Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts

Free Radical Biology and Medicine

Volumn 72, Issue , 2014, Pages 134-148

  Palsamy, Periyasamy ^a   Bidasee, Keshore R ^b   Ayaki, Masahiko ^c   Augusteyn, Robert C ^d,e   Chan, Jefferson Y ^f   Shinohara, Toshimichi ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c KEIO UNIVERSITY   (Japan)

^d BRIEN HOLDEN VISION INSTITUTE   (Australia)

^e UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cataracts; DNA methylation; ER stress; Free radicals; Keap1 promoter demethylation; Methylglyoxal; Nrf2 dependent antioxidant protection; Unfolded protein response

Indexed keywords

5 METHYLCYTOSINE; DNA; DNA METHYLTRANSFERASE; GENOMIC DNA; KELCH LIKE ECH ASSOCIATED PROTEIN 1; METHYLGLYOXAL; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; KEAP1 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CELL DEATH; CONTROLLED STUDY; DIABETES MELLITUS; DNA METHYLATION; DNA SEQUENCE; ENDOPLASMIC RETICULUM STRESS; EPITHELIUM CELL; HUMAN; HUMAN CELL; LENS EPITHELIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SENILE CATARACT; UNFOLDED PROTEIN RESPONSE; AGING; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; GENETICS; KNOCKOUT MOUSE; LENS; METABOLISM; PHYSIOLOGY; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AGING; ANIMALS; BLOTTING, WESTERN; CATARACT; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DNA METHYLATION; ENDOPLASMIC RETICULUM STRESS; EPITHELIAL CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LENS, CRYSTALLINE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROMOTER REGIONS, GENETIC; PYRUVALDEHYDE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UNFOLDED PROTEIN RESPONSE;

EID: 84900490382     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.04.010     Document Type: Article

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