Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer

Molecular Cancer

Volumn 12, Issue 1, 2013, Pages

  Martinez, Victor D ^a   Vucic, Emily A ^a   Pikor, Larissa A ^a   Thu, Kelsie L ^a   Hubaux, Roland ^a   Lam, Wan L ^a  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

Author keywords

Gene disruption; KEAP1 CUL3 RBX1 E3 ubiquitin ligase complex; NRF2; Thyroid cancer

Indexed keywords

DNA; E3 UBIQUITIN LIGASE KEAP1; E3 UBIQUITIN LIGASE RBX1; KELCH LIKE ECH ASSOCIATED PROTEIN 1; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTOME; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; CANCER GENETICS; CANCER TISSUE; EPIGENETICS; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MOLECULAR MECHANICS; SIGNAL TRANSDUCTION; THYROID CARCINOMA; THYROID FUNCTION; TUMOR GENE;

CARCINOMA; CARRIER PROTEINS; CULLIN PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUTATION; NF-E2-RELATED FACTOR 2; REACTIVE OXYGEN SPECIES; THYROID NEOPLASMS; UBIQUITIN-PROTEIN LIGASES;

EID: 84885524071     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-12-124     Document Type: Article

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