Convergence of melatonin and serotonin (5-HT) signaling at MT2/5-HT2C receptor heteromers

Journal of Biological Chemistry

Volumn 290, Issue 18, 2015, Pages 11537-11546

  Kamal, Maud ^a,b,c   Gbahou, Florence ^a,b,c   Guillaume, Jean Luc ^a,b,c   Daulat, Avais M ^a,b,c   Benleulmi Chaachoua, Abla ^a,b,c   Luka, Marine ^a,b,c   Chen, Patty ^a,b,c   Anaraki, Dina Kalbasi ^a,b,c   Baroncini, Marc ^d   La Cour, Clotilde Mannoury ^e   Millan, Mark J ^e   Prevot, Vincent ^d   Delagrange, Philippe ^e   Jockers, Ralf ^a,b,c  

^a INSTITUT COCHIN   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d JEAN PIERRE AUBERT RESEARCH CENTER   (France)

^e INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ENERGY TRANSFER;

BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CO-IMMUNOPRECIPITATIONS; FUNCTIONAL PROPERTIES; MAJOR DEPRESSIONS; PSYCHIATRIC DISORDERS; THERAPEUTIC EFFECTS; TRANSACTIVATION; TRANSFECTED CELLS;

HORMONES;

AGOMELATINE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; MELATONIN 2 RECEPTOR; PHOSPHOLIPASE C; SEROTONIN 2C RECEPTOR; ACETAMIDE DERIVATIVE; BETA ARRESTIN; MELATONIN; MELATONIN 1 RECEPTOR; RETINA S ANTIGEN; SEROTONIN;

ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; BRAIN CORTEX; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG TARGETING; EMBRYO; GENE AMPLIFICATION; GENERALIZED ANXIETY DISORDER; GENETIC TRANSFECTION; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MAJOR DEPRESSION; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSACTIVATION; CHEMISTRY; DRUG EFFECTS; DRUG POTENTIATION; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN TRANSPORT; TRANSCRIPTION INITIATION;

ACETAMIDES; ARRESTINS; DRUG SYNERGISM; GENE EXPRESSION REGULATION; HEK293 CELLS; HELA CELLS; HUMANS; MELATONIN; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN TRANSPORT; RECEPTOR, MELATONIN, MT1; RECEPTOR, MELATONIN, MT2; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONIN; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; TYPE C PHOSPHOLIPASES;

EID: 84929492265     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.559542     Document Type: Article

References (31)

1. Millan, M. J., Marin, P., Bockaert, J., and Mannoury La Cour, C. (2008) Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions. Trends Pharmacol. Sci. 29, 454-464
2. Jockers, R., Maurice, P., Boutin, J. A., and Delagrange, P. (2008) Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new? Br. J. Pharmacol. 154, 1182-1195
3. Prosser, R. A. (1999) Melatonin inhibits in vitro serotonergic phase shifts of the suprachiasmatic circadian clock. Brain Res. 818, 408-413
4. Milligan, G. (2009) Gprotein-coupled receptor hetero-dimerization: contribution to pharmacology and function. Br. J. Pharmacol. 158, 5-14
5. González-Maeso, J., Ang, R. L., Yuen, T., Chan, P., Weisstaub, N. V., López-Giménez, J. F., Zhou, M., Okawa, Y., Callado, L. F., Milligan, G., Gingrich, J. A., Filizola, M., Meana, J. J., and Sealfon, S. C. (2008) Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature 452, 93-97
6. Pei, L., Li, S., Wang, M., Diwan, M., Anisman, H., Fletcher, P. J., Nobrega, J. N., and Liu, F. (2010) Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects. Nat. Med. 16, 1393-1395
7. 2 receptors. Naunyn Schmiedebergs Arch. Pharmacol. 367, 553-561
8. Millan, M. J., Gobert, A., Lejeune, F., Dekeyne, A., Newman-Tancredi, A., Pasteau, V., Rivet, J. M., and Cussac, D. (2003) The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine 2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J. Pharmacol. Exp. Ther. 306, 954-964
9. 2C receptors. World J. Biol. Psychiatry 12, 574-587
10. Petit, L., Lacroix, I., De Coppet, P., Strosberg, A. D., and Jockers, R. (1999) Differential signaling of human Mel1a and Mel1b melatonin receptors through the cyclic guanosine 3'-5'-monophosphate pathway. Biochem. Pharmacol. 58, 633-639
11. Kamal, M., Marquez, M., Vauthier, V., Leloire, A., Froguel, P., Jockers, R., and Couturier, C. (2009) Improved donor/acceptor BRET couples for monitoring β-arrestin recruitment to G protein-coupled receptors. Biotechnol. J. 4, 1337-1344
12. Berthouze, M., Ayoub, M., Russo, O., Rivail, L., Sicsic, S., Fischmeister, R., Berque-Bestel, I., Jockers, R., and Lezoualc'h, F. (2005) Constitutive dimerization of human serotonin 5-HT4 receptors in living cells. FEBS Lett. 579, 2973-2980
13. Jockers, R., Issad, T., Zilberfarb, V., De Coppet, P., Marullo, S., and Strosberg, A. D. (1998) Desensitization of the β-adrenergic response in human brown adipocytes. Endocrinology 139, 2676-2684
14. 2 melatonin receptor expression in Alzheimer's disease. J. Pineal Res. 38, 10-16
15. Guillaume, J. L., Daulat, A. M., Maurice, P., Levoye, A., Migaud, M., Brydon, L., Malpaux, B., Borg-Capra, C., and Jockers, R. (2008) The PDZ protein mupp1 promotes Gi coupling and signaling of the Mt1 melatonin receptor. J. Biol. Chem. 283, 16762-16771
16. Bonnefond, A., Clément, N., Fawcett, K., Yengo, L., Vaillant, E., Guillaume, J. L., Dechaume, A., Payne, F., Roussel, R., Czernichow, S., Hercberg, S., Hadjadj, S., Balkau, B., Marre, M., Lantieri, O., Langenberg, C., Bouatia-Naji, N., Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC), Charpentier, G., Vaxillaire, M., Rocheleau, G., Wareham, N. J., Sladek, R., McCarthy, M. I., Dina, C., Barroso, I., Jockers, R., and Froguel, P. (2012) Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nat. Genet. 44, 297-301
17. Chaste, P., Clement, N., Mercati, O., Guillaume, J. L., Delorme, R., Botros, H. G., Pagan, C., Périvier, S., Scheid, I., Nygren, G., Anckarsäter, H., Rastam, M., Ståhlberg, O., Gillberg, C., Serrano, E., Lemière, N., Launay, J. M., Mouren-Simeoni, M. C., Leboyer, M., Gillberg, C., Jockers, R., and Bourgeron, T. (2010) Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population. PLoS One 5, e11495
18. Mercier, J. F., Salahpour, A., Angers, S., Breit, A., and Bouvier, M. (2002) Quantitative assessment of β1- and α2-adrenergic receptor homo and hetero-dimerization by bioluminescence resonance energy transfer. J. Biol. Chem. 277, 44925-44931
19. Couturier, C., and Jockers, R. (2003) Activation of leptin receptor by a ligand-induced conformational change of constitutive receptor dimers. J. Biol. Chem. 278, 26604-26611
20. 2 are decreased in Alzheimer's disease. Eur. J. Histochem. 50, 311-316
21. 2C receptor messenger RNA in human brain. Neuroscience 92, 601-611
22. Herrick-Davis, K., Grinde, E., Harrigan, T. J., and Mazurkiewicz, J. E. (2005) Inhibition of serotonin 5-hydroxytryptamine 2c receptor function through heterodimerization: receptor dimers bind two molecules of ligand and one G-protein. J. Biol. Chem. 280, 40144-40151
23. Charest, P. G., Terrillon, S., and Bouvier, M. (2005) Monitoring agonistpromoted conformational changes of β-arrestin in living cells by intramolecular BRET. EMBO Rep. 6, 334-340
24. Ying, S. W., Rusak, B., Delagrange, P., Mocaer, E., Renard, P., and Guardiola-Lemaitre, B. (1996) Melatonin analogues as agonists and antagonists in the circadian system and other brain areas. Eur. J. Pharmacol. 296, 33-42
25. 2 melatonin receptors to cyclic AMP and phosphoinositide signal transduction cascades and their regulation following melatonin exposure. Biochem. Pharmacol. 63, 587-595
26. Marion, S., Weiner, D. M., and Caron, M. G. (2004) RNA editing induces variation in desensitization and trafficking of 5-hydroxytryptamine 2c receptor isoforms. J. Biol. Chem. 279, 2945-2954
27. Galvez, T., Duthey, B., Kniazeff, J., Blahos, J., Rovelli, G., Bettler, B., Prézeau, L., and Pin, J. P. (2001) Allosteric interactions between GB1 and GB2 subunits are required for optimalGABAB receptor function. EMBOJ. 20, 2152-2159
28. Han, Y., Moreira, I. S., Urizar, E., Weinstein, H., and Javitch, J. A. (2009) Allosteric communication between protomers of dopamine classAGPCR dimers modulates activation. Nat. Chem. Biol. 5, 688-695
29. Fribourg, M., Moreno, J. L., Holloway, T., Provasi, D., Baki, L., Mahajan, R., Park, G., Adney, S. K., Hatcher, C., Eltit, J. M., Ruta, J. D., Albizu, L., Li, Z., Umali, A., Shim, J., Fabiato, A., MacKerell, A. D., Jr., Brezina, V., Sealfon, S. C., Filizola, M., González-Maeso, J., and Logothetis, D. E. (2011) Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell 147, 1011-1023
30. Millan, M. J. (2006) Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol. Ther. 110, 135-370
31. Wong, E. H., Tarazi, F. I., and Shahid, M. (2010) The effectiveness of multi-target agents in schizophrenia and mood disorders: relevance of receptor signature to clinical action. Pharmacol. Ther. 126, 173-185