Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT 2-selective melatonin agonists: Improving metabolic stability

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 2, 2013, Pages 547-552

  Hu, Yueqing ^a   Zhu, Jing ^a   Chan, King H ^a   Wong, Yung H ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Agonist; Ligand; Melatonin; Phenylpropyl amide

Indexed keywords

3 (2 BENZYLOXY 5 METHOXY PHENYL) ACRYLONITRILE; 3 (2 BENZYLOXY 5 METHOXY PHENYL) PROPYLAMINE; CARBON; ETHER DERIVATIVE; HORMONE RECEPTOR STIMULATING AGENT; MELATONIN 2 RECEPTOR; N [3 (2 BENZYLOXY 5 METHOXY PHENYL) PROPYL] PROPIONAMIDE; N [3 (2 HYDROXY 5 METHOXY PHENYL) PROPYL] PROPIONAMIDE; N [3 (2 TRIFLUOROMETHYLSULFONYL 5 METHOXY PHENYL) PROPYL] PROPIONAMIDE; N [3 (3 METHOXYLPHENYL)PROPYL] AMIDE DERIVATIVE; N [3 (4,3' DIMETHOXY BIPHENYL 2 YL) PROPYL] PROPIONAMIDE; N [3 [5 METHOXY 2 (3 METHOXY BENZYL) PHENYL] PROPYL] PROPIONAMIDE; N [3 [5 METHOXY 2 (3 METHOXY PHENYLETHYNYL) PHENYL] PROPYL] PROPIONAMIDE; N [3 [5 METHOXY 2 [2 (3 METHOXY PHENYL) ETHYL] PHENYL] PROPYL] PROPIONAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHEMICAL BOND; CONTROLLED STUDY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; OXIDATION; RAT; STRUCTURE ANALYSIS;

AMIDES; ANIMALS; HUMANS; MICROSOMES; PROTEIN BINDING; RATS; RECEPTOR, MELATONIN, MT1; RECEPTOR, MELATONIN, MT2;

EID: 84871628099     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.10.060     Document Type: Article

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