-
1
-
-
0030913366
-
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
-
Chun TW, Carruth L, Finzi D, et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature. 1997;387(6629):183-188.
-
(1997)
Nature
, vol.387
, Issue.6629
, pp. 183-188
-
-
Chun, T.W.1
Carruth, L.2
Finzi, D.3
-
2
-
-
14444273439
-
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
-
Finzi D, Hermankova M, Pierson T, et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science. 1997;278(5341):1295-1300.
-
(1997)
Science
, vol.278
, Issue.5341
, pp. 1295-1300
-
-
Finzi, D.1
Hermankova, M.2
Pierson, T.3
-
3
-
-
0032953920
-
Latent infection of CD41 T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
-
Finzi D, Blankson J, Siliciano JD, et al. Latent infection of CD41 T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med. 1999;5(5):512-517.
-
(1999)
Nat Med
, vol.5
, Issue.5
, pp. 512-517
-
-
Finzi, D.1
Blankson, J.2
Siliciano, J.D.3
-
4
-
-
0038579210
-
Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
-
Siliciano JD, Kajdas J, Finzi D, et al. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat Med. 2003;9(6):727-728.
-
(2003)
Nat Med
, vol.9
, Issue.6
, pp. 727-728
-
-
Siliciano, J.D.1
Kajdas, J.2
Finzi, D.3
-
6
-
-
62449222132
-
Incomplete peripheral CD41 cell count restoration in HIV-infected patients receiving long-term antiretroviral treatment
-
Kelley CF, Kitchen CM, Hunt PW, et al. Incomplete peripheral CD41 cell count restoration in HIV-infected patients receiving long-term antiretroviral treatment. Clin Infect Dis. 2009;48(6):787-794.
-
(2009)
Clin Infect Dis
, vol.48
, Issue.6
, pp. 787-794
-
-
Kelley, C.F.1
Kitchen, C.M.2
Hunt, P.W.3
-
8
-
-
84875959697
-
T-cell therapies for HIV
-
Lam S, Bollard C. T-cell therapies for HIV. Immunotherapy. 2013;5(4):407-414.
-
(2013)
Immunotherapy
, vol.5
, Issue.4
, pp. 407-414
-
-
Lam, S.1
Bollard, C.2
-
10
-
-
24944441656
-
Preferential survival of CD4+ T lymphocytes engineered with anti-human immunodeficiency virus (HIV) genes in HIV-infected individuals
-
Morgan RA, Walker R, Carter CS, et al. Preferential survival of CD4+ T lymphocytes engineered with anti-human immunodeficiency virus (HIV) genes in HIV-infected individuals. Hum Gene Ther. 2005;16(9):1065-1074.
-
(2005)
Hum Gene Ther
, vol.16
, Issue.9
, pp. 1065-1074
-
-
Morgan, R.A.1
Walker, R.2
Carter, C.S.3
-
11
-
-
27744605569
-
Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy
-
Li MJ, Kim J, Li S, et al. Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy. Mol Ther. 2005;12(5):900-909.
-
(2005)
Mol Ther
, vol.12
, Issue.5
, pp. 900-909
-
-
Li, M.J.1
Kim, J.2
Li, S.3
-
12
-
-
20844440241
-
Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(1) cells
-
Podsakoff GM, Engel BC, Carbonaro DA, et al. Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(1) cells. Mol Ther. 2005;12(1):77-86.
-
(2005)
Mol Ther
, vol.12
, Issue.1
, pp. 77-86
-
-
Podsakoff, G.M.1
Engel, B.C.2
Carbonaro, D.A.3
-
13
-
-
33751251058
-
Gene transfer in humans using a conditionally replicating lentiviral vector
-
Levine BL, Humeau LM, Boyer J, et al. Gene transfer in humans using a conditionally replicating lentiviral vector. Proc Natl Acad Sci USA. 2006;103(46):17372-17377.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.46
, pp. 17372-17377
-
-
Levine, B.L.1
Humeau, L.M.2
Boyer, J.3
-
14
-
-
34247208235
-
Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus
-
van Lunzen J, Glaunsinger T, Stahmer I, et al. Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus. Mol Ther. 2007;15(5):1024-1033.
-
(2007)
Mol Ther
, vol.15
, Issue.5
, pp. 1024-1033
-
-
Van Lunzen, J.1
Glaunsinger, T.2
Stahmer, I.3
-
15
-
-
62049083710
-
Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD341 cells
-
Mitsuyasu RT, Merigan TC, Carr A, et al. Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD341 cells. Nat Med. 2009;15(3):285-292.
-
(2009)
Nat Med
, vol.15
, Issue.3
, pp. 285-292
-
-
Mitsuyasu, R.T.1
Merigan, T.C.2
Carr, A.3
-
16
-
-
77955608799
-
RNA-based gene therapy for HIV with lentiviral vectormodified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma
-
DiGiusto DL, Krishnan A, Li L, et al. RNA-based gene therapy for HIV with lentiviral vectormodified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma. Sci Transl Med. 2010;2(36):36ra43.
-
(2010)
Sci Transl Med
, vol.2
, Issue.36
-
-
DiGiusto, D.L.1
Krishnan, A.2
Li, L.3
-
17
-
-
33646887376
-
Genotoxicity of retroviral integration in hematopoietic cells
-
Nienhuis AW, Dunbar CE, Sorrentino BP. Genotoxicity of retroviral integration in hematopoietic cells. Mol Ther. 2006;13(6):1031-1049.
-
(2006)
Mol Ther
, vol.13
, Issue.6
, pp. 1031-1049
-
-
Nienhuis, A.W.1
Dunbar, C.E.2
Sorrentino, B.P.3
-
18
-
-
79953844921
-
Genotoxicity of retroviral hematopoietic stem cell gene therapy
-
Trobridge GD. Genotoxicity of retroviral hematopoietic stem cell gene therapy. Expert Opin Biol Ther. 2011;11(5):581-593.
-
(2011)
Expert Opin Biol Ther
, vol.11
, Issue.5
, pp. 581-593
-
-
Trobridge, G.D.1
-
19
-
-
0030812487
-
Homing endonucleases: Keeping the house in order
-
Belfort M, Roberts RJ. Homing endonucleases: keeping the house in order. Nucleic Acids Res. 1997;25(17):3379-3388.
-
(1997)
Nucleic Acids Res
, vol.25
, Issue.17
, pp. 3379-3388
-
-
Belfort, M.1
Roberts, R.J.2
-
20
-
-
84879264708
-
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
-
Gaj T, Gersbach CA, Barbas CF III. ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol. 2013;31(7):397-405.
-
(2013)
Trends Biotechnol
, vol.31
, Issue.7
, pp. 397-405
-
-
Gaj, T.1
Gersbach, C.A.2
Barbas, C.F.3
-
21
-
-
3142768860
-
Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells
-
Saleh-Gohari N, Helleday T. Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells. Nucleic Acids Res. 2004;32(12):3683-3688.
-
(2004)
Nucleic Acids Res
, vol.32
, Issue.12
, pp. 3683-3688
-
-
Saleh-Gohari, N.1
Helleday, T.2
-
22
-
-
84864321774
-
Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase
-
Karanam K, Kafri R, Loewer A, Lahav G. Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase. Mol Cell. 2012;47(2):320-329.
-
(2012)
Mol Cell
, vol.47
, Issue.2
, pp. 320-329
-
-
Karanam, K.1
Kafri, R.2
Loewer, A.3
Lahav, G.4
-
23
-
-
35548939825
-
The epidemiology of HIV coreceptor tropism
-
Hoffmann C. The epidemiology of HIV coreceptor tropism. Eur J Med Res. 2007;12(9):385-390.
-
(2007)
Eur J Med Res
, vol.12
, Issue.9
, pp. 385-390
-
-
Hoffmann, C.1
-
24
-
-
16044373004
-
Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
-
Samson M, Libert F, Doranz BJ, et al. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature. 1996;382(6593):722-725.
-
(1996)
Nature
, vol.382
, Issue.6593
, pp. 722-725
-
-
Samson, M.1
Libert, F.2
Doranz, B.J.3
-
25
-
-
16044367526
-
The role of a mutant CCR5 allele in HIV-1 transmission and disease progression
-
Huang Y, Paxton WA, Wolinsky SM, et al. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med. 1996;2(11):1240-1243.
-
(1996)
Nat Med
, vol.2
, Issue.11
, pp. 1240-1243
-
-
Huang, Y.1
Paxton, W.A.2
Wolinsky, S.M.3
-
26
-
-
15844388931
-
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
-
Liu R, Paxton WA, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell. 1996;86(3):367-377.
-
(1996)
Cell
, vol.86
, Issue.3
, pp. 367-377
-
-
Liu, R.1
Paxton, W.A.2
Choe, S.3
-
27
-
-
60549090253
-
Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation
-
Hütter G, Nowak D, Mossner M, et al. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med. 2009;360(7):692-698.
-
(2009)
N Engl J Med
, vol.360
, Issue.7
, pp. 692-698
-
-
Hütter, G.1
Nowak, D.2
Mossner, M.3
-
28
-
-
79953117041
-
Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation
-
Allers K, Hütter G, Hofmann J, et al. Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation. Blood. 2011;117(10):2791-2799.
-
(2011)
Blood
, vol.117
, Issue.10
, pp. 2791-2799
-
-
Allers, K.1
Hütter, G.2
Hofmann, J.3
-
29
-
-
84877278315
-
Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation
-
Henrich TJ, Hu Z, Li JZ, et al. Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation. J Infect Dis. 2013;207(11):1694-1702.
-
(2013)
J Infect Dis
, vol.207
, Issue.11
, pp. 1694-1702
-
-
Henrich, T.J.1
Hu, Z.2
Li, J.Z.3
-
30
-
-
84900870642
-
HIV eradication-from Berlin to Boston
-
Cannon PM, Kohn DB, Kiem HP. HIV eradication-from Berlin to Boston. Nat Biotechnol. 2014;32(4):315-316.
-
(2014)
Nat Biotechnol
, vol.32
, Issue.4
, pp. 315-316
-
-
Cannon, P.M.1
Kohn, D.B.2
Kiem, H.P.3
-
31
-
-
79953123523
-
Chemokine receptor 5 knockout strategies
-
Cannon P, June C. Chemokine receptor 5 knockout strategies. Curr Opin HIV AIDS. 2011;6(1):74-79.
-
(2011)
Curr Opin HIV AIDS
, vol.6
, Issue.1
, pp. 74-79
-
-
Cannon, P.1
June, C.2
-
32
-
-
0030881882
-
Phenotypic knockout of HIV type 1 chemokine coreceptor CCR-5 by intrakines as potential therapeutic approach for HIV-1 infection
-
Yang AG, Bai X, Huang XF, Yao C, Chen S. Phenotypic knockout of HIV type 1 chemokine coreceptor CCR-5 by intrakines as potential therapeutic approach for HIV-1 infection. Proc Natl Acad Sci USA. 1997;94(21):11567-11572.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, Issue.21
, pp. 11567-11572
-
-
Yang, A.G.1
Bai, X.2
Huang, X.F.3
Yao, C.4
Chen, S.5
-
33
-
-
0034149743
-
Characterization of anti-CCR5 ribozyme-transduced CD34+ hematopoietic progenitor cells in vitro and in a SCID-hu mouse model in vivo
-
Bai J, Gorantla S, Banda N, Cagnon L, Rossi J, Akkina R. Characterization of anti-CCR5 ribozyme-transduced CD34+ hematopoietic progenitor cells in vitro and in a SCID-hu mouse model in vivo. Mol Ther. 2000;1(3):244-254.
-
(2000)
Mol Ther
, vol.1
, Issue.3
, pp. 244-254
-
-
Bai, J.1
Gorantla, S.2
Banda, N.3
Cagnon, L.4
Rossi, J.5
Akkina, R.6
-
34
-
-
8844259701
-
Protecting from R5-tropic HIV: Individual and combined effectiveness of a hammerhead ribozyme and a single-chain Fv antibody that targets CCR5
-
Cordelier P, Kulkowsky JW, Ko C, et al. Protecting from R5-tropic HIV: individual and combined effectiveness of a hammerhead ribozyme and a single-chain Fv antibody that targets CCR5. Gene Ther. 2004;11(22):1627-1637.
-
(2004)
Gene Ther
, vol.11
, Issue.22
, pp. 1627-1637
-
-
Cordelier, P.1
Kulkowsky, J.W.2
Ko, C.3
-
35
-
-
0037422583
-
Inhibiting HIV-1 infection in human T cells by lentiviralmediated delivery of small interfering RNA against CCR5
-
Qin XF, An DS,Chen IS, Baltimore D. Inhibiting HIV-1 infection in human T cells by lentiviralmediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci USA. 2003;100(1):183-188.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.1
, pp. 183-188
-
-
Qin, X.F.1
An, D.S.2
Chen, I.S.3
Baltimore, D.4
-
36
-
-
33845221484
-
HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector
-
Anderson J, Akkina R. HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector. AIDS Res Ther. 2005;2(1):1.
-
(2005)
AIDS Res Ther
, vol.2
, Issue.1
, pp. 1
-
-
Anderson, J.1
Akkina, R.2
-
37
-
-
84928948209
-
Genome editing technologies: Defining a path to clinic
-
Corrigan-Curay J, O'Reilly M, Kohn DB, et al. Genome editing technologies: defining a path to clinic. Mol Ther. 2015;23(5):796-806.
-
(2015)
Mol Ther
, vol.23
, Issue.5
, pp. 796-806
-
-
Corrigan-Curay, J.1
O'Reilly, M.2
Kohn, D.B.3
-
38
-
-
46949095221
-
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
-
Perez EE, Wang J, Miller JC, et al. Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nat Biotechnol. 2008;26(7):808-816.
-
(2008)
Nat Biotechnol
, vol.26
, Issue.7
, pp. 808-816
-
-
Perez, E.E.1
Wang, J.2
Miller, J.C.3
-
39
-
-
78650735673
-
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
-
Holt N, Wang J, Kim K, et al. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol. 2010;28(8):839-847.
-
(2010)
Nat Biotechnol
, vol.28
, Issue.8
, pp. 839-847
-
-
Holt, N.1
Wang, J.2
Kim, K.3
-
40
-
-
84875420616
-
Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV coreceptor CCR5
-
Maier DA, Brennan AL, Jiang S, et al. Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV coreceptor CCR5. Hum Gene Ther. 2013;24(3):245-258.
-
(2013)
Hum Gene Ther
, vol.24
, Issue.3
, pp. 245-258
-
-
Maier, D.A.1
Brennan, A.L.2
Jiang, S.3
-
41
-
-
84895487305
-
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV
-
Tebas P, Stein D, Tang WW, et al. Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N Engl J Med. 2014;370(10):901-910.
-
(2014)
N Engl J Med
, vol.370
, Issue.10
, pp. 901-910
-
-
Tebas, P.1
Stein, D.2
Tang, W.W.3
-
43
-
-
84974531525
-
HIV protected autologous zinc finger nuclease CCR5 modified CD4 cells (SB-728-T) reduce Viral Load (VL) in HIV subjects during treatment interruption (TI): Correlates of effect, and effect of cytoxan conditioning
-
Accessed January 12, 2016
-
Ando D, Lalezari J, Blick G, et al. HIV protected autologous zinc finger nuclease CCR5 modified CD4 cells (SB-728-T) reduce Viral Load (VL) in HIV subjects during treatment interruption (TI): correlates of effect, and effect of cytoxan conditioning. ICAAC 2014. http://www.natap.org/2014/ICAAC/ICAAC-36.htm. Accessed January 12, 2016.
-
ICAAC 2014
-
-
Ando, D.1
Lalezari, J.2
Blick, G.3
-
45
-
-
84923266604
-
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
-
Tsai SQ, Zheng Z, Nguyen NT, et al. GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases. Nat Biotechnol. 2015;33(2):187-197.
-
(2015)
Nat Biotechnol
, vol.33
, Issue.2
, pp. 187-197
-
-
Tsai, S.Q.1
Zheng, Z.2
Nguyen, N.T.3
-
46
-
-
84923275611
-
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
-
Frock RL, Hu J, Meyers RM, Ho YJ, Kii E, Alt FW. Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. Nat Biotechnol. 2015;33(2):179-186.
-
(2015)
Nat Biotechnol
, vol.33
, Issue.2
, pp. 179-186
-
-
Frock, R.L.1
Hu, J.2
Meyers, R.M.3
Ho, Y.J.4
Kii, E.5
Alt, F.W.6
-
47
-
-
0030860210
-
CCR2 chemokine receptor and AIDS progression
-
Smith MW, Carrington M, Winkler C, et al. CCR2 chemokine receptor and AIDS progression. Nat Med. 1997;3(10):1052-1053.
-
(1997)
Nat Med
, vol.3
, Issue.10
, pp. 1052-1053
-
-
Smith, M.W.1
Carrington, M.2
Winkler, C.3
-
48
-
-
84878528467
-
Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases
-
Li L, Krymskaya L, Wang J, et al. Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases. Mol Ther. 2013;21(6):1259-1269.
-
(2013)
Mol Ther
, vol.21
, Issue.6
, pp. 1259-1269
-
-
Li, L.1
Krymskaya, L.2
Wang, J.3
-
49
-
-
84949814888
-
Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors
-
Wang J, Exline CM, DeClercq JJ, et al. Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors. Nat Biotechnol. 2015;33(12):1256-1263.
-
(2015)
Nat Biotechnol
, vol.33
, Issue.12
, pp. 1256-1263
-
-
Wang, J.1
Exline, C.M.2
DeClercq, J.J.3
-
50
-
-
84890350615
-
Pre-clinical modeling of CCR5 knockout in human hematopoietic stem cells by zinc finger nucleases using humanized mice
-
Hofer U, Henley JE, Exline CM, Mulhern O, Lopez E, Cannon PM. Pre-clinical modeling of CCR5 knockout in human hematopoietic stem cells by zinc finger nucleases using humanized mice. J Infect Dis. 2013;208(Suppl 2):S160-S164.
-
(2013)
J Infect Dis.
, vol.208
, pp. S160-S164
-
-
Hofer, U.1
Henley, J.E.2
Exline, C.M.3
Mulhern, O.4
Lopez, E.5
Cannon, P.M.6
-
51
-
-
85002994386
-
Zinc finger nuclease editing of hematopoietic stem cells as an anti-HIV therapy
-
Poluektova LY, Garcia-Martinez JV, Koyanagi Y, Manz MG, Tager AM, eds. New York: Springer
-
Holt N, Exline CM, Mulhern O, et al. Zinc finger nuclease editing of hematopoietic stem cells as an anti-HIV therapy.In: Poluektova LY, Garcia-Martinez JV, Koyanagi Y, Manz MG, Tager AM, eds. Humanized Mice for HIV Research. New York: Springer; 2014:407-416.
-
(2014)
Humanized Mice for HIV Research
, pp. 407-416
-
-
Holt, N.1
Exline, C.M.2
Mulhern, O.3
-
52
-
-
85002949800
-
Electroporation of ZFN mRNA enables efficient CCR5 gene disruption in mobilized blood hematopoietic stem cells at clinical scale
-
Cannon PM, Henley J, Wood T, et al. Electroporation of ZFN mRNA enables efficient CCR5 gene disruption in mobilized blood hematopoietic stem cells at clinical scale. Mol Ther. 2013;21(S1):S71-S72.
-
(2013)
Mol Ther
, vol.21
, Issue.S1
, pp. S71-S72
-
-
Cannon, P.M.1
Henley, J.2
Wood, T.3
-
53
-
-
84902315464
-
Targeted genome editing in human repopulating haematopoietic stem cells
-
Genovese P, Schiroli G, Escobar G, et al. Targeted genome editing in human repopulating haematopoietic stem cells. Nature. 2014;510(7504):235-240.
-
(2014)
Nature
, vol.510
, Issue.7504
, pp. 235-240
-
-
Genovese, P.1
Schiroli, G.2
Escobar, G.3
-
54
-
-
65249102249
-
Hematopoietic and endothelial differentiation of human induced pluripotent stem cells
-
Choi KD, Yu J, Smuga-Otto K, et al. Hematopoietic and endothelial differentiation of human induced pluripotent stem cells. Stem Cells. 2009;27(3):559-567.
-
(2009)
Stem Cells
, vol.27
, Issue.3
, pp. 559-567
-
-
Choi, K.D.1
Yu, J.2
Smuga-Otto, K.3
-
55
-
-
84863116293
-
Generation of CD34+ cells from CCR5-disrupted human embryonic and induced pluripotent stem cells
-
Yao Y, Nashun B, Zhou T, et al. Generation of CD34+ cells from CCR5-disrupted human embryonic and induced pluripotent stem cells. Hum Gene Ther. 2012;23(2):238-242.
-
(2012)
Hum Gene Ther
, vol.23
, Issue.2
, pp. 238-242
-
-
Yao, Y.1
Nashun, B.2
Zhou, T.3
-
56
-
-
84903729497
-
Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection
-
Ye L, Wang J, Beyer AI, et al. Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection. Proc Natl Acad Sci USA. 2014;111(26):9591-9596.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, Issue.26
, pp. 9591-9596
-
-
Ye, L.1
Wang, J.2
Beyer, A.I.3
-
57
-
-
84903212620
-
TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity
-
Mussolino C, Alzubi J, Fine EJ, et al. TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity. Nucleic Acids Res. 2014;42(10):6762-6773.
-
(2014)
Nucleic Acids Res
, vol.42
, Issue.10
, pp. 6762-6773
-
-
Mussolino, C.1
Alzubi, J.2
Fine, E.J.3
-
58
-
-
84942921684
-
Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template
-
Sather BD, Romano Ibarra GS, Sommer K, et al. Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template. Sci Transl Med. 2015;7(307):307ra156.
-
(2015)
Sci Transl Med
, vol.7
, Issue.307
-
-
Sather, B.D.1
Romano Ibarra, G.S.2
Sommer, K.3
-
59
-
-
84922671463
-
Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9
-
Mandal PK, Ferreira LM, Collins R, et al. Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9. Cell Stem Cell. 2014;15(5):643-652.
-
(2014)
Cell Stem Cell
, vol.15
, Issue.5
, pp. 643-652
-
-
Mandal, P.K.1
Ferreira, L.M.2
Collins, R.3
-
60
-
-
84940203001
-
Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9
-
Li C, Guan X, Du T, et al. Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9. J Gen Virol. 2015;96(8):2381-2393.
-
(2015)
J Gen Virol
, vol.96
, Issue.8
, pp. 2381-2393
-
-
Li, C.1
Guan, X.2
Du, T.3
-
61
-
-
84937905397
-
Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells
-
Hendel A, Bak RO, Clark JT, et al. Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells. Nat Biotechnol. 2015;33(9):985-989.
-
(2015)
Nat Biotechnol
, vol.33
, Issue.9
, pp. 985-989
-
-
Hendel, A.1
Bak, R.O.2
Clark, J.T.3
-
62
-
-
0031575431
-
Change in coreceptor use correlates with disease progression in HIV-1-infected individuals
-
Connor RI, Sheridan KE, Ceradini D, Choe S, Landau NR. Change in coreceptor use correlates with disease progression in HIV-1-infected individuals. J Exp Med. 1997;185(4):621-628.
-
(1997)
J Exp Med
, vol.185
, Issue.4
, pp. 621-628
-
-
Connor, R.I.1
Sheridan, K.E.2
Ceradini, D.3
Choe, S.4
Landau, N.R.5
-
63
-
-
0033524834
-
Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
-
Peled A, Petit I, Kollet O, et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science. 1999;283(5403):845-848.
-
(1999)
Science
, vol.283
, Issue.5403
, pp. 845-848
-
-
Peled, A.1
Petit, I.2
Kollet, O.3
-
64
-
-
79955785236
-
Engineering HIV-resistant human CD41 T cells with CXCR4-specific zinc-finger nucleases
-
Wilen CB, Wang J, Tilton JC, et al. Engineering HIV-resistant human CD41 T cells with CXCR4-specific zinc-finger nucleases. PLoS Pathog. 2011;7(4):e1002020.
-
(2011)
PLoS Pathog
, vol.7
, Issue.4
-
-
Wilen, C.B.1
Wang, J.2
Tilton, J.C.3
-
65
-
-
84862777608
-
Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment
-
Yuan J, Wang J, Crain K, et al. Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment. Mol Ther. 2012;20(4):849-859.
-
(2012)
Mol Ther
, vol.20
, Issue.4
, pp. 849-859
-
-
Yuan, J.1
Wang, J.2
Crain, K.3
-
66
-
-
84891772031
-
Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection
-
Didigu CA, Wilen CB, Wang J, et al. Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection. Blood. 2014;123(1):61-69.
-
(2014)
Blood
, vol.123
, Issue.1
, pp. 61-69
-
-
Didigu, C.A.1
Wilen, C.B.2
Wang, J.3
-
67
-
-
84878568502
-
Generation of an HIV resistant T-cell line by targeted "stacking" of restriction factors
-
Voit RA, McMahon MA, Sawyer SL, Porteus MH. Generation of an HIV resistant T-cell line by targeted "stacking" of restriction factors. Mol Ther. 2013;21(4):786-795.
-
(2013)
Mol Ther
, vol.21
, Issue.4
, pp. 786-795
-
-
Voit, R.A.1
McMahon, M.A.2
Sawyer, S.L.3
Porteus, M.H.4
-
69
-
-
1842732157
-
A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion
-
Xu H, Svarovskaia ES, Barr R, et al. A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion. Proc Natl Acad Sci USA. 2004;101(15):5652-5657.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.15
, pp. 5652-5657
-
-
Xu, H.1
Svarovskaia, E.S.2
Barr, R.3
-
70
-
-
11844278251
-
A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restriction
-
Yap MW, Nisole S, Stoye JP. A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restriction. Curr Biol. 2005;15(1):73-78.
-
(2005)
Curr Biol
, vol.15
, Issue.1
, pp. 73-78
-
-
Yap, M.W.1
Nisole, S.2
Stoye, J.P.3
-
71
-
-
67249100279
-
Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion
-
Gupta RK, Hué S, Schaller T, Verschoor E, Pillay D, Towers GJ. Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion. PLoS Pathog. 2009;5(5):e1000443.
-
(2009)
PLoS Pathog
, vol.5
, Issue.5
-
-
Gupta, R.K.1
Hué, S.2
Schaller, T.3
Verschoor, E.4
Pillay, D.5
Towers, G.J.6
-
72
-
-
78650381228
-
Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection
-
Chinn LW, Tang M, Kessing BD, et al. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. J Infect Dis. 2010;202(12):1836-1845.
-
(2010)
J Infect Dis
, vol.202
, Issue.12
, pp. 1836-1845
-
-
Chinn, L.W.1
Tang, M.2
Kessing, B.D.3
-
73
-
-
80053452766
-
Network-based prediction and analysis of HIV dependency factors
-
Murali TM, Dyer MD, Badger D, Tyler BM, Katze MG. Network-based prediction and analysis of HIV dependency factors. PLOS Comput Biol. 2011;7(9):e1002164.
-
(2011)
PLOS Comput Biol
, vol.7
, Issue.9
-
-
Murali, T.M.1
Dyer, M.D.2
Badger, D.3
Tyler, B.M.4
Katze, M.G.5
-
74
-
-
84949753192
-
Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach
-
Cleret-Buhot A, Zhang Y, Planas D, et al. Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach. Retrovirology. 2015;12(1):102.
-
(2015)
Retrovirology
, vol.12
, Issue.1
, pp. 102
-
-
Cleret-Buhot, A.1
Zhang, Y.2
Planas, D.3
-
75
-
-
34548134145
-
A whole-genome association study of major determinants for host control of HIV-1
-
Fellay J, Shianna KV, Ge D, et al. A whole-genome association study of major determinants for host control of HIV-1. Science. 2007; 317(5840):944-947.
-
(2007)
Science
, vol.317
, Issue.5840
, pp. 944-947
-
-
Fellay, J.1
Shianna, K.V.2
Ge, D.3
-
76
-
-
35948946526
-
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
-
Lombardo A, Genovese P, Beausejour CM, et al. Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nat Biotechnol. 2007;25(11):1298-1306.
-
(2007)
Nat Biotechnol
, vol.25
, Issue.11
, pp. 1298-1306
-
-
Lombardo, A.1
Genovese, P.2
Beausejour, C.M.3
-
77
-
-
84898046908
-
Quantifying genome-editing outcomes at endogenous loci with SMRT sequencing
-
Hendel A, Kildebeck EJ, Fine EJ, et al. Quantifying genome-editing outcomes at endogenous loci with SMRT sequencing. Cell Reports. 2014;7(1):293-305.
-
(2014)
Cell Reports
, vol.7
, Issue.1
, pp. 293-305
-
-
Hendel, A.1
Kildebeck, E.J.2
Fine, E.J.3
-
78
-
-
18944373328
-
Highly efficient endogenous human gene correction using designed zinc-finger nucleases
-
Urnov FD, Miller JC, Lee YL, et al. Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature. 2005;435(7042):646-651.
-
(2005)
Nature
, vol.435
, Issue.7042
, pp. 646-651
-
-
Urnov, F.D.1
Miller, J.C.2
Lee, Y.L.3
-
79
-
-
0347086143
-
In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning
-
Zielske SP, Reese JS, Lingas KT, Donze JR, Gerson SL. In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning. J Clin Invest. 2003;112(10):1561-1570.
-
(2003)
J Clin Invest
, vol.112
, Issue.10
, pp. 1561-1570
-
-
Zielske, S.P.1
Reese, J.S.2
Lingas, K.T.3
Donze, J.R.4
Gerson, S.L.5
-
80
-
-
1342290228
-
In vivo selection for human and murine hematopoietic cells transduced with a therapeutic MGMT lentiviral vector that inhibits HIV replication
-
Davis BM, Humeau L, Dropulic B. In vivo selection for human and murine hematopoietic cells transduced with a therapeutic MGMT lentiviral vector that inhibits HIV replication. Mol Ther. 2004;9(2):160-172.
-
(2004)
Mol Ther
, vol.9
, Issue.2
, pp. 160-172
-
-
Davis, B.M.1
Humeau, L.2
Dropulic, B.3
-
81
-
-
34347398120
-
HIV-1 proviral DNA excision using an evolved recombinase
-
Sarkar I, Hauber I, Hauber J, Buchholz F. HIV-1 proviral DNA excision using an evolved recombinase. Science. 2007;316(5833):1912-1915.
-
(2007)
Science
, vol.316
, Issue.5833
, pp. 1912-1915
-
-
Sarkar, I.1
Hauber, I.2
Hauber, J.3
Buchholz, F.4
-
82
-
-
84953243844
-
Universal Tre (uTre) recombinase specifically targets the majority of HIV-1 isolates
-
Karpinski J, Chemnitz J, Hauber I, et al. Universal Tre (uTre) recombinase specifically targets the majority of HIV-1 isolates. J Int AIDS Soc. 2014;17(4 Suppl 3):19706.
-
(2014)
J Int AIDS Soc
, vol.17
, Issue.4
-
-
Karpinski, J.1
Chemnitz, J.2
Hauber, I.3
-
83
-
-
84885008722
-
Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells
-
Qu X, Wang P, Ding D, et al. Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells. Nucleic Acids Res. 2013;41(16):7771-7782.
-
(2013)
Nucleic Acids Res
, vol.41
, Issue.16
, pp. 7771-7782
-
-
Qu, X.1
Wang, P.2
Ding, D.3
-
84
-
-
84883305437
-
Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus
-
Ebina H, Misawa N, Kanemura Y, Koyanagi Y. Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus. Sci Rep. 2013;3:2510.
-
(2013)
Sci Rep
, vol.3
, pp. 2510
-
-
Ebina, H.1
Misawa, N.2
Kanemura, Y.3
Koyanagi, Y.4
-
85
-
-
84905643812
-
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
-
Hu W, Kaminski R, Yang F, et al. RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection. Proc Natl Acad Sci USA. 2014;111(31):11461-11466.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, Issue.31
, pp. 11461-11466
-
-
Hu, W.1
Kaminski, R.2
Yang, F.3
-
86
-
-
84928739868
-
The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA
-
Zhu W, Lei R, Le Duff Y, et al. The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA. Retrovirology. 2015;12:22.
-
(2015)
Retrovirology
, vol.12
, pp. 22
-
-
Zhu, W.1
Lei, R.2
Le Duff, Y.3
-
87
-
-
84924943941
-
A high excision potential of TALENs for integrated DNA of HIV-based lentiviral vector
-
Ebina H, Kanemura Y, Misawa N, et al. A high excision potential of TALENs for integrated DNA of HIV-based lentiviral vector. PLoS One. 2015;10(3):e0120047.
-
(2015)
PLoS One
, vol.10
, Issue.3
-
-
Ebina, H.1
Kanemura, Y.2
Misawa, N.3
-
88
-
-
79951783813
-
Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI
-
Aubert M, Ryu BY, Banks L, Rawlings DJ, Scharenberg AM, Jerome KR. Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI. PLoS One. 2011;6(2):e16825.
-
(2011)
PLoS One
, vol.6
, Issue.2
-
-
Aubert, M.1
Ryu, B.Y.2
Banks, L.3
Rawlings, D.J.4
Scharenberg, A.M.5
Jerome, K.R.6
-
89
-
-
84939830659
-
Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors
-
Münch RC, Muth A, Muik A, et al. Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors. Nat Commun. 2015;6:6246.
-
(2015)
Nat Commun
, vol.6
, pp. 6246
-
-
Münch, R.C.1
Muth, A.2
Muik, A.3
-
90
-
-
84940105412
-
Exclusive transduction of human CD4+ T cells upon systemic delivery of CD4-targeted lentiviral vectors
-
Zhou Q, Uhlig KM, MuthA, et al. Exclusive transduction of human CD4+ T cells upon systemic delivery of CD4-targeted lentiviral vectors. J Immunol. 2015;195(5):2493-2501.
-
(2015)
J Immunol
, vol.195
, Issue.5
, pp. 2493-2501
-
-
Zhou, Q.1
Uhlig, K.M.2
Muth, A.3
|