Targeted deletions of Mel1a and Mel1b melatonin receptors affect pCREB levels in lactotroph and pars intermedia cells of mice

Neuroscience Letters

Volumn 407, Issue 1, 2006, Pages 48-52

  Sheynzon, Pjotr ^a   Korf, Horst Werner ^a  

^a GOETHE UNIVERSITY MEDICAL SCHOOL   (Germany)

Author keywords

Adenohypophysis; Melatonin receptor knockout mice; Pars distalis; Prolactin; Transcription factor

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; G PROTEIN COUPLED RECEPTOR; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; PROLACTIN; SERINE;

ADENOHYPOPHYSIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE DELETION; HYPOPHYSIS CELL; HYPOPHYSIS INTERMEDIATE LOBE; IMMUNOCYTOCHEMISTRY; KNOCKOUT MOUSE; LACTOTROPH CELL; LIGHT DARK CYCLE; MOUSE; NONHUMAN; PARS INTERMEDIA CELL; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; CELL COUNT; CELL CYCLE PROTEINS; CELL NUCLEUS; CIRCADIAN RHYTHM; CREB-BINDING PROTEIN; CYTOPLASM; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, KNOCKOUT; NUCLEAR PROTEINS; PITUITARY GLAND; PROLACTIN; RECEPTOR, MELATONIN, MT1; RECEPTOR, MELATONIN, MT2; SIGNAL TRANSDUCTION;

EID: 33748433857     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.08.016     Document Type: Article

References (19)

1. Cajochen C., Krauchi K., and Wirz-Justice A. Role of melatonin in the regulation of human circadian rhythms and sleep. J. Neuroendocrinol. 15 (2003) 432-437
2. Ebisawa T., Karne S., Lerner M.R., and Reppert S.M. Expression cloning of a high-affinity melatonin receptor from Xenopus dermal melanophores. Proc. Natl. Acad. Sci. U.S.A. 21 (1994) 6133-6137
3. Guerin M.V., Deed J.R., and Matthews C.D. The coincidence of light and melatonin with a specific phase of the circadian pacemaker is important for the timing of seasonal breeding in the ewe. J. Biol. Rhythms 15 (2000) 514-523
4. Guerra M., and Rodriguez E.M. Identification, cellular and subcellular distribution of 21 and 72 kDa proteins (tuberalins?) secreted by specific cells of the pars tuberalis. J. Endocrinol. 168 (2001) 363-379
5. Jilg A., Moek J., Weaver D.R., Korf H.W., Stehle J.H., and von Gall C. Rhythms in clock proteins in the mouse pars tuberalis depend on MT1 melatonin receptor signalling. Eur. J. Neurosci. 22 (2005) 2845-2854
6. Jin X., von Gall C., Pieschl R.L., Gribkoff V.K., Stehle J.H., Reppert S.M., and Weaver D.R. Targeted disruption of the mouse Mel(1b) melatonin receptor. Mol. Cell. Biol. 23 (2003) 1054-1060
7. Liu C., Weaver D.R., Jin X., Shearman L.P., Pieschl R.L., Gribkoff V.K., and Reppert S.M. Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. Neuron 19 (1997) 91-102
8. Luger T.A., Scholzen T.E., Brzoska T., and Bohm M. New insights into the functions of alpha-MSH and related peptides in the immune system. Ann. N.Y. Acad. Sci. 994 (2003) 133-140
9. McArthur A.J., Gillette M.U., and Prosser R.A. Melatonin directly resets the rat suprachiasmatic circadian clock in vitro. Brain Res. 22 (1991) 158-161
10. McNulty S., Schurov I.L., Sloper P.J., and Hastings M.H. Stimuli which entrain the circadian clock of the neonatal Syrian hamster in vivo regulate the phosphorylation of the transcription factor CREB in the suprachiasmatic nucleus in vitro. Eur. J. Neurosci. 10 (1998) 1063-1072
11. Morgan P.J., Webster C.A., Mercer J.G., Ross A.W., Hazlerigg D.G., MacLean A., and Barrett P. The ovine pars tuberalis secretes a factor(s) that regulates gene expression in both lactotropic and nonlactotropic pituitary cells. Endocrinology 137 (1996) 4018-4026
12. Mutoh T., Shibata S., Korf H.W., and Okamura H. Melatonin modulates the light-induced sympathoexcitation and vagal suppression with participation of the suprachiasmatic nucleus in mice. J. Physiol. 15 (2003) 317-332
13. Ross A.W., and Morgan P.J. The pars tuberalis as a target of the central clock. Cell Tissue Res. 309 (2002) 163-171
14. Sabatier N., and Leng G. Presynaptic actions of endocannabinoids mediate alpha-MSH-induced inhibition of oxytocin cells. Am. J. Physiol. Regul. Integr. Comp. Physiol. 290 (2006) R577-R584
15. Sheynzon P., Karolczak M., Dehghani F., and Korf H.W. Diurnal variation in CREB phosphorylation and PER1 protein levels in lactotroph cells of melatonin-proficient C3H and melatonin-deficient C57BL mice: similarities and differences. Cell Tissue Res. 321 (2005) 211-217
16. Vanecek J., and Klein D.C. Mechanism of melatonin signal transduction in the neonatal rat pituitary. Neurochem. Int. 27 (1995) 273-278
17. von Gall C., Duffield G.E., Hastings M.H., Kopp M.D., Dehghani F., Korf H.W., and Stehle J.H. CREB in the mouse SCN: a molecular interface coding the phase-adjusting stimuli light, glutamate, PACAP, and melatonin for clockwork access. J. Neurosci. 15 (1998) 10389-10397
18. von Gall C., Garabette M.L., Kell C.A., Frenzel S., Dehghani F., Schumm-Draeger P.M., Weaver D.R., Korf H.W., Hastings M.H., and Stehle J.H. Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin. Nature Neurosci. 5 (2002) 234-238
19. von Gall C., Weaver D.R., Moek J., Jilg A., Stehle J.H., and Korf H.W. Melatonin plays a crucial role in the regulation of rhythmic clock gene expression in the mouse pars tuberalis. Ann. N.Y. Acad. Sci. 1040 (2005) 508-511