Synthesis of 3-phenylnaphthalenic derivatives as new selective MT2 melatoninergic ligands

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 18, 2008, Pages 8339-8348

  Poissonnier Durieux, Sophie ^a   Ettaoussi, Mohamed ^a   Pérès, Basile ^a   Boutin, Jean A ^b   Audinot, Valérie ^b   Bennejean, Caroline ^c   Delagrange, Philippe ^c   Caignard, Daniel Henri ^c   Renard, Pierre ^c   Berthelot, Pascal ^a   Lesieur, Daniel ^a   Yous, Saïd ^a  

^a UNIV LILLE   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

3 Phenylnaphthalene; Melatonin; MT2 receptors; Selective antagonists

Indexed keywords

3 PHENYLNAPHTHALENE DERIVATIVE; AGOMELATINE; HORMONE ANTAGONIST; MELATONIN 2 RECEPTOR; MELATONIN 2 RECEPTOR ANTAGONIST; N [2 [3 (3 HYDROXYMETHYLPHENYL) 7 METHOXYNAPHTH 1 YL]ETHYL]ACETAMIDE; NAPHTHALENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; REACTION ANALYSIS; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ACETAMIDES; ANIMALS; BINDING SITES; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DESIGN; FURANS; HUMANS; INDOLES; LIGANDS; MELATONIN; NAPHTHALENES; RADIOLIGAND ASSAY; RECEPTOR, MELATONIN, MT2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 51449120935     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.08.052     Document Type: Article

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