-
1
-
-
0032953192
-
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
-
K. Itoh, N. Wakabayashi, Y. Katoh, T. Ishii, K. Igarashi, J.D. Engel, and M. Yamamoto Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain Genes Dev 13 1999 76 86
-
(1999)
Genes Dev
, vol.13
, pp. 76-86
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
Ishii, T.4
Igarashi, K.5
Engel, J.D.6
Yamamoto, M.7
-
2
-
-
77956915802
-
When Nrf2 talks, who's listening?
-
N. Wakabayashi, S.L. Slocum, J.J. Skoko, S. Shin, and T.W. Kensler When Nrf2 talks, who's listening? Antioxidants & redox signaling 13 2010 1649 1663
-
(2010)
Antioxidants & Redox Signaling
, vol.13
, pp. 1649-1663
-
-
Wakabayashi, N.1
Slocum, S.L.2
Skoko, J.J.3
Shin, S.4
Kensler, T.W.5
-
3
-
-
33644649421
-
Nrf2: A potential molecular target for cancer chemoprevention by natural compounds
-
W.S. Jeong, M. Jun, and A.N. Kong Nrf2: a potential molecular target for cancer chemoprevention by natural compounds Antioxidants & redox signaling 8 2006 99 106
-
(2006)
Antioxidants & Redox Signaling
, vol.8
, pp. 99-106
-
-
Jeong, W.S.1
Jun, M.2
Kong, A.N.3
-
4
-
-
63549121490
-
Nrf2 and Keap1 mutations: Permanent activation of an adaptive response in cancer
-
J.D. Hayes, and M. McMahon Nrf2 and Keap1 mutations: permanent activation of an adaptive response in cancer Trends in biochemical sciences 34 2009 176 188
-
(2009)
Trends in Biochemical Sciences
, vol.34
, pp. 176-188
-
-
Hayes, J.D.1
McMahon, M.2
-
5
-
-
84864348569
-
Nrf2 and cancer: The good, the bad and the importance of context
-
M.B. Sporn, and K.T. Liby Nrf2 and cancer: the good, the bad and the importance of context Nature reviews. Cancer 12 2012 564 571
-
(2012)
Nature Reviews. Cancer
, vol.12
, pp. 564-571
-
-
Sporn, M.B.1
Liby, K.T.2
-
6
-
-
46949099638
-
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
-
X.J. Wang, Z. Sun, N.F. Villeneuve, S. Zhang, F. Zhao, Y. Li, W. Chen, X. Yi, W. Zheng, G.T. Wondrak, P.K. Wong, and D.D. Zhang Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2 Carcinogenesis 29 2008 1235 1243
-
(2008)
Carcinogenesis
, vol.29
, pp. 1235-1243
-
-
Wang, X.J.1
Sun, Z.2
Villeneuve, N.F.3
Zhang, S.4
Zhao, F.5
Li, Y.6
Chen, W.7
Yi, X.8
Zheng, W.9
Wondrak, G.T.10
Wong, P.K.11
Zhang, D.D.12
-
7
-
-
33750885385
-
Dysfunctional Keap1-Nrf2 interaction in non-small-cell lung cancer
-
A. Singh, V. Misra, R.K. Thimmulappa, H. Lee, S. Ames, M.O. Hoque, J.G. Herman, S.B. Baylin, D. Sidransky, E. Gabrielson, M.V. Brock, and S. Biswal Dysfunctional Keap1-Nrf2 interaction in non-small-cell lung cancer PLoS medicine 3 2006 e420
-
(2006)
PLoS Medicine
, vol.3
, pp. e420
-
-
Singh, A.1
Misra, V.2
Thimmulappa, R.K.3
Lee, H.4
Ames, S.5
Hoque, M.O.6
Herman, J.G.7
Baylin, S.B.8
Sidransky, D.9
Gabrielson, E.10
Brock, M.V.11
Biswal, S.12
-
8
-
-
77954695549
-
Wistuba, II. Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features
-
L.M. Solis, C. Behrens, W. Dong, M. Suraokar, N.C. Ozburn, C.A. Moran, A.H. Corvalan, S. Biswal, S.G. Swisher, B.N. Bekele, J.D. Minna, and D.J. Stewart Wistuba, II. Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features Clinical cancer research: an official journal of the American Association for Cancer Research 16 2010 3743 3753
-
(2010)
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
, vol.16
, pp. 3743-3753
-
-
Solis, L.M.1
Behrens, C.2
Dong, W.3
Suraokar, M.4
Ozburn, N.C.5
Moran, C.A.6
Corvalan, A.H.7
Biswal, S.8
Swisher, S.G.9
Bekele, B.N.10
Minna, J.D.11
Stewart, D.J.12
-
9
-
-
0033569641
-
Epigenetics: Regulation through repression
-
A.P. Wolffe, and M.A. Matzke Epigenetics: regulation through repression Science 286 1999 481 486
-
(1999)
Science
, vol.286
, pp. 481-486
-
-
Wolffe, A.P.1
Matzke, M.A.2
-
11
-
-
0036733675
-
Chromatin modification and epigenetic reprogramming in mammalian development
-
E. Li Chromatin modification and epigenetic reprogramming in mammalian development Nature reviews. Genetics 3 2002 662 673
-
(2002)
Nature Reviews. Genetics
, vol.3
, pp. 662-673
-
-
Li, E.1
-
12
-
-
2642531973
-
Epigenetics in human disease and prospects for epigenetic therapy
-
G. Egger, G. Liang, A. Aparicio, and P.A. Jones Epigenetics in human disease and prospects for epigenetic therapy Nature 429 2004 457 463
-
(2004)
Nature
, vol.429
, pp. 457-463
-
-
Egger, G.1
Liang, G.2
Aparicio, A.3
Jones, P.A.4
-
13
-
-
84884784742
-
Age-associated epigenetic drift: Implications, and a case of epigenetic thrift?
-
A.E. Teschendorff, J. West, and S. Beck Age-associated epigenetic drift: implications, and a case of epigenetic thrift? Human molecular genetics 22 2013 R7 R15
-
(2013)
Human Molecular Genetics
, vol.22
, pp. R7-R15
-
-
Teschendorff, A.E.1
West, J.2
Beck, S.3
-
14
-
-
84855956247
-
Epigenetics and the environment: Emerging patterns and implications
-
R. Feil, and M.F. Fraga Epigenetics and the environment: emerging patterns and implications Nature reviews. Genetics 13 2011 97 109
-
(2011)
Nature Reviews. Genetics
, vol.13
, pp. 97-109
-
-
Feil, R.1
Fraga, M.F.2
-
16
-
-
84863770814
-
Cancer genetics and epigenetics: Two sides of the same coin?
-
J.S. You, and P.A. Jones Cancer genetics and epigenetics: two sides of the same coin? Cancer cell 22 2012 9 20
-
(2012)
Cancer Cell
, vol.22
, pp. 9-20
-
-
You, J.S.1
Jones, P.A.2
-
17
-
-
33947315736
-
Cancer epigenomics: DNA methylomes and histone-modification maps
-
M. Esteller Cancer epigenomics: DNA methylomes and histone-modification maps Nature reviews. Genetics 8 2007 286 298
-
(2007)
Nature Reviews. Genetics
, vol.8
, pp. 286-298
-
-
Esteller, M.1
-
18
-
-
77957970301
-
Epigenetic modifications and human disease
-
A. Portela, and M. Esteller Epigenetic modifications and human disease Nature biotechnology 28 2010 1057 1068
-
(2010)
Nature Biotechnology
, vol.28
, pp. 1057-1068
-
-
Portela, A.1
Esteller, M.2
-
19
-
-
73249133400
-
Epigenetics: A molecular link between environmental factors and type 2 diabetes
-
C. Ling, and L. Groop Epigenetics: a molecular link between environmental factors and type 2 diabetes Diabetes 58 2009 2718 2725
-
(2009)
Diabetes
, vol.58
, pp. 2718-2725
-
-
Ling, C.1
Groop, L.2
-
20
-
-
84929998105
-
Epigenetics in immune development and in allergic and autoimmune diseases
-
D. Martino, D.A. Kesper, M. Amarasekera, H. Harb, H. Renz, and S. Prescott Epigenetics in immune development and in allergic and autoimmune diseases Journal of reproductive immunology 104-105 2014 43 48
-
(2014)
Journal of Reproductive Immunology
, vol.104-105
, pp. 43-48
-
-
Martino, D.1
Kesper, D.A.2
Amarasekera, M.3
Harb, H.4
Renz, H.5
Prescott, S.6
-
21
-
-
79957463780
-
Epigenetic modifications: Basic mechanisms and role in cardiovascular disease
-
D.E. Handy, R. Castro, and J. Loscalzo Epigenetic modifications: basic mechanisms and role in cardiovascular disease Circulation 123 2011 2145 2156
-
(2011)
Circulation
, vol.123
, pp. 2145-2156
-
-
Handy, D.E.1
Castro, R.2
Loscalzo, J.3
-
23
-
-
36549056015
-
Epigenetic changes in cancer
-
K. Gronbaek, C. Hother, and P.A. Jones Epigenetic changes in cancer APMIS: acta pathologica, microbiologica, et immunologica Scandinavica 115 2007 1039 1059
-
(2007)
APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
, vol.115
, pp. 1039-1059
-
-
Gronbaek, K.1
Hother, C.2
Jones, P.A.3
-
25
-
-
84994347120
-
Current Perspectives on Epigenetic Modifications by Dietary Chemopreventive and Herbal Phytochemicals
-
Y. Guo, Z.-Y. Su, and A.-N.T. Kong Current Perspectives on Epigenetic Modifications by Dietary Chemopreventive and Herbal Phytochemicals Current Pharmacology Reports 2015 1 13
-
(2015)
Current Pharmacology Reports
, pp. 1-13
-
-
Guo, Y.1
Su, Z.-Y.2
Kong, A.-N.T.3
-
26
-
-
84902182150
-
Mechanism and function of oxidative reversal of DNA and RNA methylation
-
L. Shen, C.X. Song, C. He, and Y. Zhang Mechanism and function of oxidative reversal of DNA and RNA methylation Annual review of biochemistry 83 2014 585 614
-
(2014)
Annual Review of Biochemistry
, vol.83
, pp. 585-614
-
-
Shen, L.1
Song, C.X.2
He, C.3
Zhang, Y.4
-
27
-
-
44449148691
-
Oxidative stress, DNA methylation and carcinogenesis
-
R. Franco, O. Schoneveld, A.G. Georgakilas, and M.I. Panayiotidis Oxidative stress, DNA methylation and carcinogenesis Cancer letters 266 2008 6 11
-
(2008)
Cancer Letters
, vol.266
, pp. 6-11
-
-
Franco, R.1
Schoneveld, O.2
Georgakilas, A.G.3
Panayiotidis, M.I.4
-
28
-
-
84924056952
-
Oxidative stress alters global histone modification and DNA methylation
-
Y. Niu, T.L. DesMarais, Z. Tong, Y. Yao, and M. Costa Oxidative stress alters global histone modification and DNA methylation Free radical biology & medicine 82 2015 22 28
-
(2015)
Free Radical Biology & Medicine
, vol.82
, pp. 22-28
-
-
Niu, Y.1
DesMarais, T.L.2
Tong, Z.3
Yao, Y.4
Costa, M.5
-
29
-
-
84874459340
-
A perspective on dietary phytochemicals and cancer chemoprevention: Oxidative stress, nrf2, and epigenomics
-
Z.Y. Su, L. Shu, T.O. Khor, J.H. Lee, F. Fuentes, and A.N. Kong A perspective on dietary phytochemicals and cancer chemoprevention: oxidative stress, nrf2, and epigenomics Topics in current chemistry 329 2013 133 162
-
(2013)
Topics in Current Chemistry
, vol.329
, pp. 133-162
-
-
Su, Z.Y.1
Shu, L.2
Khor, T.O.3
Lee, J.H.4
Fuentes, F.5
Kong, A.N.6
-
30
-
-
14844290235
-
Hypermethylation of NAD(P)H: Quinone oxidoreductase 1 (NQO1) gene in human hepatocellular carcinoma
-
M. Tada, O. Yokosuka, K. Fukai, T. Chiba, F. Imazeki, T. Tokuhisa, and H. Saisho Hypermethylation of NAD(P)H: quinone oxidoreductase 1 (NQO1) gene in human hepatocellular carcinoma Journal of hepatology 42 2005 511 519
-
(2005)
Journal of Hepatology
, vol.42
, pp. 511-519
-
-
Tada, M.1
Yokosuka, O.2
Fukai, K.3
Chiba, T.4
Imazeki, F.5
Tokuhisa, T.6
Saisho, H.7
-
31
-
-
34250220644
-
Glutathione S-transferase pi (GSTP1) hypermethylation in prostate cancer: Review 2007
-
I. Meiers, J.H. Shanks, and D.G. Bostwick Glutathione S-transferase pi (GSTP1) hypermethylation in prostate cancer: review 2007 Pathology 39 2007 299 304
-
(2007)
Pathology
, vol.39
, pp. 299-304
-
-
Meiers, I.1
Shanks, J.H.2
Bostwick, D.G.3
-
32
-
-
77649322609
-
Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells
-
A.S. Belanger, J. Tojcic, M. Harvey, and C. Guillemette Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells BMC molecular biology 11 2010 9
-
(2010)
BMC Molecular Biology
, vol.11
, pp. 9
-
-
Belanger, A.S.1
Tojcic, J.2
Harvey, M.3
Guillemette, C.4
-
33
-
-
0035839057
-
The role of DNA methylation in mammalian epigenetics
-
P.A. Jones, and D. Takai The role of DNA methylation in mammalian epigenetics Science 293 2001 1068 1070
-
(2001)
Science
, vol.293
, pp. 1068-1070
-
-
Jones, P.A.1
Takai, D.2
-
34
-
-
84922621952
-
Function and information content of DNA methylation
-
D. Schubeler Function and information content of DNA methylation Nature 517 2015 321 326
-
(2015)
Nature
, vol.517
, pp. 321-326
-
-
Schubeler, D.1
-
36
-
-
33645658128
-
Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer
-
J.F. Gagnon, O. Bernard, L. Villeneuve, B. Tetu, and C. Guillemette Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer Clinical cancer research: an official journal of the American Association for Cancer Research 12 2006 1850 1858
-
(2006)
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
, vol.12
, pp. 1850-1858
-
-
Gagnon, J.F.1
Bernard, O.2
Villeneuve, L.3
Tetu, B.4
Guillemette, C.5
-
37
-
-
35348847129
-
Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines
-
E.M. Hurt, S.B. Thomas, B. Peng, and W.L. Farrar Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines British journal of cancer 97 2007 1116 1123
-
(2007)
British Journal of Cancer
, vol.97
, pp. 1116-1123
-
-
Hurt, E.M.1
Thomas, S.B.2
Peng, B.3
Farrar, W.L.4
-
38
-
-
84897521025
-
Promoter hypermethylation and suppression of glutathione peroxidase 3 are associated with inflammatory breast carcinogenesis
-
M.M. Mohamed, S. Sabet, D.F. Peng, M.A. Nouh, M. El-Shinawi, and W. El-Rifai Promoter hypermethylation and suppression of glutathione peroxidase 3 are associated with inflammatory breast carcinogenesis Oxidative medicine and cellular longevity 2014 2014 787195
-
(2014)
Oxidative Medicine and Cellular Longevity
, vol.2014
, pp. 787195
-
-
Mohamed, M.M.1
Sabet, S.2
Peng, D.F.3
Nouh, M.A.4
El-Shinawi, M.5
El-Rifai, W.6
-
39
-
-
33748089664
-
Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2
-
C. Xu, M.T. Huang, G. Shen, X. Yuan, W. Lin, T.O. Khor, A.H. Conney, and A.N. Kong Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2 Cancer research 66 2006 8293 8296
-
(2006)
Cancer Research
, vol.66
, pp. 8293-8296
-
-
Xu, C.1
Huang, M.T.2
Shen, G.3
Yuan, X.4
Lin, W.5
Khor, T.O.6
Conney, A.H.7
Kong, A.N.8
-
40
-
-
61449135219
-
Gamma-tocopherol-enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice
-
A. Barve, T.O. Khor, S. Nair, K. Reuhl, N. Suh, B. Reddy, H. Newmark, and A.N. Kong Gamma-tocopherol-enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice International journal of cancer. Journal international du cancer 124 2009 1693 1699
-
(2009)
International Journal of Cancer. Journal International du Cancer
, vol.124
, pp. 1693-1699
-
-
Barve, A.1
Khor, T.O.2
Nair, S.3
Reuhl, K.4
Suh, N.5
Reddy, B.6
Newmark, H.7
Kong, A.N.8
-
41
-
-
47549098593
-
The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis
-
D.A. Frohlich, M.T. McCabe, R.S. Arnold, and M.L. Day The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis Oncogene 27 2008 4353 4362
-
(2008)
Oncogene
, vol.27
, pp. 4353-4362
-
-
Frohlich, D.A.1
McCabe, M.T.2
Arnold, R.S.3
Day, M.L.4
-
42
-
-
77649163840
-
Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice
-
S. Yu, T.O. Khor, K.L. Cheung, W. Li, T.Y. Wu, Y. Huang, B.A. Foster, Y.W. Kan, and A.N. Kong Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice PloS one 5 2010 e8579
-
(2010)
PloS One
, vol.5
, pp. e8579
-
-
Yu, S.1
Khor, T.O.2
Cheung, K.L.3
Li, W.4
Wu, T.Y.5
Huang, Y.6
Foster, B.A.7
Kan, Y.W.8
Kong, A.N.9
-
43
-
-
84919346523
-
Epigenetic DNA Methylation of Antioxidative Stress Regulator Nrf2 in Human Prostate Cancer
-
T.O. Khor, F. Fuentes, L. Shu, X. Paredes-Gonzalez, A.Y. Yang, Y. Liu, D.J. Smiraglia, S. Yegnasubramanian, W.G. Nelson, and A.N. Kong Epigenetic DNA Methylation of Antioxidative Stress Regulator Nrf2 in Human Prostate Cancer Cancer prevention research 7 2014 1186 1197
-
(2014)
Cancer Prevention Research
, vol.7
, pp. 1186-1197
-
-
Khor, T.O.1
Fuentes, F.2
Shu, L.3
Paredes-Gonzalez, X.4
Yang, A.Y.5
Liu, Y.6
Smiraglia, D.J.7
Yegnasubramanian, S.8
Nelson, W.G.9
Kong, A.N.10
-
44
-
-
84862074144
-
A gamma-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation
-
Y. Huang, T.O. Khor, L. Shu, C.L. Saw, T.Y. Wu, N. Suh, C.S. Yang, and A.N. Kong A gamma-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation The Journal of nutrition 142 2012 818 823
-
(2012)
The Journal of Nutrition
, vol.142
, pp. 818-823
-
-
Huang, Y.1
Khor, T.O.2
Shu, L.3
Saw, C.L.4
Wu, T.Y.5
Suh, N.6
Yang, C.S.7
Kong, A.N.8
-
45
-
-
84923864187
-
Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1
-
Y. Guo, L. Shu, C. Zhang, Z.Y. Su, and A.N. Kong Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1 Biochemical pharmacology 94 2015 69 78
-
(2015)
Biochemical Pharmacology
, vol.94
, pp. 69-78
-
-
Guo, Y.1
Shu, L.2
Zhang, C.3
Su, Z.Y.4
Kong, A.N.5
-
47
-
-
0345275879
-
Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines
-
M.Z. Fang, Y. Wang, N. Ai, Z. Hou, Y. Sun, H. Lu, W. Welsh, and C.S. Yang Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines Cancer research 63 2003 7563 7570
-
(2003)
Cancer Research
, vol.63
, pp. 7563-7570
-
-
Fang, M.Z.1
Wang, Y.2
Ai, N.3
Hou, Z.4
Sun, Y.5
Lu, H.6
Welsh, W.7
Yang, C.S.8
-
48
-
-
84895922467
-
Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells
-
Q. Xie, Q. Bai, L.Y. Zou, Q.Y. Zhang, Y. Zhou, H. Chang, L. Yi, J.D. Zhu, and M.T. Mi Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells Genes, chromosomes & cancer 53 2014 422 431
-
(2014)
Genes, Chromosomes & Cancer
, vol.53
, pp. 422-431
-
-
Xie, Q.1
Bai, Q.2
Zou, L.Y.3
Zhang, Q.Y.4
Zhou, Y.5
Chang, H.6
Yi, L.7
Zhu, J.D.8
Mi, M.T.9
-
49
-
-
80053978389
-
Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation
-
T.O. Khor, Y. Huang, T.Y. Wu, L. Shu, J. Lee, and A.N. Kong Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation Biochemical pharmacology 82 2011 1073 1078
-
(2011)
Biochemical Pharmacology
, vol.82
, pp. 1073-1078
-
-
Khor, T.O.1
Huang, Y.2
Wu, T.Y.3
Shu, L.4
Lee, J.5
Kong, A.N.6
-
50
-
-
84879793030
-
Epigenetic modifications of Nrf2 by 3,3'-diindolylmethane in vitro in TRAMP C1 cell line and in vivo TRAMP prostate tumors
-
T.Y. Wu, T.O. Khor, Z.Y. Su, C.L. Saw, L. Shu, K.L. Cheung, Y. Huang, S. Yu, and A.N. Kong Epigenetic modifications of Nrf2 by 3,3'-diindolylmethane in vitro in TRAMP C1 cell line and in vivo TRAMP prostate tumors The AAPS journal 15 2013 864 874
-
(2013)
The AAPS Journal
, vol.15
, pp. 864-874
-
-
Wu, T.Y.1
Khor, T.O.2
Su, Z.Y.3
Saw, C.L.4
Shu, L.5
Cheung, K.L.6
Huang, Y.7
Yu, S.8
Kong, A.N.9
-
51
-
-
84875746160
-
Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation
-
C. Zhang, Z.Y. Su, T.O. Khor, L. Shu, and A.N. Kong Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation Biochem Pharmacol 85 2013 1398 1404
-
(2013)
Biochem Pharmacol
, vol.85
, pp. 1398-1404
-
-
Zhang, C.1
Su, Z.Y.2
Khor, T.O.3
Shu, L.4
Kong, A.N.5
-
52
-
-
84875202416
-
Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation
-
Z.Y. Su, T.O. Khor, L. Shu, J.H. Lee, C.L. Saw, T.Y. Wu, Y. Huang, N. Suh, C.S. Yang, A.H. Conney, Q. Wu, and A.N. Kong Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation Chemical research in toxicology 26 2013 477 485
-
(2013)
Chemical Research in Toxicology
, vol.26
, pp. 477-485
-
-
Su, Z.Y.1
Khor, T.O.2
Shu, L.3
Lee, J.H.4
Saw, C.L.5
Wu, T.Y.6
Huang, Y.7
Suh, N.8
Yang, C.S.9
Conney, A.H.10
Wu, Q.11
Kong, A.N.12
-
53
-
-
84903640329
-
Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P+cells through epigenetics modifications
-
X. Paredes-Gonzalez, F. Fuentes, Z.Y. Su, and A.N. Kong Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P+cells through epigenetics modifications The AAPS journal 16 2014 727 735
-
(2014)
The AAPS Journal
, vol.16
, pp. 727-735
-
-
Paredes-Gonzalez, X.1
Fuentes, F.2
Su, Z.Y.3
Kong, A.N.4
-
54
-
-
84897130844
-
Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane
-
Z.Y. Su, C. Zhang, J.H. Lee, L. Shu, T.Y. Wu, T.O. Khor, A.H. Conney, Y.P. Lu, and A.N. Kong Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane Cancer Prev Res (Phila) 7 2014 319 329
-
(2014)
Cancer Prev Res (Phila)
, vol.7
, pp. 319-329
-
-
Su, Z.Y.1
Zhang, C.2
Lee, J.H.3
Shu, L.4
Wu, T.Y.5
Khor, T.O.6
Conney, A.H.7
Lu, Y.P.8
Kong, A.N.9
-
55
-
-
84938797144
-
Blocking of JB6 cell transformation by tanshinone IIA: Epigenetic reactivation of Nrf2 antioxidative stress pathway
-
L. Wang, C. Zhang, Y. Guo, Z.Y. Su, Y. Yang, L. Shu, and A.N. Kong Blocking of JB6 cell transformation by tanshinone IIA: epigenetic reactivation of Nrf2 antioxidative stress pathway The AAPS journal 16 2014 1214 1225
-
(2014)
The AAPS Journal
, vol.16
, pp. 1214-1225
-
-
Wang, L.1
Zhang, C.2
Guo, Y.3
Su, Z.Y.4
Yang, Y.5
Shu, L.6
Kong, A.N.7
-
56
-
-
45849133744
-
Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
-
R. Wang, J. An, F. Ji, H. Jiao, H. Sun, and D. Zhou Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues Biochemical and biophysical research communications 373 2008 151 154
-
(2008)
Biochemical and Biophysical Research Communications
, vol.373
, pp. 151-154
-
-
Wang, R.1
An, J.2
Ji, F.3
Jiao, H.4
Sun, H.5
Zhou, D.6
-
57
-
-
84868363002
-
A possible gene silencing mechanism: Hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cells
-
D. Guo, B. Wu, J. Yan, X. Li, H. Sun, and D. Zhou A possible gene silencing mechanism: hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cells Biochemical and biophysical research communications 428 2012 80 85
-
(2012)
Biochemical and Biophysical Research Communications
, vol.428
, pp. 80-85
-
-
Guo, D.1
Wu, B.2
Yan, J.3
Li, X.4
Sun, H.5
Zhou, D.6
-
58
-
-
79958702879
-
Frequent epigenetics inactivation of Keap1 gene in non-small cell lung cancer
-
L.A. Muscarella, P. Parrella, V. D'Alessandro, A. la Torre, R. Barbano, A. Fontana, A. Tancredi, V. Guarnieri, T. Balsamo, M. Coco, M. Copetti, F. Pellegrini, P. De Bonis, M. Bisceglia, G. Scaramuzzi, E. Maiello, V.M. Valori, G. Merla, G. Vendemiale, and V.M. Fazio Frequent epigenetics inactivation of Keap1 gene in non-small cell lung cancer Epigenetics: official journal of the DNA Methylation Society 6 2011 710 719
-
(2011)
Epigenetics: Official Journal of the DNA Methylation Society
, vol.6
, pp. 710-719
-
-
Muscarella, L.A.1
Parrella, P.2
D'Alessandro, V.3
La Torre, A.4
Barbano, R.5
Fontana, A.6
Tancredi, A.7
Guarnieri, V.8
Balsamo, T.9
Coco, M.10
Copetti, M.11
Pellegrini, F.12
De Bonis, P.13
Bisceglia, M.14
Scaramuzzi, G.15
Maiello, E.16
Valori, V.M.17
Merla, G.18
Vendemiale, G.19
Fazio, V.M.20
more..
-
59
-
-
79952377052
-
Regulation of Keap1 expression by promoter methylation in malignant gliomas and association with patient's outcome
-
L.A. Muscarella, R. Barbano, V. D'Angelo, M. Copetti, M. Coco, T. Balsamo, A. la Torre, A. Notarangelo, M. Troiano, S. Parisi, N. Icolaro, D. Catapano, V.M. Valori, F. Pellegrini, G. Merla, M. Carella, V.M. Fazio, and P. Parrella Regulation of Keap1 expression by promoter methylation in malignant gliomas and association with patient's outcome Epigenetics: official journal of the DNA Methylation Society 6 2011 317 325
-
(2011)
Epigenetics: Official Journal of the DNA Methylation Society
, vol.6
, pp. 317-325
-
-
Muscarella, L.A.1
Barbano, R.2
D'Angelo, V.3
Copetti, M.4
Coco, M.5
Balsamo, T.6
La Torre, A.7
Notarangelo, A.8
Troiano, M.9
Parisi, S.10
Icolaro, N.11
Catapano, D.12
Valori, V.M.13
Pellegrini, F.14
Merla, G.15
Carella, M.16
Fazio, V.M.17
Parrella, P.18
-
60
-
-
84872038941
-
Aberrant Keap1 methylation in breast cancer and association with clinicopathological features
-
R. Barbano, L.A. Muscarella, B. Pasculli, V.M. Valori, A. Fontana, M. Coco, A. la Torre, T. Balsamo, M.L. Poeta, G.F. Marangi, E. Maiello, M. Castelvetere, F. Pellegrini, R. Murgo, V.M. Fazio, and P. Parrella Aberrant Keap1 methylation in breast cancer and association with clinicopathological features Epigenetics: official journal of the DNA Methylation Society 8 2013 105 112
-
(2013)
Epigenetics: Official Journal of the DNA Methylation Society
, vol.8
, pp. 105-112
-
-
Barbano, R.1
Muscarella, L.A.2
Pasculli, B.3
Valori, V.M.4
Fontana, A.5
Coco, M.6
La Torre, A.7
Balsamo, T.8
Poeta, M.L.9
Marangi, G.F.10
Maiello, E.11
Castelvetere, M.12
Pellegrini, F.13
Murgo, R.14
Fazio, V.M.15
Parrella, P.16
-
61
-
-
84857997256
-
Methylation of the Keap1 gene promoter region in human colorectal cancer
-
N. Hanada, T. Takahata, Q. Zhou, X. Ye, R. Sun, J. Itoh, A. Ishiguro, H. Kijima, J. Mimura, K. Itoh, S. Fukuda, and Y. Saijo Methylation of the Keap1 gene promoter region in human colorectal cancer BMC cancer 12 2012 66
-
(2012)
BMC Cancer
, vol.12
, pp. 66
-
-
Hanada, N.1
Takahata, T.2
Zhou, Q.3
Ye, X.4
Sun, R.5
Itoh, J.6
Ishiguro, A.7
Kijima, H.8
Mimura, J.9
Itoh, K.10
Fukuda, S.11
Saijo, Y.12
-
62
-
-
84969838906
-
Is there a decrease in Keap1 RNA expression in colorectal cancer cells, and is this decrease in expression due to hypermethylation?
-
A.R. Jazirehi, P.B. Wenn, and D. Arle Is there a decrease in Keap1 RNA expression in colorectal cancer cells, and is this decrease in expression due to hypermethylation? Epigenomics 4 2012 253 254
-
(2012)
Epigenomics
, vol.4
, pp. 253-254
-
-
Jazirehi, A.R.1
Wenn, P.B.2
Arle, D.3
-
63
-
-
76649089973
-
Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth
-
P. Zhang, A. Singh, S. Yegnasubramanian, D. Esopi, P. Kombairaju, M. Bodas, H. Wu, S.G. Bova, and S. Biswal Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth Molecular cancer therapeutics 9 2010 336 346
-
(2010)
Molecular Cancer Therapeutics
, vol.9
, pp. 336-346
-
-
Zhang, P.1
Singh, A.2
Yegnasubramanian, S.3
Esopi, D.4
Kombairaju, P.5
Bodas, M.6
Wu, H.7
Bova, S.G.8
Biswal, S.9
-
64
-
-
84885524071
-
Frequent concerted genetic mechanisms disrupt multiple components of the Nrf2 inhibitor Keap1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer
-
V.D. Martinez, E.A. Vucic, L.A. Pikor, K.L. Thu, R. Hubaux, and W.L. Lam Frequent concerted genetic mechanisms disrupt multiple components of the Nrf2 inhibitor Keap1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer Mol Cancer 12 2013 124
-
(2013)
Mol Cancer
, vol.12
, pp. 124
-
-
Martinez, V.D.1
Vucic, E.A.2
Pikor, L.A.3
Thu, K.L.4
Hubaux, R.5
Lam, W.L.6
-
65
-
-
84866867120
-
Age-related cataracts: Homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection
-
R. Elanchezhian, P. Palsamy, C.J. Madson, D.W. Lynch, and T. Shinohara Age-related cataracts: homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection Chemico-biological interactions 200 2012 1 10
-
(2012)
Chemico-biological Interactions
, vol.200
, pp. 1-10
-
-
Elanchezhian, R.1
Palsamy, P.2
Madson, C.J.3
Lynch, D.W.4
Shinohara, T.5
-
66
-
-
77249083614
-
Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract
-
M. von Otter, S. Landgren, S. Nilsson, M. Zetterberg, D. Celojevic, P. Bergstrom, L. Minthon, N. Bogdanovic, N. Andreasen, D.R. Gustafson, I. Skoog, A. Wallin, G. Tasa, K. Blennow, M. Nilsson, O. Hammarsten, and H. Zetterberg Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract Mechanisms of ageing and development 131 2010 105 110
-
(2010)
Mechanisms of Ageing and Development
, vol.131
, pp. 105-110
-
-
Von Otter, M.1
Landgren, S.2
Nilsson, S.3
Zetterberg, M.4
Celojevic, D.5
Bergstrom, P.6
Minthon, L.7
Bogdanovic, N.8
Andreasen, N.9
Gustafson, D.R.10
Skoog, I.11
Wallin, A.12
Tasa, G.13
Blennow, K.14
Nilsson, M.15
Hammarsten, O.16
Zetterberg, H.17
-
68
-
-
84916221789
-
Human agerelated cataracts: Epigenetic suppression of the nuclear factor erythroid 2related factor 2mediated antioxidant system
-
Y. Gao, Y. Yan, and T. Huang Human agerelated cataracts: Epigenetic suppression of the nuclear factor erythroid 2related factor 2mediated antioxidant system Molecular medicine reports 11 2015 1442 1447
-
(2015)
Molecular Medicine Reports
, vol.11
, pp. 1442-1447
-
-
Gao, Y.1
Yan, Y.2
Huang, T.3
-
69
-
-
84926620070
-
Acetyllcarnitine prevents homocysteineinduced suppression of Nrf2/Keap1 mediated antioxidation in human lens epithelial cells
-
S.P. Yang, X.Z. Yang, and G.P. Cao Acetyllcarnitine prevents homocysteineinduced suppression of Nrf2/Keap1 mediated antioxidation in human lens epithelial cells Molecular medicine reports 12 2015 1145 1150
-
(2015)
Molecular Medicine Reports
, vol.12
, pp. 1145-1150
-
-
Yang, S.P.1
Yang, X.Z.2
Cao, G.P.3
-
70
-
-
84904411046
-
Selenite cataracts: Activation of endoplasmic reticulum stress and loss of Nrf2/Keap1-dependent stress protection
-
P. Palsamy, K.R. Bidasee, and T. Shinohara Selenite cataracts: activation of endoplasmic reticulum stress and loss of Nrf2/Keap1-dependent stress protection Biochimica et biophysica acta 1794-1805 1842 2014
-
(1842)
Biochimica et Biophysica Acta
, vol.1794-1805
, pp. 2014
-
-
Palsamy, P.1
Bidasee, K.R.2
Shinohara, T.3
-
71
-
-
84900490382
-
Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts
-
P. Palsamy, K.R. Bidasee, M. Ayaki, R.C. Augusteyn, J.Y. Chan, and T. Shinohara Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts Free radical biology & medicine 72 2014 134 148
-
(2014)
Free Radical Biology & Medicine
, vol.72
, pp. 134-148
-
-
Palsamy, P.1
Bidasee, K.R.2
Ayaki, M.3
Augusteyn, R.C.4
Chan, J.Y.5
Shinohara, T.6
-
72
-
-
84895948105
-
Valproic acid suppresses Nrf2/Keap1 dependent antioxidant protection through induction of endoplasmic reticulum stress and Keap1 promoter DNA demethylation in human lens epithelial cells
-
P. Palsamy, K.R. Bidasee, and T. Shinohara Valproic acid suppresses Nrf2/Keap1 dependent antioxidant protection through induction of endoplasmic reticulum stress and Keap1 promoter DNA demethylation in human lens epithelial cells Experimental eye research 121 2014 26 34
-
(2014)
Experimental Eye Research
, vol.121
, pp. 26-34
-
-
Palsamy, P.1
Bidasee, K.R.2
Shinohara, T.3
-
74
-
-
0033529565
-
Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome
-
R.D. Kornberg, and Y. Lorch Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome Cell 98 1999 285 294
-
(1999)
Cell
, vol.98
, pp. 285-294
-
-
Kornberg, R.D.1
Lorch, Y.2
-
75
-
-
33644994575
-
The contradictory definitions of heterochromatin: Transcription and silencing
-
K.L. Huisinga, B. Brower-Toland, and S.C. Elgin The contradictory definitions of heterochromatin: transcription and silencing Chromosoma 115 2006 110 122
-
(2006)
Chromosoma
, vol.115
, pp. 110-122
-
-
Huisinga, K.L.1
Brower-Toland, B.2
Elgin, S.C.3
-
76
-
-
0030998534
-
Histone acetylation: Influence on transcription, nucleosome mobility and positioning, and linker histone-dependent transcriptional repression
-
K. Ura, H. Kurumizaka, S. Dimitrov, G. Almouzni, and A.P. Wolffe Histone acetylation: influence on transcription, nucleosome mobility and positioning, and linker histone-dependent transcriptional repression The EMBO journal 16 1997 2096 2107
-
(1997)
The EMBO Journal
, vol.16
, pp. 2096-2107
-
-
Ura, K.1
Kurumizaka, H.2
Dimitrov, S.3
Almouzni, G.4
Wolffe, A.P.5
-
77
-
-
41949141296
-
NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
-
G.H. Liu, J. Qu, and X. Shen NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK Biochimica et biophysica acta 713-727 1783 2008
-
(1783)
Biochimica et Biophysica Acta
, vol.713-727
, pp. 2008
-
-
Liu, G.H.1
Qu, J.2
Shen, X.3
-
78
-
-
79961127422
-
Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: Restoring effects of inhibitors of HDACs, p38 MAPK and GSK3beta
-
F. Correa, C. Mallard, M. Nilsson, and M. Sandberg Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: restoring effects of inhibitors of HDACs, p38 MAPK and GSK3beta Neurobiology of disease 44 2011 142 151
-
(2011)
Neurobiology of Disease
, vol.44
, pp. 142-151
-
-
Correa, F.1
Mallard, C.2
Nilsson, M.3
Sandberg, M.4
-
79
-
-
84862824580
-
Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage
-
B. Wang, X. Zhu, Y. Kim, J. Li, S. Huang, S. Saleem, R.C. Li, Y. Xu, S. Dore, and W. Cao Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage Free radical biology & medicine 52 2012 928 936
-
(2012)
Free Radical Biology & Medicine
, vol.52
, pp. 928-936
-
-
Wang, B.1
Zhu, X.2
Kim, Y.3
Li, J.4
Huang, S.5
Saleem, S.6
Li, R.C.7
Xu, Y.8
Dore, S.9
Cao, W.10
-
80
-
-
79952439646
-
Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress
-
N. Mercado, R. Thimmulappa, C.M. Thomas, P.S. Fenwick, K.K. Chana, L.E. Donnelly, S. Biswal, K. Ito, and P.J. Barnes Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress Biochemical and biophysical research communications 406 2011 292 298
-
(2011)
Biochemical and Biophysical Research Communications
, vol.406
, pp. 292-298
-
-
Mercado, N.1
Thimmulappa, R.2
Thomas, C.M.3
Fenwick, P.S.4
Chana, K.K.5
Donnelly, L.E.6
Biswal, S.7
Ito, K.8
Barnes, P.J.9
-
81
-
-
78650176368
-
Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction
-
D. Adenuga, S. Caito, H. Yao, I.K. Sundar, J.W. Hwang, S. Chung, and I. Rahman Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction Biochemical and biophysical research communications 403 2010 452 456
-
(2010)
Biochemical and Biophysical Research Communications
, vol.403
, pp. 452-456
-
-
Adenuga, D.1
Caito, S.2
Yao, H.3
Sundar, I.K.4
Hwang, J.W.5
Chung, S.6
Rahman, I.7
-
82
-
-
84890025789
-
Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction
-
H.C. Lam, S.M. Cloonan, A.R. Bhashyam, J.A. Haspel, A. Singh, J.F. Sathirapongsasuti, M. Cervo, H. Yao, A.L. Chung, K. Mizumura, C.H. An, B. Shan, J.M. Franks, K.J. Haley, C.A. Owen, Y. Tesfaigzi, G.R. Washko, J. Quackenbush, E.K. Silverman, I. Rahman, H.P. Kim, A. Mahmood, S.S. Biswal, S.W. Ryter, and A.M. Choi Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction The Journal of clinical investigation 123 2013 5212 5230
-
(2013)
The Journal of Clinical Investigation
, vol.123
, pp. 5212-5230
-
-
Lam, H.C.1
Cloonan, S.M.2
Bhashyam, A.R.3
Haspel, J.A.4
Singh, A.5
Sathirapongsasuti, J.F.6
Cervo, M.7
Yao, H.8
Chung, A.L.9
Mizumura, K.10
An, C.H.11
Shan, B.12
Franks, J.M.13
Haley, K.J.14
Owen, C.A.15
Tesfaigzi, Y.16
Washko, G.R.17
Quackenbush, J.18
Silverman, E.K.19
Rahman, I.20
Kim, H.P.21
Mahmood, A.22
Biswal, S.S.23
Ryter, S.W.24
Choi, A.M.25
more..
-
83
-
-
79953225194
-
Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization
-
Y. Kawai, L. Garduno, M. Theodore, J. Yang, and I.J. Arinze Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization The Journal of biological chemistry 286 2011 7629 7640
-
(2011)
The Journal of Biological Chemistry
, vol.286
, pp. 7629-7640
-
-
Kawai, Y.1
Garduno, L.2
Theodore, M.3
Yang, J.4
Arinze, I.J.5
-
84
-
-
66349129338
-
Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response
-
Z. Sun, Y.E. Chin, and D.D. Zhang Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response Molecular and cellular biology 29 2009 2658 2672
-
(2009)
Molecular and Cellular Biology
, vol.29
, pp. 2658-2672
-
-
Sun, Z.1
Chin, Y.E.2
Zhang, D.D.3
-
85
-
-
84902121544
-
The histone acetylranseferase hMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung cancer
-
Z. Chen, X. Ye, N. Tang, S. Shen, Z. Li, X. Niu, S. Lu, and L. Xu The histone acetylranseferase hMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung cancer British journal of pharmacology 171 2014 3196 3211
-
(2014)
British Journal of Pharmacology
, vol.171
, pp. 3196-3211
-
-
Chen, Z.1
Ye, X.2
Tang, N.3
Shen, S.4
Li, Z.5
Niu, X.6
Lu, S.7
Xu, L.8
-
86
-
-
2942746263
-
Transcription factor Nrf2/MafK regulates rat placental glutathione S-transferase gene during hepatocarcinogenesis
-
H. Ikeda, S. Nishi, and M. Sakai Transcription factor Nrf2/MafK regulates rat placental glutathione S-transferase gene during hepatocarcinogenesis The Biochemical journal 380 2004 515 521
-
(2004)
The Biochemical Journal
, vol.380
, pp. 515-521
-
-
Ikeda, H.1
Nishi, S.2
Sakai, M.3
-
87
-
-
33947257007
-
Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis
-
K. Ohta, M. Ohigashi, A. Naganawa, H. Ikeda, M. Sakai, J. Nishikawa, M. Imagawa, S. Osada, and T. Nishihara Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis The Biochemical journal 402 2007 559 566
-
(2007)
The Biochemical Journal
, vol.402
, pp. 559-566
-
-
Ohta, K.1
Ohigashi, M.2
Naganawa, A.3
Ikeda, H.4
Sakai, M.5
Nishikawa, J.6
Imagawa, M.7
Osada, S.8
Nishihara, T.9
-
88
-
-
84884417014
-
Gender matters: Estrogen receptor alpha (ERalpha) and histone deacetylase (HDAC) 1 and 2 control the gender-specific transcriptional regulation of human uridine diphosphate glucuronosyltransferases genes (UGT1A)
-
S. Kalthoff, A. Winkler, N. Freiberg, M.P. Manns, and C.P. Strassburg Gender matters: estrogen receptor alpha (ERalpha) and histone deacetylase (HDAC) 1 and 2 control the gender-specific transcriptional regulation of human uridine diphosphate glucuronosyltransferases genes (UGT1A) Journal of hepatology 59 2013 797 804
-
(2013)
Journal of Hepatology
, vol.59
, pp. 797-804
-
-
Kalthoff, S.1
Winkler, A.2
Freiberg, N.3
Manns, M.P.4
Strassburg, C.P.5
-
89
-
-
84859893371
-
Histone methylation: A dynamic mark in health, disease and inheritance
-
E.L. Greer, and Y. Shi Histone methylation: a dynamic mark in health, disease and inheritance Nature reviews. Genetics 13 2012 343 357
-
(2012)
Nature Reviews. Genetics
, vol.13
, pp. 343-357
-
-
Greer, E.L.1
Shi, Y.2
-
91
-
-
33846019277
-
Methylation of lysine 4 on histone H3: Intricacy of writing and reading a single epigenetic mark
-
A.J. Ruthenburg, C.D. Allis, and J. Wysocka Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark Molecular cell 25 2007 15 30
-
(2007)
Molecular Cell
, vol.25
, pp. 15-30
-
-
Ruthenburg, A.J.1
Allis, C.D.2
Wysocka, J.3
-
92
-
-
84867818118
-
A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level
-
S. Balasubramanian, S. Kanade, B. Han, and R.L. Eckert A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level The Journal of biological chemistry 287 2012 36179 36189
-
(2012)
The Journal of Biological Chemistry
, vol.287
, pp. 36179-36189
-
-
Balasubramanian, S.1
Kanade, S.2
Han, B.3
Eckert, R.L.4
-
93
-
-
84906257946
-
The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2
-
Z. Li, L. Xu, N. Tang, Y. Xu, X. Ye, S. Shen, X. Niu, S. Lu, and Z. Chen The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2 FEBS letters 588 2014 3000 3007
-
(2014)
FEBS Letters
, vol.588
, pp. 3000-3007
-
-
Li, Z.1
Xu, L.2
Tang, N.3
Xu, Y.4
Ye, X.5
Shen, S.6
Niu, X.7
Lu, S.8
Chen, Z.9
-
94
-
-
84921318899
-
Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma
-
S.K. Knutson, S. Kawano, Y. Minoshima, N.M. Warholic, K.C. Huang, Y. Xiao, T. Kadowaki, M. Uesugi, G. Kuznetsov, N. Kumar, T.J. Wigle, C.R. Klaus, C.J. Allain, A. Raimondi, N.J. Waters, J.J. Smith, M. Porter-Scott, R. Chesworth, M.P. Moyer, R.A. Copeland, V.M. Richon, T. Uenaka, R.M. Pollock, K.W. Kuntz, A. Yokoi, and H. Keilhack Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma Molecular cancer therapeutics 13 2014 842 854
-
(2014)
Molecular Cancer Therapeutics
, vol.13
, pp. 842-854
-
-
Knutson, S.K.1
Kawano, S.2
Minoshima, Y.3
Warholic, N.M.4
Huang, K.C.5
Xiao, Y.6
Kadowaki, T.7
Uesugi, M.8
Kuznetsov, G.9
Kumar, N.10
Wigle, T.J.11
Klaus, C.R.12
Allain, C.J.13
Raimondi, A.14
Waters, N.J.15
Smith, J.J.16
Porter-Scott, M.17
Chesworth, R.18
Moyer, M.P.19
Copeland, R.A.20
Richon, V.M.21
Uenaka, T.22
Pollock, R.M.23
Kuntz, K.W.24
Yokoi, A.25
Keilhack, H.26
more..
-
95
-
-
84867987203
-
EZH2 inhibition: Targeting the crossroad of tumor invasion and angiogenesis
-
F. Crea, L. Fornaro, G. Bocci, L. Sun, W.L. Farrar, A. Falcone, and R. Danesi EZH2 inhibition: targeting the crossroad of tumor invasion and angiogenesis Cancer metastasis reviews 31 2012 753 761
-
(2012)
Cancer Metastasis Reviews
, vol.31
, pp. 753-761
-
-
Crea, F.1
Fornaro, L.2
Bocci, G.3
Sun, L.4
Farrar, W.L.5
Falcone, A.6
Danesi, R.7
-
96
-
-
84921889428
-
Epigenetic modifications of Keap1 regulate its interaction with the protective factor Nrf2 in the development of diabetic retinopathy
-
M. Mishra, Q. Zhong, and R.A. Kowluru Epigenetic modifications of Keap1 regulate its interaction with the protective factor Nrf2 in the development of diabetic retinopathy Investigative ophthalmology & visual science 55 2014 7256 7265
-
(2014)
Investigative Ophthalmology & Visual Science
, vol.55
, pp. 7256-7265
-
-
Mishra, M.1
Zhong, Q.2
Kowluru, R.A.3
-
97
-
-
84874534208
-
Epigenetic modification of Sod2 in the development of diabetic retinopathy and in the metabolic memory: Role of histone methylation
-
Q. Zhong, and R.A. Kowluru Epigenetic modification of Sod2 in the development of diabetic retinopathy and in the metabolic memory: role of histone methylation Investigative ophthalmology & visual science 54 2013 244 250
-
(2013)
Investigative Ophthalmology & Visual Science
, vol.54
, pp. 244-250
-
-
Zhong, Q.1
Kowluru, R.A.2
-
98
-
-
84906331499
-
Epigenetic modifications of Nrf2-mediated glutamate-cysteine ligase: Implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression
-
M. Mishra, Q. Zhong, and R.A. Kowluru Epigenetic modifications of Nrf2-mediated glutamate-cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression Free radical biology & medicine 75 2014 129 139
-
(2014)
Free Radical Biology & Medicine
, vol.75
, pp. 129-139
-
-
Mishra, M.1
Zhong, Q.2
Kowluru, R.A.3
-
99
-
-
21644455413
-
[Oxidative stress in a model for experimental diabetic retinopathy: Treatment with antioxidants]
-
M. Miranda, M. Muriach, S. Johnsen, F. Bosch-Morell, J. Araiz, J. Roma, and F.J. Romero [Oxidative stress in a model for experimental diabetic retinopathy: treatment with antioxidants] Archivos de la Sociedad Espanola de Oftalmologia 79 2004 289 294
-
(2004)
Archivos de la Sociedad Espanola de Oftalmologia
, vol.79
, pp. 289-294
-
-
Miranda, M.1
Muriach, M.2
Johnsen, S.3
Bosch-Morell, F.4
Araiz, J.5
Roma, J.6
Romero, F.J.7
-
100
-
-
0035839136
-
Translating the histone code
-
T. Jenuwein, and C.D. Allis Translating the histone code Science 293 2001 1074 1080
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
101
-
-
70149105669
-
The role of human bromodomains in chromatin biology and gene transcription
-
R. Sanchez, and M.M. Zhou The role of human bromodomains in chromatin biology and gene transcription Current opinion in drug discovery & development 12 2009 659 665
-
(2009)
Current Opinion in Drug Discovery & Development
, vol.12
, pp. 659-665
-
-
Sanchez, R.1
Zhou, M.M.2
-
102
-
-
34250357662
-
The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation
-
S.Y. Wu, and C.M. Chiang The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation The Journal of biological chemistry 282 2007 13141 13145
-
(2007)
The Journal of Biological Chemistry
, vol.282
, pp. 13141-13145
-
-
Wu, S.Y.1
Chiang, C.M.2
-
103
-
-
84901256398
-
Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression
-
C. Michaeloudes, N. Mercado, C. Clarke, P.K. Bhavsar, I.M. Adcock, P.J. Barnes, and K.F. Chung Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression Journal of immunology 192 2014 4913 4920
-
(2014)
Journal of Immunology
, vol.192
, pp. 4913-4920
-
-
Michaeloudes, C.1
Mercado, N.2
Clarke, C.3
Bhavsar, P.K.4
Adcock, I.M.5
Barnes, P.J.6
Chung, K.F.7
-
104
-
-
84901004504
-
The bromodomain protein BRD4 regulates the Keap1/Nrf2-dependent oxidative stress response
-
M. Hussong, S.T. Borno, M. Kerick, A. Wunderlich, A. Franz, H. Sultmann, B. Timmermann, H. Lehrach, M. Hirsch-Kauffmann, and M.R. Schweiger The bromodomain protein BRD4 regulates the Keap1/Nrf2-dependent oxidative stress response Cell death & disease 5 2014 e1195
-
(2014)
Cell Death & Disease
, vol.5
, pp. e1195
-
-
Hussong, M.1
Borno, S.T.2
Kerick, M.3
Wunderlich, A.4
Franz, A.5
Sultmann, H.6
Timmermann, B.7
Lehrach, H.8
Hirsch-Kauffmann, M.9
Schweiger, M.R.10
-
105
-
-
78549277802
-
MicroRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease
-
C. Sangokoya, M.J. Telen, and J.T. Chi microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease Blood 116 2010 4338 4348
-
(2010)
Blood
, vol.116
, pp. 4338-4348
-
-
Sangokoya, C.1
Telen, M.J.2
Chi, J.T.3
-
106
-
-
84870859466
-
Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells
-
M. Narasimhan, D. Patel, D. Vedpathak, M. Rathinam, G. Henderson, and L. Mahimainathan Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells PloS one 7 2012 e51111
-
(2012)
PloS One
, vol.7
, pp. e51111
-
-
Narasimhan, M.1
Patel, D.2
Vedpathak, D.3
Rathinam, M.4
Henderson, G.5
Mahimainathan, L.6
-
107
-
-
2542626605
-
Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival
-
J. Takamizawa, H. Konishi, K. Yanagisawa, S. Tomida, H. Osada, H. Endoh, T. Harano, Y. Yatabe, M. Nagino, Y. Nimura, T. Mitsudomi, and T. Takahashi Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival Cancer research 64 2004 3753 3756
-
(2004)
Cancer Research
, vol.64
, pp. 3753-3756
-
-
Takamizawa, J.1
Konishi, H.2
Yanagisawa, K.3
Tomida, S.4
Osada, H.5
Endoh, H.6
Harano, T.7
Yatabe, Y.8
Nagino, M.9
Nimura, Y.10
Mitsudomi, T.11
Takahashi, T.12
-
109
-
-
80052570740
-
MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism
-
M. Yang, Y. Yao, G. Eades, Y. Zhang, and Q. Zhou MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism Breast cancer research and treatment 129 2011 983 991
-
(2011)
Breast Cancer Research and Treatment
, vol.129
, pp. 983-991
-
-
Yang, M.1
Yao, Y.2
Eades, G.3
Zhang, Y.4
Zhou, Q.5
-
110
-
-
84877113289
-
MicroRNA-93 regulates Nrf2 expression and is associated with breast carcinogenesis
-
B. Singh, A.M. Ronghe, A. Chatterjee, N.K. Bhat, and H.K. Bhat MicroRNA-93 regulates Nrf2 expression and is associated with breast carcinogenesis Carcinogenesis 34 2013 1165 1172
-
(2013)
Carcinogenesis
, vol.34
, pp. 1165-1172
-
-
Singh, B.1
Ronghe, A.M.2
Chatterjee, A.3
Bhat, N.K.4
Bhat, H.K.5
-
111
-
-
81755171451
-
MiR-200 a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells
-
G. Eades, M. Yang, Y. Yao, Y. Zhang, and Q. Zhou miR-200 a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells The Journal of biological chemistry 286 2011 40725 40733
-
(2011)
The Journal of Biological Chemistry
, vol.286
, pp. 40725-40733
-
-
Eades, G.1
Yang, M.2
Yao, Y.3
Zhang, Y.4
Zhou, Q.5
-
112
-
-
84914172382
-
Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3
-
J.H. Kim, K.S. Lee, D.K. Lee, J. Kim, S.N. Kwak, K.S. Ha, J. Choe, M.H. Won, B.R. Cho, D. Jeoung, H. Lee, Y.G. Kwon, and Y.M. Kim Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3 Antioxidants & redox signaling 21 2014 2469 2482
-
(2014)
Antioxidants & Redox Signaling
, vol.21
, pp. 2469-2482
-
-
Kim, J.H.1
Lee, K.S.2
Lee, D.K.3
Kim, J.4
Kwak, S.N.5
Ha, K.S.6
Choe, J.7
Won, M.H.8
Cho, B.R.9
Jeoung, D.10
Lee, H.11
Kwon, Y.G.12
Kim, Y.M.13
-
113
-
-
37549050907
-
Heme oxygenase-1 induction by Nrf2 requires inactivation of the transcriptional repressor BACH1
-
J.F. Reichard, G.T. Motz, and A. Puga Heme oxygenase-1 induction by Nrf2 requires inactivation of the transcriptional repressor BACH1 Nucleic acids research 35 2007 7074 7086
-
(2007)
Nucleic Acids Research
, vol.35
, pp. 7074-7086
-
-
Reichard, J.F.1
Motz, G.T.2
Puga, A.3
-
114
-
-
70249138697
-
Characterization of the cancer chemopreventive Nrf2-dependent gene battery in human keratinocytes: Demonstration that the Keap1-Nrf2 pathway, and not the BACH1-Nrf2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds
-
A.K. MacLeod, M. McMahon, S.M. Plummer, L.G. Higgins, T.M. Penning, K. Igarashi, and J.D. Hayes Characterization of the cancer chemopreventive Nrf2-dependent gene battery in human keratinocytes: demonstration that the Keap1-Nrf2 pathway, and not the BACH1-Nrf2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds Carcinogenesis 30 2009 1571 1580
-
(2009)
Carcinogenesis
, vol.30
, pp. 1571-1580
-
-
MacLeod, A.K.1
McMahon, M.2
Plummer, S.M.3
Higgins, L.G.4
Penning, T.M.5
Igarashi, K.6
Hayes, J.D.7
-
115
-
-
84867050326
-
The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes
-
W. Hou, Q. Tian, N.M. Steuerwald, L.W. Schrum, and H.L. Bonkovsky The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes Biochimica et biophysica acta 1113-1122 1819 2012
-
(1819)
Biochimica et Biophysica Acta
, vol.1113-1122
, pp. 2012
-
-
Hou, W.1
Tian, Q.2
Steuerwald, N.M.3
Schrum, L.W.4
Bonkovsky, H.L.5
-
116
-
-
80255137252
-
Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells
-
K.H. Pulkkinen, S. Yla-Herttuala, and A.L. Levonen Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells Free radical biology & medicine 51 2011 2124 2131
-
(2011)
Free Radical Biology & Medicine
, vol.51
, pp. 2124-2131
-
-
Pulkkinen, K.H.1
Yla-Herttuala, S.2
Levonen, A.L.3
-
117
-
-
84860745555
-
Anti-inflammatory potential of allyl-isothiocyanate - Role of Nrf2, NF-(kappa) B and microRNA-155
-
A.E. Wagner, C. Boesch-Saadatmandi, J. Dose, G. Schultheiss, and G. Rimbach Anti-inflammatory potential of allyl-isothiocyanate - role of Nrf2, NF-(kappa) B and microRNA-155 Journal of cellular and molecular medicine 16 2012 836 843
-
(2012)
Journal of Cellular and Molecular Medicine
, vol.16
, pp. 836-843
-
-
Wagner, A.E.1
Boesch-Saadatmandi, C.2
Dose, J.3
Schultheiss, G.4
Rimbach, G.5
-
118
-
-
84884334947
-
Understanding the role of Nrf2-regulated miRNAs in human malignancies
-
N.M. Shah, S.A. Rushworth, M.Y. Murray, K.M. Bowles, and D.J. MacEwan Understanding the role of Nrf2-regulated miRNAs in human malignancies Oncotarget 4 2013 1130 1142
-
(2013)
Oncotarget
, vol.4
, pp. 1130-1142
-
-
Shah, N.M.1
Rushworth, S.A.2
Murray, M.Y.3
Bowles, K.M.4
MacEwan, D.J.5
-
119
-
-
84862494503
-
The Nrf2-related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops
-
D. Papp, K. Lenti, D. Modos, D. Fazekas, Z. Dul, D. Turei, L. Foldvari-Nagy, R. Nussinov, P. Csermely, and T. Korcsmaros The Nrf2-related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops FEBS letters 586 2012 1795 1802
-
(2012)
FEBS Letters
, vol.586
, pp. 1795-1802
-
-
Papp, D.1
Lenti, K.2
Modos, D.3
Fazekas, D.4
Dul, Z.5
Turei, D.6
Foldvari-Nagy, L.7
Nussinov, R.8
Csermely, P.9
Korcsmaros, T.10
-
120
-
-
70449701913
-
Epigenetic cross-talk between DNA methylation and histone modifications in human cancers
-
Y. Kondo Epigenetic cross-talk between DNA methylation and histone modifications in human cancers Yonsei medical journal 50 2009 455 463
-
(2009)
Yonsei Medical Journal
, vol.50
, pp. 455-463
-
-
Kondo, Y.1
-
121
-
-
47849083984
-
Epigenetic interplay between histone modifications and DNA methylation in gene silencing
-
T. Vaissiere, C. Sawan, and Z. Herceg Epigenetic interplay between histone modifications and DNA methylation in gene silencing Mutation research 659 2008 40 48
-
(2008)
Mutation Research
, vol.659
, pp. 40-48
-
-
Vaissiere, T.1
Sawan, C.2
Herceg, Z.3
-
122
-
-
77649251655
-
Role for DNA methylation in the regulation of miR-200 c and miR-141 expression in normal and cancer cells
-
L. Vrba, T.J. Jensen, J.C. Garbe, R.L. Heimark, A.E. Cress, S. Dickinson, M.R. Stampfer, and B.W. Futscher Role for DNA methylation in the regulation of miR-200 c and miR-141 expression in normal and cancer cells PloS one 5 2010 e8697
-
(2010)
PloS One
, vol.5
, pp. e8697
-
-
Vrba, L.1
Jensen, T.J.2
Garbe, J.C.3
Heimark, R.L.4
Cress, A.E.5
Dickinson, S.6
Stampfer, M.R.7
Futscher, B.W.8
-
123
-
-
79960391940
-
MiR-200 a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells
-
G. Eades, Y. Yao, M. Yang, Y. Zhang, S. Chumsri, and Q. Zhou miR-200 a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells The Journal of biological chemistry 286 2011 25992 26002
-
(2011)
The Journal of Biological Chemistry
, vol.286
, pp. 25992-26002
-
-
Eades, G.1
Yao, Y.2
Yang, M.3
Zhang, Y.4
Chumsri, S.5
Zhou, Q.6
-
124
-
-
84885674655
-
Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism
-
T. Murray-Stewart, C.L. Hanigan, P.M. Woster, L.J. Marton, and R.A. Casero Jr. Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism Mol Cancer Ther 12 2013 2088 2099
-
(2013)
Mol Cancer Ther
, vol.12
, pp. 2088-2099
-
-
Murray-Stewart, T.1
Hanigan, C.L.2
Woster, P.M.3
Marton, L.J.4
Casero, R.A.5
|