Mechanism and function of oxidative reversal of DNA and RNA methylation

Annual Review of Biochemistry

Volumn 83, Issue , 2014, Pages 585-614

  Shen, Li ^a,b,c   Song, Chun Xiao ^d   He, Chuan ^d   Zhang, Yi ^a,b,c  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

5 methylcytosine oxidation; DNA RNA demethylation; Fe(II) ketoglutarate dependent dioxygenases; Tet

Indexed keywords

5 CARBOXYLCYTOSINE; 5 FORMYLCYTOSINE; 5 HYDROXYMETHYLCYTOSINE; 5 METHYLCYTOSINE; CYTOSINE DERIVATIVE; DIOXYGENASE; PROTEIN; TET FAMILY DIOXYGENASE; TET PROTEIN; UNCLASSIFIED DRUG; 5-CARBOXYLCYTOSINE; 5-FORMYLCYTOSINE; CYTOSINE; DNA; OXYGEN; RNA; TRANSCRIPTOME;

BINDING AFFINITY; BIOLOGICAL FUNCTIONS; DEMETHYLATION; DNA DEMETHYLATION; DNA METHYLATION; EMBRYO DEVELOPMENT; EXCISION REPAIR; GERM CELL; HUMAN; IMPLANTATION; MALIGNANT NEOPLASTIC DISEASE; METABOLITE; NONHUMAN; NUCLEAR REPROGRAMMING; NUCLEIC ACID STRUCTURE, METABOLISM AND FUNCTION; OXIDATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; RNA METHYLATION; SOMATIC CELL; STEM CELL; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; CYTOLOGY; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENETICS; GENOME; HEK293 CELL LINE; METABOLISM; METHYLATION; MOUSE; NEOPLASM;

5-METHYLCYTOSINE; ANIMALS; CYTOSINE; DNA; DNA METHYLATION; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENOME; GERM CELLS; HEK293 CELLS; HUMANS; METHYLATION; MICE; NEOPLASMS; OXYGEN; RNA; STEM CELLS; TRANSCRIPTOME;

EID: 84902182150     PISSN: 00664154     EISSN: 15454509     Source Type: Book Series    
DOI: 10.1146/annurev-biochem-060713-035513     Document Type: Review

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