Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4 T cell resistance and enrichment

Molecular Therapy

Volumn 20, Issue 4, 2012, Pages 849-859

  Yuan, Jinyun ^a   Wang, Jianbin ^b   Crain, Karen ^a   Fearns, Colleen ^a   Kim, Kenneth A ^b   Hua, Kevin L ^b   Gregory, Philip D ^b   Holmes, Michael C ^b   Torbett, Bruce E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SANGAMO BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; LENTIVIRUS VECTOR; SHORT HAIRPIN RNA; ZINC FINGER PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CELL SURVIVAL; CELLULAR IMMUNITY; CONTROLLED STUDY; CXCR4 GENE; ENRICHMENT CULTURE; GENE; GENE DISRUPTION; GENE FREQUENCY; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNITY; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; SIGNAL TRANSDUCTION; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS; MUS;

EID: 84862777608     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2011.310     Document Type: Article

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