Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT 1/MT 2) and serotoninergic 5-HT 2C dual ligands (I)

European Journal of Medicinal Chemistry

Volumn 49, Issue , 2012, Pages 310-323

  Ettaoussi, Mohamed ^a   Sabaouni, Ahmed ^a   Rami, Marouan ^a   Boutin, Jean A ^c   Delagrange, Philippe ^b   Renard, Pierre ^b   Spedding, Michael ^b   Caignard, Daniel Henri ^b   Berthelot, Pascal ^a   Yous, Saïd ^a  

^a UNIV LILLE   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

^c INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

5 HT 2C; Agomelatine; Agonist; Antagonist; Depression; MT 1; MT 2

Indexed keywords

2 (BENZYL METHYLAMINO) N [2 ( 7 METHOXY NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; 2 FLUORO N [2 (7 METHOXY NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; 2,2 DIFLUORO N [2 (7 METHOXY NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; 3 HYDROXY N [2 (7 METHOXY NAPHTHALEN 1 YL)ETHYL]PROPANAMIDE; AGOMELATINE; ANTIDEPRESSANT AGENT; ETHYL N [2 (7 METHOXY NAPHTHALEN 1 YL)ETHYL]MALONATE; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; N [2 (3 ACETYL 7 METHOXY NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; N [2 (3 BENZOYL 7 METHOXY NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; N [2 (3 BENZYL 7 METHOXY NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; N [2 (3 CYCLOBUTANECARBONYL 7 METHOXY NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; N [2 (3 CYCLOBUTYLMETHYL 7 METHOXY NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; N [2 (3 CYCLOHEXANECARBONYL 7 METHOXY NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; N [2 (3 CYCLOPENTANECARBONYL 7 METHOXY NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; N [2 (3 CYCLOPENTYLMETHYL 7 METHOXY NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; N [2 (3 CYCLOPROPANECARBONYL 7 METHOXY NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; N [2 (3 CYCLOPROPYLMETHYL 7 METHOXY NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; N [2 (3 ETHYL 7 METHOXY NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; N [2 (3 ISOBUTYL 7 METHOXY NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; N [2 (3 ISOBUTYRYL 7 METHOXY NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; N [2 (3 ISOVALERYL 7 METHOXY NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; N [2 (7 METHOXY 3 PROPANOYL NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; N [2 (7 METHOXY 3 PROPYL NAPHTHALEN 1 YL)ETHYL]ACETAMIDE; N [2 (7 METHOXY NAPHTHALEN 1 YL)ETHYL] 2 (METHYLAMINO)ACETAMIDE HYDROCHLORIDE; N [2 [7 METHOXY 3 (3 METHYLBUTYL)NAPHTHALEN 1 YL]ETHYL]ACETAMIDE; NAPHTHALENE DERIVATIVE; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; RECEPTOR BINDING;

ACETAMIDES; CELL LINE; DRUG DESIGN; HUMANS; NAPHTHALENES; PROTEIN BINDING; RECEPTOR, MELATONIN, MT1; RECEPTOR, MELATONIN, MT2; RECEPTOR, SEROTONIN, 5-HT2C; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857237872     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.01.027     Document Type: Article

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