-
1
-
-
84859893371
-
Histone methylation: A dynamic mark in health, disease and inheritance
-
E.L. Greer, and Y. Shi Histone methylation: a dynamic mark in health, disease and inheritance Nat. Rev. Genet. 13 2012 343 357
-
(2012)
Nat. Rev. Genet.
, vol.13
, pp. 343-357
-
-
Greer, E.L.1
Shi, Y.2
-
2
-
-
84870375316
-
Histone lysine methylation dynamics: Establishment, regulation, and biological impact
-
Joshua C. Black, C. Van Rechem, and Johnathan R. Whetstine Histone lysine methylation dynamics: establishment, regulation, and biological impact Mol. Cell 48 2012 491 507
-
(2012)
Mol. Cell
, vol.48
, pp. 491-507
-
-
Black, J.C.1
Van Rechem, C.2
Whetstine, J.R.3
-
3
-
-
79955513100
-
Aberrations of EZH2 in cancer
-
A. Chase, and N.C.P. Cross Aberrations of EZH2 in Cancer Clin. Cancer Res. 17 2011 2613 2618
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 2613-2618
-
-
Chase, A.1
Cross, N.C.P.2
-
4
-
-
77953995002
-
Covalent histone modifications - Miswritten, misinterpreted and mis-erased in human cancers
-
P. Chi, C.D. Allis, and G.G. Wang Covalent histone modifications - miswritten, misinterpreted and mis-erased in human cancers Nat. Rev. Cancer 10 2010 457 469
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 457-469
-
-
Chi, P.1
Allis, C.D.2
Wang, G.G.3
-
5
-
-
77049099785
-
Histone methyltransferases in cancer
-
M. Albert, and K. Helin Histone methyltransferases in cancer Semin. Cell Dev. Biol. 21 2010 209 220
-
(2010)
Semin. Cell Dev. Biol.
, vol.21
, pp. 209-220
-
-
Albert, M.1
Helin, K.2
-
6
-
-
18644382388
-
The polycomb group protein EZH2 is involved in progression of prostate cancer
-
S. Varambally, S.M. Dhanasekaran, M. Zhou, T.R. Barrette, C. Kumar-Sinha, M.G. Sanda, D. Ghosh, K.J. Pienta, R.G. Sewalt, A.P. Otte, M.A. Rubin, and A.M. Chinnaiyan The polycomb group protein EZH2 is involved in progression of prostate cancer Nature 419 2002 624 629
-
(2002)
Nature
, vol.419
, pp. 624-629
-
-
Varambally, S.1
Dhanasekaran, S.M.2
Zhou, M.3
Barrette, T.R.4
Kumar-Sinha, C.5
Sanda, M.G.6
Ghosh, D.7
Pienta, K.J.8
Sewalt, R.G.9
Otte, A.P.10
Rubin, M.A.11
Chinnaiyan, A.M.12
-
7
-
-
0141816752
-
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
-
C.G. Kleer, Q. Cao, S. Varambally, R. Shen, I. Ota, S.A. Tomlins, D. Ghosh, R.G. Sewalt, A.P. Otte, D.F. Hayes, M.S. Sabel, D. Livant, S.J. Weiss, M.A. Rubin, and A.M. Chinnaiyan EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells Proc. Natl. Acad. Sci. U.S.A. 100 2003 11606 11611
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 11606-11611
-
-
Kleer, C.G.1
Cao, Q.2
Varambally, S.3
Shen, R.4
Ota, I.5
Tomlins, S.A.6
Ghosh, D.7
Sewalt, R.G.8
Otte, A.P.9
Hayes, D.F.10
Sabel, M.S.11
Livant, D.12
Weiss, S.J.13
Rubin, M.A.14
Chinnaiyan, A.M.15
-
8
-
-
0035050744
-
The polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma
-
H.P. Visser, M.J. Gunster, H.C. Kluin-Nelemans, E.M. Manders, F.M. Raaphorst, C.J. Meijer, R. Willemze, and A.P. Otte The polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma Br. J. Haematol. 112 2001 950 958
-
(2001)
Br. J. Haematol.
, vol.112
, pp. 950-958
-
-
Visser, H.P.1
Gunster, M.J.2
Kluin-Nelemans, H.C.3
Manders, E.M.4
Raaphorst, F.M.5
Meijer, C.J.6
Willemze, R.7
Otte, A.P.8
-
10
-
-
1942520367
-
Nrf2 signaling in coordinated activation of antioxidant gene expression
-
A.K. Jaiswal Nrf2 signaling in coordinated activation of antioxidant gene expression Free Radic. Biol. Med. 36 2004 1199 1207
-
(2004)
Free Radic. Biol. Med.
, vol.36
, pp. 1199-1207
-
-
Jaiswal, A.K.1
-
11
-
-
66149168685
-
Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer
-
S. Homma, Y. Ishii, Y. Morishima, T. Yamadori, Y. Matsuno, N. Haraguchi, N. Kikuchi, H. Satoh, T. Sakamoto, N. Hizawa, K. Itoh, and M. Yamamoto Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer Clin. Cancer Res. 15 2009 3423 3432
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 3423-3432
-
-
Homma, S.1
Ishii, Y.2
Morishima, Y.3
Yamadori, T.4
Matsuno, Y.5
Haraguchi, N.6
Kikuchi, N.7
Satoh, H.8
Sakamoto, T.9
Hizawa, N.10
Itoh, K.11
Yamamoto, M.12
-
12
-
-
79953236274
-
Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis
-
T.M. Stȩpkowski, and M.K. Kruszewski Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis Free Radic. Biol. Med. 50 2011 1186 1195
-
(2011)
Free Radic. Biol. Med.
, vol.50
, pp. 1186-1195
-
-
Stȩpkowski, T.M.1
Kruszewski, M.K.2
-
13
-
-
77958140054
-
The Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer
-
D.D. Zhang The Nrf2-Keap1-ARE signaling pathway: the regulation and dual function of Nrf2 in cancer Antioxid. Redox Signal. 13 2010 1623 1626
-
(2010)
Antioxid. Redox Signal.
, vol.13
, pp. 1623-1626
-
-
Zhang, D.D.1
-
14
-
-
33750885385
-
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
-
A. Singh, V. Misra, R.K. Thimmulappa, H. Lee, S. Ames, M.O. Hoque, J.G. Herman, S.B. Baylin, D. Sidransky, E. Gabrielson, M.V. Brock, and S. Biswal Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer PLoS Med. 3 2006 e420
-
(2006)
PLoS Med.
, vol.3
, pp. 420
-
-
Singh, A.1
Misra, V.2
Thimmulappa, R.K.3
Lee, H.4
Ames, S.5
Hoque, M.O.6
Herman, J.G.7
Baylin, S.B.8
Sidransky, D.9
Gabrielson, E.10
Brock, M.V.11
Biswal, S.12
-
15
-
-
40449107193
-
Loss of Keap1 function activates nrf2 and provides advantages for lung cancer cell growth
-
T. Ohta, K. Iijima, M. Miyamoto, I. Nakahara, H. Tanaka, M. Ohtsuji, T. Suzuki, A. Kobayashi, J. Yokota, T. Sakiyama, T. Shibata, M. Yamamoto, and S. Hirohashi Loss of Keap1 function activates nrf2 and provides advantages for lung cancer cell growth Cancer Res. 68 2008 1303 1309
-
(2008)
Cancer Res.
, vol.68
, pp. 1303-1309
-
-
Ohta, T.1
Iijima, K.2
Miyamoto, M.3
Nakahara, I.4
Tanaka, H.5
Ohtsuji, M.6
Suzuki, T.7
Kobayashi, A.8
Yokota, J.9
Sakiyama, T.10
Shibata, T.11
Yamamoto, M.12
Hirohashi, S.13
-
16
-
-
33344456501
-
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
-
B. Padmanabhan, K.I. Tong, T. Ohta, Y. Nakamura, M. Scharlock, M. Ohtsuji, M.-I. Kang, A. Kobayashi, S. Yokoyama, and M. Yamamoto Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer Mol. Cell 21 2006 689 700
-
(2006)
Mol. Cell
, vol.21
, pp. 689-700
-
-
Padmanabhan, B.1
Tong, K.I.2
Ohta, T.3
Nakamura, Y.4
Scharlock, M.5
Ohtsuji, M.6
Kang, M.-I.7
Kobayashi, A.8
Yokoyama, S.9
Yamamoto, M.10
-
17
-
-
77958129306
-
Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance
-
A. Singh, M. Bodas, N. Wakabayashi, F. Bunz, and S. Biswal Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance Antioxid. Redox Signal. 13 2010 1627 1637
-
(2010)
Antioxid. Redox Signal.
, vol.13
, pp. 1627-1637
-
-
Singh, A.1
Bodas, M.2
Wakabayashi, N.3
Bunz, F.4
Biswal, S.5
-
18
-
-
84902121544
-
HMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung cancer
-
Z. Chen, X. Ye, N. Tang, S. Shen, Z. Li, X. Niu, S. Lu, and L. Xu HMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung cancer Br. J. Pharmacol. 171 2014 3196 3211
-
(2014)
Br. J. Pharmacol.
, vol.171
, pp. 3196-3211
-
-
Chen, Z.1
Ye, X.2
Tang, N.3
Shen, S.4
Li, Z.5
Niu, X.6
Lu, S.7
Xu, L.8
-
19
-
-
84888294166
-
Sirt2 suppresses glioma cell growth through targeting NF-κB-miR-21 axis
-
Y.n. Li, D. Dai, Q. Lu, M. Fei, M. Li, and X. Wu Sirt2 suppresses glioma cell growth through targeting NF-κB-miR-21 axis Biochem. Biophys. Res. Commun. 441 2013 661 667
-
(2013)
Biochem. Biophys. Res. Commun.
, vol.441
, pp. 661-667
-
-
Li, Y.N.1
Dai, D.2
Lu, Q.3
Fei, M.4
Li, M.5
Wu, X.6
-
20
-
-
84877103458
-
RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3
-
W. Han, Z. Xin, Z. Zhao, W. Bao, X. Lin, B. Yin, J. Zhao, J. Yuan, B. Qiang, and X. Peng RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3 J. Clin. Invest. 123 2013 2103 2118
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 2103-2118
-
-
Han, W.1
Xin, Z.2
Zhao, Z.3
Bao, W.4
Lin, X.5
Yin, B.6
Zhao, J.7
Yuan, J.8
Qiang, B.9
Peng, X.10
-
21
-
-
84869087891
-
Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers
-
T. Yamadori, Y. Ishii, S. Homma, Y. Morishima, K. Kurishima, K. Itoh, M. Yamamoto, Y. Minami, M. Noguchi, and N. Hizawa Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers Oncogene 31 2012 4768 4777
-
(2012)
Oncogene
, vol.31
, pp. 4768-4777
-
-
Yamadori, T.1
Ishii, Y.2
Homma, S.3
Morishima, Y.4
Kurishima, K.5
Itoh, K.6
Yamamoto, M.7
Minami, Y.8
Noguchi, M.9
Hizawa, N.10
-
22
-
-
77954087127
-
Increased cell migration and plasticity in Nrf2-deficient cancer cell lines
-
G. Rachakonda, K.R. Sekhar, D. Jowhar, P.C. Samson, J.P. Wikswo, R.D. Beauchamp, P.K. Datta, and M.L. Freeman Increased cell migration and plasticity in Nrf2-deficient cancer cell lines Oncogene 29 2010 3703 3714
-
(2010)
Oncogene
, vol.29
, pp. 3703-3714
-
-
Rachakonda, G.1
Sekhar, K.R.2
Jowhar, D.3
Samson, P.C.4
Wikswo, J.P.5
Beauchamp, R.D.6
Datta, P.K.7
Freeman, M.L.8
-
23
-
-
84867818118
-
A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level
-
S. Balasubramanian, S. Kanade, B. Han, and R.L. Eckert A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level J. Biol. Chem. 287 2012 36179 36189
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 36179-36189
-
-
Balasubramanian, S.1
Kanade, S.2
Han, B.3
Eckert, R.L.4
-
24
-
-
57649124289
-
Repression of E-cadherin by the polycomb group protein EZH2 in cancer
-
Q. Cao, J. Yu, S.M. Dhanasekaran, J.H. Kim, R.S. Mani, S.A. Tomlins, R. Mehra, B. Laxman, X. Cao, J. Yu, C.G. Kleer, S. Varambally, and A.M. Chinnaiyan Repression of E-cadherin by the polycomb group protein EZH2 in cancer Oncogene 27 2008 7274 7284
-
(2008)
Oncogene
, vol.27
, pp. 7274-7284
-
-
Cao, Q.1
Yu, J.2
Dhanasekaran, S.M.3
Kim, J.H.4
Mani, R.S.5
Tomlins, S.A.6
Mehra, R.7
Laxman, B.8
Cao, X.9
Yu, J.10
Kleer, C.G.11
Varambally, S.12
Chinnaiyan, A.M.13
-
25
-
-
0142105414
-
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
-
A.P. Bracken, D. Pasini, M. Capra, E. Prosperini, E. Colli, and K. Helin EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer EMBO J. 22 2003 5323 5335
-
(2003)
EMBO J.
, vol.22
, pp. 5323-5335
-
-
Bracken, A.P.1
Pasini, D.2
Capra, M.3
Prosperini, E.4
Colli, E.5
Helin, K.6
-
26
-
-
33644822360
-
EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, and breast
-
I.M. Bachmann, O.J. Halvorsen, K. Collett, I.M. Stefansson, O. Straume, S.A. Haukaas, H.B. Salvesen, A.P. Otte, and L.A. Akslen EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, and breast J. Clin. Oncol. 24 2006 268 273
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 268-273
-
-
Bachmann, I.M.1
Halvorsen, O.J.2
Collett, K.3
Stefansson, I.M.4
Straume, O.5
Haukaas, S.A.6
Salvesen, H.B.7
Otte, A.P.8
Akslen, L.A.9
-
27
-
-
77955087290
-
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
-
G. Nikoloski, S.M. Langemeijer, R.P. Kuiper, R. Knops, M. Massop, E.R. Tonnissen, A. van der Heijden, T.N. Scheele, P. Vandenberghe, T. de Witte, B.A. van der Reijden, and J.H. Jansen Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes Nat. Genet. 42 2010 665 667
-
(2010)
Nat. Genet.
, vol.42
, pp. 665-667
-
-
Nikoloski, G.1
Langemeijer, S.M.2
Kuiper, R.P.3
Knops, R.4
Massop, M.5
Tonnissen, E.R.6
Van Der Heijden, A.7
Scheele, T.N.8
Vandenberghe, P.9
De Witte, T.10
Van Der Reijden, B.A.11
Jansen, J.H.12
-
28
-
-
51649130168
-
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
-
T. Shibata, T. Ohta, K.I. Tong, A. Kokubu, R. Odogawa, K. Tsuta, H. Asamura, M. Yamamoto, and S. Hirohashi Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy Proc. Natl. Acad. Sci. 105 2008 13568 13573
-
(2008)
Proc. Natl. Acad. Sci.
, vol.105
, pp. 13568-13573
-
-
Shibata, T.1
Ohta, T.2
Tong, K.I.3
Kokubu, A.4
Odogawa, R.5
Tsuta, K.6
Asamura, H.7
Yamamoto, M.8
Hirohashi, S.9
|