메뉴 건너뛰기




Volumn 146, Issue 6, 2014, Pages 1477-1488

Regulation of the immune system by the resident intestinal bacteria

Author keywords

IgA; Innate Lymphoid Cells; Microbiota; Regulatory T Cell; Th17

Indexed keywords

IMMUNOGLOBULIN A; TRANSCRIPTION FACTOR FOXP3;

EID: 84898789502     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.01.060     Document Type: Article
Times cited : (220)

References (108)
  • 1
    • 77649086402 scopus 로고    scopus 로고
    • Immune adaptations that maintain homeostasis with the intestinal microbiota
    • L.V. Hooper, and A.J. Macpherson Immune adaptations that maintain homeostasis with the intestinal microbiota Nat Rev Immunol 10 2010 159 169
    • (2010) Nat Rev Immunol , vol.10 , pp. 159-169
    • Hooper, L.V.1    Macpherson, A.J.2
  • 2
    • 84876913132 scopus 로고    scopus 로고
    • Role of the gut microbiota in immunity and inflammatory disease
    • N. Kamada, S.U. Seo, and G.Y. Chen et al. Role of the gut microbiota in immunity and inflammatory disease Nat Rev Immunol 13 2013 321 335
    • (2013) Nat Rev Immunol , vol.13 , pp. 321-335
    • Kamada, N.1    Seo, S.U.2    Chen, G.Y.3
  • 3
    • 84866146940 scopus 로고    scopus 로고
    • Diversity, stability and resilience of the human gut microbiota
    • C.A. Lozupone, J.I. Stombaugh, and J.I. Gordon et al. Diversity, stability and resilience of the human gut microbiota Nature 489 2012 220 230
    • (2012) Nature , vol.489 , pp. 220-230
    • Lozupone, C.A.1    Stombaugh, J.I.2    Gordon, J.I.3
  • 4
    • 84879343905 scopus 로고    scopus 로고
    • Control of pathogens and pathobionts by the gut microbiota
    • N. Kamada, G.Y. Chen, and N. Inohara et al. Control of pathogens and pathobionts by the gut microbiota Nat Immunol 14 2013 685 690
    • (2013) Nat Immunol , vol.14 , pp. 685-690
    • Kamada, N.1    Chen, G.Y.2    Inohara, N.3
  • 5
    • 77049194735 scopus 로고
    • Germfree research: A basic study in host-contaminant relationship. I. General and theoretical aspects of the problem
    • J.A. Reyniers, and P.C. Trexler Germfree research: a basic study in host-contaminant relationship. I. General and theoretical aspects of the problem Bull N Y Acad Med 31 1955 231 235
    • (1955) Bull N y Acad Med , vol.31 , pp. 231-235
    • Reyniers, J.A.1    Trexler, P.C.2
  • 6
    • 0013931933 scopus 로고
    • Aging in germ-free mice: Life tables and lesions observed at natural death
    • H.A. Gordon, E. Bruckner-Kardoss, and B.S. Wostmann Aging in germ-free mice: life tables and lesions observed at natural death J Gerontol 21 1966 380 387
    • (1966) J Gerontol , vol.21 , pp. 380-387
    • Gordon, H.A.1    Bruckner-Kardoss, E.2    Wostmann, B.S.3
  • 7
    • 0036136321 scopus 로고    scopus 로고
    • Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine
    • H. Hamada, T. Hiroi, and Y. Nishiyama et al. Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine J Immunol 168 2002 57 64
    • (2002) J Immunol , vol.168 , pp. 57-64
    • Hamada, H.1    Hiroi, T.2    Nishiyama, Y.3
  • 8
    • 56749146467 scopus 로고    scopus 로고
    • Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
    • D. Bouskra, C. Brezillon, and M. Berard et al. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis Nature 456 2008 507 510
    • (2008) Nature , vol.456 , pp. 507-510
    • Bouskra, D.1    Brezillon, C.2    Berard, M.3
  • 9
    • 0019453345 scopus 로고
    • Origin and fate of IgE-bearing lymphocytes. I. Peyer's patches as differentiation site of cells. Simultaneously bearing IgA and IgE
    • H.G. Durkin, H. Bazin, and B.H. Waksman Origin and fate of IgE-bearing lymphocytes. I. Peyer's patches as differentiation site of cells. Simultaneously bearing IgA and IgE J Exp Med 154 1981 640 648
    • (1981) J Exp Med , vol.154 , pp. 640-648
    • Durkin, H.G.1    Bazin, H.2    Waksman, B.H.3
  • 10
    • 0029155360 scopus 로고
    • Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut
    • K.E. Shroff, K. Meslin, and J.J. Cebra Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut Infect Immun 63 1995 3904 3913
    • (1995) Infect Immun , vol.63 , pp. 3904-3913
    • Shroff, K.E.1    Meslin, K.2    Cebra, J.J.3
  • 11
    • 0033004028 scopus 로고    scopus 로고
    • Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system
    • G.L. Talham, H.Q. Jiang, and N.A. Bos et al. Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system Infect Immun 67 1999 1992 2000
    • (1999) Infect Immun , vol.67 , pp. 1992-2000
    • Talham, G.L.1    Jiang, H.Q.2    Bos, N.A.3
  • 12
    • 84873528605 scopus 로고    scopus 로고
    • Role of the gut microbiota in the development and function of lymphoid cells
    • N. Kamada, and G. Nunez Role of the gut microbiota in the development and function of lymphoid cells J Immunol 190 2013 1389 1395
    • (2013) J Immunol , vol.190 , pp. 1389-1395
    • Kamada, N.1    Nunez, G.2
  • 13
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • S.K. Mazmanian, C.H. Liu, and A.O. Tzianabos et al. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system Cell 122 2005 107 118
    • (2005) Cell , vol.122 , pp. 107-118
    • Mazmanian, S.K.1    Liu, C.H.2    Tzianabos, A.O.3
  • 14
    • 84862637797 scopus 로고    scopus 로고
    • Gut immune maturation depends on colonization with a host-specific microbiota
    • H. Chung, S.J. Pamp, and J.A. Hill et al. Gut immune maturation depends on colonization with a host-specific microbiota Cell 149 2012 1578 1593
    • (2012) Cell , vol.149 , pp. 1578-1593
    • Chung, H.1    Pamp, S.J.2    Hill, J.A.3
  • 15
    • 0034326645 scopus 로고    scopus 로고
    • Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa
    • F. Luzza, T. Parrello, and G. Monteleone et al. Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa J Immunol 165 2000 5332 5337
    • (2000) J Immunol , vol.165 , pp. 5332-5337
    • Luzza, F.1    Parrello, T.2    Monteleone, G.3
  • 16
    • 53349173070 scopus 로고    scopus 로고
    • Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
    • Ivanov II, R.L. de Frutos, and N. Manel et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine Cell Host Microbe 4 2008 337 349
    • (2008) Cell Host Microbe , vol.4 , pp. 337-349
    • Ivanov, I.I.1    De Frutos, R.L.2    Manel, N.3
  • 17
    • 70349742524 scopus 로고    scopus 로고
    • The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses
    • V. Gaboriau-Routhiau, S. Rakotobe, and E. Lecuyer et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses Immunity 31 2009 677 689
    • (2009) Immunity , vol.31 , pp. 677-689
    • Gaboriau-Routhiau, V.1    Rakotobe, S.2    Lecuyer, E.3
  • 18
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • Ivanov II, K. Atarashi, and N. Manel et al. Induction of intestinal Th17 cells by segmented filamentous bacteria Cell 139 2009 485 498
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1    Atarashi, K.2    Manel, N.3
  • 19
    • 77950349016 scopus 로고    scopus 로고
    • Th17 and regulatory T cells in mediating and restraining inflammation
    • D.R. Littman, and A.Y. Rudensky Th17 and regulatory T cells in mediating and restraining inflammation Cell 140 2010 845 858
    • (2010) Cell , vol.140 , pp. 845-858
    • Littman, D.R.1    Rudensky, A.Y.2
  • 20
    • 53649100675 scopus 로고    scopus 로고
    • ATP drives lamina propria T(H)17 cell differentiation
    • K. Atarashi, J. Nishimura, and T. Shima et al. ATP drives lamina propria T(H)17 cell differentiation Nature 455 2008 808 812
    • (2008) Nature , vol.455 , pp. 808-812
    • Atarashi, K.1    Nishimura, J.2    Shima, T.3
  • 21
    • 53349164200 scopus 로고    scopus 로고
    • Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses
    • J.A. Hall, N. Bouladoux, and C.M. Sun et al. Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses Immunity 29 2008 637 649
    • (2008) Immunity , vol.29 , pp. 637-649
    • Hall, J.A.1    Bouladoux, N.2    Sun, C.M.3
  • 22
    • 79956315886 scopus 로고    scopus 로고
    • Intestinal bacterial colonization induces mutualistic regulatory T cell responses
    • M.B. Geuking, J. Cahenzli, and M.A. Lawson et al. Intestinal bacterial colonization induces mutualistic regulatory T cell responses Immunity 34 2011 794 806
    • (2011) Immunity , vol.34 , pp. 794-806
    • Geuking, M.B.1    Cahenzli, J.2    Lawson, M.A.3
  • 23
    • 84861972274 scopus 로고    scopus 로고
    • Regulated virulence controls the ability of a pathogen to compete with the gut microbiota
    • N. Kamada, Y.G. Kim, and H.P. Sham et al. Regulated virulence controls the ability of a pathogen to compete with the gut microbiota Science 336 2012 1325 1329
    • (2012) Science , vol.336 , pp. 1325-1329
    • Kamada, N.1    Kim, Y.G.2    Sham, H.P.3
  • 24
    • 84881477044 scopus 로고    scopus 로고
    • T induction by a rationally selected mixture of Clostridia strains from the human microbiota
    • K. Atarashi, T. Tanoue, and K. Oshima et al. T induction by a rationally selected mixture of Clostridia strains from the human microbiota Nature 500 2013 232 236
    • (2013) Nature , vol.500 , pp. 232-236
    • Atarashi, K.1    Tanoue, T.2    Oshima, K.3
  • 25
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory T cells by indigenous Clostridium species
    • K. Atarashi, T. Tanoue, and T. Shima et al. Induction of colonic regulatory T cells by indigenous Clostridium species Science 331 2011 337 341
    • (2011) Science , vol.331 , pp. 337-341
    • Atarashi, K.1    Tanoue, T.2    Shima, T.3
  • 26
    • 0032803862 scopus 로고    scopus 로고
    • Phylogeny of the defined murine microbiota: Altered Schaedler flora
    • F.E. Dewhirst, C.C. Chien, and B.J. Paster et al. Phylogeny of the defined murine microbiota: altered Schaedler flora Appl Environ Microbiol 65 1999 3287 3292
    • (1999) Appl Environ Microbiol , vol.65 , pp. 3287-3292
    • Dewhirst, F.E.1    Chien, C.C.2    Paster, B.J.3
  • 27
    • 77954738601 scopus 로고    scopus 로고
    • Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
    • J.L. Round, and S.K. Mazmanian Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota Proc Natl Acad Sci U S A 107 2010 12204 12209
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 12204-12209
    • Round, J.L.1    Mazmanian, S.K.2
  • 28
    • 79956311926 scopus 로고    scopus 로고
    • The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    • J.L. Round, S.M. Lee, and J. Li et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota Science 332 2011 974 977
    • (2011) Science , vol.332 , pp. 974-977
    • Round, J.L.1    Lee, S.M.2    Li, J.3
  • 29
    • 84859164917 scopus 로고    scopus 로고
    • Homeland security: IgA immunity at the frontiers of the body
    • A.J. Macpherson, M.B. Geuking, and K.D. McCoy Homeland security: IgA immunity at the frontiers of the body Trends Immunol 33 2012 160 167
    • (2012) Trends Immunol , vol.33 , pp. 160-167
    • Macpherson, A.J.1    Geuking, M.B.2    McCoy, K.D.3
  • 30
    • 84883741301 scopus 로고    scopus 로고
    • Microbial colonization influences early B-lineage development in the gut lamina propria
    • D.R. Wesemann, A.J. Portuguese, and R.M. Meyers et al. Microbial colonization influences early B-lineage development in the gut lamina propria Nature 501 2013 112 115
    • (2013) Nature , vol.501 , pp. 112-115
    • Wesemann, D.R.1    Portuguese, A.J.2    Meyers, R.M.3
  • 31
    • 77952311371 scopus 로고    scopus 로고
    • Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis
    • S. Fagarasan, S. Kawamoto, and O. Kanagawa et al. Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis Annu Rev Immunol 28 2010 243 273
    • (2010) Annu Rev Immunol , vol.28 , pp. 243-273
    • Fagarasan, S.1    Kawamoto, S.2    Kanagawa, O.3
  • 32
    • 84867807929 scopus 로고    scopus 로고
    • Innate lymphoid cell interactions with microbiota: Implications for intestinal health and disease
    • G.F. Sonnenberg, and D. Artis Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease Immunity 37 2012 601 610
    • (2012) Immunity , vol.37 , pp. 601-610
    • Sonnenberg, G.F.1    Artis, D.2
  • 33
    • 57449118239 scopus 로고    scopus 로고
    • Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
    • N. Satoh-Takayama, C.A. Vosshenrich, and S. Lesjean-Pottier et al. Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense Immunity 29 2008 958 970
    • (2008) Immunity , vol.29 , pp. 958-970
    • Satoh-Takayama, N.1    Vosshenrich, C.A.2    Lesjean-Pottier, S.3
  • 34
    • 57849117363 scopus 로고    scopus 로고
    • RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells
    • S.L. Sanos, V.L. Bui, and A. Mortha et al. RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells Nat Immunol 10 2009 83 91
    • (2009) Nat Immunol , vol.10 , pp. 83-91
    • Sanos, S.L.1    Bui, V.L.2    Mortha, A.3
  • 35
    • 78049385155 scopus 로고    scopus 로고
    • Lineage relationship analysis of RORgammat+ innate lymphoid cells
    • S. Sawa, M. Cherrier, and M. Lochner et al. Lineage relationship analysis of RORgammat+ innate lymphoid cells Science 330 2010 665 669
    • (2010) Science , vol.330 , pp. 665-669
    • Sawa, S.1    Cherrier, M.2    Lochner, M.3
  • 36
    • 78649360369 scopus 로고    scopus 로고
    • Regulated expression of nuclear receptor RORgammat confers distinct functional fates to NK cell receptor-expressing RORgammat(+) innate lymphocytes
    • C. Vonarbourg, A. Mortha, and V.L. Bui et al. Regulated expression of nuclear receptor RORgammat confers distinct functional fates to NK cell receptor-expressing RORgammat(+) innate lymphocytes Immunity 33 2010 736 751
    • (2010) Immunity , vol.33 , pp. 736-751
    • Vonarbourg, C.1    Mortha, A.2    Bui, V.L.3
  • 37
    • 79952986650 scopus 로고    scopus 로고
    • RORgammat+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
    • S. Sawa, M. Lochner, and N. Satoh-Takayama et al. RORgammat+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota Nat Immunol 12 2011 320 326
    • (2011) Nat Immunol , vol.12 , pp. 320-326
    • Sawa, S.1    Lochner, M.2    Satoh-Takayama, N.3
  • 38
    • 84859911615 scopus 로고    scopus 로고
    • NLRC4-driven production of IL-1beta discriminates between pathogenic and commensal bacteria and promotes host intestinal defense
    • L. Franchi, N. Kamada, and Y. Nakamura et al. NLRC4-driven production of IL-1beta discriminates between pathogenic and commensal bacteria and promotes host intestinal defense Nat Immunol 13 2012 449 456
    • (2012) Nat Immunol , vol.13 , pp. 449-456
    • Franchi, L.1    Kamada, N.2    Nakamura, Y.3
  • 39
    • 27744437941 scopus 로고    scopus 로고
    • Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria
    • N. Kamada, T. Hisamatsu, and S. Okamoto et al. Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria J Immunol 175 2005 6900 6908
    • (2005) J Immunol , vol.175 , pp. 6900-6908
    • Kamada, N.1    Hisamatsu, T.2    Okamoto, S.3
  • 40
    • 34548764423 scopus 로고    scopus 로고
    • Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses
    • T.L. Denning, Y.C. Wang, and S.R. Patel et al. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses Nat Immunol 8 2007 1086 1094
    • (2007) Nat Immunol , vol.8 , pp. 1086-1094
    • Denning, T.L.1    Wang, Y.C.2    Patel, S.R.3
  • 41
    • 84856815290 scopus 로고    scopus 로고
    • Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon
    • A. Rivollier, J. He, and A. Kole et al. Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon J Exp Med 209 2012 139 155
    • (2012) J Exp Med , vol.209 , pp. 139-155
    • Rivollier, A.1    He, J.2    Kole, A.3
  • 42
    • 84866158239 scopus 로고    scopus 로고
    • Protective role of commensals against clostridium difficile infection via an IL-1beta-mediated positive-feedback loop
    • M. Hasegawa, N. Kamada, and Y. Jiao et al. Protective role of commensals against clostridium difficile infection via an IL-1beta-mediated positive-feedback loop J Immunol 189 2012 3085 3091
    • (2012) J Immunol , vol.189 , pp. 3085-3091
    • Hasegawa, M.1    Kamada, N.2    Jiao, Y.3
  • 43
    • 76249120134 scopus 로고    scopus 로고
    • Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity
    • T.B. Clarke, K.M. Davis, and E.S. Lysenko et al. Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity Nat Med 16 2010 228 231
    • (2010) Nat Med , vol.16 , pp. 228-231
    • Clarke, T.B.1    Davis, K.M.2    Lysenko, E.S.3
  • 44
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • E. Bettelli, Y. Carrier, and W. Gao et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells Nature 441 2006 235 238
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3
  • 45
    • 33646560950 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces development of the T(H)17 lineage
    • P.R. Mangan, L.E. Harrington, and D.B. O'Quinn et al. Transforming growth factor-beta induces development of the T(H)17 lineage Nature 441 2006 231 234
    • (2006) Nature , vol.441 , pp. 231-234
    • Mangan, P.R.1    Harrington, L.E.2    O'Quinn, D.B.3
  • 46
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov II, B.S. McKenzie, and L. Zhou et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells Cell 126 2006 1121 1133
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3
  • 47
    • 34547204946 scopus 로고    scopus 로고
    • Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    • R. Nurieva, X.O. Yang, and G. Martinez et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells Nature 448 2007 480 483
    • (2007) Nature , vol.448 , pp. 480-483
    • Nurieva, R.1    Yang, X.O.2    Martinez, G.3
  • 48
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • L. Zhou, Ivanov II, and R. Spolski et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways Nat Immunol 8 2007 967 974
    • (2007) Nat Immunol , vol.8 , pp. 967-974
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3
  • 49
    • 84863151799 scopus 로고    scopus 로고
    • Microbiota-induced IL-1beta, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine
    • M.H. Shaw, N. Kamada, and Y.G. Kim et al. Microbiota-induced IL-1beta, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine J Exp Med 209 2012 251 258
    • (2012) J Exp Med , vol.209 , pp. 251-258
    • Shaw, M.H.1    Kamada, N.2    Kim, Y.G.3
  • 50
    • 76749110853 scopus 로고    scopus 로고
    • Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development
    • M. Hasegawa, T. Osaka, and K. Tawaratsumida et al. Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development Infect Immun 78 2010 639 650
    • (2010) Infect Immun , vol.78 , pp. 639-650
    • Hasegawa, M.1    Osaka, T.2    Tawaratsumida, K.3
  • 51
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    • P.M. Smith, M.R. Howitt, and N. Panikov et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis Science 341 2013 569 573
    • (2013) Science , vol.341 , pp. 569-573
    • Smith, P.M.1    Howitt, M.R.2    Panikov, N.3
  • 52
    • 84890564250 scopus 로고    scopus 로고
    • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
    • Y. Furusawa, Y. Obata, and S. Fukuda et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells Nature 504 2013 446 450
    • (2013) Nature , vol.504 , pp. 446-450
    • Furusawa, Y.1    Obata, Y.2    Fukuda, S.3
  • 53
    • 84890550163 scopus 로고    scopus 로고
    • Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
    • N. Arpaia, C. Campbell, and X. Fan et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation Nature 504 2013 451 455
    • (2013) Nature , vol.504 , pp. 451-455
    • Arpaia, N.1    Campbell, C.2    Fan, X.3
  • 54
    • 0038491435 scopus 로고    scopus 로고
    • Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation
    • E. Le Poul, C. Loison, and S. Struyf et al. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation J Biol Chem 278 2003 25481 25489
    • (2003) J Biol Chem , vol.278 , pp. 25481-25489
    • Le Poul, E.1    Loison, C.2    Struyf, S.3
  • 55
    • 80054980812 scopus 로고    scopus 로고
    • Regulation of inflammation by short chain fatty acids
    • M.A. Vinolo, H.G. Rodrigues, and R.T. Nachbar et al. Regulation of inflammation by short chain fatty acids Nutrients 3 2011 858 876
    • (2011) Nutrients , vol.3 , pp. 858-876
    • Vinolo, M.A.1    Rodrigues, H.G.2    Nachbar, R.T.3
  • 56
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    • J.L. Coombes, K.R. Siddiqui, and C.V. Arancibia-Carcamo et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism J Exp Med 204 2007 1757 1764
    • (2007) J Exp Med , vol.204 , pp. 1757-1764
    • Coombes, J.L.1    Siddiqui, K.R.2    Arancibia-Carcamo, C.V.3
  • 57
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • C.M. Sun, J.A. Hall, and R.B. Blank et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid J Exp Med 204 2007 1775 1785
    • (2007) J Exp Med , vol.204 , pp. 1775-1785
    • Sun, C.M.1    Hall, J.A.2    Blank, R.B.3
  • 58
    • 34447503805 scopus 로고    scopus 로고
    • Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    • D. Mucida, Y. Park, and G. Kim et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid Science 317 2007 256 260
    • (2007) Science , vol.317 , pp. 256-260
    • Mucida, D.1    Park, Y.2    Kim, G.3
  • 59
    • 84885447087 scopus 로고    scopus 로고
    • Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism
    • N.E. Welty, C. Staley, and N. Ghilardi et al. Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism J Exp Med 210 2013 2011 2024
    • (2013) J Exp Med , vol.210 , pp. 2011-2024
    • Welty, N.E.1    Staley, C.2    Ghilardi, N.3
  • 60
    • 84892449521 scopus 로고    scopus 로고
    • Activation of gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
    • N. Singh, A. Gurav, and S. Sivaprakasam et al. Activation of gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis Immunity 40 2014 128 139
    • (2014) Immunity , vol.40 , pp. 128-139
    • Singh, N.1    Gurav, A.2    Sivaprakasam, S.3
  • 61
    • 84879254845 scopus 로고    scopus 로고
    • GPR15-mediated homing controls immune homeostasis in the large intestine mucosa
    • S.V. Kim, W.V. Xiang, and C. Kwak et al. GPR15-mediated homing controls immune homeostasis in the large intestine mucosa Science 340 2013 1456 1459
    • (2013) Science , vol.340 , pp. 1456-1459
    • Kim, S.V.1    Xiang, W.V.2    Kwak, C.3
  • 62
    • 84866166162 scopus 로고    scopus 로고
    • Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon
    • M. Kinoshita, H. Kayama, and T. Kusu et al. Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon J Immunol 189 2012 2869 2878
    • (2012) J Immunol , vol.189 , pp. 2869-2878
    • Kinoshita, M.1    Kayama, H.2    Kusu, T.3
  • 63
    • 79952055276 scopus 로고    scopus 로고
    • Folate production by probiotic bacteria
    • M. Rossi, A. Amaretti, and S. Raimondi Folate production by probiotic bacteria Nutrients 3 2011 118 134
    • (2011) Nutrients , vol.3 , pp. 118-134
    • Rossi, M.1    Amaretti, A.2    Raimondi, S.3
  • 64
    • 44449106055 scopus 로고    scopus 로고
    • A microbial symbiosis factor prevents intestinal inflammatory disease
    • S.K. Mazmanian, J.L. Round, and D.L. Kasper A microbial symbiosis factor prevents intestinal inflammatory disease Nature 453 2008 620 625
    • (2008) Nature , vol.453 , pp. 620-625
    • Mazmanian, S.K.1    Round, J.L.2    Kasper, D.L.3
  • 65
    • 84877726564 scopus 로고    scopus 로고
    • Microbe-dependent CD11b(+) IgA(+) plasma cells mediate robust early-phase intestinal IgA responses in mice
    • J. Kunisawa, M. Gohda, and E. Hashimoto et al. Microbe-dependent CD11b(+) IgA(+) plasma cells mediate robust early-phase intestinal IgA responses in mice Nat Commun 4 2013 1772
    • (2013) Nat Commun , vol.4 , pp. 1772
    • Kunisawa, J.1    Gohda, M.2    Hashimoto, E.3
  • 66
    • 77954898661 scopus 로고    scopus 로고
    • The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut
    • K. Suzuki, M. Maruya, and S. Kawamoto et al. The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut Immunity 33 2010 71 83
    • (2010) Immunity , vol.33 , pp. 71-83
    • Suzuki, K.1    Maruya, M.2    Kawamoto, S.3
  • 67
    • 34548176272 scopus 로고    scopus 로고
    • Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells
    • H. Tezuka, Y. Abe, and M. Iwata et al. Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells Nature 448 2007 929 933
    • (2007) Nature , vol.448 , pp. 929-933
    • Tezuka, H.1    Abe, Y.2    Iwata, M.3
  • 68
    • 33751223544 scopus 로고    scopus 로고
    • Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells
    • J.R. Mora, M. Iwata, and B. Eksteen et al. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells Science 314 2006 1157 1160
    • (2006) Science , vol.314 , pp. 1157-1160
    • Mora, J.R.1    Iwata, M.2    Eksteen, B.3
  • 69
    • 45549099429 scopus 로고    scopus 로고
    • Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5
    • S. Uematsu, K. Fujimoto, and M.H. Jang et al. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5 Nat Immunol 9 2008 769 776
    • (2008) Nat Immunol , vol.9 , pp. 769-776
    • Uematsu, S.1    Fujimoto, K.2    Jang, M.H.3
  • 70
    • 0033006564 scopus 로고    scopus 로고
    • Differential roles of segmented filamentous bacteria and clostridia in development of the intestinal immune system
    • Y. Umesaki, H. Setoyama, and S. Matsumoto et al. Differential roles of segmented filamentous bacteria and clostridia in development of the intestinal immune system Infect Immun 67 1999 3504 3511
    • (1999) Infect Immun , vol.67 , pp. 3504-3511
    • Umesaki, Y.1    Setoyama, H.2    Matsumoto, S.3
  • 71
    • 77954051526 scopus 로고    scopus 로고
    • Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses
    • S. Hapfelmeier, M.A. Lawson, and E. Slack et al. Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses Science 328 2010 1705 1709
    • (2010) Science , vol.328 , pp. 1705-1709
    • Hapfelmeier, S.1    Lawson, M.A.2    Slack, E.3
  • 72
    • 78650183459 scopus 로고    scopus 로고
    • Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by Toll-like receptor 2
    • N.K. Crellin, S. Trifari, and C.D. Kaplan et al. Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by Toll-like receptor 2 Immunity 33 2010 752 764
    • (2010) Immunity , vol.33 , pp. 752-764
    • Crellin, N.K.1    Trifari, S.2    Kaplan, C.D.3
  • 73
    • 84882664672 scopus 로고    scopus 로고
    • Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22
    • T. Zelante, R.G. Iannitti, and C. Cunha et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22 Immunity 39 2013 372 385
    • (2013) Immunity , vol.39 , pp. 372-385
    • Zelante, T.1    Iannitti, R.G.2    Cunha, C.3
  • 74
    • 84874082076 scopus 로고    scopus 로고
    • CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium
    • C. Manta, E. Heupel, and K. Radulovic et al. CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium Mucosal Immunol 6 2013 177 188
    • (2013) Mucosal Immunol , vol.6 , pp. 177-188
    • Manta, C.1    Heupel, E.2    Radulovic, K.3
  • 75
    • 77949911050 scopus 로고    scopus 로고
    • Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions
    • J.H. Niess, and G. Adler Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions J Immunol 184 2010 2026 2037
    • (2010) J Immunol , vol.184 , pp. 2026-2037
    • Niess, J.H.1    Adler, G.2
  • 76
    • 84857444876 scopus 로고    scopus 로고
    • Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense
    • M.A. Kinnebrew, C.G. Buffie, and G.E. Diehl et al. Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense Immunity 36 2012 276 287
    • (2012) Immunity , vol.36 , pp. 276-287
    • Kinnebrew, M.A.1    Buffie, C.G.2    Diehl, G.E.3
  • 77
    • 83855160821 scopus 로고    scopus 로고
    • Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles
    • E.A. Kiss, C. Vonarbourg, and S. Kopfmann et al. Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles Science 334 2011 1561 1565
    • (2011) Science , vol.334 , pp. 1561-1565
    • Kiss, E.A.1    Vonarbourg, C.2    Kopfmann, S.3
  • 78
    • 84856237141 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells
    • J. Qiu, J.J. Heller, and X. Guo et al. The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells Immunity 36 2012 92 104
    • (2012) Immunity , vol.36 , pp. 92-104
    • Qiu, J.1    Heller, J.J.2    Guo, X.3
  • 79
    • 70350666634 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
    • K.M. Maslowski, A.T. Vieira, and A. Ng et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43 Nature 461 2009 1282 1286
    • (2009) Nature , vol.461 , pp. 1282-1286
    • Maslowski, K.M.1    Vieira, A.T.2    Ng, A.3
  • 80
    • 54449083567 scopus 로고    scopus 로고
    • The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
    • M.E. Johansson, M. Phillipson, and J. Petersson et al. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria Proc Natl Acad Sci U S A 105 2008 15064 15069
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 15064-15069
    • Johansson, M.E.1    Phillipson, M.2    Petersson, J.3
  • 81
    • 77953610970 scopus 로고    scopus 로고
    • Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa
    • K.S. Bergstrom, V. Kissoon-Singh, and D.L. Gibson et al. Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa PLoS Pathog 6 2010 e1000902
    • (2010) PLoS Pathog , vol.6 , pp. 1000902
    • Bergstrom, K.S.1    Kissoon-Singh, V.2    Gibson, D.L.3
  • 82
    • 58549111588 scopus 로고    scopus 로고
    • Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
    • S. Vaishnava, C.L. Behrendt, and A.S. Ismail et al. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface Proc Natl Acad Sci U S A 105 2008 20858 20863
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 20858-20863
    • Vaishnava, S.1    Behrendt, C.L.2    Ismail, A.S.3
  • 83
    • 84861989207 scopus 로고    scopus 로고
    • Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria
    • G.F. Sonnenberg, L.A. Monticelli, and T. Alenghat et al. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria Science 336 2012 1321 1325
    • (2012) Science , vol.336 , pp. 1321-1325
    • Sonnenberg, G.F.1    Monticelli, L.A.2    Alenghat, T.3
  • 84
    • 77955657786 scopus 로고    scopus 로고
    • The role of secretory antibodies in infection immunity
    • R.A. Strugnell, and O.L. Wijburg The role of secretory antibodies in infection immunity Nat Rev Microbiol 8 2010 656 667
    • (2010) Nat Rev Microbiol , vol.8 , pp. 656-667
    • Strugnell, R.A.1    Wijburg, O.L.2
  • 85
    • 0034705397 scopus 로고    scopus 로고
    • A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria
    • A.J. Macpherson, D. Gatto, and E. Sainsbury et al. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria Science 288 2000 2222 2226
    • (2000) Science , vol.288 , pp. 2222-2226
    • Macpherson, A.J.1    Gatto, D.2    Sainsbury, E.3
  • 86
    • 84883858159 scopus 로고    scopus 로고
    • Intraluminal containment of commensal outgrowth in the gut during infection-induced dysbiosis
    • M.J. Molloy, J.R. Grainger, and N. Bouladoux et al. Intraluminal containment of commensal outgrowth in the gut during infection-induced dysbiosis Cell Host Microbe 14 2013 318 328
    • (2013) Cell Host Microbe , vol.14 , pp. 318-328
    • Molloy, M.J.1    Grainger, J.R.2    Bouladoux, N.3
  • 87
    • 34548131112 scopus 로고    scopus 로고
    • Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10
    • C.L. Maynard, L.E. Harrington, and K.M. Janowski et al. Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10 Nat Immunol 8 2007 931 941
    • (2007) Nat Immunol , vol.8 , pp. 931-941
    • Maynard, C.L.1    Harrington, L.E.2    Janowski, K.M.3
  • 88
    • 0027517545 scopus 로고
    • Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
    • F. Powrie, M.W. Leach, and S. Mauze et al. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice Int Immunol 5 1993 1461 1471
    • (1993) Int Immunol , vol.5 , pp. 1461-1471
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3
  • 89
    • 0037136284 scopus 로고    scopus 로고
    • Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis
    • M.C. Kullberg, D. Jankovic, and P.L. Gorelick et al. Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis J Exp Med 196 2002 505 515
    • (2002) J Exp Med , vol.196 , pp. 505-515
    • Kullberg, M.C.1    Jankovic, D.2    Gorelick, P.L.3
  • 90
    • 0346734121 scopus 로고    scopus 로고
    • Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope
    • M.C. Kullberg, J.F. Andersen, and P.L. Gorelick et al. Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope Proc Natl Acad Sci U S A 100 2003 15830 15835
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15830-15835
    • Kullberg, M.C.1    Andersen, J.F.2    Gorelick, P.L.3
  • 91
    • 77953486362 scopus 로고    scopus 로고
    • Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis
    • T. Feng, L. Wang, and T.R. Schoeb et al. Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis J Exp Med 207 2010 1321 1332
    • (2010) J Exp Med , vol.207 , pp. 1321-1332
    • Feng, T.1    Wang, L.2    Schoeb, T.R.3
  • 92
    • 84878737123 scopus 로고    scopus 로고
    • Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria
    • M.R. Hepworth, L.A. Monticelli, and T.C. Fung et al. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria Nature 498 2013 113 117
    • (2013) Nature , vol.498 , pp. 113-117
    • Hepworth, M.R.1    Monticelli, L.A.2    Fung, T.C.3
  • 93
    • 28544446111 scopus 로고    scopus 로고
    • Monocyte and macrophage heterogeneity
    • S. Gordon, and P.R. Taylor Monocyte and macrophage heterogeneity Nat Rev Immunol 5 2005 953 964
    • (2005) Nat Rev Immunol , vol.5 , pp. 953-964
    • Gordon, S.1    Taylor, P.R.2
  • 94
    • 13744256812 scopus 로고    scopus 로고
    • Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity
    • L.E. Smythies, M. Sellers, and R.H. Clements et al. Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity J Clin Invest 115 2005 66 75
    • (2005) J Clin Invest , vol.115 , pp. 66-75
    • Smythies, L.E.1    Sellers, M.2    Clements, R.H.3
  • 95
    • 0037112050 scopus 로고    scopus 로고
    • Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora
    • S. Fagarasan, M. Muramatsu, and K. Suzuki et al. Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora Science 298 2002 1424 1427
    • (2002) Science , vol.298 , pp. 1424-1427
    • Fagarasan, S.1    Muramatsu, M.2    Suzuki, K.3
  • 96
    • 79951602552 scopus 로고    scopus 로고
    • Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense
    • M. Wei, R. Shinkura, and Y. Doi et al. Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense Nat Immunol 12 2011 264 270
    • (2011) Nat Immunol , vol.12 , pp. 264-270
    • Wei, M.1    Shinkura, R.2    Doi, Y.3
  • 97
    • 84860123211 scopus 로고    scopus 로고
    • The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut
    • S. Kawamoto, T.H. Tran, and M. Maruya et al. The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut Science 336 2012 485 489
    • (2012) Science , vol.336 , pp. 485-489
    • Kawamoto, S.1    Tran, T.H.2    Maruya, M.3
  • 98
    • 35848931007 scopus 로고    scopus 로고
    • IgA response to symbiotic bacteria as a mediator of gut homeostasis
    • D.A. Peterson, N.P. McNulty, and J.L. Guruge et al. IgA response to symbiotic bacteria as a mediator of gut homeostasis Cell Host Microbe 2 2007 328 339
    • (2007) Cell Host Microbe , vol.2 , pp. 328-339
    • Peterson, D.A.1    McNulty, N.P.2    Guruge, J.L.3
  • 99
    • 84882668842 scopus 로고    scopus 로고
    • Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora
    • J. Qiu, X. Guo, and Z.M. Chen et al. Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora Immunity 39 2013 386 399
    • (2013) Immunity , vol.39 , pp. 386-399
    • Qiu, J.1    Guo, X.2    Chen, Z.M.3
  • 100
    • 84877839153 scopus 로고    scopus 로고
    • IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic
    • L.A. Zenewicz, X. Yin, and G. Wang et al. IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic J Immunol 190 2013 5306 5312
    • (2013) J Immunol , vol.190 , pp. 5306-5312
    • Zenewicz, L.A.1    Yin, X.2    Wang, G.3
  • 101
    • 34848889673 scopus 로고    scopus 로고
    • Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system
    • W.S. Garrett, G.M. Lord, and S. Punit et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system Cell 131 2007 33 45
    • (2007) Cell , vol.131 , pp. 33-45
    • Garrett, W.S.1    Lord, G.M.2    Punit, S.3
  • 102
    • 77956569409 scopus 로고    scopus 로고
    • Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis
    • W.S. Garrett, C.A. Gallini, and T. Yatsunenko et al. Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis Cell Host Microbe 8 2010 292 300
    • (2010) Cell Host Microbe , vol.8 , pp. 292-300
    • Garrett, W.S.1    Gallini, C.A.2    Yatsunenko, T.3
  • 103
    • 84867856710 scopus 로고    scopus 로고
    • The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor(+) innate lymphoid cells
    • N. Powell, A.W. Walker, and E. Stolarczyk et al. The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor(+) innate lymphoid cells Immunity 37 2012 674 684
    • (2012) Immunity , vol.37 , pp. 674-684
    • Powell, N.1    Walker, A.W.2    Stolarczyk, E.3
  • 104
    • 79957576718 scopus 로고    scopus 로고
    • NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    • E. Elinav, T. Strowig, and A.L. Kau et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis Cell 145 2011 745 757
    • (2011) Cell , vol.145 , pp. 745-757
    • Elinav, E.1    Strowig, T.2    Kau, A.L.3
  • 105
    • 84866461477 scopus 로고    scopus 로고
    • Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice
    • C. Ubeda, L. Lipuma, and A. Gobourne et al. Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice J Exp Med 209 2012 1445 1456
    • (2012) J Exp Med , vol.209 , pp. 1445-1456
    • Ubeda, C.1    Lipuma, L.2    Gobourne, A.3
  • 106
    • 84885573828 scopus 로고    scopus 로고
    • Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens
    • K.M. Ng, J.A. Ferreyra, and S.K. Higginbottom et al. Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens Nature 502 2013 96 99
    • (2013) Nature , vol.502 , pp. 96-99
    • Ng, K.M.1    Ferreyra, J.A.2    Higginbottom, S.K.3
  • 107
    • 77957157893 scopus 로고    scopus 로고
    • Gut inflammation provides a respiratory electron acceptor for Salmonella
    • S.E. Winter, P. Thiennimitr, and M.G. Winter et al. Gut inflammation provides a respiratory electron acceptor for Salmonella Nature 467 2010 426 429
    • (2010) Nature , vol.467 , pp. 426-429
    • Winter, S.E.1    Thiennimitr, P.2    Winter, M.G.3
  • 108
    • 84873513423 scopus 로고    scopus 로고
    • Host-derived nitrate boosts growth of E. Coli in the inflamed gut
    • S.E. Winter, M.G. Winter, and M.N. Xavier et al. Host-derived nitrate boosts growth of E. coli in the inflamed gut Science 339 2013 708 711
    • (2013) Science , vol.339 , pp. 708-711
    • Winter, S.E.1    Winter, M.G.2    Xavier, M.N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.