MT 1-Selective Melatonin Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Dynamics Investigation of N-{[(3-O-Substituted)anilino]alkyl}amides

ChemMedChem

Volumn 7, Issue 11, 2012, Pages 1954-1964

  Rivara, Silvia ^a   Pala, Daniele ^a   Lodola, Alessio ^a   Mor, Marco ^a   Lucini, Valeria ^b   Dugnani, Silvana ^b   Scaglione, Francesco ^b   Bedini, Annalida ^c   Lucarini, Simone ^c   Tarzia, Giorgio ^c   Spadoni, Gilberto ^c  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF URBINO   (Italy)

Author keywords

Melatonin; Molecular modeling; MT 1 selectivity; Structure activity relationships

Indexed keywords

ACETAMIDE DERIVATIVE; ANILINE DERIVATIVE; HORMONE RECEPTOR AFFECTING AGENT; MELATONIN 1 RECEPTOR; MELATONIN 1 RECEPTOR AGONIST; MELATONIN 2 RECEPTOR; MELATONIN 2 RECEPTOR AGONIST; MELATONIN 2 RECEPTOR ANTAGONIST; N [2 [(3 BENZYLOXYPHENYL)METHYLAMINO]ETHYL]ACETAMIDE; N [2 [(3 BUTOXYPHENYL)METHYLAMINO]ETHYL]ACETAMIDE; N [2 [(3 HEXYLOXYPHENYL)METHYLAMINO]ETHYL]ACETAMIDE; N [2 [[3 (2 BENZYLOXYETHOXY)PHENYL]METHYLAMINO]ETHYL]ACETAMIDE; N [2 [[3 (2 HYDROXYETHOXY)PHENYL]METHYLAMINO]ETHYL]ACETAMIDE; N [2 [[3 (BIPHENYL 3 YLMETHOXY)PHENYL]METHYLAMINO]ETHYL]ACETAMIDE; N [2 [[3 (BIPHENYL 4 YLMETHOXY)PHENYL]METHYLAMINO]ETHYL]ACETAMIDE; N [2 [METHYL (3 OCTYLOXYPHENYL)AMINO]ETHYL]ACETAMIDE; N [2 [METHYL [3 (2 NAPHTHALEN 2 YLETHOXY)PHENYL]AMINO]ETHYL]ACETAMIDE; N [2 [METHYL [3 (4 PHENYLBUTOXY)PHENYL]AMINO]ETHYL]ACETAMIDE; N [2 [METHYL [3 (6 PHENYLHEXYLOXY)PHENYL]AMINO]ETHYL]ACETAMIDE; N [2 [METHYL [3 (8 PHENYLOCTYLOXY)PHENYL]AMINO]ETHYL]ACETAMIDE; N [2 [PHENYL [3 (4 PHENYLBUTOXY)PHENYL]AMINO]ETHYL]ACETAMIDE; N [3 [METHYL [3 (4 PHENYLBUTOXY)PHENYL]AMINO]PROPYL]ACETAMIDE; UNCLASSIFIED DRUG; AMIDE; LIGAND; MELATONIN;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG POTENTIATION; HUMAN; METABOLISM; MOLECULAR MODEL; MT1 SELECTIVITY; STRUCTURE-ACTIVITY RELATIONSHIPS;

MELATONIN; MOLECULAR MODELING; MT1 SELECTIVITY; STRUCTURE-ACTIVITY RELATIONSHIPS;

AMIDES; ANILINE COMPOUNDS; DRUG DESIGN; HUMANS; LIGANDS; MOLECULAR DYNAMICS SIMULATION; RECEPTOR, MELATONIN, MT1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84868091994     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200303     Document Type: Article

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