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Volumn , Issue , 2016, Pages 2702-2725

Update on melatonin receptors: IUPHAR Review 20

Author keywords

[No Author keywords available]

Indexed keywords

2 IODOMELATONIN; 2 METHOXY ALPHA, BETA DIDEHYDRO AGOMELATINE; 5 HEAT; 5 METHOXYLUZINDOLE; 6 CHLOROMELATONIN; 6 HYDROXYMELATONIN; AGOMELATINE; BOMPPA; CIFEA; DIMER; EFPPEA; GR 128107; GR 196429; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; MELATONIN RECEPTOR; MELATONIN RECEPTOR AGONIST; RADIOLIGAND; RAMELTEON; RECEPTOR BLOCKING AGENT; RECEPTOR LIGAND; S 22153; S 24014; S 24773; SCAVENGER; TASIMELTEON; TIK 301; UCM 1014; UCM 793; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84982890576     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.13536     Document Type: Review
Times cited : (333)

References (208)
  • 2
    • 0036739259 scopus 로고    scopus 로고
    • Functional melatonin receptors and metabolic coupling in cultured chick astrocytes
    • Adachi A, Natesan AK, Whitfield-Rucker MG, Weigum SE, Cassone VM (2002). Functional melatonin receptors and metabolic coupling in cultured chick astrocytes. Glia 39: 268–278.
    • (2002) Glia , vol.39 , pp. 268-278
    • Adachi, A.1    Natesan, A.K.2    Whitfield-Rucker, M.G.3    Weigum, S.E.4    Cassone, V.M.5
  • 3
    • 84874357645 scopus 로고    scopus 로고
    • Automated video analysis system reveals distinct diurnal behaviors in C57BL/6 and C3H/HeN mice
    • Adamah-Biassi EB, Stepien I, Hudson RL, Dubocovich ML (2013). Automated video analysis system reveals distinct diurnal behaviors in C57BL/6 and C3H/HeN mice. Behav Brain Res 243: 306–312.
    • (2013) Behav Brain Res , vol.243 , pp. 306-312
    • Adamah-Biassi, E.B.1    Stepien, I.2    Hudson, R.L.3    Dubocovich, M.L.4
  • 5
    • 68249110951 scopus 로고    scopus 로고
    • 5-MCA-NAT does not act through NQO2 to reduce intraocular pressure in New-Zealand white rabbit
    • Alarma-Estrany P, Crooke A, Pintor J (2009). 5-MCA-NAT does not act through NQO2 to reduce intraocular pressure in New-Zealand white rabbit. J Pineal Res 47: 201–209.
    • (2009) J Pineal Res , vol.47 , pp. 201-209
    • Alarma-Estrany, P.1    Crooke, A.2    Pintor, J.3
  • 6
    • 79953045716 scopus 로고    scopus 로고
    • Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse
    • Alcantara-Contreras S, Baba K, Tosini G (2011). Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse. Neurosci Lett 494: 61–64.
    • (2011) Neurosci Lett , vol.494 , pp. 61-64
    • Alcantara-Contreras, S.1    Baba, K.2    Tosini, G.3
  • 11
    • 77953212878 scopus 로고    scopus 로고
    • MTNR1B G24E variant associates with BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans
    • Andersson EA, Holst B, Sparso T, Grarup N, Banasik K, Holmkvist J et al. (2010). MTNR1B G24E variant associates with BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. Diabetes 59: 1539–1548.
    • (2010) Diabetes , vol.59 , pp. 1539-1548
    • Andersson, E.A.1    Holst, B.2    Sparso, T.3    Grarup, N.4    Banasik, K.5    Holmkvist, J.6
  • 13
    • 0037077208 scopus 로고    scopus 로고
    • Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer
    • Ayoub MA, Couturier C, Lucas-Meunier E, Angers S, Fossier P, Bouvier M et al. (2002). Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer. J Biol Chem 277: 21522–21528.
    • (2002) J Biol Chem , vol.277 , pp. 21522-21528
    • Ayoub, M.A.1    Couturier, C.2    Lucas-Meunier, E.3    Angers, S.4    Fossier, P.5    Bouvier, M.6
  • 14
    • 3342965731 scopus 로고    scopus 로고
    • Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers
    • Ayoub MA, Levoye A, Delagrange P, Jockers R (2004). Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers. Mol Pharmacol 66: 312–321.
    • (2004) Mol Pharmacol , vol.66 , pp. 312-321
    • Ayoub, M.A.1    Levoye, A.2    Delagrange, P.3    Jockers, R.4
  • 16
    • 84939623967 scopus 로고    scopus 로고
    • Melatonin Entrains PER2::LUC Bioluminescence Circadian Rhythm in the Mouse Cornea
    • Baba K, Davidson AJ, Tosini G (2015). Melatonin Entrains PER2::LUC Bioluminescence Circadian Rhythm in the Mouse Cornea. Invest Ophthalmol Vis Sci 56: 4753–4758.
    • (2015) Invest Ophthalmol Vis Sci , vol.56 , pp. 4753-4758
    • Baba, K.1    Davidson, A.J.2    Tosini, G.3
  • 17
    • 70349270675 scopus 로고    scopus 로고
    • Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor
    • Baba K, Pozdeyev N, Mazzoni F, Contreras-Alcantara S, Liu C, Kasamatsu M et al. (2009). Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor. Proc Natl Acad Sci U S A 106: 15043–15048.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 15043-15048
    • Baba, K.1    Pozdeyev, N.2    Mazzoni, F.3    Contreras-Alcantara, S.4    Liu, C.5    Kasamatsu, M.6
  • 18
    • 84954536679 scopus 로고    scopus 로고
    • Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons
    • Benleulmi-Chaachoua A, Chen L, Sokolina K, Wong V, Jurisica I, Emerit MB et al. (2016). Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. J Pineal Res 60: 95–108.
    • (2016) J Pineal Res , vol.60 , pp. 95-108
    • Benleulmi-Chaachoua, A.1    Chen, L.2    Sokolina, K.3    Wong, V.4    Jurisica, I.5    Emerit, M.B.6
  • 19
    • 84857654651 scopus 로고    scopus 로고
    • Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes
    • Bonnefond A, Clement N, Fawcett K, Yengo L, Vaillant E, Guillaume JL et al. (2012). Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nat Genet 44: 297–301.
    • (2012) Nat Genet , vol.44 , pp. 297-301
    • Bonnefond, A.1    Clement, N.2    Fawcett, K.3    Yengo, L.4    Vaillant, E.5    Guillaume, J.L.6
  • 20
    • 58149175143 scopus 로고    scopus 로고
    • A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
    • Bouatia-Naji N, Bonnefond A, Cavalcanti-Proenca C, Sparso T, Holmkvist J, Marchand M et al. (2009). A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet 41: 89–94.
    • (2009) Nat Genet , vol.41 , pp. 89-94
    • Bouatia-Naji, N.1    Bonnefond, A.2    Cavalcanti-Proenca, C.3    Sparso, T.4    Holmkvist, J.5    Marchand, M.6
  • 21
    • 0034054081 scopus 로고    scopus 로고
    • Pharmacological characterization of human recombinant melatonin mt(1) and MT2 receptors
    • Browning C, Beresford I, Fraser N, Giles H (2000). Pharmacological characterization of human recombinant melatonin mt(1) and MT2 receptors. Br J Pharmacol 129: 877–886.
    • (2000) Br J Pharmacol , vol.129 , pp. 877-886
    • Browning, C.1    Beresford, I.2    Fraser, N.3    Giles, H.4
  • 22
    • 78549284583 scopus 로고    scopus 로고
    • Clinical aspects of melatonin intervention in Alzheimer's disease progression
    • Cardinali DP, Furio AM, Brusco LI (2010). Clinical aspects of melatonin intervention in Alzheimer's disease progression. Curr Neuropharmacol 8: 218–227.
    • (2010) Curr Neuropharmacol , vol.8 , pp. 218-227
    • Cardinali, D.P.1    Furio, A.M.2    Brusco, L.I.3
  • 23
    • 2442648067 scopus 로고    scopus 로고
    • Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance
    • Carrillo VA, Calvo JR, Abreu P, Lardone PJ, Garcia MS, Reiter RJ et al. (2004). Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance. FASEB J 18: 537–539.
    • (2004) FASEB J , vol.18 , pp. 537-539
    • Carrillo, V.A.1    Calvo, J.R.2    Abreu, P.3    Lardone, P.J.4    Garcia, M.S.5    Reiter, R.J.6
  • 25
    • 84933567266 scopus 로고    scopus 로고
    • Amyloid beta peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway
    • Cecon E, Chen M, Marcola M, Fernandes PA, Jockers R, Markus RP (2015). Amyloid beta peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway. FASEB J 29: 2566–2582.
    • (2015) FASEB J , vol.29 , pp. 2566-2582
    • Cecon, E.1    Chen, M.2    Marcola, M.3    Fernandes, P.A.4    Jockers, R.5    Markus, R.P.6
  • 26
    • 84950124598 scopus 로고    scopus 로고
    • Melatonin inhibits granulocyte adhesion to ICAM via MT3/QR2 and MT2 receptors
    • Cernysiov V, Mauricas M, Girkontaite I (2015). Melatonin inhibits granulocyte adhesion to ICAM via MT3/QR2 and MT2 receptors. Int Immunol 27: 599–608.
    • (2015) Int Immunol , vol.27 , pp. 599-608
    • Cernysiov, V.1    Mauricas, M.2    Girkontaite, I.3
  • 27
    • 84877962180 scopus 로고    scopus 로고
    • Characterization of substituted phenylpropylamides as highly selective agonists at the melatonin MT2 receptor
    • Chan KH, Hu Y, Ho MK, Wong YH (2013). Characterization of substituted phenylpropylamides as highly selective agonists at the melatonin MT2 receptor. Curr Med Chem 20: 289–300.
    • (2013) Curr Med Chem , vol.20 , pp. 289-300
    • Chan, K.H.1    Hu, Y.2    Ho, M.K.3    Wong, Y.H.4
  • 28
    • 80054800543 scopus 로고    scopus 로고
    • Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders
    • Chaste P, Clement N, Botros HG, Guillaume JL, Konyukh M, Pagan C et al. (2011). Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders. J Pineal Res 51: 394–399.
    • (2011) J Pineal Res , vol.51 , pp. 394-399
    • Chaste, P.1    Clement, N.2    Botros, H.G.3    Guillaume, J.L.4    Konyukh, M.5    Pagan, C.6
  • 29
    • 77955389706 scopus 로고    scopus 로고
    • Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population
    • Chaste P, Clement N, Mercati O, Guillaume JL, Delorme R, Botros HG et al. (2010). Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population. PLoS One 5: e11495.
    • (2010) PLoS One , vol.5
    • Chaste, P.1    Clement, N.2    Mercati, O.3    Guillaume, J.L.4    Delorme, R.5    Botros, H.G.6
  • 30
    • 84925835406 scopus 로고    scopus 로고
    • 2 activation
    • Chen X, Li X, Du Z, Shi W, Yao Y, Wang C et al. (2014). Melatonin promotes the acquisition of neural identity through extracellular-signal-regulated kinases1/2activation. J Pineal Res 57: 168–176.
    • (2014) J Pineal Res , vol.57 , pp. 168-176
    • Chen, X.1    Li, X.2    Du, Z.3    Shi, W.4    Yao, Y.5    Wang, C.6
  • 31
    • 33749996489 scopus 로고    scopus 로고
    • Differences in binding sites of two melatonin receptors help to explain their selectivity to some melatonin analogs: a molecular modeling study
    • Chugunov AO, Farce A, Chavatte P, Efremov RG (2006). Differences in binding sites of two melatonin receptors help to explain their selectivity to some melatonin analogs: a molecular modeling study. J Biomol Struct Dyn 24: 91–107.
    • (2006) J Biomol Struct Dyn , vol.24 , pp. 91-107
    • Chugunov, A.O.1    Farce, A.2    Chavatte, P.3    Efremov, R.G.4
  • 32
    • 84901046826 scopus 로고    scopus 로고
    • Genetic deletion of the MT1 or MT2 melatonin receptors abrogates methamphetamine-induced reward in C3H/HeN mice
    • Clough SJ, Hutchinson AJ, Hudson RL, Dubocovich ML (2014). Genetic deletion of the MT1 or MT2 melatonin receptors abrogates methamphetamine-induced reward in C3H/HeN mice. Physiol Behav 132: 79–86.
    • (2014) Physiol Behav , vol.132 , pp. 79-86
    • Clough, S.J.1    Hutchinson, A.J.2    Hudson, R.L.3    Dubocovich, M.L.4
  • 33
    • 84873504658 scopus 로고    scopus 로고
    • Sleep–wake characterization of double MT(1)/MT(2) receptor knockout mice and comparison with MT(1) and MT(2) receptor knockout mice
    • Comai S, Ochoa-Sanchez R, Gobbi G (2013). Sleep–wake characterization of double MT(1)/MT(2) receptor knockout mice and comparison with MT(1) and MT(2) receptor knockout mice. Behav Brain Res 243: 231–238.
    • (2013) Behav Brain Res , vol.243 , pp. 231-238
    • Comai, S.1    Ochoa-Sanchez, R.2    Gobbi, G.3
  • 35
    • 77956095525 scopus 로고    scopus 로고
    • Removal of melatonin receptor type 1 induces insulin resistance in the mouse
    • Contreras-Alcantara S, Baba K, Tosini G (2010). Removal of melatonin receptor type 1 induces insulin resistance in the mouse. Obesity (Silver Spring) 18: 1861–1863.
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 1861-1863
    • Contreras-Alcantara, S.1    Baba, K.2    Tosini, G.3
  • 36
    • 0034810597 scopus 로고    scopus 로고
    • Serine residues 110 and 114 are required for agonist binding but not antagonist binding to the melatonin MT(1) receptor
    • Conway S, Mowat ES, Drew JE, Barrett P, Delagrange P, Morgan PJ (2001). Serine residues 110 and 114 are required for agonist binding but not antagonist binding to the melatonin MT(1) receptor. Biochem Biophys Res Commun 282: 1229–1236.
    • (2001) Biochem Biophys Res Commun , vol.282 , pp. 1229-1236
    • Conway, S.1    Mowat, E.S.2    Drew, J.E.3    Barrett, P.4    Delagrange, P.5    Morgan, P.J.6
  • 37
    • 34249670262 scopus 로고    scopus 로고
    • Purification and identification of G protein-coupled receptor protein complexes under native conditions
    • Daulat AM, Maurice P, Froment C, Guillaume JL, Broussard C, Monsarrat B et al. (2007). Purification and identification of G protein-coupled receptor protein complexes under native conditions. Mol Cell Proteomics 6: 835–844.
    • (2007) Mol Cell Proteomics , vol.6 , pp. 835-844
    • Daulat, A.M.1    Maurice, P.2    Froment, C.3    Guillaume, J.L.4    Broussard, C.5    Monsarrat, B.6
  • 39
    • 84933055330 scopus 로고    scopus 로고
    • Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential
    • de la Fuente Revenga M, Fernandez-Saez N, Herrera-Arozamena C, Morales-Garcia JA, Alonso-Gil S, Perez-Castillo A et al. (2015). Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential. J Med Chem 58: 4998–5014.
    • (2015) J Med Chem , vol.58 , pp. 4998-5014
    • de la Fuente Revenga, M.1    Fernandez-Saez, N.2    Herrera-Arozamena, C.3    Morales-Garcia, J.A.4    Alonso-Gil, S.5    Perez-Castillo, A.6
  • 41
    • 84921488132 scopus 로고    scopus 로고
    • Melatonin stimulates dendrite formation and complexity in the hilar zone of the rat hippocampus: participation of the Ca++/Calmodulin complex
    • Dominguez-Alonso A, Valdes-Tovar M, Solis-Chagoyan H, Benitez-King G (2015). Melatonin stimulates dendrite formation and complexity in the hilar zone of the rat hippocampus: participation of the Ca++/Calmodulin complex. Int J Mol Sci 16: 1907–1927.
    • (2015) Int J Mol Sci , vol.16 , pp. 1907-1927
    • Dominguez-Alonso, A.1    Valdes-Tovar, M.2    Solis-Chagoyan, H.3    Benitez-King, G.4
  • 42
    • 84887620421 scopus 로고    scopus 로고
    • Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
    • Dror RO, Green HF, Valant C, Borhani DW, Valcourt JR, Pan AC et al. (2013). Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs. Nature 503: 295–299.
    • (2013) Nature , vol.503 , pp. 295-299
    • Dror, R.O.1    Green, H.F.2    Valant, C.3    Borhani, D.W.4    Valcourt, J.R.5    Pan, A.C.6
  • 43
    • 0022364015 scopus 로고
    • Characterization of a retinal melatonin receptor
    • Dubocovich ML (1985). Characterization of a retinal melatonin receptor. J Pharmacol Exp Ther 234: 395–401.
    • (1985) J Pharmacol Exp Ther , vol.234 , pp. 395-401
    • Dubocovich, M.L.1
  • 44
    • 0023783020 scopus 로고
    • Luzindole (N-0774): a novel melatonin receptor antagonist
    • Dubocovich ML (1988). Luzindole (N-0774): a novel melatonin receptor antagonist. J Pharmacol Exp Ther 246: 902–910.
    • (1988) J Pharmacol Exp Ther , vol.246 , pp. 902-910
    • Dubocovich, M.L.1
  • 45
    • 0021051982 scopus 로고
    • Melatonin is a potent modulator of dopamine release in the retina
    • Dubocovich ML (1983). Melatonin is a potent modulator of dopamine release in the retina. Nature 306: 782–784.
    • (1983) Nature , vol.306 , pp. 782-784
    • Dubocovich, M.L.1
  • 46
    • 0028907243 scopus 로고
    • Melatonin receptors: Are there multiple subtypes?
    • Dubocovich ML (1995). Melatonin receptors: Are there multiple subtypes? Trends Pharmacol Sci 16: 50–56.
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 50-56
    • Dubocovich, M.L.1
  • 47
    • 36248957048 scopus 로고    scopus 로고
    • Melatonin receptors: role on sleep and circadian rhythm regulation
    • Dubocovich ML (2007). Melatonin receptors: role on sleep and circadian rhythm regulation. Sleep Med 8 (Suppl 3): 34–42.
    • (2007) Sleep Med , vol.8 , pp. 34-42
    • Dubocovich, M.L.1
  • 48
    • 77956289235 scopus 로고    scopus 로고
    • International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors
    • Dubocovich ML, Delagrange P, Krause DN, Sugden D, Cardinali DP, Olcese J (2010). International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors. Pharmacol Rev 62: 343–380.
    • (2010) Pharmacol Rev , vol.62 , pp. 343-380
    • Dubocovich, M.L.1    Delagrange, P.2    Krause, D.N.3    Sugden, D.4    Cardinali, D.P.5    Olcese, J.6
  • 49
    • 23744445174 scopus 로고    scopus 로고
    • Effect of MT1 melatonin receptor deletion on melatonin-mediated phase shift of circadian rhythms in the C57BL/6 mouse
    • Dubocovich ML, Hudson RL, Sumaya IC, Masana MI, Manna E (2005). Effect of MT1 melatonin receptor deletion on melatonin-mediated phase shift of circadian rhythms in the C57BL/6 mouse. J Pineal Res 39: 113–120.
    • (2005) J Pineal Res , vol.39 , pp. 113-120
    • Dubocovich, M.L.1    Hudson, R.L.2    Sumaya, I.C.3    Masana, M.I.4    Manna, E.5
  • 50
    • 0030964398 scopus 로고    scopus 로고
    • Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor
    • Dubocovich ML, Masana MI, Iacob S, Sauri DM (1997). Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn Schmiedebergs Arch Pharmacol 355: 365–375.
    • (1997) Naunyn Schmiedebergs Arch Pharmacol , vol.355 , pp. 365-375
    • Dubocovich, M.L.1    Masana, M.I.2    Iacob, S.3    Sauri, D.M.4
  • 51
    • 2942580561 scopus 로고    scopus 로고
    • Molecular pharmacology, regulation and function of mammalian melatonin receptors
    • Dubocovich ML, Rivera-Bermudez MA, Gerdin MJ, Masana MI (2003). Molecular pharmacology, regulation and function of mammalian melatonin receptors. Front Biosci 8: d1093–d1108.
    • (2003) Front Biosci , vol.8 , pp. d1093-d1108
    • Dubocovich, M.L.1    Rivera-Bermudez, M.A.2    Gerdin, M.J.3    Masana, M.I.4
  • 52
    • 0023353416 scopus 로고
    • Use of 2-[125I]iodomelatonin to characterize melatonin binding sites in chicken retina
    • Dubocovich ML, Takahashi JS (1987). Use of 2-[125I]iodomelatonin to characterize melatonin binding sites in chicken retina. Proc Natl Acad Sci U S A 84: 3916–3920.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 3916-3920
    • Dubocovich, M.L.1    Takahashi, J.S.2
  • 53
    • 0032161469 scopus 로고    scopus 로고
    • Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms
    • Dubocovich ML, Yun K, AlGhoul WM, Benloucif S, Masana MI (1998). Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms. FASEB J 12: 1211–1220.
    • (1998) FASEB J , vol.12 , pp. 1211-1220
    • Dubocovich, M.L.1    Yun, K.2    AlGhoul, W.M.3    Benloucif, S.4    Masana, M.I.5
  • 54
    • 0033533386 scopus 로고    scopus 로고
    • Alleic variants of human melatonin 1a receptor: Function and prevalence in subjects with circadian rhythm sleep disorders
    • Ebisawa T, Kajimura N, Uchiyama M, Katoh M, Sekimoto M, Watanabe T et al. (1999). Alleic variants of human melatonin 1a receptor: Function and prevalence in subjects with circadian rhythm sleep disorders. Biochem Biophys Res Commun 262: 832–837.
    • (1999) Biochem Biophys Res Commun , vol.262 , pp. 832-837
    • Ebisawa, T.1    Kajimura, N.2    Uchiyama, M.3    Katoh, M.4    Sekimoto, M.5    Watanabe, T.6
  • 56
    • 84857237872 scopus 로고    scopus 로고
    • Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I)
    • Ettaoussi M, Sabaouni A, Rami M, Boutin JA, Delagrange P, Renard P et al. (2012). Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I). Eur J Med Chem 49: 310–323.
    • (2012) Eur J Med Chem , vol.49 , pp. 310-323
    • Ettaoussi, M.1    Sabaouni, A.2    Rami, M.3    Boutin, J.A.4    Delagrange, P.5    Renard, P.6
  • 57
    • 84961202813 scopus 로고    scopus 로고
    • Melatonin receptor activation increases glutamatergic synaptic transmission in the rat medial lateral habenula
    • Evely KM, Hudson RL, Dubocovich ML, Haj-Dahmane S (2016). Melatonin receptor activation increases glutamatergic synaptic transmission in the rat medial lateral habenula. Synapse 70: 181–186.
    • (2016) Synapse , vol.70 , pp. 181-186
    • Evely, K.M.1    Hudson, R.L.2    Dubocovich, M.L.3    Haj-Dahmane, S.4
  • 58
    • 0025332798 scopus 로고
    • Activation of melatonin receptor sites retarded the depletion of norepinephrine following inhibition of synthesis in the C3H/HeN mouse hypothalamus
    • Fang JM, Dubocovich ML (1990). Activation of melatonin receptor sites retarded the depletion of norepinephrine following inhibition of synthesis in the C3H/HeN mouse hypothalamus. J Neurochem 55: 76–82.
    • (1990) J Neurochem , vol.55 , pp. 76-82
    • Fang, J.M.1    Dubocovich, M.L.2
  • 61
    • 0034704888 scopus 로고    scopus 로고
    • Mapping the melatonin receptor. 6. Melatonin agonists and antagonists derived from 6H-isoindolo[2,1-a]indoles, 5,6-dihydroindolo[2,1-a]isoquinolines, and 6,7-dihydro-5H-benzo[c]azepino[2,1-a]indoles
    • Faust R, Garratt PJ, Jones R, Yeh LK, Tsotinis A, Panoussopoulou M et al. (2000). Mapping the melatonin receptor. 6. Melatonin agonists and antagonists derived from 6H-isoindolo[2,1-a]indoles, 5,6-dihydroindolo[2,1-a]isoquinolines, and 6,7-dihydro-5H-benzo[c]azepino[2,1-a]indoles. J Med Chem 43: 1050–1061.
    • (2000) J Med Chem , vol.43 , pp. 1050-1061
    • Faust, R.1    Garratt, P.J.2    Jones, R.3    Yeh, L.K.4    Tsotinis, A.5    Panoussopoulou, M.6
  • 62
    • 84893642127 scopus 로고    scopus 로고
    • G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives
    • Ferre S, Casado V, Devi LA, Filizola M, Jockers R, Lohse MJ et al. (2014). G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives. Pharmacol Rev 66: 413–434.
    • (2014) Pharmacol Rev , vol.66 , pp. 413-434
    • Ferre, S.1    Casado, V.2    Devi, L.A.3    Filizola, M.4    Jockers, R.5    Lohse, M.J.6
  • 63
    • 67349108317 scopus 로고    scopus 로고
    • Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat
    • Fisher SP, Sugden D (2009). Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat. Neurosci Lett 457: 93–96.
    • (2009) Neurosci Lett , vol.457 , pp. 93-96
    • Fisher, S.P.1    Sugden, D.2
  • 64
    • 7744244600 scopus 로고    scopus 로고
    • Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin
    • Gerdin MJ, Masana MI, Rivera-Bermudez MA, Hudson RL, Earnest DJ, Gillette MU et al. (2004). Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin. FASEB J 18: 1646–1656.
    • (2004) FASEB J , vol.18 , pp. 1646-1656
    • Gerdin, M.J.1    Masana, M.I.2    Rivera-Bermudez, M.A.3    Hudson, R.L.4    Earnest, D.J.5    Gillette, M.U.6
  • 65
    • 0038771257 scopus 로고    scopus 로고
    • Mutagenesis studies of the human MT2 melatonin receptor
    • Gerdin MJ, Mseeh F, Dubocovich ML (2003). Mutagenesis studies of the human MT2 melatonin receptor. Biochem Pharmacol 66: 315–320.
    • (2003) Biochem Pharmacol , vol.66 , pp. 315-320
    • Gerdin, M.J.1    Mseeh, F.2    Dubocovich, M.L.3
  • 68
    • 84929606922 scopus 로고    scopus 로고
    • Photoperiod programs dorsal raphe serotonergic neurons and affective behaviors
    • Green NH, Jackson CR, Iwamoto H, Tackenberg MC, McMahon DG (2015). Photoperiod programs dorsal raphe serotonergic neurons and affective behaviors. Curr Biol 25: 1389–1394.
    • (2015) Curr Biol , vol.25 , pp. 1389-1394
    • Green, N.H.1    Jackson, C.R.2    Iwamoto, H.3    Tackenberg, M.C.4    McMahon, D.G.5
  • 69
    • 80053597542 scopus 로고    scopus 로고
    • 2-[(1,3-Dihydro-2H-isoindol-2yl)methyl]-melatonin- a novel MT2-selective melatonin receptor antagonist
    • Heckman D, Attia MI, Behnam MAM, Mohsen AMY, Markl C, Julius J et al. (2011). 2-[(1,3-Dihydro-2H-isoindol-2yl)methyl]-melatonin- a novel MT2-selective melatonin receptor antagonist. Med Chem Commun 2: 991–994.
    • (2011) Med Chem Commun , vol.2 , pp. 991-994
    • Heckman, D.1    Attia, M.I.2    Behnam, M.A.M.3    Mohsen, A.M.Y.4    Markl, C.5    Julius, J.6
  • 72
    • 77950040001 scopus 로고    scopus 로고
    • Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT2-selective melatonin ligands
    • Hu Y, Ho MKC, Chan KH, New DC, Wong YH (2010). Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT2-selective melatonin ligands. Bioorg Med Chem Lett 20: 2582–2585.
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 2582-2585
    • Hu, Y.1    Ho, M.K.C.2    Chan, K.H.3    New, D.C.4    Wong, Y.H.5
  • 73
    • 84871628099 scopus 로고    scopus 로고
    • Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT(2)-selective melatonin agonists: improving metabolic stability
    • Hu Y, Zhu J, Chan KH, Wong YH (2013). Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT(2)-selective melatonin agonists: improving metabolic stability. Bioorg Med Chem 21: 547–552.
    • (2013) Bioorg Med Chem , vol.21 , pp. 547-552
    • Hu, Y.1    Zhu, J.2    Chan, K.H.3    Wong, Y.H.4
  • 74
    • 0035008125 scopus 로고    scopus 로고
    • Activation of MT2 melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock
    • Hunt AE, AlGhoul WM, Gillette MU, Dubocovich ML (2001). Activation of MT2 melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock. Am J Physiol Cell Physiol 280: C110–C118.
    • (2001) Am J Physiol Cell Physiol , vol.280 , pp. C110-C118
    • Hunt, A.E.1    AlGhoul, W.M.2    Gillette, M.U.3    Dubocovich, M.L.4
  • 75
    • 84867741169 scopus 로고    scopus 로고
    • Genetic deletion of MT(1) and MT(2) melatonin receptors differentially abrogates the development and expression of methamphetamine-induced locomotor sensitization during the day and the night in C3H/HeN mice
    • Hutchinson AJ, Hudson RL, Dubocovich ML (2012). Genetic deletion of MT(1) and MT(2) melatonin receptors differentially abrogates the development and expression of methamphetamine-induced locomotor sensitization during the day and the night in C3H/HeN mice. J Pineal Res 53: 399–409.
    • (2012) J Pineal Res , vol.53 , pp. 399-409
    • Hutchinson, A.J.1    Hudson, R.L.2    Dubocovich, M.L.3
  • 76
    • 29144518647 scopus 로고    scopus 로고
    • Rhythms in clock proteins in the mouse pars tuberalis depend on MT1 melatonin receptor signalling
    • Jilg A, Moek J, Weaver DR, Korf HW, Stehle JH, von Gall C (2005). Rhythms in clock proteins in the mouse pars tuberalis depend on MT1 melatonin receptor signalling. Eur J Neurosci 22: 2845–2854.
    • (2005) Eur J Neurosci , vol.22 , pp. 2845-2854
    • Jilg, A.1    Moek, J.2    Weaver, D.R.3    Korf, H.W.4    Stehle, J.H.5    von Gall, C.6
  • 78
    • 47249088189 scopus 로고    scopus 로고
    • Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?
    • Jockers R, Maurice P, Boutin JA, Delagrange P (2008). Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new? Br J Pharmacol 154: 1182–1195.
    • (2008) Br J Pharmacol , vol.154 , pp. 1182-1195
    • Jockers, R.1    Maurice, P.2    Boutin, J.A.3    Delagrange, P.4
  • 79
    • 84942580316 scopus 로고    scopus 로고
    • 60 YEARS OF NEUROENDOCRINOLOGY: Regulation of mammalian neuroendocrine physiology and rhythms by melatonin
    • Johnston JD, Skene DJ (2015). 60 YEARS OF NEUROENDOCRINOLOGY: Regulation of mammalian neuroendocrine physiology and rhythms by melatonin. J Endocrinol 226: T187–T198.
    • (2015) J Endocrinol , vol.226 , pp. T187-T198
    • Johnston, J.D.1    Skene, D.J.2
  • 80
    • 84934442413 scopus 로고    scopus 로고
    • Beyond standard molecular dynamics: investigating the molecular mechanisms of G protein-coupled receptors with enhanced molecular dynamics methods
    • Johnston JM, Filizola M (2014). Beyond standard molecular dynamics: investigating the molecular mechanisms of G protein-coupled receptors with enhanced molecular dynamics methods. Adv Exp Med Biol 796: 95–125.
    • (2014) Adv Exp Med Biol , vol.796 , pp. 95-125
    • Johnston, J.M.1    Filizola, M.2
  • 81
    • 84937848389 scopus 로고    scopus 로고
    • Promising Role of Melatonin as Neuroprotectant in Neurodegenerative Pathology
    • Joshi N, Biswas J, Nath C, Singh S (2015). Promising Role of Melatonin as Neuroprotectant in Neurodegenerative Pathology. Mol Neurobiol 52: 330–340.
    • (2015) Mol Neurobiol , vol.52 , pp. 330-340
    • Joshi, N.1    Biswas, J.2    Nath, C.3    Singh, S.4
  • 83
    • 84929492265 scopus 로고    scopus 로고
    • Convergence of melatonin and serotonin (5-HT) signaling at MT2/5-HT2C receptor heteromers
    • Kamal M, Gbahou F, Guillaume JL, Daulat AM, Benleulmi-Chaachoua A, Luka M et al. (2015). Convergence of melatonin and serotonin (5-HT) signaling at MT2/5-HT2C receptor heteromers. J Biol Chem 290: 11537–11546.
    • (2015) J Biol Chem , vol.290 , pp. 11537-11546
    • Kamal, M.1    Gbahou, F.2    Guillaume, J.L.3    Daulat, A.M.4    Benleulmi-Chaachoua, A.5    Luka, M.6
  • 84
    • 84938359988 scopus 로고    scopus 로고
    • Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
    • Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A et al. (2015). Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. Nature 523: 561–567.
    • (2015) Nature , vol.523 , pp. 561-567
    • Kang, Y.1    Zhou, X.E.2    Gao, X.3    He, Y.4    Liu, W.5    Ishchenko, A.6
  • 86
    • 84880774466 scopus 로고    scopus 로고
    • Minireview: Toward the Establishment of a Link between Melatonin and Glucose Homeostasis: Association of Melatonin MT2 Receptor Variants with Type 2 Diabetes
    • Karamitri A, Renault N, Clement N, Guillaume JL, Jockers R (2013). Minireview: Toward the Establishment of a Link between Melatonin and Glucose Homeostasis: Association of Melatonin MT2 Receptor Variants with Type 2 Diabetes. Mol Endocrinol 27: 1217–1233.
    • (2013) Mol Endocrinol , vol.27 , pp. 1217-1233
    • Karamitri, A.1    Renault, N.2    Clement, N.3    Guillaume, J.L.4    Jockers, R.5
  • 87
    • 13444259587 scopus 로고    scopus 로고
    • Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist
    • Kato K, Hirai K, Nishiyama K, Uchikawa O, Fukatsu K, Ohkawa S et al. (2005). Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist. Neuropharmacology 48: 301–310.
    • (2005) Neuropharmacology , vol.48 , pp. 301-310
    • Kato, K.1    Hirai, K.2    Nishiyama, K.3    Uchikawa, O.4    Fukatsu, K.5    Ohkawa, S.6
  • 88
    • 79955814739 scopus 로고    scopus 로고
    • 1,6-Dihydro-2H-indeno[5,4-b]furan derivatives: design, synthesis, and pharmacological characterization of a novel class of highly potent MT(2)-selective agonists
    • Koike T, Hoashi Y, Takai T, Nakayama M, Yukuhiro N, Ishikawa T et al. (2011). 1,6-Dihydro-2H-indeno[5,4-b]furan derivatives: design, synthesis, and pharmacological characterization of a novel class of highly potent MT(2)-selective agonists. J Med Chem 54: 3436–3444.
    • (2011) J Med Chem , vol.54 , pp. 3436-3444
    • Koike, T.1    Hoashi, Y.2    Takai, T.3    Nakayama, M.4    Yukuhiro, N.5    Ishikawa, T.6
  • 90
    • 43049123138 scopus 로고    scopus 로고
    • Melatonin regulates the viability and differentiation of rat midbrain neural stem cells
    • Kong X, Li X, Cai Z, Yang N, Liu Y, Shu J et al. (2008). Melatonin regulates the viability and differentiation of rat midbrain neural stem cells. Cell Mol Neurobiol 28: 569–579.
    • (2008) Cell Mol Neurobiol , vol.28 , pp. 569-579
    • Kong, X.1    Li, X.2    Cai, Z.3    Yang, N.4    Liu, Y.5    Shu, J.6
  • 91
    • 0026746216 scopus 로고
    • Optic nerve transection decreases 2-[125I]iodomelatonin binding in the chick optic tectum
    • Krause DN, Siuciak JA, Dubocovich ML (1992). Optic nerve transection decreases 2-[125I]iodomelatonin binding in the chick optic tectum. Brain Res 590: 325–328.
    • (1992) Brain Res , vol.590 , pp. 325-328
    • Krause, D.N.1    Siuciak, J.A.2    Dubocovich, M.L.3
  • 92
    • 0027959038 scopus 로고
    • Unilateral optic nerve transection decreases 2-[125I]-iodomelatonin binding in retinorecipient areas and visual pathways of chick brain
    • Krause DN, Siuciak JA, Dubocovich ML (1994). Unilateral optic nerve transection decreases 2-[125I]-iodomelatonin binding in retinorecipient areas and visual pathways of chick brain. Brain Res 654: 63–74.
    • (1994) Brain Res , vol.654 , pp. 63-74
    • Krause, D.N.1    Siuciak, J.A.2    Dubocovich, M.L.3
  • 93
    • 73649091088 scopus 로고    scopus 로고
    • Response of melatonin receptor MT1 in spleen of a tropical Indian rodent, Funambulus pennanti, to natural solar insolation and different photoperiodic conditions
    • Lahiri S, Haldar C (2009). Response of melatonin receptor MT1 in spleen of a tropical Indian rodent, Funambulus pennanti, to natural solar insolation and different photoperiodic conditions. Chronobiol Int 26: 1559–1574.
    • (2009) Chronobiol Int , vol.26 , pp. 1559-1574
    • Lahiri, S.1    Haldar, C.2
  • 94
    • 65549159290 scopus 로고    scopus 로고
    • Antagonism of serotonergic 5-HT2A/2C receptors: mutual improvement of sleep, cognition and mood?
    • Landolt HP, Wehrle R (2009). Antagonism of serotonergic 5-HT2A/2C receptors: mutual improvement of sleep, cognition and mood? Eur J Neurosci 29: 1795–1809.
    • (2009) Eur J Neurosci , vol.29 , pp. 1795-1809
    • Landolt, H.P.1    Wehrle, R.2
  • 98
    • 28444443829 scopus 로고    scopus 로고
    • Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice
    • Larson J, Jessen RE, Uz T, Arslan AD, Kurtuncu M, Imbesi M et al. (2006). Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice. Neurosci Lett 393: 23–26.
    • (2006) Neurosci Lett , vol.393 , pp. 23-26
    • Larson, J.1    Jessen, R.E.2    Uz, T.3    Arslan, A.D.4    Kurtuncu, M.5    Imbesi, M.6
  • 99
    • 84921059225 scopus 로고    scopus 로고
    • Tasimelteon: a selective and unique receptor binding profile
    • Lavedan C, Forsberg M, Gentile AJ (2015). Tasimelteon: a selective and unique receptor binding profile. Neuropharmacology 91: 142–147.
    • (2015) Neuropharmacology , vol.91 , pp. 142-147
    • Lavedan, C.1    Forsberg, M.2    Gentile, A.J.3
  • 101
    • 84897901749 scopus 로고    scopus 로고
    • Melatonin from cerebrospinal fluid but not from blood reaches sheep cerebral tissues under physiological conditions
    • Legros C, Chesneau D, Boutin JA, Barc C, Malpaux B (2014). Melatonin from cerebrospinal fluid but not from blood reaches sheep cerebral tissues under physiological conditions. J Neuroendocrinol 26: 151–163.
    • (2014) J Neuroendocrinol , vol.26 , pp. 151-163
    • Legros, C.1    Chesneau, D.2    Boutin, J.A.3    Barc, C.4    Malpaux, B.5
  • 102
    • 84876900594 scopus 로고    scopus 로고
    • New Radioligands for Describing the Molecular Pharmacology of MT1 and MT2 Melatonin Receptors
    • Legros C, Matthey U, Grelak T, Pedragona-Moreau S, Hassler W, Yous S et al. (2013). New Radioligands for Describing the Molecular Pharmacology of MT1 and MT2 Melatonin Receptors. Int J Mol Sci 14: 8948–8962.
    • (2013) Int J Mol Sci , vol.14 , pp. 8948-8962
    • Legros, C.1    Matthey, U.2    Grelak, T.3    Pedragona-Moreau, S.4    Hassler, W.5    Yous, S.6
  • 103
    • 33746290412 scopus 로고    scopus 로고
    • The orphan GPR50 receptor specifically inhibits MT(1) melatonin receptor function through heterodimerization
    • Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P et al. (2006a). The orphan GPR50 receptor specifically inhibits MT(1) melatonin receptor function through heterodimerization. EMBO J 25: 3012–3023.
    • (2006) EMBO J , vol.25 , pp. 3012-3023
    • Levoye, A.1    Dam, J.2    Ayoub, M.A.3    Guillaume, J.L.4    Couturier, C.5    Delagrange, P.6
  • 104
    • 33750502435 scopus 로고    scopus 로고
    • Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers
    • Levoye A, Dam J, Ayoub MA, Guillaume JL, Jockers R (2006b). Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers. EMBO Rep 7: 1094–1098.
    • (2006) EMBO Rep , vol.7 , pp. 1094-1098
    • Levoye, A.1    Dam, J.2    Ayoub, M.A.3    Guillaume, J.L.4    Jockers, R.5
  • 105
    • 0000665443 scopus 로고
    • Enzymatic oxidation of some non-phosphorylated derivatives of dihydronicotinamide
    • Liao S, Williams-Ashman HG (1961). Enzymatic oxidation of some non-phosphorylated derivatives of dihydronicotinamide. Biochem Biophys Res Commun 4: 208–213.
    • (1961) Biochem Biophys Res Commun , vol.4 , pp. 208-213
    • Liao, S.1    Williams-Ashman, H.G.2
  • 106
    • 0030761518 scopus 로고    scopus 로고
    • Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock
    • Liu C, Weaver DR, Jin X, Shearman LP, Pieschl RL, Gribkoff VK et al. (1997). Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. Neuron 19: 91–102.
    • (1997) Neuron , vol.19 , pp. 91-102
    • Liu, C.1    Weaver, D.R.2    Jin, X.3    Shearman, L.P.4    Pieschl, R.L.5    Gribkoff, V.K.6
  • 107
    • 84925482594 scopus 로고    scopus 로고
    • The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling
    • Liu D, Wei N, Man HY, Lu Y, Zhu LQ, Wang JZ (2015). The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling. Cell Death Differ 22: 583–596.
    • (2015) Cell Death Differ , vol.22 , pp. 583-596
    • Liu, D.1    Wei, N.2    Man, H.Y.3    Lu, Y.4    Zhu, L.Q.5    Wang, J.Z.6
  • 109
    • 0035798409 scopus 로고    scopus 로고
    • Melatonin and N-acetylserotonin inhibit leukocyte rolling and adhesion to rat microcirculation
    • Lotufo CM, Lopes C, Dubocovich ML, Farsky SH, Markus RP (2001). Melatonin and N-acetylserotonin inhibit leukocyte rolling and adhesion to rat microcirculation. Eur J Pharmacol 430: 351–357.
    • (2001) Eur J Pharmacol , vol.430 , pp. 351-357
    • Lotufo, C.M.1    Lopes, C.2    Dubocovich, M.L.3    Farsky, S.H.4    Markus, R.P.5
  • 110
    • 58149175669 scopus 로고    scopus 로고
    • Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
    • Lyssenko V, Nagorny CL, Erdos MR, Wierup N, Jonsson A, Spegel P et al. (2009). Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet 41: 82–88.
    • (2009) Nat Genet , vol.41 , pp. 82-88
    • Lyssenko, V.1    Nagorny, C.L.2    Erdos, M.R.3    Wierup, N.4    Jonsson, A.5    Spegel, P.6
  • 111
    • 0027196665 scopus 로고
    • Th immunoneuroendocrine role of melatonin
    • Maestroni G (1993). Th immunoneuroendocrine role of melatonin. J Pineal Res 14: 1–10.
    • (1993) J Pineal Res , vol.14 , pp. 1-10
    • Maestroni, G.1
  • 113
    • 84878461203 scopus 로고    scopus 로고
    • Immune-Pineal Axis: Nuclear Factor Œ∫B (NF-kB) Mediates the Shift in the Melatonin Source from Pinealocytes to Immune Competent Cells
    • Immune-Pineal Axis Nuclear Factor Œ∫B (NF-kB) Mediates the Shift in the Melatonin Source from Pinealocytes to Immune Competent Cells %@ 11422-10067
    • Markus RP, Cecon E, Pires-Lapa MA (2013). Immune-Pineal Axis: Nuclear Factor Œ∫B (NF-kB) Mediates the Shift in the Melatonin Source from Pinealocytes to Immune Competent Cells. Int J Mol Sci 14: 10979–10997 %! Immune-Pineal Axis: Nuclear Factor Œ∫B (NF-kB) Mediates the Shift in the Melatonin Source from Pinealocytes to Immune Competent Cells %@ 11422-10067.
    • (2013) Int J Mol Sci , vol.14 , pp. 10979-10997
    • Markus, R.P.1    Cecon, E.2    Pires-Lapa, M.A.3
  • 114
    • 47249083145 scopus 로고    scopus 로고
    • A generic approach for the purification of signaling complexes that specifically interact with the carboxy-terminal domain of G protein-coupled receptors
    • Maurice P, Daulat AM, Broussard C, Mozo J, Clary G, Hotellier F et al. (2008). A generic approach for the purification of signaling complexes that specifically interact with the carboxy-terminal domain of G protein-coupled receptors. Mol Cell Proteomics 7: 1556–1569.
    • (2008) Mol Cell Proteomics , vol.7 , pp. 1556-1569
    • Maurice, P.1    Daulat, A.M.2    Broussard, C.3    Mozo, J.4    Clary, G.5    Hotellier, F.6
  • 115
    • 80052027428 scopus 로고    scopus 로고
    • Asymmetry of GPCR oligomers supports their functional relevance
    • Maurice P, Kamal M, Jockers R (2011). Asymmetry of GPCR oligomers supports their functional relevance. Trends Pharmacol Sci 32: 514–520.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 514-520
    • Maurice, P.1    Kamal, M.2    Jockers, R.3
  • 116
    • 20844445439 scopus 로고    scopus 로고
    • Molecular modeling of human MT2 melatonin receptor: the role of Val204, Leu272 and Tyr298 in ligand binding
    • Mazna P, Obsilova V, Jelinkova I, Balik A, Berka K, Sovova Z et al. (2004). Molecular modeling of human MT2 melatonin receptor: the role of Val204, Leu272 and Tyr298 in ligand binding. J Neurochem 91: 836–842.
    • (2004) J Neurochem , vol.91 , pp. 836-842
    • Mazna, P.1    Obsilova, V.2    Jelinkova, I.3    Balik, A.4    Berka, K.5    Sovova, Z.6
  • 117
    • 0031054011 scopus 로고    scopus 로고
    • Melatonin action and signal transduction in the rat suprachiasmatic circadian clock: Activation of protein kinase C at dusk and dawn
    • McArthur A, Hunt A, Gillette M (1997). Melatonin action and signal transduction in the rat suprachiasmatic circadian clock: Activation of protein kinase C at dusk and dawn. Endocrinology 138: 627–634.
    • (1997) Endocrinology , vol.138 , pp. 627-634
    • McArthur, A.1    Hunt, A.2    Gillette, M.3
  • 118
    • 34249072817 scopus 로고    scopus 로고
    • Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's disease. A randomized, double blind, placebo-controlled study
    • Medeiros CA, Carvalhedo de Bruin PF, Lopes LA, Magalhaes MC, de Lourdes Seabra M, de Bruin VM (2007). Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's disease. A randomized, double blind, placebo-controlled study. J Neurol 254: 459–464.
    • (2007) J Neurol , vol.254 , pp. 459-464
    • Medeiros, C.A.1    Carvalhedo de Bruin, P.F.2    Lopes, L.A.3    Magalhaes, M.C.4    de Lourdes Seabra, M.5    de Bruin, V.M.6
  • 119
    • 77953133206 scopus 로고    scopus 로고
    • Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands
    • Mesangeau C, Peres B, Descamps-Francois C, Chavatte P, Audinot V, Coumailleau S et al. (2010). Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands. Bioorg Med Chem 18: 3426–3436.
    • (2010) Bioorg Med Chem , vol.18 , pp. 3426-3436
    • Mesangeau, C.1    Peres, B.2    Descamps-Francois, C.3    Chavatte, P.4    Audinot, V.5    Coumailleau, S.6
  • 120
    • 0041932292 scopus 로고    scopus 로고
    • The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways
    • Millan MJ, Gobert A, Lejeune F, Dekeyne A, Newman-Tancredi A, Pasteau V et al. (2003). The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther 306: 954–964.
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 954-964
    • Millan, M.J.1    Gobert, A.2    Lejeune, F.3    Dekeyne, A.4    Newman-Tancredi, A.5    Pasteau, V.6
  • 121
    • 35748932915 scopus 로고    scopus 로고
    • Self-reported efficacy and tolerability of ramelteon 8 mg in older adults experiencing severe sleep-onset difficulty
    • Mini LJ, Wang-Weigand S, Zhang J (2007). Self-reported efficacy and tolerability of ramelteon 8 mg in older adults experiencing severe sleep-onset difficulty. Am J Geriatr Pharmacother 5: 177–184.
    • (2007) Am J Geriatr Pharmacother , vol.5 , pp. 177-184
    • Mini, L.J.1    Wang-Weigand, S.2    Zhang, J.3
  • 122
    • 0029658993 scopus 로고    scopus 로고
    • 2-[I-125]iodo-5-methoxycarbonylamino-N-acetyltryptamine: A selective radioligand for the characterization of melatonin ML(2) binding sites
    • Molinari EJ, North PC, Dubocovich ML (1996). 2-[I-125]iodo-5-methoxycarbonylamino-N-acetyltryptamine: A selective radioligand for the characterization of melatonin ML(2) binding sites. Eur J Pharmacol 301: 159–168.
    • (1996) Eur J Pharmacol , vol.301 , pp. 159-168
    • Molinari, E.J.1    North, P.C.2    Dubocovich, M.L.3
  • 123
    • 84871716059 scopus 로고    scopus 로고
    • Synthesis of new N-(arylcyclopropyl)acetamides and N-(arylvinyl)acetamides as conformationally-restricted ligands for melatonin receptors
    • Morellato L, Lefas-Le Gall M, Langlois M, Caignard DH, Renard P, Delagrange P et al. (2013). Synthesis of new N-(arylcyclopropyl)acetamides and N-(arylvinyl)acetamides as conformationally-restricted ligands for melatonin receptors. Bioorg Med Chem Lett 23: 430–434.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 430-434
    • Morellato, L.1    Lefas-Le Gall, M.2    Langlois, M.3    Caignard, D.H.4    Renard, P.5    Delagrange, P.6
  • 124
    • 60949103794 scopus 로고    scopus 로고
    • Loss of melatonin signalling and its impact on circadian rhythms in mouse organs regulating blood glucose
    • Muhlbauer E, Gross E, Labucay K, Wolgast S, Peschke E (2009). Loss of melatonin signalling and its impact on circadian rhythms in mouse organs regulating blood glucose. Eur J Pharmacol 606: 61–71.
    • (2009) Eur J Pharmacol , vol.606 , pp. 61-71
    • Muhlbauer, E.1    Gross, E.2    Labucay, K.3    Wolgast, S.4    Peschke, E.5
  • 125
    • 4043067948 scopus 로고    scopus 로고
    • A single blind, placebo controlled, across groups dose escalation study of the safety, tolerability, pharmacokinetics and pharmacodynamics of the melatonin analog beta-methyl-6-chloromelatonin
    • Mulchahey JJ, Goldwater DR, Zemlan FP (2004). A single blind, placebo controlled, across groups dose escalation study of the safety, tolerability, pharmacokinetics and pharmacodynamics of the melatonin analog beta-methyl-6-chloromelatonin. Life Sci 75: 1843–1856.
    • (2004) Life Sci , vol.75 , pp. 1843-1856
    • Mulchahey, J.J.1    Goldwater, D.R.2    Zemlan, F.P.3
  • 126
    • 84959308458 scopus 로고    scopus 로고
    • The RelA/cRel nuclear factor-kappaB (NF-kappaB) dimer, crucial for inflammation resolution, mediates the transcription of the key enzyme in melatonin synthesis in RAW 264.7 macrophages
    • Muxel SM, Laranjeira-Silva MF, de Carvalho Sousa CE, Floeter-Winter LM, Markus RP (2016). The RelA/cRel nuclear factor-kappaB (NF-kappaB) dimer, crucial for inflammation resolution, mediates the transcription of the key enzyme in melatonin synthesis in RAW 264.7 macrophages. J Pineal Res 60: 394–404.
    • (2016) J Pineal Res , vol.60 , pp. 394-404
    • Muxel, S.M.1    Laranjeira-Silva, M.F.2    de Carvalho Sousa, C.E.3    Floeter-Winter, L.M.4    Markus, R.P.5
  • 127
    • 84871351771 scopus 로고    scopus 로고
    • NF-kappaB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene
    • Muxel SM, Pires-Lapa MA, Monteiro AW, Cecon E, Tamura EK, Floeter-Winter LM et al. (2012). NF-kappaB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene. PLoS One 7: e52010.
    • (2012) PLoS One , vol.7
    • Muxel, S.M.1    Pires-Lapa, M.A.2    Monteiro, A.W.3    Cecon, E.4    Tamura, E.K.5    Floeter-Winter, L.M.6
  • 128
    • 84924707221 scopus 로고    scopus 로고
    • Melatonin enhances L-DOPA therapeutic effects, helps to reduce its dose, and protects dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice
    • Naskar A, Prabhakar V, Singh R, Dutta D, Mohanakumar KP (2015). Melatonin enhances L-DOPA therapeutic effects, helps to reduce its dose, and protects dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice. J Pineal Res 58: 262–274.
    • (2015) J Pineal Res , vol.58 , pp. 262-274
    • Naskar, A.1    Prabhakar, V.2    Singh, R.3    Dutta, D.4    Mohanakumar, K.P.5
  • 129
    • 84863541347 scopus 로고    scopus 로고
    • An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people
    • Nelson MR, Wegmann D, Ehm MG, Kessner D, St Jean P, Verzilli C et al. (2012). An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science 337: 100–104.
    • (2012) Science , vol.337 , pp. 100-104
    • Nelson, M.R.1    Wegmann, D.2    Ehm, M.G.3    Kessner, D.4    St Jean, P.5    Verzilli, C.6
  • 130
    • 0033786778 scopus 로고    scopus 로고
    • A new melatonin receptor ligand with mt(1)-agonist and MT2-antagonist properties
    • Nonno R, Lucini V, Spadoni G, Pannacci M, Croce A, Esposti D et al. (2000). A new melatonin receptor ligand with mt(1)-agonist and MT2-antagonist properties. J Pineal Res 29: 234–240.
    • (2000) J Pineal Res , vol.29 , pp. 234-240
    • Nonno, R.1    Lucini, V.2    Spadoni, G.3    Pannacci, M.4    Croce, A.5    Esposti, D.6
  • 131
    • 0034613342 scopus 로고    scopus 로고
    • Identification of the melatonin-binding site MT3 as the quinone reductase 2
    • Nosjean O, Ferro M, Cogé F, Beauverger P, Henlin JM, Lefoulon F et al. (2000). Identification of the melatonin-binding site MT3 as the quinone reductase 2. J Biol Chem 275: 31311–31317.
    • (2000) J Biol Chem , vol.275 , pp. 31311-31317
    • Nosjean, O.1    Ferro, M.2    Cogé, F.3    Beauverger, P.4    Henlin, J.M.5    Lefoulon, F.6
  • 132
    • 84936946857 scopus 로고    scopus 로고
    • Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in AbetaPP(swe)/PS1 mice
    • O'Neal-Moffitt G, Delic V, Bradshaw PC, Olcese J (2015). Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in AbetaPP(swe)/PS1 mice. Mol Neurodegener 10: 27.
    • (2015) Mol Neurodegener , vol.10 , pp. 27
    • O'Neal-Moffitt, G.1    Delic, V.2    Bradshaw, P.C.3    Olcese, J.4
  • 133
    • 84907027160 scopus 로고    scopus 로고
    • Genetic deletion of MT1/MT2 melatonin receptors enhances murine cognitive and motor performance
    • O'Neal-Moffitt G, Pilli J, Kumar SS, Olcese J (2014). Genetic deletion of MT1/MT2 melatonin receptors enhances murine cognitive and motor performance. Neuroscience 277: 506–521.
    • (2014) Neuroscience , vol.277 , pp. 506-521
    • O'Neal-Moffitt, G.1    Pilli, J.2    Kumar, S.S.3    Olcese, J.4
  • 134
    • 83455199095 scopus 로고    scopus 로고
    • Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand
    • Ochoa-Sanchez R, Comai S, Lacoste B, Bambico FR, Dominguez-Lopez S, Spadoni G et al. (2011). Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand. J Neurosci 31: 18439–18452.
    • (2011) J Neurosci , vol.31 , pp. 18439-18452
    • Ochoa-Sanchez, R.1    Comai, S.2    Lacoste, B.3    Bambico, F.R.4    Dominguez-Lopez, S.5    Spadoni, G.6
  • 136
    • 4344581120 scopus 로고    scopus 로고
    • The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure
    • Okada T, Sugihara M, Bondar AN, Elstner M, Entel P, Buss V (2004). The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure. J Mol Biol 342: 571–583.
    • (2004) J Mol Biol , vol.342 , pp. 571-583
    • Okada, T.1    Sugihara, M.2    Bondar, A.N.3    Elstner, M.4    Entel, P.5    Buss, V.6
  • 137
    • 67649905028 scopus 로고    scopus 로고
    • Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease
    • Olcese JM, Cao C, Mori T, Mamcarz MB, Maxwell A, Runfeldt MJ et al. (2009). Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease. J Pineal Res 47: 82–96.
    • (2009) J Pineal Res , vol.47 , pp. 82-96
    • Olcese, J.M.1    Cao, C.2    Mori, T.3    Mamcarz, M.B.4    Maxwell, A.5    Runfeldt, M.J.6
  • 138
    • 84887247980 scopus 로고    scopus 로고
    • Fish oil, melatonin and vitamin E attenuates midbrain cyclooxygenase-2 activity and oxidative stress after the administration of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine
    • Ortiz GG, Pacheco-Moises FP, Gomez-Rodriguez VM, Gonzalez-Renovato ED, Torres-Sanchez ED, Ramirez-Anguiano AC (2013). Fish oil, melatonin and vitamin E attenuates midbrain cyclooxygenase-2 activity and oxidative stress after the administration of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine. Metab Brain Dis 28: 705–709.
    • (2013) Metab Brain Dis , vol.28 , pp. 705-709
    • Ortiz, G.G.1    Pacheco-Moises, F.P.2    Gomez-Rodriguez, V.M.3    Gonzalez-Renovato, E.D.4    Torres-Sanchez, E.D.5    Ramirez-Anguiano, A.C.6
  • 139
    • 84959018109 scopus 로고    scopus 로고
    • Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks
    • Owino S, Contreras-Alcantara S, Baba K, Tosini G (2016). Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks. PLoS One 11: e0148214.
    • (2016) PLoS One , vol.11
    • Owino, S.1    Contreras-Alcantara, S.2    Baba, K.3    Tosini, G.4
  • 140
    • 84876530471 scopus 로고    scopus 로고
    • Structure-based virtual screening of MT2 melatonin receptor: influence of template choice and structural refinement
    • Pala D, Beuming T, Sherman W, Lodola A, Rivara S, Mor M (2013). Structure-based virtual screening of MT2 melatonin receptor: influence of template choice and structural refinement. J Chem Inf Model 53: 821–835.
    • (2013) J Chem Inf Model , vol.53 , pp. 821-835
    • Pala, D.1    Beuming, T.2    Sherman, W.3    Lodola, A.4    Rivara, S.5    Mor, M.6
  • 142
    • 84875270977 scopus 로고    scopus 로고
    • Disease-modified glycogen synthase kinase-3beta intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model
    • Peng CX, Hu J, Liu D, Hong XP, Wu YY, Zhu LQ et al. (2013). Disease-modified glycogen synthase kinase-3beta intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model. Neurobiol Aging 34: 1555–1563.
    • (2013) Neurobiol Aging , vol.34 , pp. 1555-1563
    • Peng, C.X.1    Hu, J.2    Liu, D.3    Hong, X.P.4    Wu, Y.Y.5    Zhu, L.Q.6
  • 143
    • 84860172267 scopus 로고    scopus 로고
    • The endogenous melatonin (MT) signal facilitates reentrainment of the circadian system to light-induced phase advances by acting upon MT2 receptors
    • Pfeffer M, Rauch A, Korf HW, von Gall C (2012). The endogenous melatonin (MT) signal facilitates reentrainment of the circadian system to light-induced phase advances by acting upon MT2 receptors. Chronobiol Int 29: 415–429.
    • (2012) Chronobiol Int , vol.29 , pp. 415-429
    • Pfeffer, M.1    Rauch, A.2    Korf, H.W.3    von Gall, C.4
  • 144
  • 145
    • 84883743499 scopus 로고    scopus 로고
    • Melatonin synthesis in human colostrum mononuclear cells enhances dectin-1-mediated phagocytosis by mononuclear cells
    • Pires-Lapa MA, Tamura EK, Salustiano EM, Markus RP (2013). Melatonin synthesis in human colostrum mononuclear cells enhances dectin-1-mediated phagocytosis by mononuclear cells. J Pineal Res 55: 240–246.
    • (2013) J Pineal Res , vol.55 , pp. 240-246
    • Pires-Lapa, M.A.1    Tamura, E.K.2    Salustiano, E.M.3    Markus, R.P.4
  • 147
    • 34848897614 scopus 로고    scopus 로고
    • Pineal melatonin and the innate immune response: the TNF-alpha increase after cesarean section suppresses nocturnal melatonin production
    • Pontes GN, Cardoso EC, Carneiro-Sampaio MM, Markus RP (2007). Pineal melatonin and the innate immune response: the TNF-alpha increase after cesarean section suppresses nocturnal melatonin production. J Pineal Res 43: 365–371.
    • (2007) J Pineal Res , vol.43 , pp. 365-371
    • Pontes, G.N.1    Cardoso, E.C.2    Carneiro-Sampaio, M.M.3    Markus, R.P.4
  • 148
    • 23044491574 scopus 로고    scopus 로고
    • Stimulation of melatonin receptors decreases calcium levels in xenopus tectal cells by activating GABA(C) receptors
    • Prada C, Udin SB, Wiechmann AF, Zhdanova IV (2005). Stimulation of melatonin receptors decreases calcium levels in xenopus tectal cells by activating GABA(C) receptors. J Neurophysiol 94: 968–978.
    • (2005) J Neurophysiol , vol.94 , pp. 968-978
    • Prada, C.1    Udin, S.B.2    Wiechmann, A.F.3    Zhdanova, I.V.4
  • 150
    • 80055099699 scopus 로고    scopus 로고
    • Ligand-induced modulation of the free-energy landscape of G protein-coupled receptors explored by adaptive biasing techniques
    • Provasi D, Artacho MC, Negri A, Mobarec JC, Filizola M (2011). Ligand-induced modulation of the free-energy landscape of G protein-coupled receptors explored by adaptive biasing techniques. PLoS Comput Biol 7: e1002193.
    • (2011) PLoS Comput Biol , vol.7
    • Provasi, D.1    Artacho, M.C.2    Negri, A.3    Mobarec, J.C.4    Filizola, M.5
  • 152
    • 59249087280 scopus 로고    scopus 로고
    • Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials
    • Rajaratnam SM, Polymeropoulos MH, Fisher DM, Roth T, Scott C, Birznieks G et al. (2009). Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials. Lancet 373: 482–491.
    • (2009) Lancet , vol.373 , pp. 482-491
    • Rajaratnam, S.M.1    Polymeropoulos, M.H.2    Fisher, D.M.3    Roth, T.4    Scott, C.5    Birznieks, G.6
  • 153
    • 78651411166 scopus 로고    scopus 로고
    • Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor
    • Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS et al. (2011a). Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor. Nature 469: 175–180.
    • (2011) Nature , vol.469 , pp. 175-180
    • Rasmussen, S.G.1    Choi, H.J.2    Fung, J.J.3    Pardon, E.4    Casarosa, P.5    Chae, P.S.6
  • 155
    • 78650777549 scopus 로고    scopus 로고
    • Circadian periods of sensitivity for ramelteon on the onset of running-wheel activity and the peak of suprachiasmatic nucleus neuronal firing rhythms in C3H/HeN mice
    • Rawashdeh O, Hudson RL, Stepien I, Dubocovich ML (2011). Circadian periods of sensitivity for ramelteon on the onset of running-wheel activity and the peak of suprachiasmatic nucleus neuronal firing rhythms in C3H/HeN mice. Chronobiol Int 28: 31–38.
    • (2011) Chronobiol Int , vol.28 , pp. 31-38
    • Rawashdeh, O.1    Hudson, R.L.2    Stepien, I.3    Dubocovich, M.L.4
  • 156
    • 10744224028 scopus 로고    scopus 로고
    • Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction
    • Ressmeyer AR, Mayo JC, Zelosko V, Sainz RM, Tan DX, Poeggeler B et al. (2003). Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction. Redox Rep 8: 205–213.
    • (2003) Redox Rep , vol.8 , pp. 205-213
    • Ressmeyer, A.R.1    Mayo, J.C.2    Zelosko, V.3    Sainz, R.M.4    Tan, D.X.5    Poeggeler, B.6
  • 157
    • 37349076564 scopus 로고    scopus 로고
    • N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands
    • Rivara S, Lodola A, Mor M, Bedini A, Spadoni G, Lucini V et al. (2007). N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands. J Med Chem 50: 6618–6626.
    • (2007) J Med Chem , vol.50 , pp. 6618-6626
    • Rivara, S.1    Lodola, A.2    Mor, M.3    Bedini, A.4    Spadoni, G.5    Lucini, V.6
  • 158
    • 20444363062 scopus 로고    scopus 로고
    • Analysis of structure–activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models
    • Rivara S, Lorenzi S, Mor M, Plazzi PV, Spadoni G, Bedini A et al. (2005). Analysis of structure–activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models. J Med Chem 48: 4049–4060.
    • (2005) J Med Chem , vol.48 , pp. 4049-4060
    • Rivara, S.1    Lorenzi, S.2    Mor, M.3    Plazzi, P.V.4    Spadoni, G.5    Bedini, A.6
  • 159
    • 84868091994 scopus 로고    scopus 로고
    • MT1-selective melatonin receptor ligands: synthesis, pharmacological evaluation, and molecular dynamics investigation of N-{[(3-O-substituted)anilino]alkyl}amides
    • Rivara S, Pala D, Lodola A, Mor M, Lucini V, Dugnani S et al. (2012). MT1-selective melatonin receptor ligands: synthesis, pharmacological evaluation, and molecular dynamics investigation of N-{[(3-O-substituted)anilino]alkyl}amides. ChemMedChem 7: 1954–1964.
    • (2012) ChemMedChem , vol.7 , pp. 1954-1964
    • Rivara, S.1    Pala, D.2    Lodola, A.3    Mor, M.4    Lucini, V.5    Dugnani, S.6
  • 160
    • 69249213707 scopus 로고    scopus 로고
    • Urinary 6-sulfatoxymelatonin level in age-related macular degeneration patients
    • Rosen R, Hu DN, Perez V, Tai K, Yu GP, Chen M et al. (2009). Urinary 6-sulfatoxymelatonin level in age-related macular degeneration patients. Mol Vis 15: 1673–1679.
    • (2009) Mol Vis , vol.15 , pp. 1673-1679
    • Rosen, R.1    Hu, D.N.2    Perez, V.3    Tai, K.4    Yu, G.P.5    Chen, M.6
  • 161
    • 84907816017 scopus 로고    scopus 로고
    • The melatonin analog 5-MCA-NAT increases endogenous dopamine levels by binding NRH:quinone reductase enzyme in the developing chick retina
    • Sampaio Lde F, Mesquita FP, de Sousa PR, Silva JL, Alves CN (2014). The melatonin analog 5-MCA-NAT increases endogenous dopamine levels by binding NRH:quinone reductase enzyme in the developing chick retina. Int J Dev Neurosci 38: 119–126.
    • (2014) Int J Dev Neurosci , vol.38 , pp. 119-126
    • Sampaio Lde, F.1    Mesquita, F.P.2    de Sousa, P.R.3    Silva, J.L.4    Alves, C.N.5
  • 162
    • 0036161698 scopus 로고    scopus 로고
    • Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients
    • Savaskan E, Olivieri G, Meier F, Brydon L, Jockers R, Ravid R et al. (2002). Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients. J Pineal Res 32: 59–62.
    • (2002) J Pineal Res , vol.32 , pp. 59-62
    • Savaskan, E.1    Olivieri, G.2    Meier, F.3    Brydon, L.4    Jockers, R.5    Ravid, R.6
  • 163
    • 33750221838 scopus 로고    scopus 로고
    • Treatment of behavioural, cognitive and circadian rest-activity cycle disturbances in Alzheimer's disease: haloperidol vs. quetiapine
    • Savaskan E, Schnitzler C, Schroder C, Cajochen C, Muller-Spahn F, Wirz-Justice A (2006). Treatment of behavioural, cognitive and circadian rest-activity cycle disturbances in Alzheimer's disease: haloperidol vs. quetiapine. Int J Neuropsychopharmacol 9: 507–516.
    • (2006) Int J Neuropsychopharmacol , vol.9 , pp. 507-516
    • Savaskan, E.1    Schnitzler, C.2    Schroder, C.3    Cajochen, C.4    Muller-Spahn, F.5    Wirz-Justice, A.6
  • 165
    • 80052554358 scopus 로고    scopus 로고
    • Localization of melatonin receptor 1 in mouse retina and its role in the circadian regulation of the electroretinogram and dopamine levels
    • Sengupta A, Baba K, Mazzoni F, Pozdeyev NV, Strettoi E, Iuvone PM et al. (2011). Localization of melatonin receptor 1 in mouse retina and its role in the circadian regulation of the electroretinogram and dopamine levels. PLoS One 6: e24483.
    • (2011) PLoS One , vol.6
    • Sengupta, A.1    Baba, K.2    Mazzoni, F.3    Pozdeyev, N.V.4    Strettoi, E.5    Iuvone, P.M.6
  • 166
    • 33746106855 scopus 로고    scopus 로고
    • Melatonin prevents X-ray irradiation induced oxidative damagein peripheral blood and spleen of the seasonally breeding rodent, Funambulus pennanti during reproductively active phase
    • Sharma S, Haldar C (2006). Melatonin prevents X-ray irradiation induced oxidative damagein peripheral blood and spleen of the seasonally breeding rodent, Funambulus pennanti during reproductively active phase. Int J Radiat Biol 82: 411–419.
    • (2006) Int J Radiat Biol , vol.82 , pp. 411-419
    • Sharma, S.1    Haldar, C.2
  • 167
    • 33748433857 scopus 로고    scopus 로고
    • Targeted deletions of Mel1a and Mel1b melatonin receptors affect pCREB levels in lactotroph and pars intermedia cells of mice
    • Sheynzon P, Korf HW (2006). Targeted deletions of Mel1a and Mel1b melatonin receptors affect pCREB levels in lactotroph and pars intermedia cells of mice. Neurosci Lett 407: 48–52.
    • (2006) Neurosci Lett , vol.407 , pp. 48-52
    • Sheynzon, P.1    Korf, H.W.2
  • 168
    • 84919625591 scopus 로고    scopus 로고
    • Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling
    • Shin IS, Shin NR, Park JW, Jeon CM, Hong JM, Kwon OK et al. (2015). Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling. J Pineal Res 58: 50–60.
    • (2015) J Pineal Res , vol.58 , pp. 50-60
    • Shin, I.S.1    Shin, N.R.2    Park, J.W.3    Jeon, C.M.4    Hong, J.M.5    Kwon, O.K.6
  • 170
    • 84976865494 scopus 로고    scopus 로고
    • The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands
    • Southan C, Sharman JL, Benson HE, Faccenda E, Pawson AJ, Alexander SPH et al. (2016). The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucl Acids Res 44 (Database Issue): D1054–D1068.
    • (2016) Nucl Acids Res , vol.44 , Issue.Database Issue , pp. D1054-D1068
    • Southan, C.1    Sharman, J.L.2    Benson, H.E.3    Faccenda, E.4    Pawson, A.J.5    Alexander, S.P.H.6
  • 171
    • 84942357938 scopus 로고    scopus 로고
    • Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines
    • Spadoni G, Bedini A, Lucarini S, Mari M, Caignard DH, Boutin JA et al. (2015). Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines. J Med Chem 58: 7512–7525.
    • (2015) J Med Chem , vol.58 , pp. 7512-7525
    • Spadoni, G.1    Bedini, A.2    Lucarini, S.3    Mari, M.4    Caignard, D.H.5    Boutin, J.A.6
  • 172
    • 79961172639 scopus 로고    scopus 로고
    • Bivalent ligand approach on N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide: synthesis, binding affinity and intrinsic activity for MT(1) and MT(2) melatonin receptors
    • Spadoni G, Bedini A, Orlando P, Lucarini S, Tarzia G, Mor M et al. (2011). Bivalent ligand approach on N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide: synthesis, binding affinity and intrinsic activity for MT(1) and MT(2) melatonin receptors. Bioorg Med Chem 19: 4910–4916.
    • (2011) Bioorg Med Chem , vol.19 , pp. 4910-4916
    • Spadoni, G.1    Bedini, A.2    Orlando, P.3    Lucarini, S.4    Tarzia, G.5    Mor, M.6
  • 173
    • 51649124759 scopus 로고    scopus 로고
    • Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells
    • Stumpf I, Muhlbauer E, Peschke E (2008). Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells. J Pineal Res 45: 318–327.
    • (2008) J Pineal Res , vol.45 , pp. 318-327
    • Stumpf, I.1    Muhlbauer, E.2    Peschke, E.3
  • 174
    • 0028909154 scopus 로고
    • Structural requirements at the melatonin receptor
    • Sugden D, Chong NW, Lewis DF (1995). Structural requirements at the melatonin receptor. Br J Pharmacol 114: 618–623.
    • (1995) Br J Pharmacol , vol.114 , pp. 618-623
    • Sugden, D.1    Chong, N.W.2    Lewis, D.F.3
  • 175
    • 0033367065 scopus 로고    scopus 로고
    • Design of subtype selective melatonin receptor agonists and antagonists
    • Sugden D, Yeh LK, Teh MT (1999). Design of subtype selective melatonin receptor agonists and antagonists. Reprod Nutr Dev 39: 335–344.
    • (1999) Reprod Nutr Dev , vol.39 , pp. 335-344
    • Sugden, D.1    Yeh, L.K.2    Teh, M.T.3
  • 177
    • 84947722068 scopus 로고    scopus 로고
    • Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism
    • Tan DX, Manchester LC, Esteban-Zubero E, Zhou Z, Reiter RJ (2015). Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism. Molecules 20: 18886–18906.
    • (2015) Molecules , vol.20 , pp. 18886-18906
    • Tan, D.X.1    Manchester, L.C.2    Esteban-Zubero, E.3    Zhou, Z.4    Reiter, R.J.5
  • 178
    • 33845536018 scopus 로고    scopus 로고
    • One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?
    • Tan DX, Manchester LC, Terron MP, Flores LJ, Reiter RJ (2007). One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 42: 28–42.
    • (2007) J Pineal Res , vol.42 , pp. 28-42
    • Tan, D.X.1    Manchester, L.C.2    Terron, M.P.3    Flores, L.J.4    Reiter, R.J.5
  • 179
    • 84954126518 scopus 로고    scopus 로고
    • Consequences of long-term treatment with agomelatine on depressive-like behavior and neurobiological abnormalities in pinealectomized rats
    • Tchekalarova J, Nenchovska Z, Atanasova D, Atanasova M, Kortenska L, Stefanova M et al. (2016). Consequences of long-term treatment with agomelatine on depressive-like behavior and neurobiological abnormalities in pinealectomized rats. Behav Brain Res 302: 11–28.
    • (2016) Behav Brain Res , vol.302 , pp. 11-28
    • Tchekalarova, J.1    Nenchovska, Z.2    Atanasova, D.3    Atanasova, M.4    Kortenska, L.5    Stefanova, M.6
  • 180
    • 84866169882 scopus 로고    scopus 로고
    • Melatonin: an underappreciated player in retinal physiology and pathophysiology
    • Tosini G, Baba K, Hwang CK, Iuvone PM (2012). Melatonin: an underappreciated player in retinal physiology and pathophysiology. Exp Eye Res 103: 82–89.
    • (2012) Exp Eye Res , vol.103 , pp. 82-89
    • Tosini, G.1    Baba, K.2    Hwang, C.K.3    Iuvone, P.M.4
  • 181
    • 84904037064 scopus 로고    scopus 로고
    • Understanding melatonin receptor pharmacology: Latest insights from mouse models, and their relevance to human disease
    • Tosini G, Owino S, Guillaume JL, Jockers R (2014). Understanding melatonin receptor pharmacology: Latest insights from mouse models, and their relevance to human disease. Bioessays 36: 778–787.
    • (2014) Bioessays , vol.36 , pp. 778-787
    • Tosini, G.1    Owino, S.2    Guillaume, J.L.3    Jockers, R.4
  • 182
    • 0037068471 scopus 로고    scopus 로고
    • Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists
    • Uchikawa O, Fukatsu K, Tokunoh R, Kawada M, Matsumoto K, Imai Y et al. (2002). Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists. J Med Chem 45: 4222–4239.
    • (2002) J Med Chem , vol.45 , pp. 4222-4239
    • Uchikawa, O.1    Fukatsu, K.2    Tokunoh, R.3    Kawada, M.4    Matsumoto, K.5    Imai, Y.6
  • 183
    • 0021261994 scopus 로고
    • Development and validation of a melatonin radioimmunoassay using radioiodinated melatonin as a tracer
    • Vakkuri O, Leppaluoto J, Vuolteenaho O (1984). Development and validation of a melatonin radioimmunoassay using radioiodinated melatonin as a tracer. Acta Endocrinol 106: 152–157.
    • (1984) Acta Endocrinol , vol.106 , pp. 152-157
    • Vakkuri, O.1    Leppaluoto, J.2    Vuolteenaho, O.3
  • 185
    • 85050578796 scopus 로고    scopus 로고
    • Therapeutic strategies for circadian rhythm and sleep disturbances in Huntington disease
    • van Wamelen DJ, Roos RA, Aziz NA (2015). Therapeutic strategies for circadian rhythm and sleep disturbances in Huntington disease. Neurodegener Dis Manag 5: 549–559.
    • (2015) Neurodegener Dis Manag , vol.5 , pp. 549-559
    • van Wamelen, D.J.1    Roos, R.A.2    Aziz, N.A.3
  • 186
    • 0023792121 scopus 로고
    • Melatonin binding sites
    • Vanecek J (1988). Melatonin binding sites. J Neurochem 51: 1436–1440.
    • (1988) J Neurochem , vol.51 , pp. 1436-1440
    • Vanecek, J.1
  • 187
    • 77749310347 scopus 로고    scopus 로고
    • Molecular and cellular pharmacological properties of 5-methoxycarbonylamino-N-acetyltryptamine (MCA-NAT): a nonspecific MT3 ligand
    • Vincent L, Cohen W, Delagrange P, Boutin JA, Nosjean O (2010). Molecular and cellular pharmacological properties of 5-methoxycarbonylamino-N-acetyltryptamine (MCA-NAT): a nonspecific MT3 ligand. J Pineal Res 48: 222–229.
    • (2010) J Pineal Res , vol.48 , pp. 222-229
    • Vincent, L.1    Cohen, W.2    Delagrange, P.3    Boutin, J.A.4    Nosjean, O.5
  • 188
    • 0036180377 scopus 로고    scopus 로고
    • Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin
    • von Gall C, Garabette ML, Kell CA, Frenzel S, Dehghani F, Schumm DP et al. (2002). Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin. Nat Neurosci 5: 234–238.
    • (2002) Nat Neurosci , vol.5 , pp. 234-238
    • von Gall, C.1    Garabette, M.L.2    Kell, C.A.3    Frenzel, S.4    Dehghani, F.5    Schumm, D.P.6
  • 190
    • 84902963042 scopus 로고    scopus 로고
    • Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial
    • Wade AG, Farmer M, Harari G, Fund N, Laudon M, Nir T et al. (2014). Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial. Clin Interv Aging 9: 947–961.
    • (2014) Clin Interv Aging , vol.9 , pp. 947-961
    • Wade, A.G.1    Farmer, M.2    Harari, G.3    Fund, N.4    Laudon, M.5    Nir, T.6
  • 192
    • 80054040251 scopus 로고    scopus 로고
    • The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity
    • Wang X, Sirianni A, Pei Z, Cormier K, Smith K, Jiang J et al. (2011). The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity. J Neurosci 31: 14496–14507.
    • (2011) J Neurosci , vol.31 , pp. 14496-14507
    • Wang, X.1    Sirianni, A.2    Pei, Z.3    Cormier, K.4    Smith, K.5    Jiang, J.6
  • 195
    • 34249291586 scopus 로고    scopus 로고
    • Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer's disease
    • Wu YH, Zhou JN, Van Heerikhuize J, Jockers R, Swaab DF (2007). Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer's disease. Neurobiol Aging 28: 1239–1247.
    • (2007) Neurobiol Aging , vol.28 , pp. 1239-1247
    • Wu, Y.H.1    Zhou, J.N.2    Van Heerikhuize, J.3    Jockers, R.4    Swaab, D.F.5
  • 196
    • 84875982757 scopus 로고    scopus 로고
    • Reciprocal interaction between melatonin receptors (Mel(1a), Mel(1b), and Mel(1c)) and androgen receptor (AR) expression in immunoregulation of a seasonally breeding bird, Perdicula asiatica: role of photoperiod
    • Yadav SK, Haldar C (2013). Reciprocal interaction between melatonin receptors (Mel(1a), Mel(1b), and Mel(1c)) and androgen receptor (AR) expression in immunoregulation of a seasonally breeding bird, Perdicula asiatica: role of photoperiod. J Photochem Photobiol B 122: 52–60.
    • (2013) J Photochem Photobiol B , vol.122 , pp. 52-60
    • Yadav, S.K.1    Haldar, C.2
  • 197
    • 63849335895 scopus 로고    scopus 로고
    • Melatonin transmits photoperiodic signals through the MT1 melatonin receptor
    • Yasuo S, Yoshimura T, Ebihara S, Korf HW (2009). Melatonin transmits photoperiodic signals through the MT1 melatonin receptor. J Neurosci 29: 2885–2889.
    • (2009) J Neurosci , vol.29 , pp. 2885-2889
    • Yasuo, S.1    Yoshimura, T.2    Ebihara, S.3    Korf, H.W.4
  • 198
    • 84928954025 scopus 로고    scopus 로고
    • Computational study on the kinetics and mechanism of the carbaryl + OH reaction
    • Zavala-Oseguera C, Galano A, Merino G (2014). Computational study on the kinetics and mechanism of the carbaryl + OH reaction. J Phys Chem A 118: 7776–7781.
    • (2014) J Phys Chem A , vol.118 , pp. 7776-7781
    • Zavala-Oseguera, C.1    Galano, A.2    Merino, G.3
  • 199
    • 79953221772 scopus 로고    scopus 로고
    • Application of the bridgehead fragments for the design of conformationally restricted melatonin analogues
    • Zefirova ON, Baranova TY, Ivanova AA, Ivanov AA, Zefirov NS (2011). Application of the bridgehead fragments for the design of conformationally restricted melatonin analogues. Bioorg Chem 39: 67–72.
    • (2011) Bioorg Chem , vol.39 , pp. 67-72
    • Zefirova, O.N.1    Baranova, T.Y.2    Ivanova, A.A.3    Ivanov, A.A.4    Zefirov, N.S.5
  • 200
    • 84955725894 scopus 로고    scopus 로고
    • Exogenous melatonin for sleep disorders in neurodegenerative diseases: a meta-analysis of randomized clinical trials
    • Zhang W, Chen XY, Su SW, Jia QZ, Ding T, Zhu ZN et al. (2016). Exogenous melatonin for sleep disorders in neurodegenerative diseases: a meta-analysis of randomized clinical trials. Neurol Sci 37: 57–65.
    • (2016) Neurol Sci , vol.37 , pp. 57-65
    • Zhang, W.1    Chen, X.Y.2    Su, S.W.3    Jia, Q.Z.4    Ding, T.5    Zhu, Z.N.6
  • 201
    • 84876721837 scopus 로고    scopus 로고
    • Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis
    • Zhang Y, Cook A, Kim J, Baranov SV, Jiang J, Smith K et al. (2013). Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 55: 26–35.
    • (2013) Neurobiol Dis , vol.55 , pp. 26-35
    • Zhang, Y.1    Cook, A.2    Kim, J.3    Baranov, S.V.4    Jiang, J.5    Smith, K.6
  • 202
    • 0042090064 scopus 로고    scopus 로고
    • Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels
    • Zhou JN, Liu RY, Kamphorst W, Hofman MA, Swaab DF (2003). Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels. J Pineal Res 35: 125–130.
    • (2003) J Pineal Res , vol.35 , pp. 125-130
    • Zhou, J.N.1    Liu, R.Y.2    Kamphorst, W.3    Hofman, M.A.4    Swaab, D.F.5
  • 203
    • 0022003590 scopus 로고
    • Circadian variations in the inhibition of dopamine release from adult and newborn rat hypothalamus by melatonin
    • Zisapel N, Egozi Y, Laudon M (1985). Circadian variations in the inhibition of dopamine release from adult and newborn rat hypothalamus by melatonin. Neuroendocrinology 40: 102–108.
    • (1985) Neuroendocrinology , vol.40 , pp. 102-108
    • Zisapel, N.1    Egozi, Y.2    Laudon, M.3
  • 204
    • 0020027477 scopus 로고
    • Dopamine release induced by electrical field stimulation of rat hypothalamus in vitro: inhibition by melatonin
    • Zisapel N, Laudon M (1982). Dopamine release induced by electrical field stimulation of rat hypothalamus in vitro: inhibition by melatonin. Biochem Biophys Res Commun 104: 1610–1616.
    • (1982) Biochem Biophys Res Commun , vol.104 , pp. 1610-1616
    • Zisapel, N.1    Laudon, M.2
  • 205
    • 84863730090 scopus 로고    scopus 로고
    • Recent progress in the development of agonists and antagonists for melatonin receptors
    • Zlotos DP (2012). Recent progress in the development of agonists and antagonists for melatonin receptors. Curr Med Chem 19: 3532–3549.
    • (2012) Curr Med Chem , vol.19 , pp. 3532-3549
    • Zlotos, D.P.1
  • 206
    • 61449191838 scopus 로고    scopus 로고
    • 2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists
    • Zlotos DP, Attia MI, Julius J, Sethi S, Witt-Enderby PA (2009). 2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists. J Med Chem 52: 826–833.
    • (2009) J Med Chem , vol.52 , pp. 826-833
    • Zlotos, D.P.1    Attia, M.I.2    Julius, J.3    Sethi, S.4    Witt-Enderby, P.A.5
  • 207
    • 84899512881 scopus 로고    scopus 로고
    • MT1 and MT2 Melatonin Receptors: Ligands, Models, Oligomers, and Therapeutic Potential
    • Zlotos DP, Jockers R, Cecon E, Rivara S, Witt-Enderby PA (2014). MT1 and MT2 Melatonin Receptors: Ligands, Models, Oligomers, and Therapeutic Potential. J Med Chem 57: 3161–3185.
    • (2014) J Med Chem , vol.57 , pp. 3161-3185
    • Zlotos, D.P.1    Jockers, R.2    Cecon, E.3    Rivara, S.4    Witt-Enderby, P.A.5
  • 208
    • 84936869757 scopus 로고    scopus 로고
    • Novel difluoroacetamide analogues of agomelatine and melatonin: probing the melatonin receptors for MT1 selectivity
    • Zlotos DP, Riad NM, Osman MB, Dodda BR, Witt-Enderby PA (2015). Novel difluoroacetamide analogues of agomelatine and melatonin: probing the melatonin receptors for MT1 selectivity. Med Chem Commun 6: 1340–1344.
    • (2015) Med Chem Commun , vol.6 , pp. 1340-1344
    • Zlotos, D.P.1    Riad, N.M.2    Osman, M.B.3    Dodda, B.R.4    Witt-Enderby, P.A.5


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