Serine residues 110 and 114 are required for agonist binding but not antagonist binding to the melatonin MT1 receptor

Biochemical and Biophysical Research Communications

Volumn 282, Issue 5, 2001, Pages 1229-1236

  Conway, Shaun ^a   Mowat, Elaine S ^a   Drew, Janice E ^a   Barrett, Perry ^a   Delagrange, Philippe ^b   Morgan, Peter J ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

Agonist; Antagonist; G protein coupled receptor; Ligand binding; Melatonin; MT1 receptor; Site directed mutagenesis; Transmembrane domain 3

Indexed keywords

5 METHOXYTRYPTOPHOL; AGOMELATINE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; HORMONE RECEPTOR STIMULATING AGENT; JAM 09; LUZINDOLE; MELATONIN; MELATONIN RECEPTOR; MELATONIN RECEPTOR BLOCKING AGENT; MELATONIN RECEPTOR STIMULATING AGENT; N ACETYLTRYPTAMINE; PARTIAL AGONIST; S 20642; SERINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HORMONE RECEPTOR INTERACTION; HUMAN; LIGAND BINDING; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

EID: 0034810597     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.4722     Document Type: Article

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