Gender matters: Estrogen receptor alpha (ERα) and histone deacetylase (HDAC) 1 and 2 control the gender-specific transcriptional regulation of human uridine diphosphate glucuronosyltransferases genes (UGT1A)

Journal of Hepatology

Volumn 59, Issue 4, 2013, Pages 797-804

  Kalthoff, Sandra ^a   Winkler, Anja ^a   Freiberg, Nicole ^a   Manns, Michael P ^a   Strassburg, Christian P ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Drug metabolism; Gender; UDP glucuronosyltransferase

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; ESTROGEN RECEPTOR ALPHA; GLUCURONOSYLTRANSFERASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; MESSENGER RNA; TAMOXIFEN; TRANSCRIPTION FACTOR NRF2; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; COLON; CONTROLLED STUDY; DNA BINDING MOTIF; DRUG DETOXIFICATION; ENZYME REGULATION; FEMALE; GENE ACTIVATION; GENE CONTROL; GENE REPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; JEJUNUM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE; TRANSACTIVATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING; XENOBIOTIC METABOLISM;

2,3,7,8-TETRACHLORDIBENZO-P-DIOXIN; AHR; ARYLHYDROCARBON RECEPTOR; CAR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYP; CYTOCHROME P450 ENZYME; DRUG METABOLISM; ERΑ; ESTROGEN RECEPTOR ALPHA; GENDER; HDAC; HEPATOCYTE NUCLEAR FACTOR 4 ALPHA; HISTONE DEACETYLASE; HNF4(Α); NRF2; NUCLEAR FACTOR ERYTHROID RELATED FACTOR 2; PCR; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA; POLYMERASE CHAIN REACTION; PPARA; PREGNANE X RECEPTOR; PXR; TBHQ; TCDD; TERT-BUTYLHYDROQUINONE; UDP-GLUCURONOSYLTRANSFERASE; UGT; XENOBIOTIC RESPONSE ELEMENT; XRE;

ANIMALS; CELL LINE; COFFEE; COLON; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCURONOSYLTRANSFERASE; HEP G2 CELLS; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HUMANS; JEJUNUM; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; RECEPTORS, ARYL HYDROCARBON; RNA, MESSENGER; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SEX CHARACTERISTICS; TAMOXIFEN;

EID: 84884417014     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.05.028     Document Type: Article

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