Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling

Journal of Pineal Research

Volumn 58, Issue 1, 2015, Pages 50-60

  Shin, In Sik ^a,b   Shin, Na Rae ^a,c   Park, Ji Won ^a,d   Jeon, Chan Mi ^a   Hong, Ju Mi ^a   Kwon, Ok Kyoung ^a   Kim, Joong Sun ^e   Lee, In Chul ^b   Kim, Jong Choon ^b   Oh, Sei Ryang ^a   Ahn, Kyung Seop ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chonnam National University   (South Korea)

^c Hannam University   (South Korea)

^d Korea University   (South Korea)

^e Research Center Dongnam Institute of Radiological and Medical Sciences ^*  (South Korea)

Author keywords

chronic obstructive pulmonary disease; cigarette smoke; Erk Sp1; Melatonin

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CIGARETTE SMOKE; CIGARETTE SMOKE CONDENSATE; GELATINASE B; INTERLEUKIN 6; INTERLEUKIN 8; LEUKOCYTE ELASTASE; LIPOPOLYSACCHARIDE; MELATONIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MUCIN 5AC; MYELOPEROXIDASE; REACTIVE OXYGEN METABOLITE; ROFLUMILAST; SP1 PROTEIN; UNCLASSIFIED DRUG; ANTIOXIDANTS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LIPOPOLYSACCHARIDES; SP1 PROTEIN, HUMAN; SP1 TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL INFILTRATION; CELL STIMULATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IN VITRO STUDY; INFLAMMATORY CELL; LUNG LAVAGE; MALE; MOUSE; MUCUS SECRETION; NEUTROPHIL; NEUTROPHIL COUNT; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RESPIRATORY TRACT INFLAMMATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOKING; ZYMOGRAPHY; ADVERSE EFFECTS; ANIMALS; CELL LINE, TUMOR; CHEMICALLY INDUCED; DISEASE MODELS, ANIMAL; DRUG EFFECTS; HUMANS; INFLAMMATION; MAP KINASE SIGNALING SYSTEM; METABOLISM; MICE; MUCUS; NEUTROPHIL INFILTRATION; NEUTROPHILS; PATHOLOGY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RATS; SECRETION;

ANIMALS; ANTIOXIDANTS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MAP KINASE SIGNALING SYSTEM; MELATONIN; MICE; MUCUS; NEUTROPHIL INFILTRATION; NEUTROPHILS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RATS; SMOKING; SP1 TRANSCRIPTION FACTOR;

EID: 84919625591     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12192     Document Type: Article

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