메뉴 건너뛰기




Volumn 20, Issue 10, 2015, Pages 18886-18906

Melatonin as a potent and inducible endogenous antioxidant: Synthesis and metabolism

Author keywords

Antioxidant; Melatonin; Metabolism; Oxidative stress; Plants; Synthesis

Indexed keywords

ANTIOXIDANT; MELATONIN; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE;

EID: 84947722068     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules201018886     Document Type: Review
Times cited : (511)

References (140)
  • 1
    • 33947460818 scopus 로고
    • Isolation of melatonin, a pineal factor that lightens melanocytes
    • Lerner, A.B.; Case, J.D.; Takahashi, Y. Isolation of melatonin, a pineal factor that lightens melanocytes. J. Am. Soc. 1958, 80, 2587.
    • (1958) J. Am. Soc. , vol.80 , pp. 2587
    • Lerner, A.B.1    Case, J.D.2    Takahashi, Y.3
  • 3
    • 0017704893 scopus 로고
    • The effects of oral melatonin on skin color and on the release of pituitary hormones
    • Nordlund, J.J.; Lerner, A.B. The effects of oral melatonin on skin color and on the release of pituitary hormones. J. Clin. Endocrinol. Metab. 1977, 45, 768-774.
    • (1977) J. Clin. Endocrinol. Metab. , vol.45 , pp. 768-774
    • Nordlund, J.J.1    Lerner, A.B.2
  • 4
    • 0025915557 scopus 로고
    • Melatonin: The chemical expression of darkness
    • Reiter, R.J. Melatonin: The chemical expression of darkness. Mol. Cell. Endocrinol. 1991, 79, C153-C158.
    • (1991) Mol. Cell. Endocrinol. , vol.79 , pp. C153-C158
    • Reiter, R.J.1
  • 5
    • 0016439815 scopus 로고
    • A serum melatonin rhythm in chickens and its abolition by pinealectomy
    • Pelham, R.W. A serum melatonin rhythm in chickens and its abolition by pinealectomy. Endocrinology 1975, 96, 543-546.
    • (1975) Endocrinology , vol.96 , pp. 543-546
    • Pelham, R.W.1
  • 6
    • 0019394209 scopus 로고
    • Persistence of circadian rhythms of melatonin and N-acetylserotonin in the serum of rats after pinealectomy
    • Yu, H.S.; Pang, S.F.; Tang, P.L.; Brown, G.M. Persistence of circadian rhythms of melatonin and N-acetylserotonin in the serum of rats after pinealectomy. Neuroendocrinology 1981, 32, 262-265.
    • (1981) Neuroendocrinology , vol.32 , pp. 262-265
    • Yu, H.S.1    Pang, S.F.2    Tang, P.L.3    Brown, G.M.4
  • 7
    • 84858439689 scopus 로고    scopus 로고
    • Both master clock output and internal time-giver in the circadian clocks network
    • Pevet, P.; Challet, E. Melatonin: Both master clock output and internal time-giver in the circadian clocks network. J. Physiol. 2011, 105, 170-182.
    • (2011) J. Physiol. , vol.105 , pp. 170-182
    • Pevet, P.1    Melatonin, C.E.2
  • 8
    • 84919625592 scopus 로고    scopus 로고
    • Melatonin feedback on clock genes: A theory involving the proteasome
    • Vriend, J.; Reiter, R.J. Melatonin feedback on clock genes: A theory involving the proteasome. J. Pineal Res. 2015, 58, 1-11.
    • (2015) J. Pineal Res. , vol.58 , pp. 1-11
    • Vriend, J.1    Reiter, R.J.2
  • 9
    • 84897901749 scopus 로고    scopus 로고
    • Melatonin from cerebrospinal fluid but not from blood reaches sheep cerebral tissues under physiological conditions
    • Legros, C.; Chesneau, D.; Boutin, J.A.; Barc, C.; Malpaux, B. Melatonin from cerebrospinal fluid but not from blood reaches sheep cerebral tissues under physiological conditions. J. Neuroendocrinol. 2014, 26, 151-163.
    • (2014) J. Neuroendocrinol. , vol.26 , pp. 151-163
    • Legros, C.1    Chesneau, D.2    Boutin, J.A.3    Barc, C.4    Malpaux, B.5
  • 10
    • 84936077755 scopus 로고    scopus 로고
    • Delivery of pineal melatonin to the brain and SCN: Role of canaliculi, cerebrospinal fluid, tanycytes and Virchow-Robin perivascular spaces
    • Reiter, R.J.; Tan, D.X.; Kim, S.J.; Cruz, M.H. Delivery of pineal melatonin to the brain and SCN: Role of canaliculi, cerebrospinal fluid, tanycytes and Virchow-Robin perivascular spaces. Brain Struct. Funct. 2014, 219, 1873-1887.
    • (2014) Brain Struct. Funct. , vol.219 , pp. 1873-1887
    • Reiter, R.J.1    Tan, D.X.2    Kim, S.J.3    Cruz, M.H.4
  • 11
    • 0035991404 scopus 로고    scopus 로고
    • Mammalian melatonin receptors: Molecular biology and signal transduction
    • Von Gall, C.; Stehle, J.H.; Weaver, D.R. Mammalian melatonin receptors: Molecular biology and signal transduction. Cell Tiss. Res. 2002, 309, 151-162.
    • (2002) Cell Tiss. Res. , vol.309 , pp. 151-162
    • Von Gall, C.1    Stehle, J.H.2    Weaver, D.R.3
  • 12
    • 0030595867 scopus 로고    scopus 로고
    • The Mel1a melatonin receptor gene is expressed in human suprachiasmatic nuclei
    • Weaver, D.R.; Reppert, S.M. The Mel1a melatonin receptor gene is expressed in human suprachiasmatic nuclei. Neuroreport 1996, 8, 109-112.
    • (1996) Neuroreport , vol.8 , pp. 109-112
    • Weaver, D.R.1    Reppert, S.M.2
  • 16
    • 0029422385 scopus 로고
    • Melatonin immunoreactivity in the photosynthetic prokaryote Rhodospirillum rubrum: Implications for an ancient antioxidant system
    • Manchester, L.C.; Poeggeler, B.; Alvares, F.L.; Ogden, G.B.; Reiter, R.J. Melatonin immunoreactivity in the photosynthetic prokaryote Rhodospirillum rubrum: Implications for an ancient antioxidant system. Cell Mol. Biol. Res. 1995, 41, 391-395.
    • (1995) Cell Mol. Biol. Res. , vol.41 , pp. 391-395
    • Manchester, L.C.1    Poeggeler, B.2    Alvares, F.L.3    Ogden, G.B.4    Reiter, R.J.5
  • 17
    • 0031087698 scopus 로고    scopus 로고
    • Melatonin production in an aerobic photosynthetic bacterium: An evolutionarily early association with darkness
    • Tilden, A.R.; Becker, M.A.; Amma, L.L.; Arciniega, J.; McGaw, A.K. Melatonin production in an aerobic photosynthetic bacterium: An evolutionarily early association with darkness. J. Pineal Res. 1997, 22, 102-106.
    • (1997) J. Pineal Res. , vol.22 , pp. 102-106
    • Tilden, A.R.1    Becker, M.A.2    Amma, L.L.3    Arciniega, J.4    McGaw, A.K.5
  • 18
    • 84885190540 scopus 로고    scopus 로고
    • Occurrence, diel patterns, and the influence of melatonin on the photosynthetic performance of cultured Symbiodinium
    • Roopin, M.; Yacobi, Y.Z.; Levy, O. Occurrence, diel patterns, and the influence of melatonin on the photosynthetic performance of cultured Symbiodinium. J. Pineal Res. 2013, 55, 89-100.
    • (2013) J. Pineal Res. , vol.55 , pp. 89-100
    • Roopin, M.1    Yacobi, Y.Z.2    Levy, O.3
  • 20
    • 84907484241 scopus 로고    scopus 로고
    • Melatonin signaling controls circadian swimming behavior in marine zooplankton
    • Tosches, M.A.; Bucher, D.; Vopalensky, P.; Arendt, D. Melatonin signaling controls circadian swimming behavior in marine zooplankton. Cell 2014, 159, 46-57.
    • (2014) Cell , vol.159 , pp. 46-57
    • Tosches, M.A.1    Bucher, D.2    Vopalensky, P.3    Arendt, D.4
  • 27
    • 0019993372 scopus 로고
    • Pineal melatonin in syrian hamsters: Circadian and seasonal rhythms in animals maintained under laboratory and natural conditions
    • Brainard, G.C.; Petterborg, L.J.; Richardson, B.A.; Reiter, R.J. Pineal melatonin in syrian hamsters: Circadian and seasonal rhythms in animals maintained under laboratory and natural conditions. Neuroendocrinology 1982, 35, 342-348.
    • (1982) Neuroendocrinology , vol.35 , pp. 342-348
    • Brainard, G.C.1    Petterborg, L.J.2    Richardson, B.A.3    Reiter, R.J.4
  • 28
    • 0027210003 scopus 로고
    • The melatonin rhythm: Both a clock and a calendar
    • Reiter, R.J. The melatonin rhythm: both a clock and a calendar. Experientia 1993, 49, 654-664.
    • (1993) Experientia , vol.49 , pp. 654-664
    • Reiter, R.J.1
  • 29
    • 0020428511 scopus 로고
    • Delayed effect of pinealectomy on hibernation of the golden-mantled ground squirrel
    • Ralph, C.L.; Harlow, H.J.; Phillips, J.A. Delayed effect of pinealectomy on hibernation of the golden-mantled ground squirrel. Int. J. Biometeorol. 1982, 26, 311-328.
    • (1982) Int. J. Biometeorol. , vol.26 , pp. 311-328
    • Ralph, C.L.1    Harlow, H.J.2    Phillips, J.A.3
  • 30
    • 0015989913 scopus 로고
    • Influence of pinealectomy on the breeding capability of hamsters maintained under natural photoperiodic and temperature conditions
    • Reiter, R.J. Influence of pinealectomy on the breeding capability of hamsters maintained under natural photoperiodic and temperature conditions. Neuroendocrinology 1974, 13, 366-370.
    • (1974) Neuroendocrinology , vol.13 , pp. 366-370
    • Reiter, R.J.1
  • 31
    • 0023119247 scopus 로고
    • Pinealectomy blocks vernal courtship behavior in red-sided garter snakes
    • Nelson, R.J.; Mason, R.T.; Krohmer, R.W.; Crews, D. Pinealectomy blocks vernal courtship behavior in red-sided garter snakes. Physiol. Behav. 1987, 39, 231-233.
    • (1987) Physiol. Behav. , vol.39 , pp. 231-233
    • Nelson, R.J.1    Mason, R.T.2    Krohmer, R.W.3    Crews, D.4
  • 33
    • 0033934335 scopus 로고    scopus 로고
    • Tryptophan is a precursor for melatonin and serotonin biosynththesis in in vitro regenerated St. John's wort (Hypericum perforatum L. Cv. Anthos) plants
    • Murch, S.J.; Krishna, R.S.; Saxena, P.K. Tryptophan is a precursor for melatonin and serotonin biosynththesis in in vitro regenerated St. John's wort (Hypericum perforatum L. cv. Anthos) plants. Plant Cell Rep. 2000, 19, 698-704.
    • (2000) Plant Cell Rep. , vol.19 , pp. 698-704
    • Murch, S.J.1    Krishna, R.S.2    Saxena, P.K.3
  • 34
    • 33746519078 scopus 로고    scopus 로고
    • Melatonin in Glycyrrhiza uralensis: Response of plant roots to spectral quality of light and UV-B radiation
    • Afreen, F.; Zobayed, S.M.; Kozai, T. Melatonin in Glycyrrhiza uralensis: response of plant roots to spectral quality of light and UV-B radiation. J. Pineal Res. 2006, 41, 108-115.
    • (2006) J. Pineal Res. , vol.41 , pp. 108-115
    • Afreen, F.1    Zobayed, S.M.2    Kozai, T.3
  • 35
    • 34249812687 scopus 로고    scopus 로고
    • Novel rhythms of N1-acetyl-N2-formyl-5-methoxykynuramine and its precursor melatonin in water hyacinth: Importance for phytoremediation
    • Tan, D.X.; Manchester, L.C.; di Mascio, P.; Martinez, G.R.; Prado, F.M.; Reiter, R.J. Novel rhythms of N1-acetyl-N2-formyl-5-methoxykynuramine and its precursor melatonin in water hyacinth: Importance for phytoremediation. FASEB J. 2007, 21, 1724-1729.
    • (2007) FASEB J. , vol.21 , pp. 1724-1729
    • Tan, D.X.1    Manchester, L.C.2    Di Mascio, P.3    Martinez, G.R.4    Prado, F.M.5    Reiter, R.J.6
  • 38
    • 84908339437 scopus 로고    scopus 로고
    • Fundamental issues related to the origin of melatonin and melatonin isomers during evolution: Relation to their biological functions
    • Tan, D.X.; Zheng, X.; Kong, J.; Manchester, L.C.; Hardeland, R.; Kim, S.J.; Xu, X.; Reiter, R.J. Fundamental issues related to the origin of melatonin and melatonin isomers during evolution: Relation to their biological functions. Int. J. Mol. Sci. 2014, 15, 15858-15890.
    • (2014) Int. J. Mol. Sci. , vol.15 , pp. 15858-15890
    • Tan, D.X.1    Zheng, X.2    Kong, J.3    Manchester, L.C.4    Hardeland, R.5    Kim, S.J.6    Xu, X.7    Reiter, R.J.8
  • 39
    • 0030879708 scopus 로고    scopus 로고
    • Rhythmic transcription: The molecular basis of circadian melatonin synthesis
    • Foulkes, N.S.; Borjigin, J.; Snyder, S.H.; Sassone-Corsi, P. Rhythmic transcription: The molecular basis of circadian melatonin synthesis. Trends Neurosci. 1997, 20, 487-492.
    • (1997) Trends Neurosci. , vol.20 , pp. 487-492
    • Foulkes, N.S.1    Borjigin, J.2    Snyder, S.H.3    Sassone-Corsi, P.4
  • 41
    • 52949108489 scopus 로고    scopus 로고
    • Analysis of serotonin N-acetyltransferase regulation in vitro and in live cells using protein semisynthesis
    • Szewczuk, L.M.; Tarrant, M.K.; Sample, V.; Drury, W.J., III; Zhang, J.; Cole, P.A. Analysis of serotonin N-acetyltransferase regulation in vitro and in live cells using protein semisynthesis. Biochemistry 2008, 47, 10407-10419.
    • (2008) Biochemistry , vol.47 , pp. 10407-10419
    • Szewczuk, L.M.1    Tarrant, M.K.2    Sample, V.3    Drury, W.J.4    Zhang, J.5    Cole, P.A.6
  • 42
    • 44649087659 scopus 로고    scopus 로고
    • Application of long-term microdialysis in circadian rhythm research
    • Borjigin, J.; Liu, T. Application of long-term microdialysis in circadian rhythm research. Pharmacol. Biochem. Behav. 2008, 90, 148-155.
    • (2008) Pharmacol. Biochem. Behav. , vol.90 , pp. 148-155
    • Borjigin, J.1    Liu, T.2
  • 43
    • 1542321095 scopus 로고    scopus 로고
    • Rhythmic melatonin secretion does not correlate with the expression of arylalkylamine N-acetyltransferase, inducible cyclic amp early repressor, period1 or cryptochrome1 mRNA in the sheep pineal
    • Johnston, J.D.; Bashforth, R.; Diack, A.; Andersson, H.; Lincoln, G.A.; Hazlerigg, D.G. Rhythmic melatonin secretion does not correlate with the expression of arylalkylamine N-acetyltransferase, inducible cyclic amp early repressor, period1 or cryptochrome1 mRNA in the sheep pineal. Neuroscience 2004, 124, 789-795.
    • (2004) Neuroscience , vol.124 , pp. 789-795
    • Johnston, J.D.1    Bashforth, R.2    Diack, A.3    Andersson, H.4    Lincoln, G.A.5    Hazlerigg, D.G.6
  • 44
    • 22044444433 scopus 로고    scopus 로고
    • N-acetyltransferase is not the rate-limiting enzyme of melatonin synthesis at night
    • Liu, T.; Borjigin, J. N-acetyltransferase is not the rate-limiting enzyme of melatonin synthesis at night. J. Pineal Res. 2005, 39, 91-96.
    • (2005) J. Pineal Res. , vol.39 , pp. 91-96
    • Liu, T.1    Borjigin, J.2
  • 45
    • 11244318203 scopus 로고    scopus 로고
    • Analysis of adrenergic regulation of melatonin synthesis in Siberian hamster pineal emphasizes the role of HIOMT
    • Ceinos, R.M.; Chansard, M.; Revel, F.; Calgari, C.; Miguez, J.M.; Simonneaux, V. Analysis of adrenergic regulation of melatonin synthesis in Siberian hamster pineal emphasizes the role of HIOMT. Neuro-Signals 2004, 13, 308-317.
    • (2004) Neuro-Signals , vol.13 , pp. 308-317
    • Ceinos, R.M.1    Chansard, M.2    Revel, F.3    Calgari, C.4    Miguez, J.M.5    Simonneaux, V.6
  • 46
    • 0018938235 scopus 로고
    • Melatonin in the retina of rats: A diurnal rhythm
    • Pang, S.F.; Yu, H.S.; Suen, H.C.; Brown, G.M. Melatonin in the retina of rats: A diurnal rhythm. J. Endocrinol. 1980, 87, 89-93.
    • (1980) J. Endocrinol. , vol.87 , pp. 89-93
    • Pang, S.F.1    Yu, H.S.2    Suen, H.C.3    Brown, G.M.4
  • 47
    • 60749125454 scopus 로고    scopus 로고
    • And expression of arylalkylamine N-acetyltranferase-2 during early development and metamorphosis in the sole Solea senegalensis
    • Isorna, E.; El M'rabet, A.; Confente, F.; Falcon, J.; Munoz-Cueto, J.A. Cloning and expression of arylalkylamine N-acetyltranferase-2 during early development and metamorphosis in the sole Solea senegalensis. Gen. Comp. Endocrinol. 2009, 161, 97-102.
    • (2009) Gen. Comp. Endocrinol. , vol.161 , pp. 97-102
    • Isorna, E.1    El M'Rabet, A.2    Confente, F.3    Falcon, J.4    Cloning, A.M.J.5
  • 48
    • 80054798022 scopus 로고    scopus 로고
    • Identification of two arylalkylamine N-acetyltranferase 1 genes with different developmental expression profiles in the flatfish Solea senegalensis
    • Isorna, E.; Aliaga-Guerrero, M.; M'Rabet, A.E.; Servili, A.; Falcon, J.; Munoz-Cueto, J.A. Identification of two arylalkylamine N-acetyltranferase 1 genes with different developmental expression profiles in the flatfish Solea senegalensis. J. Pineal Res. 2011, 51, 434-444.
    • (2011) J. Pineal Res. , vol.51 , pp. 434-444
    • Isorna, E.1    Aliaga-Guerrero, M.2    M'Rabet, A.E.3    Servili, A.4    Falcon, J.5    Munoz-Cueto, J.A.6
  • 50
    • 33845536018 scopus 로고    scopus 로고
    • One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species?
    • Tan, D.X.; Manchester, L.C.; Terron, M.P.; Flores, L.J.; Reiter, R.J. One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species? J. Pineal Res. 2007, 42, 28-42.
    • (2007) J. Pineal Res. , vol.42 , pp. 28-42
    • Tan, D.X.1    Manchester, L.C.2    Terron, M.P.3    Flores, L.J.4    Reiter, R.J.5
  • 52
    • 0027313442 scopus 로고
    • The contribution of extrapineal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates
    • Huether, G. The contribution of extrapineal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates. Experientia 1993, 49, 665-670.
    • (1993) Experientia , vol.49 , pp. 665-670
    • Huether, G.1
  • 54
    • 84873458408 scopus 로고    scopus 로고
    • And chloroplasts as the original sites of melatonin synthesis: A hypothesis related to melatonin's primary function and evolution in eukaryotes
    • Tan, D.X.; Manchester, L.C.; Liu, X.; Rosales-Corral, S.A.; Acuna-Castroviejo, D.; Reiter, R.J. Mitochondria and chloroplasts as the original sites of melatonin synthesis: A hypothesis related to melatonin's primary function and evolution in eukaryotes. J. Pineal Res. 2013, 54, 127-138.
    • (2013) J. Pineal Res. , vol.54 , pp. 127-138
    • Tan, D.X.1    Manchester, L.C.2    Liu, X.3    Rosales-Corral, S.A.4    Acuna-Castroviejo, D.5    Mitochondria, J.R.R.6
  • 57
    • 0029104550 scopus 로고
    • Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography-mass spectrometry
    • Dubbels, R.; Reiter, R.J.; Klenke, E.; Goebel, A.; Schnakenberg, E.; Ehlers, C.; Schiwara, H.W.; Schloot, W. Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography-mass spectrometry. J. Pineal Res. 1995, 18, 28-31.
    • (1995) J. Pineal Res. , vol.18 , pp. 28-31
    • Dubbels, R.1    Reiter, R.J.2    Klenke, E.3    Goebel, A.4    Schnakenberg, E.5    Ehlers, C.6    Schiwara, H.W.7    Schloot, W.8
  • 58
    • 84890117208 scopus 로고    scopus 로고
    • Cellular localization and kinetics of the rice melatonin biosynthetic enzymes SNAT and ASMT
    • Byeon, Y.; Lee, H.Y.; Lee, K.; Park, S.; Back, K. Cellular localization and kinetics of the rice melatonin biosynthetic enzymes SNAT and ASMT. J. Pineal Res. 2014, 56, 107-114.
    • (2014) J. Pineal Res. , vol.56 , pp. 107-114
    • Byeon, Y.1    Lee, H.Y.2    Lee, K.3    Park, S.4    Back, K.5
  • 60
    • 84885184502 scopus 로고    scopus 로고
    • Transcriptional suppression of tryptamine 5-hydroxylase, a terminal serotonin biosynthetic gene, induces melatonin biosynthesis in rice (Oryza sativa L.)
    • Park, S.; Byeon, Y.; Back, K. Transcriptional suppression of tryptamine 5-hydroxylase, a terminal serotonin biosynthetic gene, induces melatonin biosynthesis in rice (Oryza sativa L.). J. Pineal Res. 2013, 55, 131-137.
    • (2013) J. Pineal Res. , vol.55 , pp. 131-137
    • Park, S.1    Byeon, Y.2    Back, K.3
  • 61
    • 84919385939 scopus 로고    scopus 로고
    • Cloning of Arabidopsis serotonin N-acetyltransferase and its role with caffeic acid O-methyltransferase in the biosynthesis of melatonin in vitro despite their different subcellular localizations
    • Lee, H.Y.; Byeon, Y.; Lee, K.; Lee, H.J.; Back, K. Cloning of Arabidopsis serotonin N-acetyltransferase and its role with caffeic acid O-methyltransferase in the biosynthesis of melatonin in vitro despite their different subcellular localizations. J. Pineal Res. 2014, 57, 418-426.
    • (2014) J. Pineal Res. , vol.57 , pp. 418-426
    • Lee, H.Y.1    Byeon, Y.2    Lee, K.3    Lee, H.J.4    Back, K.5
  • 62
    • 84923183082 scopus 로고    scopus 로고
    • Caffeic acid O-methyltransferase is involved in the synthesis of melatonin by methylating N-acetylserotonin in Arabidopsis
    • Byeon, Y.; Lee, H.Y.; Lee, K.; Back, K. Caffeic acid O-methyltransferase is involved in the synthesis of melatonin by methylating N-acetylserotonin in Arabidopsis. J. Pineal Res. 2014, 57, 219-227.
    • (2014) J. Pineal Res. , vol.57 , pp. 219-227
    • Byeon, Y.1    Lee, H.Y.2    Lee, K.3    Back, K.4
  • 67
    • 84891796133 scopus 로고    scopus 로고
    • Determination of melatonin and its isomer in foods by liquid chromatography tandem mass spectrometry
    • Kocadagli, T.; Yilmaz, C.; Gokmen, V. Determination of melatonin and its isomer in foods by liquid chromatography tandem mass spectrometry. Food Chem. 2014, 153, 151-156.
    • (2014) Food Chem. , vol.153 , pp. 151-156
    • Kocadagli, T.1    Yilmaz, C.2    Gokmen, V.3
  • 68
    • 84897524114 scopus 로고    scopus 로고
    • Formation of melatonin and its isomer during bread dough fermentation and effect of baking
    • Yilmaz, C.; Kocadagli, T.; Gokmen, V. Formation of melatonin and its isomer during bread dough fermentation and effect of baking. J. Agric. Food Chem. 2014, 62, 2900-2905.
    • (2014) J. Agric. Food Chem. , vol.62 , pp. 2900-2905
    • Yilmaz, C.1    Kocadagli, T.2    Gokmen, V.3
  • 70
    • 84874946271 scopus 로고    scopus 로고
    • Melatonin, melatonin isomers and stilbenes in Italian traditional grape products and their antiradical capacity
    • Vitalini, S.; Gardana, C.; Simonetti, P.; Fico, G.; Iriti, M. Melatonin, melatonin isomers and stilbenes in Italian traditional grape products and their antiradical capacity. J. Pineal Res. 2013, 54, 322-333.
    • (2013) J. Pineal Res. , vol.54 , pp. 322-333
    • Vitalini, S.1    Gardana, C.2    Simonetti, P.3    Fico, G.4    Iriti, M.5
  • 71
    • 84918792016 scopus 로고    scopus 로고
    • Melatonin isomer" in wine is not an isomer of the melatonin but tryptophan-ethylester
    • Gardana, C.; Iriti, M.; Stuknyte, M.; de Noni, I.; Simonetti, P. "Melatonin isomer" in wine is not an isomer of the melatonin but tryptophan-ethylester. J. Pineal Res. 2014, 57, 435-441.
    • (2014) J. Pineal Res. , vol.57 , pp. 435-441
    • Gardana, C.1    Iriti, M.2    Stuknyte, M.3    De Noni, I.4    Simonetti, P.5
  • 73
    • 84885678865 scopus 로고    scopus 로고
    • Molecular cloning and functional analysis of serotonin N-acetyltransferase from the cyanobacterium Synechocystis sp. PCC 6803
    • Byeon, Y.; Lee, K.; Park, Y.I.; Park, S.; Back, K. Molecular cloning and functional analysis of serotonin N-acetyltransferase from the cyanobacterium Synechocystis sp. PCC 6803. J. Pineal Res. 2013, 55, 371-376.
    • (2013) J. Pineal Res. , vol.55 , pp. 371-376
    • Byeon, Y.1    Lee, K.2    Park, Y.I.3    Park, S.4    Back, K.5
  • 74
    • 53749094817 scopus 로고    scopus 로고
    • Metabolism of melatonin by cytochrome P450s in rat liver mitochondria and microsomes
    • Semak, I.; Korik, E.; Antonova, M.; Wortsman, J.; Slominski, A. Metabolism of melatonin by cytochrome P450s in rat liver mitochondria and microsomes. J. Pineal Res. 2008, 45, 515-523.
    • (2008) J. Pineal Res. , vol.45 , pp. 515-523
    • Semak, I.1    Korik, E.2    Antonova, M.3    Wortsman, J.4    Slominski, A.5
  • 75
    • 84884669648 scopus 로고
    • Evolution of cytochrome bc complexes: From membrane-anchored dehydrogenases of ancient bacteria to triggers of apoptosis in vertebrates
    • Dibrova, D.V.; Cherepanov, D.A.; Galperin, M.Y.; Skulachev, V.P.; Mulkidjanian, A.Y. Evolution of cytochrome bc complexes: From membrane-anchored dehydrogenases of ancient bacteria to triggers of apoptosis in vertebrates. Biochim. Biophys. Acta 2013, 1827, 1407-1427.
    • (1827) Biochim. Biophys. Acta , vol.2013 , pp. 1407-1427
    • Dibrova, D.V.1    Cherepanov, D.A.2    Galperin, M.Y.3    Skulachev, V.P.4    Mulkidjanian, A.Y.5
  • 77
    • 84899888264 scopus 로고    scopus 로고
    • Cyclic-3-hydroxymelatonin (C3HOM), a potent antioxidant, scavenges free radicals and suppresses oxidative reactions
    • Tan, D.X.; Hardeland, R.; Manchester, L.C.; Galano, A.; Reiter, R.J. Cyclic-3-hydroxymelatonin (C3HOM), a potent antioxidant, scavenges free radicals and suppresses oxidative reactions. Curr. Med. Chem. 2014, 21, 1557-1565.
    • (2014) Curr. Med. Chem. , vol.21 , pp. 1557-1565
    • Tan, D.X.1    Hardeland, R.2    Manchester, L.C.3    Galano, A.4    Reiter, R.J.5
  • 78
    • 68249129060 scopus 로고    scopus 로고
    • Kynuramines, metabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines
    • Hardeland, R.; Tan, D.X.; Reiter, R.J. Kynuramines, metabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines. J. Pineal Res. 2009, 47, 109-126.
    • (2009) J. Pineal Res. , vol.47 , pp. 109-126
    • Hardeland, R.1    Tan, D.X.2    Reiter, R.J.3
  • 79
    • 84928982934 scopus 로고    scopus 로고
    • The levels of melatonin and its metabolites in conditioned corn (Zea mays L.) and cucumber (Cucumis sativus L.) seeds during storage
    • Kołodziejczyk, I.; Bałabusta, M.; Szewczyk, R.; Posmyk, M.M. The levels of melatonin and its metabolites in conditioned corn (Zea mays L.) and cucumber (Cucumis sativus L.) seeds during storage. Acta Physiol. Plant 2015, 37, 1-11.
    • (2015) Acta Physiol. Plant , vol.37 , pp. 1-11
    • Kołodziejczyk, I.1    Bałabusta, M.2    Szewczyk, R.3    Posmyk, M.M.4
  • 80
    • 84946485039 scopus 로고    scopus 로고
    • Predominance of 2-hydroxymelatonin over melatonin in plants
    • Byeon, Y.; Tan, D.X.; Reiter, R.J.; Back, K. Predominance of 2-hydroxymelatonin over melatonin in plants. J. Pineal Res. 2015, doi:10.1111/jpi.12274
    • (2015) J. Pineal Res.
    • Byeon, Y.1    Tan, D.X.2    Reiter, R.J.3    Back, K.4
  • 81
    • 84924736667 scopus 로고    scopus 로고
    • Molecular cloning of melatonin 2-hydroxylase responsible for 2-hydroxymelatonin production in rice (Oryza sativa)
    • Byeon, Y.; Back, K. Molecular cloning of melatonin 2-hydroxylase responsible for 2-hydroxymelatonin production in rice (Oryza sativa). J. Pineal Res. 2015, 58, 343-351.
    • (2015) J. Pineal Res. , vol.58 , pp. 343-351
    • Byeon, Y.1    Back, K.2
  • 82
    • 0037404895 scopus 로고    scopus 로고
    • Mechanistic and comparative studies of melatonin and classic antioxidants in terms of their interactions with the ABTS cation radical
    • Tan, D.X.; Hardeland, R.; Manchester, L.C.; Poeggeler, B.; Lopez-Burillo, S.; Mayo, J.C.; Sainz, R.M.; Reiter, R.J. Mechanistic and comparative studies of melatonin and classic antioxidants in terms of their interactions with the ABTS cation radical. J. Pineal Res. 2003, 34, 249-259.
    • (2003) J. Pineal Res. , vol.34 , pp. 249-259
    • Tan, D.X.1    Hardeland, R.2    Manchester, L.C.3    Poeggeler, B.4    Lopez-Burillo, S.5    Mayo, J.C.6    Sainz, R.M.7    Reiter, R.J.8
  • 83
    • 84874355329 scopus 로고    scopus 로고
    • Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis
    • Lowes, D.A.; Webster, N.R.; Murphy, M.P.; Galley, H.F. Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis. Br. J. Anaesth. 2013, 110, 472-480.
    • (2013) Br. J. Anaesth. , vol.110 , pp. 472-480
    • Lowes, D.A.1    Webster, N.R.2    Murphy, M.P.3    Galley, H.F.4
  • 84
    • 0034763416 scopus 로고    scopus 로고
    • Individual and synergistic antioxidative actions of melatonin: Studies with Vitamin E, Vitamin C, glutathione and desferrioxamine (desferoxamine) in rat liver homogenates
    • Gitto, E.; Tan, D.X.; Reiter, R.J.; Karbownik, M.; Manchester, L.C.; Cuzzocrea, S.; Fulia, F.; Barberi, I. Individual and synergistic antioxidative actions of melatonin: Studies with vitamin E, vitamin C, glutathione and desferrioxamine (desferoxamine) in rat liver homogenates. J. Pharm. Pharmacol. 2001, 53, 1393-1401.
    • (2001) J. Pharm. Pharmacol. , vol.53 , pp. 1393-1401
    • Gitto, E.1    Tan, D.X.2    Reiter, R.J.3    Karbownik, M.4    Manchester, L.C.5    Cuzzocrea, S.6    Fulia, F.7    Barberi, I.8
  • 85
    • 33746106855 scopus 로고    scopus 로고
    • Melatonin prevents X-ray irradiation induced oxidative damagein peripheral blood and spleen of the seasonally breeding rodent, Funambulus pennanti during reproductively active phase
    • Sharma, S.; Haldar, C. Melatonin prevents X-ray irradiation induced oxidative damagein peripheral blood and spleen of the seasonally breeding rodent, Funambulus pennanti during reproductively active phase. Int. J. Radiat. Biol. 2006, 82, 411-419.
    • (2006) Int. J. Radiat. Biol. , vol.82 , pp. 411-419
    • Sharma, S.1    Haldar, C.2
  • 86
    • 33947141411 scopus 로고    scopus 로고
    • Comparison of melatonin, Vitamin E and L-carnitine in the treatment of neuro- and hepatotoxicity induced by thioacetamide
    • Tunez, I.; Munoz, M.C.; Medina, F.J.; Salcedo, M.; Feijoo, M.; Montilla, P. Comparison of melatonin, vitamin E and L-carnitine in the treatment of neuro- and hepatotoxicity induced by thioacetamide. Cell Biochem. Funct. 2007, 25, 119-127.
    • (2007) Cell Biochem. Funct. , vol.25 , pp. 119-127
    • Tunez, I.1    Munoz, M.C.2    Medina, F.J.3    Salcedo, M.4    Feijoo, M.5    Montilla, P.6
  • 87
    • 84919667875 scopus 로고    scopus 로고
    • Amelioration of streptozotocin-induced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats
    • Elbe, H.; Vardi, N.; Esrefoglu, M.; Ates, B.; Yologlu, S.; Taskapan, C. Amelioration of streptozotocin-induced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats. Hum. Exp. Toxicol. 2015, 34, 100-113.
    • (2015) Hum. Exp. Toxicol. , vol.34 , pp. 100-113
    • Elbe, H.1    Vardi, N.2    Esrefoglu, M.3    Ates, B.4    Yologlu, S.5    Taskapan, C.6
  • 88
    • 84887247980 scopus 로고    scopus 로고
    • Fish oil, melatonin and Vitamin E attenuates midbrain cyclooxygenase-2 activity and oxidative stress after the administration of 1-methyl-4- phenyl-1,2,3,6- tetrahydropyridine
    • Ortiz, G.G.; Pacheco-Moises, F.P.; Gomez-Rodriguez, V.M.; Gonzalez-Renovato, E.D.; Torres-Sanchez, E.D.; Ramirez-Anguiano, A.C. Fish oil, melatonin and vitamin E attenuates midbrain cyclooxygenase-2 activity and oxidative stress after the administration of 1-methyl-4- phenyl-1,2,3,6- tetrahydropyridine. Metab. Brain Dis. 2013, 28, 705-709.
    • (2013) Metab. Brain Dis. , vol.28 , pp. 705-709
    • Ortiz, G.G.1    Pacheco-Moises, F.P.2    Gomez-Rodriguez, V.M.3    Gonzalez-Renovato, E.D.4    Torres-Sanchez, E.D.5    Ramirez-Anguiano, A.C.6
  • 89
    • 84919667055 scopus 로고    scopus 로고
    • Melatonin and its metabolites as copper chelating agents and their role in inhibiting oxidative stress: A physicochemical analysis
    • Galano, A.; Medina, M.E.; Tan, D.X.; Reiter, R.J. Melatonin and its metabolites as copper chelating agents and their role in inhibiting oxidative stress: A physicochemical analysis. J. Pineal Res. 2015, 58, 107-116.
    • (2015) J. Pineal Res. , vol.58 , pp. 107-116
    • Galano, A.1    Medina, M.E.2    Tan, D.X.3    Reiter, R.J.4
  • 90
    • 84949117036 scopus 로고    scopus 로고
    • Melatonin reduces lipid peroxidation and membrane viscosity
    • Reiter, R.J.; Tan, D.X.; Galano, A. Melatonin reduces lipid peroxidation and membrane viscosity. Front Physiol. 2014, 5, 377.
    • (2014) Front Physiol. , vol.5 , pp. 377
    • Reiter, R.J.1    Tan, D.X.2    Galano, A.3
  • 91
    • 84928954025 scopus 로고    scopus 로고
    • Computational study on the kinetics and mechanism of the carbaryl + OH reaction
    • Zavala-Oseguera, C.; Galano, A.; Merino, G. Computational study on the kinetics and mechanism of the carbaryl + OH reaction. J. Phys. Chem. A 2014, 118, 7776-7781.
    • (2014) J. Phys. Chem. A , vol.118 , pp. 7776-7781
    • Zavala-Oseguera, C.1    Galano, A.2    Merino, G.3
  • 92
    • 10744224028 scopus 로고    scopus 로고
    • Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): Scavenging of free radicals and prevention of protein destruction
    • Ressmeyer, A.R.; Mayo, J.C.; Zelosko, V.; Sainz, R.M.; Tan, D.X.; Poeggeler, B.; Antolin, I.; Zsizsik, B.K.; Reiter, R.J.; Hardeland, R. Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): Scavenging of free radicals and prevention of protein destruction. Redox Rep. 2003, 8, 205-213.
    • (2003) Redox Rep. , vol.8 , pp. 205-213
    • Ressmeyer, A.R.1    Mayo, J.C.2    Zelosko, V.3    Sainz, R.M.4    Tan, D.X.5    Poeggeler, B.6    Antolin, I.7    Zsizsik, B.K.8    Reiter, R.J.9    Hardeland, R.10
  • 93
    • 22144498398 scopus 로고    scopus 로고
    • Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages
    • Mayo, J.C.; Sainz, R.M.; Tan, D.X.; Hardeland, R.; Leon, J.; Rodriguez, C.; Reiter, R.J. Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages. J. Neuroimmunol. 2005, 165, 139-149.
    • (2005) J. Neuroimmunol. , vol.165 , pp. 139-149
    • Mayo, J.C.1    Sainz, R.M.2    Tan, D.X.3    Hardeland, R.4    Leon, J.5    Rodriguez, C.6    Reiter, R.J.7
  • 94
    • 84874949228 scopus 로고    scopus 로고
    • On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK
    • Galano, A.; Tan, D.X.; Reiter, R.J. On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. J. Pineal Res. 2013, 54, 245-257.
    • (2013) J. Pineal Res. , vol.54 , pp. 245-257
    • Galano, A.1    Tan, D.X.2    Reiter, R.J.3
  • 96
    • 84907882646 scopus 로고    scopus 로고
    • Theoretical insight into the antioxidant properties of melatonin and derivatives
    • Johns, J.R.; Platts, J.A. Theoretical insight into the antioxidant properties of melatonin and derivatives. Org. Biomol. Chem. 2014, 12, 7820-7827.
    • (2014) Org. Biomol. Chem. , vol.12 , pp. 7820-7827
    • Johns, J.R.1    Platts, J.A.2
  • 98
    • 0021277141 scopus 로고
    • N-acetyl-5-methoxy kynurenamine, a brain metabolite of melatonin, is a potent inhibitor of prostaglandin biosynthesis
    • Kelly, R.W.; Amato, F.; Seamark, R.F. N-acetyl-5-methoxy kynurenamine, a brain metabolite of melatonin, is a potent inhibitor of prostaglandin biosynthesis. Biochem. Biophys. Res. Commun. 1984, 121, 372-379.
    • (1984) Biochem. Biophys. Res. Commun. , vol.121 , pp. 372-379
    • Kelly, R.W.1    Amato, F.2    Seamark, R.F.3
  • 99
    • 84872685423 scopus 로고    scopus 로고
    • A review of the molecular aspects of melatonin's anti-inflammatory actions: Recent insights and new perspectives
    • Mauriz, J.L.; Collado, P.S.; Veneroso, C.; Reiter, R.J.; Gonzalez-Gallego, J. A review of the molecular aspects of melatonin's anti-inflammatory actions: Recent insights and new perspectives. J. Pineal Res. 2013, 54, 1-14.
    • (2013) J. Pineal Res. , vol.54 , pp. 1-14
    • Mauriz, J.L.1    Collado, P.S.2    Veneroso, C.3    Reiter, R.J.4    Gonzalez-Gallego, J.5
  • 100
    • 34147201601 scopus 로고    scopus 로고
    • AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice
    • Manda, K.; Ueno, M.; Anzai, K. AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. J. Pineal Res. 2007, 42, 386-393.
    • (2007) J. Pineal Res. , vol.42 , pp. 386-393
    • Manda, K.1    Ueno, M.2    Anzai, K.3
  • 101
    • 53749104127 scopus 로고    scopus 로고
    • Space radiation-induced inhibition of neurogenesis in the hippocampal dentate gyrus and memory impairment in mice: Ameliorative potential of the melatonin metabolite, AFMK
    • Manda, K.; Ueno, M.; Anzai, K. Space radiation-induced inhibition of neurogenesis in the hippocampal dentate gyrus and memory impairment in mice: Ameliorative potential of the melatonin metabolite, AFMK. J. Pineal Res. 2008, 45, 430-438.
    • (2008) J. Pineal Res. , vol.45 , pp. 430-438
    • Manda, K.1    Ueno, M.2    Anzai, K.3
  • 105
    • 79956150165 scopus 로고    scopus 로고
    • Wrapping bacteria by graphene nanosheets for isolation from environment, reactivation by sonication, and inactivation by near-infrared irradiation
    • Akhavan, O.; Ghaderi, E.; Esfandiar, A. Wrapping bacteria by graphene nanosheets for isolation from environment, reactivation by sonication, and inactivation by near-infrared irradiation. J. Phys. Chem. B 2011, 115, 6279-6288.
    • (2011) J. Phys. Chem. B , vol.115 , pp. 6279-6288
    • Akhavan, O.1    Ghaderi, E.2    Esfandiar, A.3
  • 106
    • 79960347520 scopus 로고    scopus 로고
    • Melatonin as a powerful bio-antioxidant for reduction of graphene oxide
    • Esfandiar, A.; Akhavan, O.; Irajizadab, A. Melatonin as a powerful bio-antioxidant for reduction of graphene oxide. J. Mater. Chem. 2011, 21, 10907-10914.
    • (2011) J. Mater. Chem. , vol.21 , pp. 10907-10914
    • Esfandiar, A.1    Akhavan, O.2    Irajizadab, A.3
  • 107
    • 0022487612 scopus 로고
    • Normal patterns of melatonin levels in the pineal gland and body fluids of humans and experimental animals
    • Reiter, R.J. Normal patterns of melatonin levels in the pineal gland and body fluids of humans and experimental animals. J. Neural Transm. 1986, 21, 35-54.
    • (1986) J. Neural Transm. , vol.21 , pp. 35-54
    • Reiter, R.J.1
  • 110
    • 84885640190 scopus 로고    scopus 로고
    • Melatonin and the theories of aging: A critical appraisal of melatonin's role in antiaging mechanisms
    • Hardeland, R. Melatonin and the theories of aging: A critical appraisal of melatonin's role in antiaging mechanisms. J. Pineal Res. 2013, 55, 325-356.
    • (2013) J. Pineal Res. , vol.55 , pp. 325-356
    • Hardeland, R.1
  • 111
    • 0022624149 scopus 로고
    • Genetic control of melatonin synthesis in the pineal gland of the mouse
    • Ebihara, S.; Marks, T.; Hudson, D. J.; Menaker, M. Genetic control of melatonin synthesis in the pineal gland of the mouse. Science 1986, 231, 491-493.
    • (1986) Science , vol.231 , pp. 491-493
    • Ebihara, S.1    Marks, T.2    Hudson, D.J.3    Menaker, M.4
  • 112
    • 0023709008 scopus 로고
    • Neither the pituitary gland nor the sympathetic nervous system is responsible for eliciting the large drop in elevated rat pineal melatonin levels due to swimming
    • Troiani, M.E.; Reiter, R.J.; Tannenbaum, M.G.; Puig-Domingo, M.; Guerrero, J.M.; Menendez-Pelaez, A. Neither the pituitary gland nor the sympathetic nervous system is responsible for eliciting the large drop in elevated rat pineal melatonin levels due to swimming. J. Neural Transm. 1988, 74, 149-160.
    • (1988) J. Neural Transm. , vol.74 , pp. 149-160
    • Troiani, M.E.1    Reiter, R.J.2    Tannenbaum, M.G.3    Puig-Domingo, M.4    Guerrero, J.M.5    Menendez-Pelaez, A.6
  • 113
    • 0023937198 scopus 로고
    • Transient reduction in pineal melatonin levels but not N-acetyltransferase activity in rats forced to swim for 15 minutes at night
    • Ueck, M.; Troiani, M.E.; Reiter, R.J. Transient reduction in pineal melatonin levels but not N-acetyltransferase activity in rats forced to swim for 15 minutes at night. Neuroendocrinol. Lett. 1988, 10, 81-90.
    • (1988) Neuroendocrinol. Lett. , vol.10 , pp. 81-90
    • Ueck, M.1    Troiani, M.E.2    Reiter, R.J.3
  • 114
    • 0032901972 scopus 로고    scopus 로고
    • Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-epsilon4/4 genotype
    • Liu, R.Y.; Zhou, J.N.; van Heerikhuize, J.; Hofman, M.A.; Swaab, D.F. Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-epsilon4/4 genotype. J. Clin. Endocrinol. Metab. 1999, 84, 323-327.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 323-327
    • Liu, R.Y.1    Zhou, J.N.2    Van Heerikhuize, J.3    Hofman, M.A.4    Swaab, D.F.5
  • 115
    • 0030839339 scopus 로고    scopus 로고
    • Loss of intraventricular fluid melatonin can explain the neuropathology of Alzheimer's disease
    • Maurizi, C.P. Loss of intraventricular fluid melatonin can explain the neuropathology of Alzheimer's disease. Med. Hypotheses 1997, 49, 153-158.
    • (1997) Med. Hypotheses , vol.49 , pp. 153-158
    • Maurizi, C.P.1
  • 116
    • 0042090064 scopus 로고    scopus 로고
    • Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels
    • Zhou, J.N.; Liu, R.Y.; Kamphorst, W.; Hofman, M.A.; Swaab, D.F. Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels. J. Pineal Res. 2003, 35, 125-130.
    • (2003) J. Pineal Res. , vol.35 , pp. 125-130
    • Zhou, J.N.1    Liu, R.Y.2    Kamphorst, W.3    Hofman, M.A.4    Swaab, D.F.5
  • 119
    • 84866263440 scopus 로고    scopus 로고
    • Decreased level of melatonin in serum predicts left ventricular remodelling after acute myocardial infarction
    • Dominguez-Rodriguez, A.; Abreu-Gonzalez, P.; Arroyo-Ucar, E.; Reiter, R.J. Decreased level of melatonin in serum predicts left ventricular remodelling after acute myocardial infarction. J. Pineal Res. 2012, 53, 319-323.
    • (2012) J. Pineal Res. , vol.53 , pp. 319-323
    • Dominguez-Rodriguez, A.1    Abreu-Gonzalez, P.2    Arroyo-Ucar, E.3    Reiter, R.J.4
  • 121
    • 0025841797 scopus 로고
    • TCDD decreases rapidly and persistently serum melatonin concentration without morphologically affecting the pineal gland in TCDD-resistant Han/Wistar rats
    • Linden, J.; Pohjanvirta, R.; Rahko, T.; Tuomisto, J. TCDD decreases rapidly and persistently serum melatonin concentration without morphologically affecting the pineal gland in TCDD-resistant Han/Wistar rats. Pharmacol. Toxicol. 1991, 69, 427-432.
    • (1991) Pharmacol. Toxicol. , vol.69 , pp. 427-432
    • Linden, J.1    Pohjanvirta, R.2    Rahko, T.3    Tuomisto, J.4
  • 122
    • 0030020772 scopus 로고    scopus 로고
    • Mechanism by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) reduces circulating melatonin levels in the rat
    • Pohjanvirta, R.; Laitinen, J.; Vakkuri, O.; Linden, J.; Kokkola, T.; Unkila, M.; Tuomisto, J. Mechanism by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) reduces circulating melatonin levels in the rat. Toxicology 1996, 107, 85-97.
    • (1996) Toxicology , vol.107 , pp. 85-97
    • Pohjanvirta, R.1    Laitinen, J.2    Vakkuri, O.3    Linden, J.4    Kokkola, T.5    Unkila, M.6    Tuomisto, J.7
  • 123
    • 84871746298 scopus 로고    scopus 로고
    • The effect of acute swimming exercise on plasma melatonin levels in rats
    • Uzun, A.; Baltaci, A.K.; Kilic, M.; Mogulkoc, R. The effect of acute swimming exercise on plasma melatonin levels in rats. Bratislav. Lekar. Listy 2012, 113, 64-66.
    • (2012) Bratislav. Lekar. Listy , vol.113 , pp. 64-66
    • Uzun, A.1    Baltaci, A.K.2    Kilic, M.3    Mogulkoc, R.4
  • 124
    • 0023704906 scopus 로고
    • Swimming depresses nighttime melatonin content without changing N-acetyltransferase activity in the rat pineal gland
    • Troiani, M.E.; Reiter, R.J.; Vaughan, M.K.; Oaknin, S.; Vaughan, G.M. Swimming depresses nighttime melatonin content without changing N-acetyltransferase activity in the rat pineal gland. Neuroendocrinology 1988, 47, 55-60.
    • (1988) Neuroendocrinology , vol.47 , pp. 55-60
    • Troiani, M.E.1    Reiter, R.J.2    Vaughan, M.K.3    Oaknin, S.4    Vaughan, G.M.5
  • 125
    • 0022370243 scopus 로고
    • Stress-induced synthesis of melatonin: Possible involvement of the endogenous monoamine oxidase inhibitor (tribulin)
    • Oxenkrug, G.F.; McIntyre, I.M. Stress-induced synthesis of melatonin: possible involvement of the endogenous monoamine oxidase inhibitor (tribulin). Life Sci. 1985, 37, 1743-1746.
    • (1985) Life Sci. , vol.37 , pp. 1743-1746
    • Oxenkrug, G.F.1    McIntyre, I.M.2
  • 129
    • 77949424755 scopus 로고    scopus 로고
    • Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production
    • Fontana, L.; Klein, S.; Holloszy, J.O. Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production. Age 2010, 32, 97-108.
    • (2010) Age , vol.32 , pp. 97-108
    • Fontana, L.1    Klein, S.2    Holloszy, J.O.3
  • 130
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span-From yeast to humans
    • Fontana, L.; Partridge, L.; Longo, V.D. Extending healthy life span-From yeast to humans. Science 2010, 328, 321-326.
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 131
    • 27644459840 scopus 로고    scopus 로고
    • Physiological ischemia/reperfusion phenomena and their relation to endogenous melatonin production: A hypothesis
    • Tan, D.X.; Manchester, L.C.; Sainz, R.M.; Mayo, J.C.; Leon, J.; Reiter, R.J. Physiological ischemia/reperfusion phenomena and their relation to endogenous melatonin production: A hypothesis. Endocrine 2005, 27, 149-158.
    • (2005) Endocrine , vol.27 , pp. 149-158
    • Tan, D.X.1    Manchester, L.C.2    Sainz, R.M.3    Mayo, J.C.4    Leon, J.5    Reiter, R.J.6
  • 133
    • 62449202823 scopus 로고    scopus 로고
    • Chemical stress by different agents affects the melatonin content of barley roots
    • Arnao, M.B.; Hernandez-Ruiz, J. Chemical stress by different agents affects the melatonin content of barley roots. J. Pineal Res. 2009, 46, 295-299.
    • (2009) J. Pineal Res. , vol.46 , pp. 295-299
    • Arnao, M.B.1    Hernandez-Ruiz, J.2
  • 134
    • 79952841864 scopus 로고    scopus 로고
    • Melatonin as an antioxidant and its semi-lunar rhythm in green macroalga Ulva sp
    • Tal, O.; Haim, A.; Harel, O.; Gerchman, Y. Melatonin as an antioxidant and its semi-lunar rhythm in green macroalga Ulva sp. J. Exp. Bot. 2011, 62, 1903-1910.
    • (2011) J. Exp. Bot. , vol.62 , pp. 1903-1910
    • Tal, O.1    Haim, A.2    Harel, O.3    Gerchman, Y.4
  • 135
    • 84885180535 scopus 로고    scopus 로고
    • Growth conditions determine different melatonin levels in Lupinus albus L
    • Arnao, M.B.; Hernandez-Ruiz, J. Growth conditions determine different melatonin levels in Lupinus albus L. J. Pineal Res. 2013, 55, 149-155.
    • (2013) J. Pineal Res. , vol.55 , pp. 149-155
    • Arnao, M.B.1    Hernandez-Ruiz, J.2
  • 136
    • 84893519936 scopus 로고    scopus 로고
    • Melatonin synthesis in rice seedlings in vivo is enhanced at high temperatures and under dark conditions due to increased serotonin N-acetyltransferase and N-acetylserotonin methyltransferase activities
    • Byeon, Y.; Back, K. Melatonin synthesis in rice seedlings in vivo is enhanced at high temperatures and under dark conditions due to increased serotonin N-acetyltransferase and N-acetylserotonin methyltransferase activities. J. Pineal Res. 2014, 56, 189-195.
    • (2014) J. Pineal Res. , vol.56 , pp. 189-195
    • Byeon, Y.1    Back, K.2
  • 137
    • 84885612151 scopus 로고    scopus 로고
    • Identification of genes for melatonin synthetic enzymes in "red Fuji" apple (Malus domestica Borkh.cv.Red) and their expression and melatonin production during fruit development
    • Lei, Q.; Wang, L.; Tan, D.X.; Zhao, Y.; Zheng, X.D.; Chen, H.; Li, Q.T.; Zuo, B.X.; Kong, J. Identification of genes for melatonin synthetic enzymes in "Red Fuji" apple (Malus domestica Borkh.cv.Red) and their expression and melatonin production during fruit development. J. Pineal Res. 2013, 55, 443-451.
    • (2013) J. Pineal Res. , vol.55 , pp. 443-451
    • Lei, Q.1    Wang, L.2    Tan, D.X.3    Zhao, Y.4    Zheng, X.D.5    Chen, H.6    Li, Q.T.7    Zuo, B.X.8    Kong, J.9
  • 138
    • 84885623020 scopus 로고    scopus 로고
    • Functional analyses of three ASMT gene family members in rice plants
    • Park, S.; Byeon, Y.; Back, K. Functional analyses of three ASMT gene family members in rice plants. J. Pineal Res. 2013, 55, 409-415.
    • (2013) J. Pineal Res. , vol.55 , pp. 409-415
    • Park, S.1    Byeon, Y.2    Back, K.3
  • 139
    • 84885178331 scopus 로고    scopus 로고
    • Molecular cloning of rice serotonin N-acetyltransferase, the penultimate gene in plant melatonin biosynthesis
    • Kang, K.; Lee, K.; Park, S.; Byeon, Y.; Back, K. Molecular cloning of rice serotonin N-acetyltransferase, the penultimate gene in plant melatonin biosynthesis. J. Pineal Res. 2013, 55, 7-13.
    • (2013) J. Pineal Res. , vol.55 , pp. 7-13
    • Kang, K.1    Lee, K.2    Park, S.3    Byeon, Y.4    Back, K.5
  • 140
    • 0030887942 scopus 로고    scopus 로고
    • Dramatic rises of melatonin and 5-methoxytryptamine in Gonyaulax exposed to decreased temperature
    • Fuhrberg, B.; Hardeland, R.; Poeggeler, B.; Behrmann, G. Dramatic rises of melatonin and 5-methoxytryptamine in Gonyaulax exposed to decreased temperature. Biol. Rhythm. Res. 1997, 28, 144-150.
    • (1997) Biol. Rhythm. Res. , vol.28 , pp. 144-150
    • Fuhrberg, B.1    Hardeland, R.2    Poeggeler, B.3    Behrmann, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.