Blocking of JB6 Cell Transformation by Tanshinone IIA: Epigenetic Reactivation of Nrf2 Antioxidative Stress Pathway

Botanical Review

Volumn 16, Issue 6, 2014, Pages 1214-1225

  Wang, Ling ^a,b   Zhang, Chengyue ^b,c   Guo, Yue ^b,c   Su, Zheng Yuan ^b,c   Yang, Yuqing ^b,c   Shu, Limin ^b,c   Kong, Ah Ng Tony ^b,c  

^a SICHUAN UNIVERSITY   (China)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

epigenetics; Nrf2; skin cancer; tanshinone IIA

Indexed keywords

SALVIA MILTIORRHIZA;

ABIETANE DERIVATIVE; ANTIOXIDANT; HERBACEOUS AGENT; NFE2L2 PROTEIN, MOUSE; RNA POLYMERASE II; TANSHINONE; TRANSCRIPTION FACTOR NRF2; BISULFITE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; HEME OXYGENASE 1; HISTONE DEACETYLASE 3; LUCIFERASE; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE) 1; TANSHINONE IIA; UNCLASSIFIED DRUG;

ANIMAL; CELL LINE; CELL SURVIVAL; CELL TRANSFORMATION; CHEMICAL STRUCTURE; CHEMISTRY; CPG ISLAND; DNA METHYLATION; DRUG EFFECTS; EPIDERMIS; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MOUSE; OXIDATIVE STRESS; PATHOLOGY; SALVIA MILTIORRHIZA; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BISULFITE GENOMIC SEQUENCING; CELL LEVEL; CHROMATIN IMMUNOPRECIPITATION; COLONY FORMATION; CONTROLLED STUDY; DEMETHYLATION; DRUG STRUCTURE; ENZYME INHIBITION; EPIDERMIS CELL; EPIGENETICS; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC PROCEDURES; HUMAN CELL; IN VITRO STUDY; JB6 CELL LINE; NONHUMAN; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION SITE;

ANIMALS; ANTIOXIDANTS; CELL LINE; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CPG ISLANDS; DITERPENES, ABIETANE; DNA METHYLATION; DRUGS, CHINESE HERBAL; EPIDERMIS; EPIGENESIS, GENETIC; HUMANS; MICE; MOLECULAR STRUCTURE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; RNA POLYMERASE II; SALVIA MILTIORRHIZA; TRANSCRIPTION, GENETIC;

EID: 84938797144     PISSN: 00068101     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-014-9666-8     Document Type: Article

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