
20. Delgado M, Chorny A, Gonzalez-Rey E, Ganea D (2005) Vasoactive intestinal peptide generates CD4+CD25+ regulatory T cells in vivo. J Leukoc Biol 78:1327-1338
21. Dhodapkar KM, Banerjee D, Connolly J, Kukreja A, Matayeva E, Veri MC, Ravetch JV, Steinman RM, Dhodapkar MV (2007) Selective blockade of the inhibitory Fcgamma receptor (FcgammaRIIB) in human dendritic cells and monocytes induces a type I interferon response program. J Exp Med 204:1359-1369
22. Dhodapkar MV, Steinman RM, Krasovsky J, Munz C, Bhardwaj N (2001) Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med 193:233-238
23. Diebold SS, Kaisho T, Hemmi H, Akira S, Reise Sousa C (2004) Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303:1529-1531
24. Dijstelbloem HM, van de Winkel JG, Kallenberg CG (2001) Inflammation in autoimmunity: receptors for IgG revisited. Trends Immunol 22:510-516
25. Dudziak D, Kamphorst AO, Heidkamp GF, Buchholz VR, Trumpfheller C, Yamazaki S, Cheong C, Liu K, Lee HW, Park CG, Steinman RM, Nussenzweig MC (2007) Differential antigen processing by dendritic cell subsets in vivo. Science 315:107-111
26. Duez C, Gosset P, Tonnel AB (2006) Dendritic cells and toll-like receptors in allergy and asthma. Eur J Dermatol 16:12-16
27. Figdor CG, van Kooyk Y, Adema GJ (2002) C-type lectin receptors on dendritic cells and Langerhans cells. Nat Rev Immunol 2:77-84
28. Gallucci S, Lolkema M, Matzinger P (1999) Natural adjuvants: endogenous activators of dendritic cells. Nat Med 5:1249-1255
29. Geijtenbeek TB, Torensma R, van Vliet SJ, van Duijnhoven GC, Adema GJ, van Kooyk Y, Figdor CG (2000) Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 100:575-585
30. Gil-Torregrosa BC, Lennon-Dumenil AM, Kessler B, Guermonprez P, Ploegh HL, Fruci D, van Endert P, Amigorena S (2004) Control of cross-presentation during dendritic cell maturation. Eur J Immunol 34:398-407
31. Guermonprez P, Amigorena S (2005) Pathways for antigen cross presentation. Springer Semin Immunopathol 26:257-271
32. Guermonprez P, Valladeau J, Zitvogel L, Thery C, Amigorena S (2002) Antigen presentation and T cell stimulation by dendritic cells. Annu Rev Immunol 20:621-667
33. Hamilton-Williams EE, Lang A, Benke D, Davey GM, Wiesmuller KH, Kurts C (2005) Cutting edge: TLR ligands are not sufficient to break cross-tolerance to self-antigens. J Immunol 174:1159-1163
34. Hawiger D, Inaba K, Dorsett Y, Guo M, Mahnke K, Rivera M, Ravetch JV, Steinman RM, Nussenzweig MC (2001) Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 194:769-779
35. Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A (2001) The innate immune response to bacterial flagellin is mediated by Toll-likereceptor 5. Nature 410:1099-1103
36. Herrada AA, Contreras FJ, Tobar JA, Pacheco R, Kalergis AM (2007) Immune complex-induced enhancement of bacterial antigen presentation requires Fcgamma receptor III expression on dendritic cells. Proc Natl Acad Sci USA 104:13402-13407
37. Holmdahl R, Andersson M, Goldschmidt TJ, Gustafsson K, Jansson L, Mo JA (1990) Type II collagen autoimmunity in animals and provocations leading to arthritis. Immunol Rev 118: 193-232
38. Hoshino K, Sugiyama T, MatsumotoM, Tanaka T, Saito M, Hemmi H, Ohara O, Akira S, Kaisho T (2006) IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature 440:949-953
39. Jongbloed SL, Lebre MC, Fraser AR, Gracie JA, Sturrock RD, Tak PP, McInnes IB (2006) Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis. Arthritis Res Ther 8:R15
40. Jonuleit H, Schmitt E, Schuler G, Knop J, Enk AH (2000) Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 192:1213-1222
41. Kawakami Y, Fujita T, Kudo C, Sakurai T, Udagawa M, Yaguchi T, Hasegawa G, Hayashi E, Ueda Y, Iwata T, Wang Q, Okada S, Tsukamoto N, Matsuzaki Y, Sumimoto H (2008) Dendritic cell based personalized immunotherapy based on cancer antigen research. Front Biosci 13:1952-1958
42. Kim SH, Kim S, Evans CH, Ghivizzani SC, Oligino T, Robbins PD (2001) Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4. J Immunol 166:3499-3505
43. Kim SH, Lechman ER, Bianco N, Menon R, Keravala A, Nash J, Mi Z, Watkins SC, Gambotto A, Robbins PD (2005) Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis. J Immunol 174:6440-6448
44. Kim SH, Bianco N, Menon R, Lechman ER, Shufesky WJ, Morelli AE, Robbins PD (2006) Exosomes derived from genetically modified DC expressing FasL are anti-inflammatory and immunosuppressive. Mol Ther 13:289-300
45. Kim SH, Bianco NR, Shufesky WJ, Morelli AE, Robbins PD (2007) Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4. J Immunol 179:2242-2249
46. Laborde EA, Vanzulli S, Beigier-Bompadre M, Isturiz MA, Ruggiero RA, Fourcade MG, Catalan Pellet AC, Sozzani S, VulcanoM(2007) Immune complexes inhibit differentiation, maturation, and function of human monocyte-derived dendritic cells. J Immunol 179:673-681
47. Langenkamp A, Casorati G, Garavaglia C, Dellabona P, Lanzavecchia A, Sallusto F (2002) T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification. Eur J Immunol 32:2046-2054
48. Lanzavecchia A, Sallusto F (2001a) Antigen decoding by T lymphocytes: from synapses to fate determination. Nat Immunol 2:487-492
49. Lanzavecchia A, Sallusto F (2001b) Regulation of T cell immunity by dendritic cells. Cell 106:263-266
50. Lanzavecchia A, Sallusto F (2001c) The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics. Curr Opin Immunol 13:291-298
51. Leung BP, Conacher M, Hunter D, McInnes IB, Liew FY, Brewer JM (2002) A novel dendritic cell-induced model of erosive inflammatory arthritis: distinct roles for dendritic cells in T cell activation and induction of local inflammation. J Immunol 169:7071-7077
52. Lien E, Sellati TJ, Yoshimura A, Flo TH, Rawadi G, Finberg RW, Carroll JD, Espevik T, Ingalls RR, Radolf JD, Golenbock DT (1999) Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem 274:33419-33425
53. Liu Y, Gao X, Masuda E, Redecha PB, Blank MC, Pricop L (2006) Regulated expression of FcgammaR in human dendritic cells controls cross-presentation of antigen-antibody complexes. J Immunol 177:8440-8447
54. Liu Y, Masuda E, Blank MC, Kirou KA, Gao X, Park MS, Pricop L (2005) Cytokine-mediated regulation of activating and inhibitory Fc gamma receptors in human monocytes. J Leukoc Biol 77:767-776
55. Lotze MT, Tracey KJ (2005) High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 5:331-342
56. Lubberts E (2007) IL-17/Th17 targeting: On the road to prevent chronic destructive arthritis? Cytokine 41:84-91
57. Luo X, Tarbell KV, Yang H, Pothoven K, Bailey SL, Ding R, Steinman RM, SuthanthiranM(2007) Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells. Proc Natl Acad Sci USA 104:2821-2826
58. Luross JA, Williams NA (2001) The genetic and immunopathological processes underlying collagen-induced arthritis. Immunology 103:407-416
59. Mahnke K, Guo M, Lee S, Sepulveda H, Swain SL, Nussenzweig M, Steinman RM (2000) The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. J Cell Biol 151:673-684
60. Mahnke K, Qian Y, Knop J, Enk AH (2003) Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells. Blood 101:4862-4869
61. Marshak-Rothstein A, Busconi L, Lau CM, Tabor AS, Leadbetter EA, Akira S, Krieg AM, Lipford GB, Viglianti GA, Rifkin IR (2004) Comparison of CpG s-ODNs, chromatin immune complexes, and dsDNA fragment immune complexes in the TLR9-dependent activation of rheumatoid factor B cells. J Endotoxin Res 10:247-251
62. Marshak-Rothstein A, Rifkin IR (2007) Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease. Annu Rev Immunol 25:419-441
63. Marshall AS, Willment JA, Lin HH, Williams DL, Gordon S, Brown GD (2004) Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes. J Biol Chem 279:14792-14802
64. Matyszak MK, Citterio S, Rescigno M, Ricciardi-Castagnoli P (2000) Differential effects of corticosteroids during different stages of dendritic cell maturation. Eur J Immunol 30:1233-1242
65. Matzinger P (2002) An innate sense of danger. Ann N Y Acad Sci 961:341-342
66. Mellman I (2005) Antigen processing and presentation by dendritic cells: cell biological mechanisms. Adv Exp Med Biol 560:63-67
67. Mellman I, Steinman RM (2001) Dendritic cells: specialized and regulated antigen processing machines. Cell 106:255-258
68. Menges M, Rossner S, Voigtlander C, Schindler H, Kukutsch NA, Bogdan C, Erb K, Schuler G, Lutz MB (2002) Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity. J Exp Med 195:15-21
69. Moghaddami M, Cleland LG, Radisic G, Mayrhofer G (2007) Recruitment of dendritic cells and macrophages during T cell-mediated synovial inflammation. Arthritis Res Ther 9:R120
70. Morita Y, Yang J, Gupta R, Shimizu K, Shelden EA, Endres J, Mule JJ, McDonagh KT, Fox DA (2001) Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. J Clin Invest 107:1275-1284
71. Napolitani G, Rinaldi A, Bertoni F, Sallusto F, Lanzavecchia A (2005) Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol 6:769-776
72. Nimmerjahn F, Ravetch JV (2006) Fcgamma receptors: old friends and new family members. Immunity 24:19-28
73. Nimmerjahn F, Ravetch JV (2007) Fc-receptors as regulators of immunity. Adv Immunol 96: 179-204
74. O'Neill LA, Fitzgerald KA, Bowie AG (2003) The Toll-IL-1 receptor adaptor family grows to five members. Trends Immunol 24:286-290
75. Okamura Y, Watari M, Jerud ES, Young DW, Ishizaka ST, Rose J, Chow JC, Strauss JF, III (2001) The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem 276:10229-10233
76. Page G, Lebecque S, Miossec P (2002) Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium. J Immunol 168:5333-5341
77. Page G, Miossec P (2004) Paired synovium and lymph nodes from rheumatoid arthritis patients differ in dendritic cell and chemokine expression. J Pathol 204:28-38
78. Penna G, Adorini L (2000) 1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol 164:2405-2411
79. Pricop L, Redecha P, Teillaud JL, Frey J, Fridman WH, Sautes-Fridman C, Salmon JE (2001) Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines. J Immunol 166:531-537
80. Probst HC, McCoy K, Okazaki T, Honjo T, van den Broek M (2005) Resting dendritic cells induce peripheral CD8+T cell tolerance through PD-1 and CTLA-4. Nat Immunol 6:280-286
81. Pulendran B, Smith JL, Caspary G, Brasel K, Pettit D, Maraskovsky E, Maliszewski CR (1999) Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc Natl Acad Sci USA 96: 1036-1041
82. Radstake TR, Blom AB, Sloetjes AW, van Gorselen EO, Pesman GJ, Engelen L, Torensma R, van den Berg WB, Figdor CG, van Lent PL, Adema GJ, Barrera P (2004a) Increased FcgammaRII expression and aberrant tumour necrosis factor alpha production by mature dendritic cells from patients with active rheumatoid arthritis. Ann Rheum Dis 63:1556-1563
83. Radstake TR, Roelofs MF, Jenniskens YM, Oppers-Walgreen B, van Riel PL, Barrera P, Joosten LA, van den Berg WB (2004b) Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma. Arthritis Rheum 50:3856-3865
84. Radstake TR, van Lent PL, Pesman GJ, Blom AB, Sweep FG, Ronnelid J, Adema GJ, Barrera P, van den Berg WB (2004c) High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcgammaR triggering. Ann Rheum Dis 63:696-702
85. Radstake TR, Nabbe KC,WeninkMH, RoelofsMF, Oosterlaar A, van Lieshout AW, Barrera P, van Lent PL, van den Berg WB (2005) Dendritic cells from patients with rheumatoid arthritis lack the interleukin 13 mediated increase of Fc gamma RII expression, which has clear functional consequences. Ann Rheum Dis 64:1737-1743
86. Radstake TR, Franke B,WeninkMH, Nabbe KC, CoenenMJ,Welsing P, Bonvini E, Koenig S, van den Berg WB, Barrera P, van Riel PL (2006) The functional variant of the inhibitory Fcgamma receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis. Arthritis Rheum 54:3828-3837
87. Randolph GJ, Sanchez-Schmitz G, Angeli V (2005) Factors and signals that govern the migration of dendritic cells via lymphatics: recent advances. Springer Semin Immunopathol 26:273-287
88. Ravetch JV, Bolland S (2001) IgG Fc receptors. Annu Rev Immunol 19:275-290
89. Reise Sousa C (2004a) Activation of dendritic cells: translating innate into adaptive immunity. Curr Opin Immunol 16:21-25
90. Reise Sousa C (2004b) Toll-like receptors and dendritic cells: for whom the bug tolls. Semin Immunol 16:27-34
91. Roelofs MF, Joosten LA, Abdollahi-Roodsaz S, van Lieshout AW, Sprong T, van den Hoogen FH, van den Berg WB, Radstake TR (2005) The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells. Arthritis Rheum 52:2313-2322
92. Roelofs MF, Boelens WC, Joosten LA, Abdollahi-Roodsaz S, Geurts J, Wunderink LU, Schreurs BW, van den Berg WB, Radstake TR (2006) Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis. J Immunol 176:7021-7027
93. Roelofs MF, Abdollahi-Roodsaz S, Joosten LA, van de berg WB, Radstake T (2008) The orchestra of Toll-Like Receptors (TLRs) and their potential role in frequently occurring rheumatic conditions. Arthritis Rheum 58:338-348
94. Ronnblom L, Alm GV (2002) The natural interferon-alpha producing cells in systemic lupus erythematosus. Hum Immunol 63:1181-1193
95. Salmon JE, Pricop L (2001) Human receptors for immunoglobulin G: key elements in the pathogenesis of rheumatic disease. Arthritis Rheum 44:739-750
96. Seder RA, Paul WE, Davis MM, Fazekas de St Groth B (1992) The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med 176:1091-1098
97. Srivastava PK, Maki RG (1991) Stress-induced proteins in immune response to cancer. Curr Top Microbiol Immunol 167:109-123
98. Steinbrink K,WolflM, Jonuleit H, Knop J, Enk AH (1997) Induction of tolerance by IL-10-treated dendritic cells. J Immunol 159:4772-4780
99. Steinman RM, Banchereau J (2007) Taking dendritic cells into medicine. Nature 449:419-426 Steinman RM, Cohn ZA (1973) Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med 137:1142-1162
100. Steinman RM, Nussenzweig MC (2002) Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci USA 99:351-358
101. Svensson L, Jirholt J, Holmdahl R, Jansson L (1998) B cell-deficient mice do not develop type II collagen-induced arthritis (CIA). Clin Exp Immunol 111:521-526
102. Tacken PJ, de Vries IJ, Torensma R, Figdor CG (2007) Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting. Nat Rev Immunol 7:790-802
103. Takeuchi O, Kawai T, Muhlradt PF, Morr M, Radolf JD, Zychlinsky A, Takeda K, Akira S (2001) Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol 13:933-940
104. Terato K, Hasty KA, Reife RA, Cremer MA, Kang AH, Stuart JM (1992) Induction of arthritis with monoclonal antibodies to collagen. J Immunol 148:2103-2108
105. Termeer C, Benedix F, Sleeman J, Fieber C, Voith U, Ahrens T, Miyake K, Freudenberg M, Galanos C, Simon JC (2002) Oligosaccharides of Hyaluronan activate dendritic cells via tolllike receptor 4. J Exp Med 195:99-111
106. Thomas R, Lipsky PE (1996a) Dendritic cells: origin and differentiation. Stem Cells 14:196-206 Thomas R, Lipsky PE (1996b) Presentation of self peptides by dendritic cells: possible implications for the pathogenesis of rheumatoid arthritis. Arthritis Rheum 39:183-190
107. Thomas R, Quinn C (1996) Functional differentiation of dendritic cells in rheumatoid arthritis: role of CD86 in the synovium. J Immunol 156:3074-3086
108. Thomas R, Davis LS, Lipsky PE (1994) Rheumatoid synovium is enriched in mature antigenpresenting dendritic cells. J Immunol 152:2613-2623
109. Trombetta ES, Mellman I (2005) Cell biology of antigen processing in vitro and in vivo. Annu Rev Immunol 23:975-1028
110. Ueno H, Klechevsky E, Morita R, Aspord C, Cao T, Matsui T, Di Pucchio T, Connolly J, Fay JW, Pascual V, Palucka AK, Banchereau J (2007) Dendritic cell subsets in health and disease. Immunol Rev 219:118-142
111. Unger WW, Hauet-Broere F, Jansen W, van Berkel LA, Kraal G, Samsom JN (2003) Early events in peripheral regulatory T cell induction via the nasal mucosa. J Immunol 171:4592-4603
112. van der Pouw Kraan TC,Wijbrandts CA, van Baarsen LG, Voskuyl AE, Rustenburg F, Baggen JM, Ibrahim SM, Fero M, Dijkmans BA, Tak PP, Verweij CL (2007) Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: assignment of a type I interferon signature in a subpopulation of patients. Ann Rheum Dis 66:1008-1014
113. van Duivenvoorde LM, Louis-Plence P, Apparailly F, van der Voort EI, Huizinga TW, Jorgensen C, Toes RE (2004) Antigen-specific immunomodulation of collagen-induced arthritis with tumor necrosis factor-stimulated dendritic cells. Arthritis Rheum 50:3354-3364
114. van Duivenvoorde LM, Han WG, Bakker AM, Louis-Plence P, Charbonnier LM, Apparailly F, van der Voort EI, Jorgensen C, Huizinga TW, Toes RE (2007) Immunomodulatory dendritic cells inhibit Th1 responses and arthritis via different mechanisms. J Immunol 179:1506-1515
115. van Vliet SJ, den Dunnen J, Gringhuis SI, Geijtenbeek TB, van Kooyk Y (2007) Innate signaling and regulation of Dendritic cell immunity. Curr Opin Immunol 19:435-440
116. Wakkach A, Fournier N, Brun V, Breittmayer JP, Cottrez F, Groux H (2003) Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 18:605-617
117. Waldner H, Collins M, Kuchroo VK (2004) Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease. J Clin Invest 113:990-997
118. Weyand CM, Goronzy JJ (2003) Ectopic germinal center formation in rheumatoid synovitis. Ann N Y Acad Sci 987:140-149
119. Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD, Basham B, Smith K, Chen T, Morel F, Lecron JC, Kastelein RA, Cua DJ, McClanahan TK, Bowman EP, de Waal Malefyt R (2007) Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 8:950-957
120. Zhang D, Facchinetti V, Wang X, Huang Q, Qin J, Su B (2006) Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways. Embo J 25:97-107
121. Zwickey HL, Unternaehrer JJ, Mellman I (2006) Presentation of self-antigens on MHC class II molecules during dendritic cell maturation. Int Immunol 18:199-209