Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection

Blood

Volumn 123, Issue 1, 2014, Pages 61-69

  Didigu, Chuka A ^a   Wilen, Craig B ^a   Wang, Jianbin ^b   Duong, Jennifer ^b   Secreto, Anthony J ^a   Danet Desnoyers, Gwenn A ^a   Riley, James L ^c   Gregory, Phillip D ^b   June, Carl H ^c   Holmes, Michael C ^b   Doms, Robert W ^a,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b SANGAMO BIOSCIENCES INC   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; ZINC FINGER NUCLEASE; CCR5 PROTEIN, HUMAN; CHEMOKINE RECEPTOR; CXCR4 PROTEIN, HUMAN; DEOXYRIBONUCLEASE; ZINC FINGER PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELL GROWTH; CELL PROTECTION; CELL SURVIVAL; CELL TRANSPLANTATION; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; DNA MODIFICATION; ENGRAFTMENT; FLOW CYTOMETRY; GENE DISRUPTION; GENE INACTIVATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; MEMORY CELL; MOUSE; NONHUMAN; POSITION WEIGHT MATRIX; PRIMARY CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; VIRUS ATTACHMENT; VIRUS REPLICATION; ANIMAL; CELL PROLIFERATION; CELL STRAIN HEK293; CYTOLOGY; FEMALE; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; MALE; METABOLISM; VIROLOGY;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; ENDODEOXYRIBONUCLEASES; FEMALE; HEK293 CELLS; HIV INFECTIONS; HIV-1; HUMANS; MALE; MICE; RECEPTORS, CCR5; RECEPTORS, CHEMOKINE; RECEPTORS, CXCR4; ZINC FINGERS;

EID: 84891772031     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-08-521229     Document Type: Article

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