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Volumn 5, Issue 4, 2013, Pages 407-414

T-cell therapies for HIV

Author keywords

adoptive T cell therapy; adoptive T cell transfer; antiretroviral therapy; ART; CAR; chimeric antigen receptor; zinc finger nuclease

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CHIMERIC ANTIGEN RECEPTOR; CHIMERIC PROTEIN; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

EID: 84875959697     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.13.23     Document Type: Review
Times cited : (36)

References (50)
  • 1
    • 33749514632 scopus 로고    scopus 로고
    • Monoculturederived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals
    • Leen AM, Myers GD, Sili U et al. Monoculturederived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. Nat. Med. 12(10), 1160-1166 (2006).
    • (2006) Nat. Med. , vol.12 , Issue.10 , pp. 1160-1166
    • Leen, A.M.1    Myers, G.D.2    Sili, U.3
  • 2
    • 0028969816 scopus 로고
    • Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression
    • Koenig S, Conley AJ, Brewah YA et al. Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression. Nat. Med. 1(4), 330-336 (1995).
    • (1995) Nat. Med. , vol.1 , Issue.4 , pp. 330-336
    • Koenig, S.1    Conley, A.J.2    Brewah, Y.A.3
  • 3
    • 0030854210 scopus 로고    scopus 로고
    • Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients
    • Lieberman J, Skolnik PR, Parkerson GR 3rd et al. Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)- specific cytotoxic T-lymphocyte infusion in HIV-infected patients. Blood 90(6), 2196-2206 (1997).
    • (1997) Blood , vol.90 , Issue.6 , pp. 2196-2206
    • Lieberman, J.1    Skolnik, P.R.2    Parkerson III, G.R.3
  • 5
    • 0023239322 scopus 로고
    • HIV-specific cytotoxic T lymphocytes in seropositive individuals
    • Walker BD, Chakrabarti S, Moss B et al. HIV-specific cytotoxic T lymphocytes in seropositive individuals. Nature 328(6128), 345-348 (1987).
    • (1987) Nature , vol.328 , Issue.6128 , pp. 345-348
    • Walker, B.D.1    Chakrabarti, S.2    Moss, B.3
  • 6
    • 0028337166 scopus 로고
    • Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
    • Koup RA, Safrit JT, Cao Y et al. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68(7), 4650-4655 (1994).
    • (1994) J. Virol. , vol.68 , Issue.7 , pp. 4650-4655
    • Koup, R.A.1    Safrit, J.T.2    Cao, Y.3
  • 8
    • 0342577762 scopus 로고    scopus 로고
    • CD8(+)-cell antiviral factor activity is not restricted to human immunodeficiency virus (HIV)-specific T cells and can block HIV replication after initiation of reverse transcription
    • Le Borgne S, Fevrier M, Callebaut C, Lee SP, Riviere Y. CD8(+)-cell antiviral factor activity is not restricted to human immunodeficiency virus (HIV)-specific T cells and can block HIV replication after initiation of reverse transcription. J. Virol. 74(10), 4456-4464 (2000).
    • (2000) J. Virol. , vol.74 , Issue.10 , pp. 4456-4464
    • Le Borgne, S.1    Fevrier, M.2    Callebaut, C.3    Lee, S.P.4    Riviere, Y.5
  • 9
    • 34249852256 scopus 로고    scopus 로고
    • HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
    • Saez-Cirion A, Lacabaratz C, Lambotte O et al. HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype. Proc. Natl Acad. Sci. USA 104(16), 6776-6781 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.16 , pp. 6776-6781
    • Saez-Cirion, A.1    Lacabaratz, C.2    Lambotte, O.3
  • 11
    • 33847667461 scopus 로고    scopus 로고
    • Suppression of HIVspecific T cell activity by lymph node CD25+ regulatory T cells from HIV-infected individuals
    • Kinter A, Mcnally J, Riggin L, Jackson R, Roby G, Fauci AS. Suppression of HIVspecific T cell activity by lymph node CD25+ regulatory T cells from HIV-infected individuals. Proc. Natl Acad. Sci. USA 104(9), 3390-3395 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.9 , pp. 3390-3395
    • Kinter, A.1    Mcnally, J.2    Riggin, L.3    Jackson, R.4    Roby, G.5    Fauci, A.S.6
  • 12
    • 67449147145 scopus 로고    scopus 로고
    • The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
    • Goonetilleke N, Liu MK, Salazar-Gonzalez JF et al. The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. J. Exp. Med. 206(6), 1253-1272 (2009).
    • (2009) J. Exp. Med. , vol.206 , Issue.6 , pp. 1253-1272
    • Goonetilleke, N.1    Liu, M.K.2    Salazar-Gonzalez, J.F.3
  • 13
    • 0037302428 scopus 로고    scopus 로고
    • Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load
    • Addo MM, Yu XG, Rathod A et al. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol. 77(3), 2081-2092 (2003).
    • (2003) J. Virol. , vol.77 , Issue.3 , pp. 2081-2092
    • Addo, M.M.1    Yu, X.G.2    Rathod, A.3
  • 14
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    • Day CL, Kaufmann DE, Kiepiela P et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 443(7109), 350-354 (2006).
    • (2006) Nature , vol.443 , Issue.7109 , pp. 350-354
    • Day, C.L.1    Kaufmann, D.E.2    Kiepiela, P.3
  • 15
    • 62749177486 scopus 로고    scopus 로고
    • HLA-B57/B.*5801 human immunodeficiency virus type 1 elite controllers select for rare Gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition
    • Miura T, Brockman MA, Schneidewind A et al. HLA-B57/B.*5801 human immunodeficiency virus type 1 elite controllers select for rare Gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition. J. Virol. 83(6), 2743-2755 (2009).
    • (2009) J. Virol. , vol.83 , Issue.6 , pp. 2743-2755
    • Miura, T.1    Brockman, M.A.2    Schneidewind, A.3
  • 16
    • 84864020166 scopus 로고    scopus 로고
    • Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses
    • Ndhlovu ZM, Proudfoot J, Cesa K et al. Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses. J. Virol. 86(12), 6959-6969 (2012).
    • (2012) J. Virol. , vol.86 , Issue.12 , pp. 6959-6969
    • Ndhlovu, Z.M.1    Proudfoot, J.2    Cesa, K.3
  • 17
    • 0032941595 scopus 로고    scopus 로고
    • HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression
    • Pitcher CJ, Quittner C, Peterson DM et al. HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression. Nat. Med. 5(5), 518-525 (1999).
    • (1999) Nat. Med. , vol.5 , Issue.5 , pp. 518-525
    • Pitcher, C.J.1    Quittner, C.2    Peterson, D.M.3
  • 18
    • 0033554677 scopus 로고    scopus 로고
    • Dual personality of memory T cells
    • Mackay CR. Dual personality of memory T cells. Nature 401(6754), 659-660 (1999).
    • (1999) Nature , vol.401 , Issue.6754 , pp. 659-660
    • Mackay, C.R.1
  • 19
    • 77957305203 scopus 로고    scopus 로고
    • Adverse events following infusion of T cells for adoptive immunotherapy: A 10-year experience
    • Cruz CR, Hanley PJ, Liu H et al. Adverse events following infusion of T cells for adoptive immunotherapy: A 10-year experience. Cytotherapy 12(6), 743-749 (2010).
    • (2010) Cytotherapy , vol.12 , Issue.6 , pp. 743-749
    • Cruz, C.R.1    Hanley, P.J.2    Liu, H.3
  • 20
    • 77649221824 scopus 로고    scopus 로고
    • Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients
    • Heslop HE, Slobod KS, Pule MA et al. Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients. Blood 115(5), 925-935 (2010).
    • (2010) Blood , vol.115 , Issue.5 , pp. 925-935
    • Heslop, H.E.1    Slobod, K.S.2    Pule, M.A.3
  • 21
    • 0033635471 scopus 로고    scopus 로고
    • HIV-1 can be recovered from a variety of cells including peripheral blood monocytes of patients receiving highly active antiretroviral therapy: A further obstacle to eradication
    • Crowe SM, Sonza S. HIV-1 can be recovered from a variety of cells including peripheral blood monocytes of patients receiving highly active antiretroviral therapy: A further obstacle to eradication. J. Leukocyte Biol. 68(3), 345-350 (2000).
    • (2000) J. Leukocyte Biol. , vol.68 , Issue.3 , pp. 345-350
    • Crowe, S.M.1    Sonza, S.2
  • 22
    • 80455162464 scopus 로고    scopus 로고
    • Inducible apoptosis as a safety switch for adoptive cell therapy
    • Di Stasi A, Tey SK, Dotti G et al. Inducible apoptosis as a safety switch for adoptive cell therapy. N. Engl. J. Med. 365(18), 1673-1683 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , Issue.18 , pp. 1673-1683
    • Di Stasi, A.1    Tey, S.K.2    Dotti, G.3
  • 23
    • 0033151621 scopus 로고    scopus 로고
    • The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
    • Cohen GB, Gandhi RT, Davis DM et al. The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity 10(6), 661-671 (1999).
    • (1999) Immunity , vol.10 , Issue.6 , pp. 661-671
    • Cohen, G.B.1    Gandhi, R.T.2    Davis, D.M.3
  • 24
    • 0036231461 scopus 로고    scopus 로고
    • Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes
    • Lundquist CA, Tobiume M, Zhou J, Unutmaz D, Aiken C. Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. J. Virol. 76(9), 4625-4633 (2002).
    • (2002) J. Virol. , vol.76 , Issue.9 , pp. 4625-4633
    • Lundquist, C.A.1    Tobiume, M.2    Zhou, J.3    Unutmaz, D.4    Aiken, C.5
  • 25
    • 80055017715 scopus 로고    scopus 로고
    • Fitness costs and diversity of the cytotoxic T lymphocyte (CTL) response determine the rate of CTL escape during acute and chronic phases of HIV infection
    • Ganusov VV, Goonetilleke N, Liu MK et al. Fitness costs and diversity of the cytotoxic T lymphocyte (CTL) response determine the rate of CTL escape during acute and chronic phases of HIV infection. J. Virol. 85(20), 10518-10528 (2011).
    • (2011) J. Virol. , vol.85 , Issue.20 , pp. 10518-10528
    • Ganusov, V.V.1    Goonetilleke, N.2    Liu, M.K.3
  • 26
    • 57349118383 scopus 로고    scopus 로고
    • Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor
    • Varela-Rohena A, Molloy PE, Dunn SM et al. Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor. Nat. Med. 14(12), 1390-1395 (2008).
    • (2008) Nat. Med. , vol.14 , Issue.12 , pp. 1390-1395
    • Varela-Rohena, A.1    Molloy, P.E.2    Dunn, S.M.3
  • 27
    • 0034254611 scopus 로고    scopus 로고
    • Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta genemodified autologous CD4(+) and CD8(+)T cells in human immunodeficiency virusinfected subjects
    • Mitsuyasu RT, Anton PA, Deeks SG et al. Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta genemodified autologous CD4(+) and CD8(+)T cells in human immunodeficiency virusinfected subjects. Blood 96(3), 785-793 (2000).
    • (2000) Blood , vol.96 , Issue.3 , pp. 785-793
    • Mitsuyasu, R.T.1    Anton, P.A.2    Deeks, S.G.3
  • 28
    • 0035989039 scopus 로고    scopus 로고
    • A Phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy
    • Deeks SG, Wagner B, Anton PA et al. A Phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy. Mol. Ther. 5(6), 788-797 (2002).
    • (2002) Mol. Ther. , vol.5 , Issue.6 , pp. 788-797
    • Deeks, S.G.1    Wagner, B.2    Anton, P.A.3
  • 29
    • 84860718270 scopus 로고    scopus 로고
    • Decade-long safety and function of retroviralmodified chimeric antigen receptor T cells
    • Scholler J, Brady TL, Binder-Scholl G et al. Decade-long safety and function of retroviralmodified chimeric antigen receptor T cells. Sci. Transl. Med. 4(132), 132ra153 (2012).
    • (2012) Sci. Transl. Med. , vol.4 , Issue.132
    • Scholler, J.1    Brady, T.L.2    Binder-Scholl, G.3
  • 30
    • 77950501752 scopus 로고    scopus 로고
    • Safer cars
    • Heslop HE. Safer CARS. Mol. Ther. 18(4), 661-662 (2010).
    • (2010) Mol. Ther. , vol.18 , Issue.4 , pp. 661-662
    • Heslop, H.E.1
  • 31
    • 41149180867 scopus 로고    scopus 로고
    • Efficient in vitro expansion of human immunodeficiency virus (HIV)-specific T-cell responses by Gag mRNA-electroporated dendritic cells from treated and untreated HIV type 1-infected individuals
    • Van Gulck ER, Vanham G, Heyndrickx L et al. Efficient in vitro expansion of human immunodeficiency virus (HIV)-specific T-cell responses by Gag mRNA-electroporated dendritic cells from treated and untreated HIV type 1-infected individuals. J. Virol. 82(7), 3561-3573 (2008).
    • (2008) J. Virol. , vol.82 , Issue.7 , pp. 3561-3573
    • Van Gulck, E.R.1    Vanham, G.2    Heyndrickx, L.3
  • 32
    • 84866169745 scopus 로고    scopus 로고
    • Expansion of polyfunctional HIV-specific T cells upon stimulation with mRNA electroporated dendritic cells in the presence of immunomodulatory drugs
    • De Keersmaecker B, Allard SD, Lacor P, Schots R, Thielemans K, Aerts JL. Expansion of polyfunctional HIV-specific T cells upon stimulation with mRNA electroporated dendritic cells in the presence of immunomodulatory drugs. J. Virol. 86(17), 9351-9360 (2012).
    • (2012) J. Virol. , vol.86 , Issue.17 , pp. 9351-9360
    • De Keersmaecker, B.1    Allard, S.D.2    Lacor, P.3    Schots, R.4    Thielemans, K.5    Aerts, J.L.6
  • 33
    • 38149117105 scopus 로고    scopus 로고
    • Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates
    • Berger C, Jensen MC, Lansdorp PM, Gough M, Elliott C, Riddell SR. Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. J. Clin. Invest. 118(1), 294-305 (2008).
    • (2008) J. Clin. Invest. , vol.118 , Issue.1 , pp. 294-305
    • Berger, C.1    Jensen, M.C.2    Lansdorp, P.M.3    Gough, M.4    Elliott, C.5    Riddell, S.R.6
  • 34
    • 79956338434 scopus 로고    scopus 로고
    • HIV-specific CD8+ T cells from HIV+ individuals receiving HAART can be expanded ex vivo to augment systemic and mucosal immunity in vivo
    • Chapuis AG, Casper C, Kuntz S et al. HIV-specific CD8+ T cells from HIV+ individuals receiving HAART can be expanded ex vivo to augment systemic and mucosal immunity in vivo. Blood 117(20), 5391-5402 (2011).
    • (2011) Blood , vol.117 , Issue.20 , pp. 5391-5402
    • Chapuis, A.G.1    Casper, C.2    Kuntz, S.3
  • 35
    • 57449099756 scopus 로고    scopus 로고
    • Increased levels of regulatory T cells (Tregs) in human immunodeficiency virus-infected patients after 5 years of highly active anti-retroviral therapy may be due to increased thymic production of naive Tregs
    • Kolte L, Gaardbo JC, Skogstrand K, Ryder LP, Ersboll AK, Nielsen SD. Increased levels of regulatory T cells (Tregs) in human immunodeficiency virus-infected patients after 5 years of highly active anti-retroviral therapy may be due to increased thymic production of naive Tregs. Clin. Exp. Immunol. 155(1), 44-52 (2009).
    • (2009) Clin. Exp. Immunol. , vol.155 , Issue.1 , pp. 44-52
    • Kolte, L.1    Gaardbo, J.C.2    Skogstrand, K.3    Ryder, L.P.4    Ersboll, A.K.5    Nielsen, S.D.6
  • 36
    • 84867079698 scopus 로고    scopus 로고
    • PD-1/PD-L1 blockade can enhance HIV-1 Gag-specific T cell immunity elicited by dendritic cell-directed lentiviral vaccines
    • Dai B, Xiao L, Bryson PD, Fang J, Wang P. PD-1/PD-L1 blockade can enhance HIV-1 Gag-specific T cell immunity elicited by dendritic cell-directed lentiviral vaccines. Mol. Ther. 20(9), 1800-1809 (2012).
    • (2012) Mol. Ther. , vol.20 , Issue.9 , pp. 1800-1809
    • Dai, B.1    Xiao, L.2    Bryson, P.D.3    Fang, J.4    Wang, P.5
  • 37
    • 77954899030 scopus 로고    scopus 로고
    • Phase I study of single-agent antiprogrammed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer JR, Drake CG, Wollner I et al. Phase I study of single-agent antiprogrammed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates. J. Clin. Oncol. 28(19), 3167-3175 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.19 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 38
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366(26), 2455-2465 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 39
    • 84860342004 scopus 로고    scopus 로고
    • From crucial to negligible: Functional CD8(+)T-cell responses and their dependence on CD4(+)T-cell help
    • Wiesel M, Oxenius A. From crucial to negligible: Functional CD8(+) T-cell responses and their dependence on CD4(+)T-cell help. Eur. J. Immunol. 42(5), 1080-1088 (2012).
    • (2012) Eur. J. Immunol. , vol.42 , Issue.5 , pp. 1080-1088
    • Wiesel, M.1    Oxenius, A.2
  • 40
    • 78049414117 scopus 로고    scopus 로고
    • Multiple roles of CD4 and CD8 in T cell activation
    • Koretzky GA. Multiple roles of CD4 and CD8 in T cell activation. J. Immunol. 185(5), 2643-2644 (2010).
    • (2010) J. Immunol. , vol.185 , Issue.5 , pp. 2643-2644
    • Koretzky, G.A.1
  • 41
    • 60549090253 scopus 로고    scopus 로고
    • Longterm control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation
    • Hutter G, Nowak D, Mossner M et al. Longterm control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N. Engl. J. Med. 360(7), 692-698 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , Issue.7 , pp. 692-698
    • Hutter, G.1    Nowak, D.2    Mossner, M.3
  • 42
    • 79953123523 scopus 로고    scopus 로고
    • Chemokine receptor 5 knockout strategies
    • Cannon P, June C. Chemokine receptor 5 knockout strategies. Curr. Opin. HIV AIDS 6(1), 74-79 (2011).
    • (2011) Curr. Opin. HIV AIDS , vol.6 , Issue.1 , pp. 74-79
    • Cannon, P.1    June, C.2
  • 43
    • 70349683000 scopus 로고    scopus 로고
    • Specific transduction of HIV-susceptible cells for CCR5 knockdown and resistance to HIV infection: A novel method for targeted gene therapy and intracellular immunization
    • Anderson JS, Walker J, Nolta JA, Bauer G. Specific transduction of HIV-susceptible cells for CCR5 knockdown and resistance to HIV infection: A novel method for targeted gene therapy and intracellular immunization. J. Acquir. Immune Defic. Syndr. 52(2), 152-161 (2009).
    • (2009) J. Acquir. Immune Defic. Syndr. , vol.52 , Issue.2 , pp. 152-161
    • Anderson, J.S.1    Walker, J.2    Nolta, J.A.3    Bauer, G.4
  • 44
    • 76349095131 scopus 로고    scopus 로고
    • RNAimediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice
    • Kim SS, Peer D, Kumar P et al. RNAimediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice. Mol. Ther. 18(2), 370-376 (2010).
    • (2010) Mol. Ther. , vol.18 , Issue.2 , pp. 370-376
    • Kim, S.S.1    Peer, D.2    Kumar, P.3
  • 45
    • 84862777608 scopus 로고    scopus 로고
    • Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment
    • Yuan J, Wang J, Crain K et al. Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment. Mol. Ther. 20(4), 849-859 (2012).
    • (2012) Mol. Ther. , vol.20 , Issue.4 , pp. 849-859
    • Yuan, J.1    Wang, J.2    Crain, K.3
  • 46
    • 73849124989 scopus 로고    scopus 로고
    • Preintegration HIV-1 inhibition by a combination lentiviral vector containing a chimeric TRIM5 alpha protein a CCR5 shRNA, and a TAR decoy
    • Anderson JS, Javien J, Nolta JA, Bauer G. Preintegration HIV-1 inhibition by a combination lentiviral vector containing a chimeric TRIM5 alpha protein, a CCR5 shRNA, and a TAR decoy. Mol. Ther. 17(12), 2103-2114 (2009).
    • (2009) Mol. Ther. , vol.17 , Issue.12 , pp. 2103-2114
    • Anderson, J.S.1    Javien, J.2    Nolta, J.A.3    Bauer, G.4
  • 47
    • 84875917260 scopus 로고    scopus 로고
    • of-haart 102 Redirected high affinity Gag-specific autologous T cells for HIV gene therapy. www.clinicaltrials.gov/ct2/show/ NCT00991224
    • Pritchard J. The side effects of HAART (2010). www.livestrong.com/ article/249257-the-sideeffects- of-haart 102 Redirected high affinity Gag-specific autologous T cells for HIV gene therapy. www.clinicaltrials.gov/ ct2/show/ NCT00991224
    • (2010) Side effects of haart
    • Pritchard, J.1
  • 50
    • 84875938557 scopus 로고    scopus 로고
    • Medco Health Solutions 2012 www.clinicaltrials.gov/ct2/show/NCT00711035 Most closely HLA-matched allogeneic irus specific cytotoxic T-lymphocytes (CTL) (CHALLAH).
    • Medco Health Solutions. CCR5 tropism testing for Maraviroc (2004-2012). www.medco.com/medco/corporate/home. jsp?ltSess=y&articleID=CorpPM-Maraviroc 107 Most closely HLA-matched allogeneic irus specific cytotoxic T-lymphocytes (CTL) (CHALLAH). www.clinicaltrials.gov/ct2/show/ NCT00711035
    • CCR5 Tropism Testing For Maraviroc (2004-2012)


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