Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9

Cell Stem Cell

Volumn 15, Issue 5, 2014, Pages 643-652

  Mandal, Pankaj K ^a,b   Ferreira, Leonardo M R ^a,c   Collins, Ryan ^d   Meissner, Torsten B ^a   Boutwell, Christian L ^e   Friesen, Max ^a   Vrbanac, Vladimir ^d,e   Garrison, Brian S ^a,b,f   Stortchevoi, Alexei ^d   Bryder, David ^g   Musunuru, Kiran ^a,h,i,j   Brand, Harrison ^d   Tager, Andrew M ^d,e   Allen, Todd M ^e   Talkowski, Michael E ^d,f,j   Rossi, Derrick J ^a,b,f,h   Cowan, Chad A ^a,h,j,k  

^a Harvard University   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD UNIVERSITY   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

^g LUND UNIVERSITY   (Sweden)

^h HARVARD STEM CELL INSTITUTE   (United States)

ⁱ BRIGHAM AND WOMEN S HOSPITAL   (United States)

^j BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^k MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CHEMOKINE RECEPTOR CCR5; CCR5 PROTEIN, HUMAN; CD34 ANTIGEN; CRISPR ASSOCIATED PROTEIN; GUIDE RNA;

ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CRISPR CAS SYSTEM; CRISPR CAS9 SYSTEM; DNA END JOINING REPAIR; EFFECTOR CELL; GENE DELETION; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; MUTAGENESIS; MUTATION RATE; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; ANIMAL; CELL CULTURE; CELL LINEAGE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CYTOLOGY; GENE LOCUS; GENE TARGETING; GENETICS; HIGH THROUGHPUT SEQUENCING; HUMAN GENOME; METABOLISM; MOUSE; RNA EDITING;

ANIMALS; ANTIGENS, CD34; CELL LINEAGE; CELLS, CULTURED; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEINS; GENE DELETION; GENE TARGETING; GENETIC LOCI; GENOME, HUMAN; HEMATOPOIETIC STEM CELLS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MICE; RECEPTORS, CCR5; RNA EDITING; RNA, GUIDE;

EID: 84922671463     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2014.10.004     Document Type: Article

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