The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response

Cell Death and Disease

Volumn 5, Issue 4, 2014, Pages

  Hussong, M ^a,b   Borno S T ^a   Kerick, M ^a   Wunderlich, A ^a   Franz, A ^a,b   Sultmann H ^c   Timmermann, B ^a   Lehrach, H ^a   Hirsch Kauffmann, M ^a   Schweiger, M R ^a,d  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Bromodomain protein BRD4; Heme oxygenase 1; Oxidative stress

Indexed keywords

HEME OXYGENASE 1; HYDROGEN PEROXIDE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; ONCOPROTEIN; PROTEIN BRD4; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; (+)-JQ1 COMPOUND; AZEPINE DERIVATIVE; BRD4 PROTEIN, HUMAN; DNA; KEAP1 PROTEIN, HUMAN; NUCLEAR PROTEIN; PROTEIN BINDING; PROTOPORPHYRIN; PROTOPORPHYRIN COBALT; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR; TRIAZOLE DERIVATIVE;

ARTICLE; BINDING SITE; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE EXPRESSION; HDAC6 GENE; HUMAN; HUMAN CELL; KEAP1 GENE; ONCOGENE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; PROTEIN DNA BINDING; REGULATORY MECHANISM; RNA SEQUENCE; SESN3 GENE; TRANSCRIPTION REGULATION; BIOLOGICAL MODEL; CELL SURVIVAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; MALE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE MOTIF; NUCLEOTIDE SEQUENCE; PATHOLOGY; PROSTATE TUMOR;

AZEPINES; BASE SEQUENCE; BINDING SITES; CELL SURVIVAL; DNA, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HEME OXYGENASE-1; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NF-E2-RELATED FACTOR 2; NUCLEAR PROTEINS; NUCLEOTIDE MOTIFS; OXIDATIVE STRESS; PROSTATIC NEOPLASMS; PROTEIN BINDING; PROTOPORPHYRINS; REACTIVE OXYGEN SPECIES; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRIAZOLES;

EID: 84901004504     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.157     Document Type: Article

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