-
1
-
-
4344638051
-
Physiological and metabolic functions of melatonin
-
Barrenetxe, J.; Delagrange, P.; Martinez, J.A. Physiological and metabolic functions of melatonin. J. Physiol. Biochem., 2004, 60, 61-72.
-
(2004)
J. Physiol. Biochem.
, vol.60
, pp. 61-72
-
-
Barrenetxe, J.1
Delagrange, P.2
Martinez, J.A.3
-
2
-
-
0035991397
-
The chronobiotic properties of melatonin
-
Pevet, P.; Bothorel, B.; Slotten, H.; Saboureau, M. The chronobiotic properties of melatonin. Cell Tissue Res., 2002, 309, 183-191.
-
(2002)
Cell Tissue Res.
, vol.309
, pp. 183-191
-
-
Pevet, P.1
Bothorel, B.2
Slotten, H.3
Saboureau, M.4
-
3
-
-
15444378210
-
Attenuation in the evolution of experimental spinal cord trauma by treatment with melatonin
-
Genovese, T.; Mazzon, E.; Muia, C.; Bramanti, P.; De Sarro, A.; Cuzzocrea, S. Attenuation in the evolution of experimental spinal cord trauma by treatment with melatonin. J. Pineal Res., 2005, 38, 198-208.
-
(2005)
J. Pineal Res.
, vol.38
, pp. 198-208
-
-
Genovese, T.1
Mazzon, E.2
Muia, C.3
Bramanti, P.4
De Sarro, A.5
Cuzzocrea, S.6
-
4
-
-
20044377634
-
Melatonin, the pineal gland and their implications for headache disorders
-
Peres, M.F.P. Melatonin, the pineal gland and their implications for headache disorders. Cephalalgia, 2005, 25, 403-411.
-
(2005)
Cephalalgia
, vol.25
, pp. 403-411
-
-
Peres, M.F.P.1
-
5
-
-
17544369648
-
Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina
-
Iuvone, P.M.; Tosini, G.; Pozdeyev, N.; Haque, R.; Klein, D.C.; Chaurasia, S.S. Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina. Prog. Retinal Eye Res., 2005, 24, 433-456.
-
(2005)
Prog. Retinal Eye Res.
, vol.24
, pp. 433-456
-
-
Iuvone, P.M.1
Tosini, G.2
Pozdeyev, N.3
Haque, R.4
Klein, D.C.5
Chaurasia, S.S.6
-
6
-
-
0036264490
-
Melatonin and the cardiovascular system
-
Sewerynek, E. Melatonin and the cardiovascular system. Neuroendocrinol. Lett., 2002, 23 (S1), 79-83.
-
(2002)
Neuroendocrinol. Lett.
, vol.23
, Issue.S1
, pp. 79-83
-
-
Sewerynek, E.1
-
7
-
-
33749317848
-
Therapeutic treatments potentially mediated by melatonin receptors: Potential clinical uses in the prevention of osteoporosis cancer and as an adjuvant therapy
-
(a) Witt-Enderby, P.A.; Radio, N.M.; Doctor, J.S.; Davis, V.L. Therapeutic Treatments Potentially Mediated by Melatonin Receptors: Potential Clinical Uses in the Prevention of Osteoporosis Cancer and as an Adjuvant Therapy. J. Pineal Res. 2006, 41, 297-305
-
(2006)
J. Pineal Res.
, vol.41
, pp. 297-305
-
-
Witt-Enderby, P.A.1
Radio, N.M.2
Doctor, J.S.3
Davis, V.L.4
-
8
-
-
0036479749
-
Melatonin as a chronobiotic/anticancer agent: Cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy
-
(b) Blask, D.E.; Sauer, L.A.; Dauchy, R.T. Melatonin as a chronobiotic/anticancer agent: Cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy. Curr. Top. Med. Chem., 2002, 2, 113-132
-
(2002)
Curr. Top. Med. Chem.
, vol.2
, pp. 113-132
-
-
Blask, D.E.1
Sauer, L.A.2
Dauchy, R.T.3
-
9
-
-
27744573253
-
Melatonin in the treatment of cancer: A systematic review of randomized controlled trials and metaanalysis
-
(c) Mills, E.; Wu, P.; Seely, D.; Guyatt, G. Melatonin in the treatment of cancer: A systematic review of randomized controlled trials and metaanalysis. J. Pineal Res., 2005, 39, 360-366.
-
(2005)
J. Pineal Res.
, vol.39
, pp. 360-366
-
-
Mills, E.1
Wu, P.2
Seely, D.3
Guyatt, G.4
-
10
-
-
20944434321
-
Antioxidant capacity of the neurohormone melatonin
-
Sofic, E.; Rimpapa, Z.; Kundurovic, Z.; Sapcanin, A.; Tahirovic, I; Rustembegovic, A.; Cao, G. Antioxidant capacity of the neurohormone melatonin. J. Neural Transm., 2005, 112, 349-358.
-
(2005)
J. Neural Transm.
, vol.112
, pp. 349-358
-
-
Sofic, E.1
Rimpapa, Z.2
Kundurovic, Z.3
Sapcanin, A.4
Tahirovic, I.5
Rustembegovic, A.6
Cao, G.7
-
11
-
-
12344325585
-
Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke
-
Macleod, M.R.; O'Collins, T; Horky, L.L.; Howells, D.W.; Donnan, G.A. Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke. J. Pineal Res., 2005, 38, 35-41.
-
(2005)
J. Pineal Res.
, vol.38
, pp. 35-41
-
-
MacLeod, M.R.1
O'Collins, T.2
Horky, L.L.3
Howells, D.W.4
Donnan, G.A.5
-
12
-
-
33745699091
-
Melatonin in Alzheimer's disease and other neurodegenerative disorders
-
No pp given
-
Srinivasan, V.; Pandi-Perumal, S.; Cardinali, D.; Poeggeler, B.; Hardeland, R. Melatonin in Alzheimer's disease and other neurodegenerative disorders. Behav. Brain Funct., 2006, 2 (No pp given)
-
(2006)
Behav. Brain Funct.
, vol.2
-
-
Srinivasan, V.1
Pandi-Perumal, S.2
Cardinali, D.3
Poeggeler, B.4
Hardeland, R.5
-
13
-
-
34249072817
-
Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's disease
-
(b) Medeiros, C.A. M.; Carvalhedo de Bruin, P.F.; Lopes, L.A.; Magalhães, M.C.; Seabra, M.de L.; Sales de Bruin, V.M. Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's disease. J. Neurol, 2007, 254, 459-464.
-
(2007)
J. Neurol
, vol.254
, pp. 459-464
-
-
Medeiros, C.A.M.1
Carvalhedo De Bruin, P.F.2
Lopes, L.A.3
Magalhães, M.C.4
Seabra, M.D.L.5
Sales De Bruin, V.M.6
-
14
-
-
0029972613
-
Melatonin receptors step into the light: Cloning and classification of subtypes
-
Reppert, SM.; Weaver, D.R.; Godson, C. Melatonin receptors step into the light: Cloning and classification of subtypes. Trends Pharmacol. Sci., 1996, 17, 100-102.
-
(1996)
Trends Pharmacol. Sci.
, vol.17
, pp. 100-102
-
-
Reppert, S.M.1
Weaver, D.R.2
Godson, C.3
-
15
-
-
0034613342
-
Identification of the melatonin-binding site MT3 as the quinone reductase 2
-
Nosjean, O.; Ferro, M.; Coge, F.; Beauverger, P.; Henlin, J.M.; Lefoulon, F.; Fauchere, J.L.; Delagrange, P.; Canet, E.; Boutin, J.A. Identification of the melatonin-binding site MT3 as the quinone reductase 2. J. Biol Chem., 2000, 275, 31311-31317.
-
(2000)
J. Biol Chem.
, vol.275
, pp. 31311-31317
-
-
Nosjean, O.1
Ferro, M.2
Coge, F.3
Beauverger, P.4
Henlin, J.M.5
Lefoulon, F.6
Fauchere, J.L.7
Delagrange, P.8
Canet, E.9
Boutin, J.A.10
-
16
-
-
0033740169
-
Melatonin receptors as potential targets for drug discovery
-
Li, P.-K.; Witt-Enderby, P.A. Melatonin receptors as potential targets for drug discovery. Drug Future, 2000, 25, 945-957.
-
(2000)
Drug Future
, vol.25
, pp. 945-957
-
-
Li, P.-K.1
Witt-Enderby, P.A.2
-
17
-
-
0032161469
-
2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms
-
2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms. FASEB J., 1998, 12, 1211-1220.
-
(1998)
FASEB J.
, vol.12
, pp. 1211-1220
-
-
Dubocovich, M.L.1
Yun, K.2
Al-Ghoul, W.M.3
Benloucif, S.4
Masana, M.I.5
-
18
-
-
0030761518
-
Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock
-
Liu, C; Weaver, D.R.; Jin, X.; Shearman, L.P; Pieschl, R.L.; Gribkoff, V.K.; Reppert, SM. Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. Neuron, 1997, 19, 91-102.
-
(1997)
Neuron
, vol.19
, pp. 91-102
-
-
Liu, C.1
Weaver, D.R.2
Jin, X.3
Shearman, L.P.4
Pieschl, R.L.5
Gribkoff, V.K.6
Reppert, S.M.7
-
19
-
-
0032510504
-
Melatonin mediates two distinct responses in vascular smooth muscle
-
Doolen, S.; Krause, D.N.; Dubocovich, M.L.; Duckles, S.P. Melatonin mediates two distinct responses in vascular smooth muscle. Eur. J. Pharmacol, 1998, 345, 67-69.
-
(1998)
Eur. J. Pharmacol
, vol.345
, pp. 67-69
-
-
Doolen, S.1
Krause, D.N.2
Dubocovich, M.L.3
Duckles, S.P.4
-
20
-
-
0035008125
-
Activation of MT(2) melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock
-
Hunt, A.E.; Al-Ghoul, W.M.; Gillette, M.U.; Dubocovich, M.L. Activation of MT(2) melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock. Am. J. Physiol, 2001, 280, C110-C118.
-
(2001)
Am. J. Physiol
, vol.280
-
-
Hunt, A.E.1
Al-Ghoul, W.M.2
Gillette, M.U.3
Dubocovich, M.L.4
-
21
-
-
27644449587
-
Functional MT1 and MT2 melatonin receptors in mammals
-
Dubocovich, M.L.; Markowska, M. Functional MT1 and MT2 melatonin receptors in mammals. Endocrine, 2005, 27, 101-110.
-
(2005)
Endocrine
, vol.27
, pp. 101-110
-
-
Dubocovich, M.L.1
Markowska, M.2
-
22
-
-
70449704975
-
New approaches in the management of insomnia: Weighing the advantages of prolonged release melatonin and synthetic melatoninerg ic agonists
-
Hardeland, R. New approaches in the management of insomnia: weighing the advantages of prolonged release melatonin and synthetic melatoninerg ic agonists. Neuropsychiatr Dis Treat., 2009, 5, 341-354.
-
(2009)
Neuropsychiatr Dis Treat.
, vol.5
, pp. 341-354
-
-
Hardeland, R.1
-
24
-
-
34247263340
-
Drug insight: The use of melatonergic agonists for the treatment of insomnia-Focus on ramelteon
-
Pandi-Perumal, S.R.; Srinivasan, V; Poeggeler, B.; Hardeland, R.; Cardinali, D.P Drug insight: The use of melatonergic agonists for the treatment of insomnia-Focus on ramelteon. Nat. Clin. Pract. Neurol, 2007, 3, 221-228.
-
(2007)
Nat. Clin. Pract. Neurol
, vol.3
, pp. 221-228
-
-
Pandi-Perumal, S.R.1
Srinivasan, V.2
Poeggeler, B.3
Hardeland, R.4
Cardinali, D.P.5
-
25
-
-
79961100327
-
11C] Ramelteon as a Positron Emission Tomography Probe for Imaging Melatonin Receptors Involved in Circadian Rhythms
-
11C] Ramelteon as a Positron Emission Tomography Probe for Imaging Melatonin Receptors Involved in Circadian Rhythms. Chem. Pharm. Bull, 2011, 59, 1062-1064.
-
(2011)
Chem. Pharm. Bull
, vol.59
, pp. 1062-1064
-
-
Takashima-Hirano, M.1
Tazawa, S.2
Takahashi, K.3
Doi, H.4
Suzuki, M.5
-
26
-
-
77955172537
-
Agomelatine, the first melatonergic antidepressant: Discovery characterization and development
-
de Bodinat, C; Guardiola-Lemaitre, B.; Mocaër, E.; Renard, P.; Muñoz, C; Millan, M.J. Agomelatine, the first melatonergic antidepressant: discovery characterization and development. Nat. Rev Drug Discov., 2010, 9, 628-642.
-
(2010)
Nat. Rev Drug Discov.
, vol.9
, pp. 628-642
-
-
De Bodinat, C.1
Guardiola-Lemaitre, B.2
Mocaër, E.3
Renard, P.4
Muñoz, C.5
Millan, M.J.6
-
27
-
-
16444367184
-
The efficacy and safety of the melatonin agonist ß-methyl-6- chloromelatonin in primary insomnia: A randomized, placebo-controlled, crossover clinical trial
-
Zemlan, FP; Mulchahey, J.J.; Scharf, M.B.; Mayleben, D.W.; Rosenberg, R.; Lankford, A. The efficacy and safety of the melatonin agonist ß-methyl-6-chloromelatonin in primary insomnia: A randomized, placebo-controlled, crossover clinical trial. J. Clin. Psychiatry, 2005, 66, 384-390.
-
(2005)
J. Clin. Psychiatry
, vol.66
, pp. 384-390
-
-
Zemlan, F.P.1
Mulchahey, J.J.2
Scharf, M.B.3
Mayleben, D.W.4
Rosenberg, R.5
Lankford, A.6
-
29
-
-
65549159290
-
Antagonism of serotonergic 5-HT2A/2C receptors: Mutual improvement of sleep, cognition and mood?
-
Landolt, H.P; Wehrle, R. Antagonism of serotonergic 5-HT2A/2C receptors: mutual improvement of sleep, cognition and mood? Eur J Neurosci., 2009; 29, 1795-1809.
-
(2009)
Eur J Neurosci.
, vol.29
, pp. 1795-1809
-
-
Landolt, H.P.1
Wehrle, R.2
-
30
-
-
36749066274
-
Search of Novel and Therapeutically Significant Melatoninerg ic Ligands
-
Mody, SM.; Hu, Y.; Ho, M.K.C., Wong, YH. In Search of Novel and Therapeutically Significant Melatoninerg ic Ligands. Recent Patents on CNS Drug Discovery, 2007, 2, 241-245.
-
(2007)
Recent Patents on CNS Drug Discovery
, vol.2
, pp. 241-245
-
-
Mody, S.M.1
Hu, Y.2
Ho, M.K.C.3
Wong, Y.H.4
-
31
-
-
48249086074
-
Melatonin Receptor Agonists: SAR and Applications to the Treatment of Sleep-Wake Disorders
-
Rivara, S.; Mor, M.; Bedini, A.; Spadoni, G.; Tarzia, G. Melatonin Receptor Agonists: SAR and Applications to the Treatment of Sleep-Wake Disorders. Curr Top Med Chem., 2008, 8, 954-968.
-
(2008)
Curr Top Med Chem.
, vol.8
, pp. 954-968
-
-
Rivara, S.1
Mor, M.2
Bedini, A.3
Spadoni, G.4
Tarzia, G.5
-
32
-
-
77954949734
-
2 receptor agonists
-
2 receptor agonists. Expert Opin. Ther. Petents, 2010, 20(8), 1059-1077.
-
(2010)
Expert Opin. Ther. Petents
, vol.20
, Issue.8
, pp. 1059-1077
-
-
Mor, M.1
Rivara, S.2
Pala, D.3
Bedini, A.4
Spadoni, G.5
Tarzia, G.6
-
33
-
-
77952378059
-
Investigational melatonin receptor agonists
-
Hardeland, R.; Investigational melatonin receptor agonists. Exp. Opin. Investig. Drugs, 2010, 19, 747-764.
-
(2010)
Exp. Opin. Investig. Drugs
, vol.19
, pp. 747-764
-
-
Hardeland, R.1
-
35
-
-
4644275718
-
Circadian rhythm entrainment with melatonin, melatonin receptor antagonist S22153 or their combination in mice exposed to constant light
-
Li, X.M.; Beau, J.; Delagrange, P.; Mocaer, E.; Lévi, F. Circadian rhythm entrainment with melatonin, melatonin receptor antagonist S22153 or their combination in mice exposed to constant light. J. Pineal Res., 2004, 37, 176-184.
-
(2004)
J. Pineal Res.
, vol.37
, pp. 176-184
-
-
Li, X.M.1
Beau, J.2
Delagrange, P.3
Mocaer, E.4
Lévi, F.5
-
36
-
-
29044449162
-
The role of ML-23 and other melatonin analogs in the treatment and management of Parkinson's disease
-
Willis, G.L. The role of ML-23 and other melatonin analogs in the treatment and management of Parkinson's disease. Drug News Perspect, 2005, 18, 437-44.
-
(2005)
Drug News Perspect
, vol.18
, pp. 437-444
-
-
Willis, G.L.1
-
37
-
-
21844433213
-
Recent advances in melatonin receptor ligands
-
Zlotos, D. P. Recent advances in melatonin receptor ligands. Arch. Pharm. Chem. Life Sci., 2005, 338, 229-247.
-
(2005)
Arch. Pharm. Chem. Life Sci.
, vol.338
, pp. 229-247
-
-
Zlotos, D.P.1
-
38
-
-
58549099535
-
Advances on the development of subtype selective melatonin ligands
-
Pandi-Perumal, S. R.; Cardinali, D.P; Nova Scotia Publishers Inc., Hauppauge
-
Spadoni, G.; Bedini, A. Advances on the development of subtype selective melatonin ligands. In Melatonin: From Molecules to Therapy, Pandi-Perumal, S. R.; Cardinali, D.P; Nova Scotia Publishers Inc., Hauppauge, 2007, pp-33-45.
-
(2007)
Melatonin: From Molecules to Therapy
, pp. 33-45
-
-
Spadoni, G.1
Bedini, A.2
-
39
-
-
35048900127
-
Synthesis of Compounds as Melatonin Agonists and Antagonists
-
Garratt, P.J.; Tsotinis, A. Synthesis of Compounds as Melatonin Agonists and Antagonists. Mini Rev. Med. Chem., 2007, 7, 1075-1088.
-
(2007)
Mini Rev. Med. Chem.
, vol.7
, pp. 1075-1088
-
-
Garratt, P.J.1
Tsotinis, A.2
-
40
-
-
0002523137
-
Melatonin receptors
-
nd ed (Girdlestone D ed) IUPHAR Media, London
-
nd ed (Girdlestone D ed) pp 270-277. IUPHAR Media, London.
-
(2000)
The IUPHAR Compendium of Receptor Characterization and Classification
, pp. 270-277
-
-
Dubocovich, M.L.1
Cardinali, D.P.2
Delagrange, P.3
Krause, D.N.4
Strosberg, A.D.5
Sugden, D.6
Yocca, F.D.7
-
41
-
-
0029930956
-
Mapping the Melatonin Receptor. 4. Comparison of the Binding Affinities of a Series of Substituted Phenylalkyl Amides
-
Garratt, P.J.; Travard, S.; Vonhoff, S.; Tsotinis, A.; Sugden, D. Mapping the Melatonin Receptor. 4. Comparison of the Binding Affinities of a Series of Substituted Phenylalkyl Amides. J. Med. Chem., 1996 39, 1797-1805.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 1797-1805
-
-
Garratt, P.J.1
Travard, S.2
Vonhoff, S.3
Tsotinis, A.4
Sugden, D.5
-
42
-
-
77955985122
-
Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors
-
Carocci, A.; Catalano, A.; Lovece, A.; Lentini, G.; Duranti, A.; Lucini, V; Pannacci, M.; Scaglione, F; Franchini, C. Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors. Bioorg. Med. Chem., 2010, 18, 6496-6551.
-
(2010)
Bioorg. Med. Chem.
, vol.18
, pp. 6496-6551
-
-
Carocci, A.1
Catalano, A.2
Lovece, A.3
Lentini, G.4
Duranti, A.5
Lucini, V.6
Pannacci, M.7
Scaglione, F.8
Franchini, C.9
-
43
-
-
33745121849
-
Mapping the Melatonin Receptor. 7. Subtype Selective Ligands Based on ß-Substituted N-Acyl-5-methoxytryptamines and N-Acyl-5-methoxy-1-methyl- tryptamines
-
Tsotinis, A.; Vlachou, M.; Papahatjis, D.P; Calogeropoulou, T.; Nikas, S.P; Garratt, P.J.; Piccio, V; Vonhoff, S.; Davidson, K.; Teh, M.T.; Sugden, D. Mapping the Melatonin Receptor. 7. Subtype Selective Ligands Based on ß-Substituted N-Acyl-5-methoxytryptamines and N-Acyl-5-methoxy-1-methyl- tryptamines. J. Med. Chem., 2006, 49, 3509-3519.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 3509-3519
-
-
Tsotinis, A.1
Vlachou, M.2
Papahatjis, D.P.3
Calogeropoulou, T.4
Nikas, S.P.5
Garratt, P.J.6
Piccio, V.7
Vonhoff, S.8
Davidson, K.9
Teh, M.T.10
Sugden, D.11
-
44
-
-
34250380676
-
Design, synthesis and melatoninerg ic potency of new N-acyl 8, 9-dihydro-4-methoxy-7H-2-benzo[de] quinolinalkanamines
-
Tsotinis, A.; Panoussopoulou, M.; Eleutheriades, A.; Davidson, K.; Sugden, D. Design, synthesis and melatoninerg ic potency of new N-acyl 8, 9-dihydro-4-methoxy-7H-2-benzo[de] quinolinalkanamines. Eur. J. Med. Chem., 2007, 42, 1004-1013.
-
(2007)
Eur. J. Med. Chem.
, vol.42
, pp. 1004-1013
-
-
Tsotinis, A.1
Panoussopoulou, M.2
Eleutheriades, A.3
Davidson, K.4
Sugden, D.5
-
45
-
-
33847769585
-
Design, synthesis and melatonin erg ic activity of new unsubstituted and ß, ß-difunctionalised 2, 3-dihydro-1 H-pyrrolo[3, 2, 1-ij] quino lin-6-alk an amides
-
Tsotinis, A.; Eleutheriades, A.; Hough, K.A.; Davidson, K.; Sugden, D. Design, synthesis and melatonin erg ic activity of new unsubstituted and ß, ß-difunctionalised 2, 3-dihydro-1 H-pyrrolo[3, 2, 1-ij] quino lin-6-alk an amides. Bioorg. Chem., 2007, 35, 189-204.
-
(2007)
Bioorg. Chem.
, vol.35
, pp. 189-204
-
-
Tsotinis, A.1
Eleutheriades, A.2
Hough, K.A.3
Davidson, K.4
Sugden, D.5
-
46
-
-
61449191838
-
2- selective melatonin receptor ligands
-
2-selective melatonin receptor ligands. Bioorg. Med. Chem., 2009, 52, 826-833.
-
(2009)
Bioorg. Med. Chem.
, vol.52
, pp. 826-833
-
-
Markl, C.1
Attia, M.I.2
Julius, J.3
Witt-Enderby, P.A.4
Zlotos, D.P.5
-
47
-
-
33845295481
-
Synthesis and pharmacological evaluation of 13a 14-dihydro-6H 13H-pyrazino [1, 2-A;4, 5-Á] diindole analogs as melatonin receptor ligands
-
Attia, M.I.; Julius, J.; Witt-Enderby, P.A.; Zlotos, D.P. Synthesis and pharmacological evaluation of 13a, 14-dihydro-6H, 13H-pyrazino [1, 2-a;4, 5-á] diindole analogs as melatonin receptor ligands. Tetrahedron, 2007, 63, 754-760.
-
(2007)
Tetrahedron
, vol.63
, pp. 754-760
-
-
Attia, M.I.1
Julius, J.2
Witt-Enderby, P.A.3
Zlotos, D.P.4
-
48
-
-
49149116600
-
Synthesis and pharmacological evaluation of pentacyclic 6a, 7-dihydrodiindole and 2, 3-dihydrodiindole derivatives as novel melatoninerg ic ligands
-
Attia, M.I; Witt-Enderby, P.A.; Julius, J. Synthesis and pharmacological evaluation of pentacyclic 6a, 7-dihydrodiindole and 2, 3-dihydrodiindole derivatives as novel melatoninerg ic ligands. Bioorg. Med. Chem., 2008, 16, 7654-7661.
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 7654-7661
-
-
Attia, M.I.1
Witt-Enderby, P.A.2
Julius, J.3
-
49
-
-
34250787583
-
Synthesis, NMR conformational analysis and pharmacological evaluation of 7, 7a, 13, 14-tetrahydro-6H-cyclobuta[b]pyrimido[1, 2-A:3, 4-Á] diindole analogs as melatonin receptor ligands
-
Attia, M.I.; Güclü, D.; Hertlein, B.; Julius, J.; Witt-Enderby, P.A.; Zlotos, D.P. Synthesis, NMR conformational analysis and pharmacological evaluation of 7, 7a, 13, 14-tetrahydro-6H-cyclobuta[b]pyrimido[1, 2-a:3, 4-á]diindole analogs as melatonin receptor ligands. Org. Biomol Chem., 2007, 5, 2129-2137.
-
(2007)
Org. Biomol Chem.
, vol.5
, pp. 2129-2137
-
-
Attia, M.I.1
Güclü, D.2
Hertlein, B.3
Julius, J.4
Witt-Enderby, P.A.5
Zlotos, D.P.6
-
50
-
-
79953221772
-
Application of the bridgehead fragments for the design of conformationally restricted melatonin analogs
-
Zefirova, O.N.; Baranova, T.Y; Ivanova, A.A.; Ivanov, A.A.; Zefirov, N.S. Application of the bridgehead fragments for the design of conformationally restricted melatonin analogs. Bioorg. Chem., 2011, 39, 67-72.
-
(2011)
Bioorg. Chem.
, vol.39
, pp. 67-72
-
-
Zefirova, O.N.1
Baranova, T.Y.2
Ivanova, A.A.3
Ivanov, A.A.4
Zefirov, N.S.5
-
51
-
-
34248657560
-
7-Substituted-melatonin and 7-substituted-1-methylmelatonin analogs: Effect of substituents on potency and binding affinity
-
Faust, R.; Garratt, P.J.; Trujillo Pèrez, M.A., Piccio, V.J.D.; Madsen, C; Stenstrom, A.; Frolund, B.; Davidson, K.; Teh, M.T.; Sugden, D. 7-Substituted-melatonin and 7-substituted-1-methylmelatonin analogs: Effect of substituents on potency and binding affinity. Bioorg. Med. Chem., 2007, 15, 4543-4551.
-
(2007)
Bioorg. Med. Chem.
, vol.15
, pp. 4543-4551
-
-
Faust, R.1
Garratt, P.J.2
Trujillo Pèrez, M.A.3
Piccio, V.J.D.4
Madsen, C.5
Stenstrom, A.6
Frolund, B.7
Davidson, K.8
Teh, M.T.9
Sugden, D.10
-
52
-
-
0037171722
-
Synthesis of Nitroindole Derivatives with High Affinity and Selectivity for Melatoninerg ic Binding Sites MT3
-
Leclerc, V; Said, Y; Delagrange, P.; Boutin, J.A.; Renard, P.; Lesieur, D. Synthesis of Nitroindole Derivatives with High Affinity and Selectivity for Melatoninerg ic Binding Sites MT3. J. Med. Chem., 2002, 45, 1853-1859.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 1853-1859
-
-
Leclerc, V.1
Said, Y.2
Delagrange, P.3
Boutin, J.A.4
Renard, P.5
Lesieur, D.6
-
53
-
-
0037423517
-
Design and synthesis of potent N1-substituted indole melatonin receptor agonists
-
Tsotinis, A.; Eleutheriades, A.; Hough, K.; Sugden, D. Design and synthesis of potent N1-substituted indole melatonin receptor agonists. Chem. Comm., 2003, 382-383.
-
(2003)
Chem. Comm.
, pp. 382-383
-
-
Tsotinis, A.1
Eleutheriades, A.2
Hough, K.3
Sugden, D.4
-
54
-
-
36448985860
-
Design and Synthesis of New N-OMe Fluoro-Indole Melatoninergics
-
Tsotinis, A.; Gourgourinis, J.; Eleutheriades, A.; Davidson, K.; Sugden, D. Design and Synthesis of New N-OMe Fluoro-Indole Melatoninergics. Med. Chem., 2007, 3, 561-571.
-
(2007)
Med. Chem.
, vol.3
, pp. 561-571
-
-
Tsotinis, A.1
Gourgourinis, J.2
Eleutheriades, A.3
Davidson, K.4
Sugden, D.5
-
55
-
-
35948944333
-
Design and Synthesis of New N-OMe Fluoro-Indole Melatoninergics
-
Tsotinis, A.; Eleutheriades, A.; Davidson, K.; Sugden, D. Design and Synthesis of New N-OMe Fluoro-Indole Melatoninergics. Curr. Drug Discov. Techn., 2007, 4, 198-207.
-
(2007)
Curr. Drug Discov. Techn.
, vol.4
, pp. 198-207
-
-
Tsotinis, A.1
Eleutheriades, A.2
Davidson, K.3
Sugden, D.4
-
56
-
-
33645919613
-
Reassessing the melatonin pharmacophore-Enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analog
-
Rivara, S.; Diamantini, G.; Di Giacomo, B.; Lamba, D.; Gatti, G.; Lucini, V.; Pannacci, M.; Mor, M.; Spadoni, G.; Tarzia, G. Reassessing the melatonin pharmacophore-Enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analog. Bioorg. Med. Chem., 2006, 14, 3383-3391.
-
(2006)
Bioorg. Med. Chem.
, vol.14
, pp. 3383-3391
-
-
Rivara, S.1
Diamantini, G.2
Di Giacomo, B.3
Lamba, D.4
Gatti, G.5
Lucini, V.6
Pannacci, M.7
Mor, M.8
Spadoni, G.9
Tarzia, G.10
-
57
-
-
34248670685
-
Synthesis and biological activity of new melatonin dimeric derivatives
-
Di Giacomo, B.; Bedini, A.; Spadoni, G.; Tarzia, G.; Fraschini, F.; Pannacci, M.; Lucini, V. Synthesis and biological activity of new melatonin dimeric derivatives. Bioorg. Med. Chem., 2007, 15, 4643-4650.
-
(2007)
Bioorg. Med. Chem.
, vol.15
, pp. 4643-4650
-
-
Di Giacomo, B.1
Bedini, A.2
Spadoni, G.3
Tarzia, G.4
Fraschini, F.5
Pannacci, M.6
Lucini, V.7
-
58
-
-
32044438419
-
Bicyclic melatonin receptor agonists containing a ring-junction nitrogen: Synthesis, biological evaluation, and molecular modelling of the putative bioactive conformation
-
Elsner, J.; Boeckler, F.; Davidson, K.; Sugden, D.; Gmeiner, P. Bicyclic melatonin receptor agonists containing a ring-junction nitrogen: Synthesis, biological evaluation, and molecular modelling of the putative bioactive conformation. Bioorg. Med. Chem., 2006, 14, 1949-1958.
-
(2006)
Bioorg. Med. Chem.
, vol.14
, pp. 1949-1958
-
-
Elsner, J.1
Boeckler, F.2
Davidson, K.3
Sugden, D.4
Gmeiner, P.5
-
59
-
-
80052922538
-
Design and synthesis of 2-phenylimidazo[1, 2-A]pyridines as a novel class of melatonin receptor ligands
-
El Kazzouli, S.; du Bellay, A.G.; Berteina-Raboin, S.; Delagrange, Philippe.; Caignard, D.H.; Guillaumet, G. Design and synthesis of 2-phenylimidazo[1, 2-a]pyridines as a novel class of melatonin receptor ligands. Eur. J. Med. Chem., 2011, 46, 4252-4257.
-
(2011)
Eur. J. Med. Chem.
, vol.46
, pp. 4252-4257
-
-
El Kazzouli, S.1
Du Bellay, A.G.2
Berteina-Raboin, S.3
Delagrange, P.4
Caignard, D.H.5
Guillaumet, G.6
-
60
-
-
79953280603
-
Design and synthesis of 1-(2-alkanamidoethyl)-6-methoxy-7- azaindolederivatives as potent melatonin agonists
-
Jeanty, M.; Suzenet, F.; Delagrange, F.; Nosjean, O.; Boutin, J.A.; Caignard, D.H.; Guillaumet, G. Design and synthesis of 1-(2-alkanamidoethyl)-6- methoxy-7-azaindolederivatives as potent melatonin agonists. Bioorg. Med. Chem. Lett., 2011, 21, 2316-2319.
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, pp. 2316-2319
-
-
Jeanty, M.1
Suzenet, F.2
Delagrange, F.3
Nosjean, O.4
Boutin, J.A.5
Caignard, D.H.6
Guillaumet, G.7
-
61
-
-
15444338704
-
1-(2-Alkanamidoethyl)-6-methoxyindole Derivatives: A New Class of Potent Indole Melatonin Analogs
-
Tarzia, G.; Diamantini, G.; Di Giacomo, B.; Spadoni, G.; Esposti, D.; Nonno, R.; Lucini, V.; Pannacci, M.; Fraschini, F.; Stankov, B. M. 1-(2-Alkanamidoethyl)-6-methoxyindole Derivatives: a New Class of Potent Indole Melatonin Analogs. J. Med. Chem., 1997, 40, 2003-2010.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 2003-2010
-
-
Tarzia, G.1
Diamantini, G.2
Di Giacomo, B.3
Spadoni, G.4
Esposti, D.5
Nonno, R.6
Lucini, V.7
Pannacci, M.8
Fraschini, F.9
Stankov, B.M.10
-
62
-
-
79955814739
-
2-Selective Agonists
-
2-Selective Agonists J. Med. Chem., 2011, 54, 3436-3444.
-
(2011)
J. Med. Chem.
, vol.54
, pp. 3436-3444
-
-
Koike, T.1
Hoashi, Y.2
Takai, T.3
Nakayama, M.4
Yukuhiro, N.5
Ishikawa, T.6
Hirai, K.7
Uchikawa, O.8
-
63
-
-
79959455122
-
Synthesis of a Novel Series of Tricyclic Dihydrofuran Derivatives: Discovery of 8, 9-Dihydrofuro [3, 2-c] pyrazolo [1, 5-A] pyridines as Melatonin Receptor (MT1/MT2) Ligands
-
Koike, T.; Takai, T.; Hoashi, Y.; Nakayama, M.; Kosugi, Y.; Nakashima, M.; Yoshikubo, S.; Hirai, K.; Uchikawa, O. Synthesis of a Novel Series of Tricyclic Dihydrofuran Derivatives: Discovery of 8, 9-Dihydrofuro [3, 2-c] pyrazolo [1, 5-a] pyridines as Melatonin Receptor (MT1/MT2) Ligands. J. Med. Chem., 2011, 54, 4207-4218.
-
(2011)
J. Med. Chem.
, vol.54
, pp. 4207-4218
-
-
Koike, T.1
Takai, T.2
Hoashi, Y.3
Nakayama, M.4
Kosugi, Y.5
Nakashima, M.6
Yoshikubo, S.7
Hirai, K.8
Uchikawa, O.9
-
64
-
-
35748934487
-
The Influence of Drug-like Concepts on Decision-Making in Medicinal Chemistry
-
Leeson, P. D.; Springthorpe, B. The Influence of Drug-like Concepts on Decision-Making in Medicinal Chemistry. Nat. Rev. Drug Discovery, 2007, 6, 881-890.
-
(2007)
Nat. Rev. Drug Discovery
, vol.6
, pp. 881-890
-
-
Leeson, P.D.1
Springthorpe, B.2
-
65
-
-
79955649962
-
Synthesis of 4-aza analog of ramelteon: A novel tricyclic 1, 6, 7, 8-tetrahydro-2H-cyclopenta [d] furo [2, 3-b] pyridine derivative as melatonin receptor ligand
-
Koike, T.; Hoashi, Y.; Takai, T.; Uchikawa, O. Synthesis of 4-aza analog of ramelteon: a novel tricyclic 1, 6, 7, 8-tetrahydro-2H-cyclopenta [d] furo [2, 3-b] pyridine derivative as melatonin receptor ligand. Tetrahedron Lett., 2011, 52 3009-3011.
-
(2011)
Tetrahedron Lett.
, vol.52
, pp. 3009-3011
-
-
Koike, T.1
Hoashi, Y.2
Takai, T.3
Uchikawa, O.4
-
66
-
-
79851511779
-
Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl- cyclopropane carboxamide derivatives as novel melatonin receptor ligands
-
Li, G.; Zhou, H.; Jiang, Y.; Keim, H.; Topiol, S.W.; Poda, S.B.; Ren, Y.; Chandrasena, G.; Doller, D. Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands. Bioorg. Med. Chem. Lett., 2011, 21, 1236-1242.
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, pp. 1236-1242
-
-
Li, G.1
Zhou, H.2
Jiang, Y.3
Keim, H.4
Topiol, S.W.5
Poda, S.B.6
Ren, Y.7
Chandrasena, G.8
Doller, D.9
-
67
-
-
0344496012
-
-
Sun, L.-Q.; Chen, J.; Mattson, R.; Epperson, J. R.; Deskus, J. A.; Li, W.; Takaki, K.; Hodges, D. B.; Iben, L.; Mahle, C. D.; Ortiz, A.; Molstad, D.; Ryan, E.; Yeleswaram, K.; Xu, C.; Luo, G. Bioorg. Med. Chem. Lett., 2003, 13, 4381-4384.
-
(2003)
Med. Chem. Lett.
, vol.13
, pp. 4381-4384
-
-
Sun, L.-Q.1
Chen, J.2
Mattson, R.3
Epperson, J.R.4
Deskus, J.A.5
Li, W.6
Takaki, K.7
Hodges, D.B.8
Iben, L.9
Mahle, C.D.10
Ortiz, A.11
Molstad, D.12
Ryan, E.13
Yeleswaram, K.14
Xu, C.15
Bioorg, L.G.16
-
68
-
-
33750354042
-
Towards the development of mixed MT1-agonist/MT2-antagonist melatonin receptor ligands
-
Spadoni, G.; Bedini, A.; Guidi, T.; Tarzia, G.; Lucini, V.; Pannacci, M.; Fraschini, F. Towards the development of mixed MT1-agonist/MT2-antagonist melatonin receptor ligands. ChemMedChem, 2006, 1, 1099-1105.
-
(2006)
ChemMedChem
, vol.1
, pp. 1099-1105
-
-
Spadoni, G.1
Bedini, A.2
Guidi, T.3
Tarzia, G.4
Lucini, V.5
Pannacci, M.6
Fraschini, F.7
-
69
-
-
37349076564
-
N-(Substituted-anilinoethyl) amides: Design, synthesis and pharmacological characterization of a new class of melatonin receptor ligands
-
Rivara, S.; Lodola, A.; Mor, M.; Bedini, A.; Spadoni, G.; Lucini, V.; Pannacci, M.; Fraschini, F.; Scaglione, F.; Sanchez, R.O.; Gobbi, G.; Tarzia, G. N-(Substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands. J. Med. Chem., 2007, 50, 6618-6626.
-
(2007)
J. Med. Chem.
, vol.50
, pp. 6618-6626
-
-
Rivara, S.1
Lodola, A.2
Mor, M.3
Bedini, A.4
Spadoni, G.5
Lucini, V.6
Pannacci, M.7
Fraschini, F.8
Scaglione, F.9
Sanchez, R.O.10
Gobbi, G.11
Tarzia, G.12
-
71
-
-
0033786778
-
A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties J
-
Nonno, R.; Lucini, V.; Spadoni, G.; Pannacci, M.; Croce, A.; Esposti, D.; Balsamini, C.; Tarzia, G.; Fraschini, F.; Stankov, B.M. A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties J. Pineal Res., 2000, 29, 234-240.
-
(2000)
Pineal Res.
, vol.29
, pp. 234-240
-
-
Nonno, R.1
Lucini, V.2
Spadoni, G.3
Pannacci, M.4
Croce, A.5
Esposti, D.6
Balsamini, C.7
Tarzia, G.8
Fraschini, F.9
Stankov, B.M.10
-
72
-
-
33750354042
-
Towards the development of mixed MT1-agonist/MT2-antagonist melatonin receptor ligands
-
Spadoni, G.; Bedini, A.; Guidi, T., Tarzia, G.; Lucini, V.; Pannacci, M.; Fraschini, F. Towards the Development of Mixed MT1-Agonist/MT2-Antagonist Melatonin Receptor Ligands ChemMedChem, 2006, 1, 1099-1105.
-
(2006)
ChemMedChem
, vol.1
, pp. 1099-1105
-
-
Spadoni, G.1
Bedini, A.2
Guidi, T.3
Tarzia, G.4
Lucini, V.5
Pannacci, M.6
Fraschini, F.7
-
73
-
-
48849104646
-
Synthesis, Enantiomeric Resolution, and Structure-Activity Relationship of a Series of 10, 11-Dihydro-5H-Dibenzo [a, d] cycloheptene MT2 Receptor Antagonists
-
Spadoni, G.; Bedini, A.; Diamantini, G.; Tarzia, G.; Rivara, S.; Lorenzi, S.; Lodola, A.; Mor, M.; Lucini, V.; Pannacci, M.; Caronno, A.; Fraschini, F. Synthesis, Enantiomeric Resolution, and Structure-Activity Relationship of a Series of 10, 11-Dihydro-5H-Dibenzo [a, d] cycloheptene MT2 Receptor Antagonists. ChemMedChem., 2007, 2, 1741-1749.
-
(2007)
ChemMedChem.
, vol.2
, pp. 1741-1749
-
-
Spadoni, G.1
Bedini, A.2
Diamantini, G.3
Tarzia, G.4
Rivara, S.5
Lorenzi, S.6
Lodola, A.7
Mor, M.8
Lucini, V.9
Pannacci, M.10
Caronno, A.11
Fraschini, F.12
-
74
-
-
20444363062
-
Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models
-
Rivara, S.; Lorenzi, S.; Mor, M.; Plazzi, P.V.; Spadoni, G.; Bedini, A.; Tarzia, G. Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models. J. Med. Chem., 2005, 48, 4049-4060.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 4049-4060
-
-
Rivara, S.1
Lorenzi, S.2
Mor, M.3
Plazzi, P.V.4
Spadoni, G.5
Bedini, A.6
Tarzia, G.7
-
75
-
-
57349190246
-
Melatonin receptor antagonist luzindole: A facile new synthesis
-
a) Tsotinis, A.; Afroudakis, P.A. Melatonin receptor antagonist luzindole: A facile new synthesis. Lett. Org. Chem., 2008, 5, 507-509
-
(2008)
Lett. Org. Chem.
, vol.5
, pp. 507-509
-
-
Tsotinis, A.1
Afroudakis, P.A.2
-
76
-
-
0030964398
-
Melatonin receptor antagonists that differentiate between the human Mel1 a and Mel 1b recombinant subtypes are used to assess the pharmacological profileof the rabbit retina ML1 presynaptic heteroreceptor
-
b) Dubocovich, M.L.; Masana, M.I.; Iacob, S.; Sauri, D.M. Melatonin receptor antagonists that differentiate between the human Mel1 a and Mel 1b recombinant subtypes are used to assess the pharmacological profileof the rabbit retina ML1 presynaptic heteroreceptor Naunyn-Schmiedeberg's Arch Pharmacol., 1997, 355, 365-375.
-
(1997)
Naunyn-Schmiedeberg's Arch Pharmacol.
, vol.355
, pp. 365-375
-
-
Dubocovich, M.L.1
Masana, M.I.2
Iacob, S.3
Sauri, D.M.4
-
77
-
-
83455163368
-
Synthesis and configuration determination of all enantiopure stereoisomers of the melatonin receptor ligand 4-phenyl-2-propionamidotetralin using an expedient optical resolution of 4-phenyl-2-tetralone Org
-
Lucarini, S.; Bartolucci, S.; Bedini, A.; Gatti, G.; Orlando, P.; Piersanti, G.; Spadoni, G. Synthesis and configuration determination of all enantiopure stereoisomers of the melatonin receptor ligand 4-phenyl-2- propionamidotetralin using an expedient optical resolution of 4-phenyl-2-tetralone Org. Biomol. Chem., 2012, 10, 305-313.
-
(2012)
Biomol. Chem.
, vol.10
, pp. 305-313
-
-
Lucarini, S.1
Bartolucci, S.2
Bedini, A.3
Gatti, G.4
Orlando, P.5
Piersanti, G.6
Spadoni, G.7
-
78
-
-
84055211841
-
Toward the Definition of Stereochemical Requirements for MT2-Selective Antagonists and Partial Agonists by Studying 4-Phenyl-2-propionamidotetralin Derivatives
-
Bedini, A.; Lucarini, S.; Spadoni, G.; Tarzia, G.; Scaglione, F.; Dugnani, S.; Pannacci, M.; Lucini, V.; Carmi, C.; Pala, D.; Rivara, S.; Mor, M. Toward the Definition of Stereochemical Requirements for MT2-Selective Antagonists and Partial Agonists by Studying 4-Phenyl-2-propionamidotetralin Derivatives. J. Med. Chem., 2011, 54, 8362-8372.
-
(2011)
J. Med. Chem.
, vol.54
, pp. 8362-8372
-
-
Bedini, A.1
Lucarini, S.2
Spadoni, G.3
Tarzia, G.4
Scaglione, F.5
Dugnani, S.6
Pannacci, M.7
Lucini, V.8
Carmi, C.9
Pala, D.10
Rivara, S.11
Mor, M.12
-
79
-
-
64049098317
-
Design and synthesis of 3-phenyltetrahydronaphthalenic derivatives as new selective MT2 melatonin erg ic ligands
-
Durieux, S.; Chanu, A.; Bochu, C.; Audinot, V.; Coumailleau, S.; Boutin, J.A.; Delagrange, P.; Caignard, D.H.; Bennejean, C.; Renard, P.; Lesieur, D.;.Berthelot, P.; Yous, S. Design and synthesis of 3- phenyltetrahydronaphthalenic derivatives as new selective MT2 melatonin erg ic ligands. Part II Bioorg. Med. Chem., 2009, 17, 2963-2974.
-
(2009)
Part II Bioorg. Med. Chem.
, vol.17
, pp. 2963-2974
-
-
Durieux, S.1
Chanu, A.2
Bochu, C.3
Audinot, V.4
Coumailleau, S.5
Boutin, J.A.6
Delagrange, P.7
Caignard, D.H.8
Bennejean, C.9
Renard, P.10
Lesieur, D.11
Berthelot, P.12
Yous, S.13
-
80
-
-
0037142332
-
2 melatonin receptor selective ligands
-
2 melatonin receptor selective ligands. J. Med. Chem., 2002, 45, 2788-2800.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 2788-2800
-
-
Wallez, V.1
Durieux-Poissonnier, S.2
Chavatte, P.3
Boutin, J.A.4
Audinot, V.5
Nicolas, J.-P.6
Bennejean, C.7
Delagrange, P.8
Renard, P.9
Lesieur, D.10
-
81
-
-
51449120935
-
2 melatonin erg ic ligands
-
2 melatonin erg ic ligands. Bioorg. Med. Chem., 2008, 16, 8339-8348.
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 8339-8348
-
-
Poissonnier-Durieux, S.1
Ettaoussi, M.2
Pérès, B.3
Boutin, J.A.4
Audinot, V.5
Bennejean, C.6
Delagrange, P.7
Caignard, D.H.8
Renard, P.9
Berthelot, P.10
Lesieur, D.11
Yous, S.12
-
82
-
-
0038303310
-
-
Audinot, V.; Mailliet, F.; Lahaye-Brasseur, C.; Bonnaud, A.; Le Gall, A.; Amossé, C.; Dromaint, S.; Rodriguez, M.; Nagel, N; Galizzi, j.P; Malpaux, B.; Guillaumet, G.; Lesieur, D.; Lefoulon, F.; Renard, P.; Delagrange, P.; Boutin, J.A. Naunyn-Schmiedeberg's Arch. Pharmacol, 2003, 367, 553-561.
-
(2003)
Naunyn-Schmiedeberg's Arch. Pharmacol
, vol.367
, pp. 553-561
-
-
Audinot, V.1
Mailliet, F.2
Lahaye-Brasseur, C.3
Bonnaud, A.4
Le Gall, A.5
Amossé, C.6
Dromaint, S.7
Rodriguez, M.8
Nagel, N.9
Galizzi, J.P.10
Malpaux, B.11
Guillaumet, G.12
Lesieur, D.13
Lefoulon, F.14
Renard, P.15
Delagrange, P.16
Boutin, J.A.17
-
83
-
-
33845497663
-
2-selective melatonin receptor ligands
-
2-selective melatonin receptor ligands. J. Med. Chem., 2006, 49, 7393-7403.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 7393-7403
-
-
Bedini, A.1
Spadoni, G.2
Gatti, G.3
Lucarini, S.4
Tarzia, G.5
Rivara, S.6
Lorenzi, S.7
Lodola, A.8
Mor, M.9
Lucini, V.10
Pannacci, M.11
Scaglione, F.12
-
84
-
-
83455199095
-
Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand
-
Ochoa-Sanchez, R.; S. Comai, Lacoste, B.; Bambico, F.R.; Dominguez-Lopez, S.; Spadoni, G.; Rivara, S.; Bedini, A.; Angeloni, D.; Fraschini, F.; Mor, M.; Tarzia, G.; Descarries, L.; Gobbi, G. Promotion of Non-Rapid Eye Movement Sleep and Activation of Reticular Thalamic Neurons by a Novel MT2 Melatonin Receptor Ligand J. Neurosci., 2011, 31, 18452-18439.
-
(2011)
J. Neurosci.
, vol.31
, pp. 18452-18439
-
-
Ochoa-Sanchez, R.1
Comai, S.2
Lacoste, B.3
Bambico, F.R.4
Dominguez-Lopez, S.5
Spadoni, G.6
Rivara, S.7
Bedini, A.8
Angeloni, D.9
Fraschini, F.10
Mor, M.11
Tarzia, G.12
Descarries, L.13
Gobbi, G.14
-
85
-
-
77950040001
-
Synthesis of substituted N-[3-(3-methoxyphenyl)propyl]. amides as highly potent MT2-selective melatonin ligands
-
Hu, Y; Ho, M. K.C.: Chan, K.H.; New, D.C.; Wong, YH. Synthesis of substituted N-[3-(3-methoxyphenyl)propyl]. amides as highly potent MT2-selective melatonin ligands, Bioorg. Med. Chem. Lett, 2010, 20, 2582-2585.
-
(2010)
Bioorg. Med. Chem. Lett
, vol.20
, pp. 2582-2585
-
-
Hu, Y.1
Ho, M.K.C.2
Chan, K.H.3
New, D.C.4
Wong, Y.H.5
-
86
-
-
80053597542
-
2-selective melatonin receptor antagonist
-
2-selective melatonin receptor antagonist. Med. Chem. Commun., 2011, 2, 991-994.
-
(2011)
Med. Chem. Commun.
, vol.2
, pp. 991-994
-
-
Heckman, D.1
Attia, M.I.2
Behnam, M.A.M.3
Mohsen, A.M.Y.4
Markl, C.5
Julius, J.6
Sethi, S.7
Witt-Enderby, P.A.8
Zlotos, D.P.9
-
87
-
-
78650220835
-
3-Methoxylphenylpropyl amides as novel receptor subtype-selective melatonin erg ic ligands: Characterization of physicochemical and pharmacokinetic properties
-
Zhu, J.; Hu, Y; Ho, M.K.C.; Wong, YH. 3-Methoxylphenylpropyl amides as novel receptor subtype-selective melatonin erg ic ligands: characterization of physicochemical and pharmacokinetic properties. Xenobiotica, 2011; 41, 35-45.
-
(2011)
Xenobiotica
, vol.41
, pp. 35-45
-
-
Zhu, J.1
Hu, Y.2
Ho, M.K.C.3
Wong, Y.H.4
-
88
-
-
61449191838
-
2-[2, 3-Dihydro-1 H-indol-1-yl)methyl] melatonin Analogs: A Novel Class of MT2-Selective Melatonin Receptor Antagonists
-
Zlotos, D.P; Attia, M.I.; Julius, J.; Sethi, S.; Witt-Enderby, P.A. 2-[(2, 3-Dihydro-1 H-indol-1-yl)methyl] melatonin Analogs: A Novel Class of MT2-Selective Melatonin Receptor Antagonists. J. Med. Chem., 2009, 52, 826-833.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 826-833
-
-
Zlotos, D.P.1
Attia, M.I.2
Julius, J.3
Sethi, S.4
Witt-Enderby, P.A.5
-
89
-
-
79953185705
-
Preparation and pharmacological evaluation of a novel series of 2-(phenylthio) benzo [b] thiophenes as selective MT2 receptor ligands
-
Mésangeau, C; Fraise, M.; Delagrange, P.; Caignard, D.H.; Boutin, J.A.; Berthelot, P.; Yous, S. Preparation and pharmacological evaluation of a novel series of 2-(phenylthio) benzo [b] thiophenes as selective MT2 receptor ligands. Eur. J. Med. Chem., 2011, 46, 1835-1840.
-
(2011)
Eur. J. Med. Chem.
, vol.46
, pp. 1835-1840
-
-
Mésangeau, C.1
Fraise, M.2
Delagrange, P.3
Caignard, D.H.4
Boutin, J.A.5
Berthelot, P.6
Yous, S.7
-
90
-
-
0037468868
-
Design and Synthesis of Naphthalenic Dimers as Selective MT1 Melatoninerg ic Ligands
-
Descamps-Francois, C; Yous, S.; Chavatte, P.; Audinot, V.; Bonnaud, A.; Boutin, J.A.; Delagrange, P.; Bennejean, C; Renard, P.; Lesieur, D. Design and Synthesis of Naphthalenic Dimers as Selective MT1 Melatoninerg ic Ligands. J. Med. Chem., 2003, 46, 1127-1129.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 1127-1129
-
-
Descamps-Francois, C.1
Yous, S.2
Chavatte, P.3
Audinot, V.4
Bonnaud, A.5
Boutin, J.A.6
Delagrange, P.7
Bennejean, C.8
Renard, P.9
Lesieur, D.10
-
91
-
-
2942538219
-
Synthesis and structure-activity relationship of novel benzoxazole derivatives as melatonin receptor agonists
-
Sun, L.Q.; Chen, J.; Bruce, M.; Deskus, J.A.; Epperson, J.R.; Takaki, K.; Johnson, G.; Iben, L.; Mahle, CD.; Ryan, E.; Xu, C. Synthesis and structure-activity relationship of novel benzoxazole derivatives as melatonin receptor agonists. Bioorg. Med. Chem. Lett., 2004, 14, 3799-3802.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 3799-3802
-
-
Sun, L.Q.1
Chen, J.2
Bruce, M.3
Deskus, J.A.4
Epperson, J.R.5
Takaki, K.6
Johnson, G.7
Iben, L.8
Mahle, C.D.9
Ryan, E.10
Xu, C.11
-
92
-
-
77953133206
-
Design synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT1 melatoninerg ic ligands
-
Mesangeau, C; Peres, B.; Descamps-Francois, C; Chavatte, P.; Audinot, V.; Coumailleau, S.; Boutin, J.A.; Delagrange, P.; Bennejean, C; Renard, P.; Caignard, D.H.; Berthelot, P.; Yous, S. Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT1 melatoninerg ic ligands Bioorg Med Chem., 2010, 18, 3426-3436.
-
(2010)
Bioorg Med Chem.
, vol.18
, pp. 3426-3436
-
-
Mesangeau, C.1
Peres, B.2
Descamps-Francois, C.3
Chavatte, P.4
Audinot, V.5
Coumailleau, S.6
Boutin, J.A.7
Delagrange, P.8
Bennejean, C.9
Renard, P.10
Caignard, D.H.11
Berthelot, P.12
Yous, S.13
-
93
-
-
80053997872
-
N-Acetyl-5-arylalkoxytryptamine Analogs: Probing the Melatonin Receptors for MT1-Selectivity
-
Markl, C; Clafshenkel, W. P.; Attia, M. I; Sethi, S.; Witt-Enderby, P. A.; Zlotos, D. P. N-Acetyl-5-arylalkoxytryptamine Analogs: Probing the Melatonin Receptors for MT1-Selectivity Arch. Pharm. Chem. Life. Sci., 2011, 334, 666-674.
-
(2011)
Arch. Pharm. Chem. Life. Sci.
, vol.334
, pp. 666-674
-
-
Markl, C.1
Clafshenkel, W.P.2
Attia, M.I.3
Sethi, S.4
Witt-Enderby, P.A.5
Zlotos, D.P.6
-
94
-
-
79961172639
-
Bivalent ligand approach on N-{2-[(3-methoxyphenyl)methylamino]ethyl}- acetamide: Synthesis binding affinity and intrinsic activity forMT1 and MT2 melatonin receptors
-
Spadoni, G.; Bedini, A.; Orlando, P.; Lucarini, S.; Tarzia, G.; Mor, M.; Rivara, S.; Lucini, V.; Pannacci, M.; Scaglione, F. Bivalent ligand approach on N-{2-[(3-methoxyphenyl)methylamino]ethyl}-acetamide: Synthesis, binding affinity and intrinsic activity forMT1 and MT2 melatonin receptors. Bioorg. Med. Chem., 2011, 19, 4910-4916.
-
(2011)
Bioorg. Med. Chem.
, vol.19
, pp. 4910-4916
-
-
Spadoni, G.1
Bedini, A.2
Orlando, P.3
Lucarini, S.4
Tarzia, G.5
Mor, M.6
Rivara, S.7
Lucini, V.8
Pannacci, M.9
Scaglione, F.10
-
95
-
-
43049125813
-
Design and synthesis of benzofuranic derivatives as new ligandsat the melatonin-binding site MT3
-
Ettaoussi, M.; Peres, B.; Klupsch, F.; Delagrange, P.; Boutin, J.A.; Renard, P.; Caignard, D.H.; Chavatte, P.; Berthelot, P.; Lesieur, D.; Yous, S. Design and synthesis of benzofuranic derivatives as new ligandsat the melatonin-binding site MT3. Bioorg. Med. Chem., 2008, 16, 4954-4962.
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 4954-4962
-
-
Ettaoussi, M.1
Peres, B.2
Klupsch, F.3
Delagrange, P.4
Boutin, J.A.5
Renard, P.6
Caignard, D.H.7
Chavatte, P.8
Berthelot, P.9
Lesieur, D.10
Yous, S.11
-
96
-
-
79953188673
-
Design and synthesis of naphthalenic derivatives as new ligands at the melatonin binding site MT3
-
Leclerc, V.; Ettaoussi, M.; Rami, M.; Farce, A.; Boutin, J.A.; Delagrange, P.; Caignard, D.H.; Renard, P.; Berthelot, P.; Yous, S. Design and synthesis of naphthalenic derivatives as new ligands at the melatonin binding site MT3. Eur. J. Med. Chem., 2011, 46, 1622-1629.
-
(2011)
Eur. J. Med. Chem.
, vol.46
, pp. 1622-1629
-
-
Leclerc, V.1
Ettaoussi, M.2
Rami, M.3
Farce, A.4
Boutin, J.A.5
Delagrange, P.6
Caignard, D.H.7
Renard, P.8
Berthelot, P.9
Yous, S.10
-
97
-
-
33645975523
-
New ligands at the melatonin binding site MT3
-
Boussard, M.F.; Truche, S.; Rousseau-Rojas, A.; Briss, S.; Descamps, S.; Droual, M.; Wierzbicki, M.; Ferry, G.; Audinot, V.; Delagrange, P.; Boutin, J.A. New ligands at the melatonin binding site MT3. Eur. J. Med. Chem., 2006, 41, 306-320.
-
(2006)
Eur. J. Med. Chem.
, vol.41
, pp. 306-320
-
-
Boussard, M.F.1
Truche, S.2
Rousseau-Rojas, A.3
Briss, S.4
Descamps, S.5
Droual, M.6
Wierzbicki, M.7
Ferry, G.8
Audinot, V.9
Delagrange, P.10
Boutin, J.A.11
-
98
-
-
79959334243
-
X-ray structural studies of quinine reductase 2 nanomolar range inhibitors
-
Pegan S.D.; Sturdy, M.; Ferry, G.; Delagrange, P.; Boutin, J.A.; Mesecar, A. D. X-ray structural studies of quinine reductase 2 nanomolar range inhibitors. Protein Science, 2011, 20, 1182-1195.
-
(2011)
Protein Science
, vol.20
, pp. 1182-1195
-
-
Pegan, S.D.1
Sturdy, M.2
Ferry, G.3
Delagrange, P.4
Boutin, J.A.5
Mesecar, A.D.6
|