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Volumn 13, Issue 8, 2016, Pages 707-719

The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance

Author keywords

Alternative splicing; embryonic stem cells; hESC; iPSC; pluripotency; telomerase; telomere; TERT

Indexed keywords

BRG1 PROTEIN; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; WNT PROTEIN; BIOLOGICAL MARKER; ISOENZYME; PROTEIN BINDING;

EID: 84969752477     PISSN: 15476286     EISSN: 15558584     Source Type: Journal    
DOI: 10.1080/15476286.2015.1134413     Document Type: Review
Times cited : (34)

References (163)
  • 2
    • 0001294157 scopus 로고
    • The stability of broken ends of chromosomes in Zea mays
    • 17247004
    • B.McClintock. The stability of broken ends of chromosomes in Zea mays. Genetics 1941; 26:234-82; PMID:17247004
    • (1941) Genetics , vol.26 , pp. 234-282
    • McClintock, B.1
  • 4
    • 50549218525 scopus 로고
    • The Limited in Vitro Lifetime of Human Diploid Cell Strains
    • 14315085
    • L.Hayflick. The Limited in Vitro Lifetime of Human Diploid Cell Strains. Exp Cell Res 1965; 37:614-36; PMID:14315085; http://dx.doi.org/10.1016/0014-4827(65)90211-9
    • (1965) Exp Cell Res , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 5
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • 13905658
    • L.Hayflick, P.S.Moorhead. The serial cultivation of human diploid cell strains. Exp Cell Res 1961; 25:585-621; PMID:13905658; http://dx.doi.org/10.1016/0014-4827(61)90192-6
    • (1961) Exp Cell Res , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 6
    • 84855473741 scopus 로고    scopus 로고
    • Telomerase and idiopathic pulmonary fibrosis
    • M.Armanios. Telomerase and idiopathic pulmonary fibrosis. Mutat Res 2012; 730:52-58; http://dx.doi.org/10.1016/j.mrfmmm.2011.10.013
    • (2012) Mutat Res , vol.730 , pp. 52-58
    • Armanios, M.1
  • 8
    • 84855481090 scopus 로고    scopus 로고
    • Genetics of leukocyte telomere length and its role in atherosclerosis
    • A.Aviv. Genetics of leukocyte telomere length and its role in atherosclerosis. Mutat Res 2012; 730:68-74; http://dx.doi.org/10.1016/j.mrfmmm.2011.05.001
    • (2012) Mutat Res , vol.730 , pp. 68-74
    • Aviv, A.1
  • 10
    • 84901486259 scopus 로고    scopus 로고
    • Telomere and telomerase in chronic liver disease and hepatocarcinoma
    • L.Carulli, C.Anzivino. Telomere and telomerase in chronic liver disease and hepatocarcinoma. World Journal of Gastroenterology:WJG 2014; 20:6287-92; PMID:24876749; http://dx.doi.org/10.3748/wjg.v20.i20.6287
    • (2014) World Journal of Gastroenterology : WJG , vol.20 , pp. 6287-6292
    • Carulli, L.1    Anzivino, C.2
  • 12
    • 77955280810 scopus 로고    scopus 로고
    • Telomeres are shorter in placental trophoblasts of pregnancies complicated with intrauterine growth restriction (IUGR)
    • 20619976
    • T.Biron-Shental, R.Sukenik Halevy, L.Goldberg-Bittman, D.Kidron, M.D.Fejgin, A.Amiel. Telomeres are shorter in placental trophoblasts of pregnancies complicated with intrauterine growth restriction (IUGR). Early human development 2010; 86:451-6; PMID:20619976; http://dx.doi.org/10.1016/j.earlhumdev.2010.06.002
    • (2010) Early human development , vol.86 , pp. 451-456
    • Biron-Shental, T.1    Sukenik Halevy, R.2    Goldberg-Bittman, L.3    Kidron, D.4    Fejgin, M.D.5    Amiel, A.6
  • 13
    • 78751607930 scopus 로고    scopus 로고
    • TERC telomerase subunit gene copy number in placentas from pregnancies complicated with intrauterine growth restriction
    • 21168289
    • T.Biron-Shental, D.Kidron, R.Sukenik-Halevy, L.Goldberg-Bittman, R.Sharony, M.D.Fejgin, A.Amiel. TERC telomerase subunit gene copy number in placentas from pregnancies complicated with intrauterine growth restriction. Early human development 2011; 87:73-5; PMID:21168289; http://dx.doi.org/10.1016/j.earlhumdev.2010.08.024
    • (2011) Early human development , vol.87 , pp. 73-75
    • Biron-Shental, T.1    Kidron, D.2    Sukenik-Halevy, R.3    Goldberg-Bittman, L.4    Sharony, R.5    Fejgin, M.D.6    Amiel, A.7
  • 14
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • 3907856
    • C.W.Greider, E.H.Blackburn. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 1985; 43:405-13; PMID:3907856; http://dx.doi.org/10.1016/0092-8674(85)90170-9
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 15
    • 84860261471 scopus 로고    scopus 로고
    • Telomerase: an RNP enzyme synthesizes DNA
    • 20660025
    • E.H.Blackburn, K.Collins. Telomerase:an RNP enzyme synthesizes DNA. Cold Spring Harb Perspect Biol 2011; 3:a003558; PMID:20660025; http://dx.doi.org/10.1101/cshperspect.a003558
    • (2011) Cold Spring Harb Perspect Biol , vol.3 , pp. a003558
    • Blackburn, E.H.1    Collins, K.2
  • 16
    • 74049111326 scopus 로고    scopus 로고
    • Telomeres and telomerase in cancer
    • 19887512
    • S.E.Artandi, R.A.DePinho. Telomeres and telomerase in cancer. Carcinogenesis 2010; 31:9-18; PMID:19887512; http://dx.doi.org/10.1093/carcin/bgp268
    • (2010) Carcinogenesis , vol.31 , pp. 9-18
    • Artandi, S.E.1    DePinho, R.A.2
  • 17
    • 0030272689 scopus 로고    scopus 로고
    • Telomerase and cancer: revisiting the telomere hypothesis
    • 8918193
    • C.Autexier, C.W.Greider. Telomerase and cancer:revisiting the telomere hypothesis. Trends Biochem Sci 1996; 21:387-91; PMID:8918193; http://dx.doi.org/10.1016/S0968-0004(96)10042-6
    • (1996) Trends Biochem Sci , vol.21 , pp. 387-391
    • Autexier, C.1    Greider, C.W.2
  • 18
    • 78649854071 scopus 로고    scopus 로고
    • Effects of long-term culture on human embryonic stem cell aging
    • 20629482
    • X.Xie, A.Hiona, A.S.Lee, F.Cao, M.Huang, Z.Li, A.Cherry, X.Pei, J.C.Wu. Effects of long-term culture on human embryonic stem cell aging. Stem Cells Dev 2010; 20:127-38; PMID:20629482; http://dx.doi.org/10.1089/scd.2009.0475
    • (2010) Stem Cells Dev , vol.20 , pp. 127-138
    • Xie, X.1    Hiona, A.2    Lee, A.S.3    Cao, F.4    Huang, M.5    Li, Z.6    Cherry, A.7    Pei, X.8    Wu, J.C.9
  • 19
    • 84898596707 scopus 로고    scopus 로고
    • Telomere regulation in pluripotent stem cells
    • 24563217
    • Y.Huang, P.Liang, D.Liu, J.Huang, Z.Songyang. Telomere regulation in pluripotent stem cells. Protein Cell 2014; 5:194-202; PMID:24563217; http://dx.doi.org/10.1007/s13238-014-0028-1
    • (2014) Protein Cell , vol.5 , pp. 194-202
    • Huang, Y.1    Liang, P.2    Liu, D.3    Huang, J.4    Songyang, Z.5
  • 20
    • 84897859335 scopus 로고    scopus 로고
    • Telomere length reprogramming in embryos and stem cells
    • 24719895
    • K.Kalmbach, L.G.Robinson, Jr, F.Wang, L.Liu, D.Keefe. Telomere length reprogramming in embryos and stem cells. Biomed Res Int 2014; 2014:925121; PMID:24719895; http://dx.doi.org/10.1155/2014/925121
    • (2014) Biomed Res Int , vol.2014 , pp. 925121
    • Kalmbach, K.1    Robinson, L.G.2    Wang, F.3    Liu, L.4    Keefe, D.5
  • 21
    • 84855487750 scopus 로고    scopus 로고
    • Therapeutic opportunities: Telomere maintenance in inducible pluripotent stem cells
    • F.A.Gourronc, A.J.Klingelhutz. Therapeutic opportunities:Telomere maintenance in inducible pluripotent stem cells. Mutat Res 2012 730:98-105; PMID:21605571; http://dx.doi.org/10.1016/j.mrfmmm.2011.05.008
    • (2012) Mutat Res , vol.730 , pp. 98-105
    • Gourronc, F.A.1    Klingelhutz, A.J.2
  • 22
    • 79955573452 scopus 로고    scopus 로고
    • Association of telomere length with authentic pluripotency of ES/iPS cells
    • 21283131
    • J.Huang, F.Wang, M.Okuka, N.Liu, G.Ji, X.Ye, B.Zuo, M.Li, P.Liang, W.W.Ge, et al. Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Res 2011; 21:779-92; PMID:21283131; http://dx.doi.org/10.1038/cr.2011.16
    • (2011) Cell Res , vol.21 , pp. 779-792
    • Huang, J.1    Wang, F.2    Okuka, M.3    Liu, N.4    Ji, G.5    Ye, X.6    Zuo, B.7    Li, M.8    Liang, P.9    Ge, W.W.10
  • 23
    • 16844384347 scopus 로고    scopus 로고
    • Telomere length predicts embryo fragmentation after in vitro fertilization in women–toward a telomere theory of reproductive aging in women
    • 15846215
    • D.L.Keefe, S.Franco, L.Liu, J.Trimarchi, B.Cao, S.Weitzen, S.Agarwal, M.A.Blasco. Telomere length predicts embryo fragmentation after in vitro fertilization in women–toward a telomere theory of reproductive aging in women. Am J Obstet Gynecol 2005; 192:1256-60; discussion 1260–1; PMID:15846215; http://dx.doi.org/10.1016/j.ajog.2005.01.036
    • (2005) Am J Obstet Gynecol , vol.192 , pp. 1256-1260
    • Keefe, D.L.1    Franco, S.2    Liu, L.3    Trimarchi, J.4    Cao, B.5    Weitzen, S.6    Agarwal, S.7    Blasco, M.A.8
  • 24
    • 84877748662 scopus 로고    scopus 로고
    • The major reverse transcriptase–incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis
    • 23610451
    • I.Listerman, J.Sun, F.S.Gazzaniga, J.L.Lukas, E.H.Blackburn. The major reverse transcriptase–incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis. Cancer Res 2013; 73:2817-28; PMID:23610451; http://dx.doi.org/10.1158/0008-5472.CAN-12-3082
    • (2013) Cancer Res , vol.73 , pp. 2817-2828
    • Listerman, I.1    Sun, J.2    Gazzaniga, F.S.3    Lukas, J.L.4    Blackburn, E.H.5
  • 25
    • 84868674716 scopus 로고    scopus 로고
    • Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation
    • 22907755
    • R.Hrdlickova, J.Nehyba, H.R.Bose, Jr. Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation. Mol Cell Biol 2012; 32:4283-96; PMID:22907755; http://dx.doi.org/10.1128/MCB.00550-12
    • (2012) Mol Cell Biol , vol.32 , pp. 4283-4296
    • Hrdlickova, R.1    Nehyba, J.2    Bose, H.R.3
  • 27
    • 0034669082 scopus 로고    scopus 로고
    • Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture
    • 11071754
    • M.Amit, M.K.Carpenter, M.S.Inokuma, C.P.Chiu, C.P.Harris, M.A.Waknitz, J.Itskovitz-Eldor, J.A.Thomson. Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. Dev Biol 2000; 227:271-278; PMID:11071754; http://dx.doi.org/10.1006/dbio.2000.9912
    • (2000) Dev Biol , vol.227 , pp. 271-278
    • Amit, M.1    Carpenter, M.K.2    Inokuma, M.S.3    Chiu, C.P.4    Harris, C.P.5    Waknitz, M.A.6    Itskovitz-Eldor, J.7    Thomson, J.A.8
  • 31
    • 84884738380 scopus 로고    scopus 로고
    • Telomere reprogramming and maintenance in porcine iPS cells
    • G.Ji, W.Ruan, K.Liu, F.Wang, D.Sakellariou, J.Chen, Y.Yang, M.Okuka, J.Han, Z.Liu, et al. Telomere reprogramming and maintenance in porcine iPS cells. PLoS ONE 2013; 8:e74202; PMID:24098638; http://dx.doi.org/10.1371/annotation/f5e4554b-18cc-46ef-ac39-73ac4d6750ae
    • (2013) PLoS ONE , vol.8 , pp. e74202
    • Ji, G.1    Ruan, W.2    Liu, K.3    Wang, F.4    Sakellariou, D.5    Chen, J.6    Yang, Y.7    Okuka, M.8    Han, J.9    Liu, Z.10
  • 32
    • 77955818622 scopus 로고    scopus 로고
    • Robust activation of the human but not mouse telomerase gene during the induction of pluripotency
    • 20354136
    • R.Mathew, W.Jia, A.Sharma, Y.Zhao, L.E.Clarke, X.Cheng, H.Wang, U.Salli, K.E.Vrana, G.P.Robertson, et al. Robust activation of the human but not mouse telomerase gene during the induction of pluripotency. FASEB J 2010; 24:2702-15; PMID:20354136; http://dx.doi.org/10.1096/fj.09-148973
    • (2010) FASEB J , vol.24 , pp. 2702-2715
    • Mathew, R.1    Jia, W.2    Sharma, A.3    Zhao, Y.4    Clarke, L.E.5    Cheng, X.6    Wang, H.7    Salli, U.8    Vrana, K.E.9    Robertson, G.P.10
  • 33
    • 84859423676 scopus 로고    scopus 로고
    • Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells
    • 22184006
    • F.Wang, Y.Yin, X.Ye, K.Liu, H.Zhu, L.Wang, M.Chiourea, M.Okuka, G.Ji, J.Dan, et al. Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells. Cell Res 2012; 22:757-68; PMID:22184006; http://dx.doi.org/10.1038/cr.2011.201
    • (2012) Cell Res , vol.22 , pp. 757-768
    • Wang, F.1    Yin, Y.2    Ye, X.3    Liu, K.4    Zhu, H.5    Wang, L.6    Chiourea, M.7    Okuka, M.8    Ji, G.9    Dan, J.10
  • 34
    • 78651228154 scopus 로고    scopus 로고
    • Reprogramming of telomeric regions during the generation of human induced pluripotent stem cells and subsequent differentiation into fibroblast-like derivatives
    • 20861676
    • S.Yehezkel, A.Rebibo-Sabbah, Y.Segev, M.Tzukerman, R.Shaked, I.Huber, L.Gepstein, K.Skorecki, S.Selig. Reprogramming of telomeric regions during the generation of human induced pluripotent stem cells and subsequent differentiation into fibroblast-like derivatives. Epigenetics 2011; 6:63-75; PMID:20861676; http://dx.doi.org/10.4161/epi.6.1.13390
    • (2011) Epigenetics , vol.6 , pp. 63-75
    • Yehezkel, S.1    Rebibo-Sabbah, A.2    Segev, Y.3    Tzukerman, M.4    Shaked, R.5    Huber, I.6    Gepstein, L.7    Skorecki, K.8    Selig, S.9
  • 35
    • 78650978037 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase related with telomerase activity regulates tumorigenic potential of mouse embryonic stem cells
    • 20486780
    • K.D.Park, S.K.Seong, Y.M.Park, Y.Choi, J.H.Park, S.H.Lee, D.H.Baek, J.W.Kang, K.S.Choi, S.N.Park, et al. Telomerase reverse transcriptase related with telomerase activity regulates tumorigenic potential of mouse embryonic stem cells. Stem Cells Dev 2010; 20:149-57; PMID:20486780; http://dx.doi.org/10.1089/scd.2009.0523
    • (2010) Stem Cells Dev , vol.20 , pp. 149-157
    • Park, K.D.1    Seong, S.K.2    Park, Y.M.3    Choi, Y.4    Park, J.H.5    Lee, S.H.6    Baek, D.H.7    Kang, J.W.8    Choi, K.S.9    Park, S.N.10
  • 36
    • 0029973653 scopus 로고    scopus 로고
    • Regulation of telomerase activity in immortal cell lines
    • 8649404
    • S.E.Holt, W.E.Wright, J.W.Shay. Regulation of telomerase activity in immortal cell lines. Mol Cell Biol 1996; 16:2932-9; PMID:8649404; http://dx.doi.org/10.1128/MCB.16.6.2932
    • (1996) Mol Cell Biol , vol.16 , pp. 2932-2939
    • Holt, S.E.1    Wright, W.E.2    Shay, J.W.3
  • 37
    • 0029872174 scopus 로고    scopus 로고
    • Telomerase activity in human germline and embryonic tissues and cells
    • 8934879
    • W.E.Wright, M.A.Piatyszek, W.E.Rainey, W.Byrd, J.W.Shay. Telomerase activity in human germline and embryonic tissues and cells. Dev Genet 1996; 18:173-9; PMID:8934879; http://dx.doi.org/10.1002/(SICI)1520-6408(1996)18:2%3c173::AID-DVG10%3e3.0.CO;2-3
    • (1996) Dev Genet , vol.18 , pp. 173-179
    • Wright, W.E.1    Piatyszek, M.A.2    Rainey, W.E.3    Byrd, W.4    Shay, J.W.5
  • 38
    • 68049088928 scopus 로고    scopus 로고
    • Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells
    • 19665970
    • Y.Zhao, A.J.Sfeir, Y.Zou, C.M.Buseman, T.T.Chow, J.W.Shay, W.E.Wright. Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells. Cell 2009; 138:463-75; PMID:19665970; http://dx.doi.org/10.1016/j.cell.2009.05.026
    • (2009) Cell , vol.138 , pp. 463-475
    • Zhao, Y.1    Sfeir, A.J.2    Zou, Y.3    Buseman, C.M.4    Chow, T.T.5    Shay, J.W.6    Wright, W.E.7
  • 41
    • 0035812845 scopus 로고    scopus 로고
    • The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
    • 11595186
    • M.T.Hemann, M.A.Strong, L.-Y.Hao, C.W.Greider. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107:67-77; PMID:11595186; http://dx.doi.org/10.1016/S0092-8674(01)00504-9
    • Cell , vol.107 , pp. 67-77
    • Hemann, M.T.1    Strong, M.A.2    Hao, L.-Y.3    Greider, C.W.4
  • 42
  • 43
    • 79955573452 scopus 로고    scopus 로고
    • Association of telomere length with authentic pluripotency of ES/iPS cells
    • 21283131
    • J.Huang, F.Wang, M.Okuka, N.Liu, G.Ji, X.Ye, B.Zuo, M.Li, P.Liang, W.W.Ge, et al. Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Res 2011; 21:779-92; PMID:21283131; http://dx.doi.org/10.1038/cr.2011.16
    • (2011) Cell Res , vol.21 , pp. 779-792
    • Huang, J.1    Wang, F.2    Okuka, M.3    Liu, N.4    Ji, G.5    Ye, X.6    Zuo, B.7    Li, M.8    Liang, P.9    Ge, W.W.10
  • 44
    • 84891724275 scopus 로고    scopus 로고
    • Enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to induced pluripotent stem cells
    • 24268696
    • R.Le, Z.Kou, Y.Jiang, M.Li, B.Huang, W.Liu, H.Li, X.Kou, W.He, K.L.Rudolph, et al. Enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to induced pluripotent stem cells. Cell Stem Cell 2014; 14:27-39; PMID:24268696; http://dx.doi.org/10.1016/j.stem.2013.11.005
    • (2014) Cell Stem Cell , vol.14 , pp. 27-39
    • Le, R.1    Kou, Z.2    Jiang, Y.3    Li, M.4    Huang, B.5    Liu, W.6    Li, H.7    Kou, X.8    He, W.9    Rudolph, K.L.10
  • 45
    • 84875935944 scopus 로고    scopus 로고
    • Short Telomeres in ESCs Lead to Unstable Differentiation
    • 23561444
    • F.Pucci, L.Gardano, L.Harrington. Short Telomeres in ESCs Lead to Unstable Differentiation. Cell Stem Cell 2013; 12:479-86; PMID:23561444; http://dx.doi.org/10.1016/j.stem.2013.01.018
    • (2013) Cell Stem Cell , vol.12 , pp. 479-486
    • Pucci, F.1    Gardano, L.2    Harrington, L.3
  • 46
    • 84874341320 scopus 로고    scopus 로고
    • Downregulation of histone methyltransferase genes SUV39H1 and SUV39H2 increases telomere length in embryonic stem-like cells and embryonic fibroblasts in pigs
    • 23018532
    • T.Q.Dang-Nguyen, S.Haraguchi, T.Furusawa, T.Somfai, M.Kaneda, S.Watanabe, S.Akagi, K.Kikuchi, A.Tajima, T.Nagai. Downregulation of histone methyltransferase genes SUV39H1 and SUV39H2 increases telomere length in embryonic stem-like cells and embryonic fibroblasts in pigs. J Reprod Dev 2013; 59:27-32; PMID:23018532
    • (2013) J Reprod Dev , vol.59 , pp. 27-32
    • Dang-Nguyen, T.Q.1    Haraguchi, S.2    Furusawa, T.3    Somfai, T.4    Kaneda, M.5    Watanabe, S.6    Akagi, S.7    Kikuchi, K.8    Tajima, A.9    Nagai, T.10
  • 47
    • 84900310861 scopus 로고    scopus 로고
    • SIRT1 is necessary for proficient telomere elongation and genomic stability of induced pluripotent stem cells
    • 24936455
    • M.L.De Bonis, S.Ortega, M.A.Blasco. SIRT1 is necessary for proficient telomere elongation and genomic stability of induced pluripotent stem cells. Stem cell reports 2014; 2:690-706; PMID:24936455; http://dx.doi.org/10.1016/j.stemcr.2014.03.002
    • (2014) Stem cell reports , vol.2 , pp. 690-706
    • De Bonis, M.L.1    Ortega, S.2    Blasco, M.A.3
  • 48
    • 77955864457 scopus 로고    scopus 로고
    • Overexpression of hTERT increases stem-like properties and decreases spontaneous differentiation in human mesenchymal stem cell lines
    • 20152059
    • C.-C.Tsai, C.L.Chen, H.C.Liu, Y.T.Lee, H.W.Wang, L.T.Hou, S.C.Hung. Overexpression of hTERT increases stem-like properties and decreases spontaneous differentiation in human mesenchymal stem cell lines. J Biomed Sci 2010; 17:10-1186; PMID:20152059; http://dx.doi.org/10.1186/1423-0127-17-10
    • (2010) J Biomed Sci , vol.17 , pp. 10-1186
    • Tsai, C.-C.1    Chen, C.L.2    Liu, H.C.3    Lee, Y.T.4    Wang, H.W.5    Hou, L.T.6    Hung, S.C.7
  • 49
    • 84894056654 scopus 로고    scopus 로고
    • Telomerase-mediated telomere elongation from human blastocysts to embryonic stem cells
    • 24338368
    • S.Zeng, L.Liu, Y.Sun, P.Xie, L.Hu, D.Yuan, D.Chen, Q.Ouyang, G.Lin, G.Lu. Telomerase-mediated telomere elongation from human blastocysts to embryonic stem cells. J Cell Sci 2014; 127:752-62; PMID:24338368; http://dx.doi.org/10.1242/jcs.131433
    • (2014) J Cell Sci , vol.127 , pp. 752-762
    • Zeng, S.1    Liu, L.2    Sun, Y.3    Xie, P.4    Hu, L.5    Yuan, D.6    Chen, D.7    Ouyang, Q.8    Lin, G.9    Lu, G.10
  • 52
    • 80053082069 scopus 로고    scopus 로고
    • Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cells
    • 21873233
    • E.Varela, R.P.Schneider, S.Ortega, M.A.Blasco. Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cells. Proc Natl Acad Sci 2011; 108(37):15207-12; PMID:21873233
    • (2011) Proc Natl Acad Sci , vol.108 , Issue.37 , pp. 15207-15212
    • Varela, E.1    Schneider, R.P.2    Ortega, S.3    Blasco, M.A.4
  • 53
    • 58949094552 scopus 로고    scopus 로고
    • Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells
    • 19200803
    • R.M.Marion, K.Strati, H.Li, A.Tejera, S.Schoeftner, S.Ortega, M.Serrano, M.A.Blasco. Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells. Cell Stem Cell 2009; 4:141-54; PMID:19200803; http://dx.doi.org/10.1016/j.stem.2008.12.010
    • (2009) Cell Stem Cell , vol.4 , pp. 141-154
    • Marion, R.M.1    Strati, K.2    Li, H.3    Tejera, A.4    Schoeftner, S.5    Ortega, S.6    Serrano, M.7    Blasco, M.A.8
  • 54
    • 84872037931 scopus 로고    scopus 로고
    • Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation
    • 23147797
    • J.Jiang, W.Lv, X.Ye, L.Wang, M.Zhang, H.Yang, M.Okuka, C.Zhou, X.Zhang, L.Liu, et al. Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation. Cell research 2013; 23:92-106; PMID:23147797; http://dx.doi.org/10.1038/cr.2012.157
    • (2013) Cell research , vol.23 , pp. 92-106
    • Jiang, J.1    Lv, W.2    Ye, X.3    Wang, L.4    Zhang, M.5    Yang, H.6    Okuka, M.7    Zhou, C.8    Zhang, X.9    Liu, L.10
  • 55
    • 84983008259 scopus 로고    scopus 로고
    • Abstract 2047: The interaction of ZSCAN4 with TRF1: Effects on regulation of telomere elongation in cancer cells
    • K.Lee, L.Gollahon,. Abstract 2047:The interaction of ZSCAN4 with TRF1:Effects on regulation of telomere elongation in cancer cells. Cancer research 2012; 72:2047; PMID:26403970; http://dx.doi.org/10.1158/1538-7445.AM2012-2047
    • (2012) Cancer research , vol.72 , pp. 2047
    • Lee, K.1    Gollahon, L.2
  • 56
    • 84898436514 scopus 로고    scopus 로고
    • Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing
    • 24735877
    • J.Dan, Y.Liu, N.Liu, M.Chiourea, M.Okuka, T.Wu, X.Ye, C.Mou, L.Wang, L.Wang, et al. Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Developmental cell 2014; 29:7-19; PMID:24735877; http://dx.doi.org/10.1016/j.devcel.2014.03.004
    • (2014) Developmental cell , vol.29 , pp. 7-19
    • Dan, J.1    Liu, Y.2    Liu, N.3    Chiourea, M.4    Okuka, M.5    Wu, T.6    Ye, X.7    Mou, C.8    Wang, L.9    Wang, L.10
  • 58
    • 84899850283 scopus 로고    scopus 로고
    • Telomere length and telomerase activity during oocyte maturation and early embryo development in mammalian species
    • 23928157
    • S.Ozturk, B.Sozen, N.Demir. Telomere length and telomerase activity during oocyte maturation and early embryo development in mammalian species. Molecular human reproduction 2014; 20:15-30; PMID:23928157; http://dx.doi.org/10.1093/molehr/gat055
    • (2014) Molecular human reproduction , vol.20 , pp. 15-30
    • Ozturk, S.1    Sozen, B.2    Demir, N.3
  • 59
    • 34548667973 scopus 로고    scopus 로고
    • Telomere length, stem cells and aging
    • 17876321
    • M.A.Blasco. Telomere length, stem cells and aging. Nature chemical biology 2007; 3:640-649; PMID:17876321; http://dx.doi.org/10.1038/nchembio.2007.38
    • (2007) Nature chemical biology , vol.3 , pp. 640-649
    • Blasco, M.A.1
  • 60
    • 61849118594 scopus 로고    scopus 로고
    • Histone H3. 3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cells
    • 19196724
    • L.H.Wong, H.Ren, E.Williams, J.McGhie, S.Ahn, M.Sim, A.Tam, E.Earle, M.A.Anderson, J.Mann, et al. Histone H3. 3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cells. Genome research 2009; 19:404-14; PMID:19196724; http://dx.doi.org/10.1101/gr.084947.108
    • (2009) Genome research , vol.19 , pp. 404-414
    • Wong, L.H.1    Ren, H.2    Williams, E.3    McGhie, J.4    Ahn, S.5    Sim, M.6    Tam, A.7    Earle, E.8    Anderson, M.A.9    Mann, J.10
  • 61
    • 84923330280 scopus 로고    scopus 로고
    • Trend of telomerase activity change during human iPSC self-renewal and differentiation revealed by a quartz crystal microbalance based assay
    • 25381797
    • Y.Zhou, P.Zhou, Y.Xin, J.Wang, Z.Zhu, J.Hu, S.Wei, H.Ma. Trend of telomerase activity change during human iPSC self-renewal and differentiation revealed by a quartz crystal microbalance based assay. Sci Rep 2014; 4:6978; PMID:25381797; http://dx.doi.org/10.1038/srep06978
    • (2014) Sci Rep , vol.4 , pp. 6978
    • Zhou, Y.1    Zhou, P.2    Xin, Y.3    Wang, J.4    Zhu, Z.5    Hu, J.6    Wei, S.7    Ma, H.8
  • 62
    • 84864459597 scopus 로고    scopus 로고
    • Induction of telomerase activity increase reprogramming efficiency of human dermal fibroblasts
    • E.B.Dashinimaev, et al. Induction of telomerase activity increase reprogramming efficiency of human dermal fibroblasts. Moscow University Biological Sciences Bulletin 2012; 67:6-12; http://dx.doi.org/10.3103/S0096392512010038
    • (2012) Moscow University Biological Sciences Bulletin , vol.67 , pp. 6-12
    • Dashinimaev, E.B.1
  • 63
    • 84901721562 scopus 로고    scopus 로고
    • Telomerase Reverse Transcriptase Has an Extratelomeric Function in Somatic Cell Reprogramming
    • 24733392
    • T.Kinoshita, G.Nagamatsu, S.Saito, K.Takubo, K.Horimoto, T.Suda. Telomerase Reverse Transcriptase Has an Extratelomeric Function in Somatic Cell Reprogramming. Journal of Biological Chemistry 2014; 289:15776-87; PMID:24733392; http://dx.doi.org/10.1074/jbc.M113.536037
    • (2014) Journal of Biological Chemistry , vol.289 , pp. 15776-15787
    • Kinoshita, T.1    Nagamatsu, G.2    Saito, S.3    Takubo, K.4    Horimoto, K.5    Suda, T.6
  • 64
    • 39149115929 scopus 로고    scopus 로고
    • Defining Molecular Cornerstones during Fibroblast to iPS Cell Reprogramming in Mouse
    • 18371448
    • M.Stadtfeld, N.Maherali, D.T.Breault, K.Hochedlinger. Defining Molecular Cornerstones during Fibroblast to iPS Cell Reprogramming in Mouse. Cell Stem Cell 2008;2:230-40; PMID:18371448; http://dx.doi.org/10.1016/j.stem.2008.02.001
    • (2008) Cell Stem Cell , vol.2 , pp. 230-240
    • Stadtfeld, M.1    Maherali, N.2    Breault, D.T.3    Hochedlinger, K.4
  • 66
    • 77958138434 scopus 로고    scopus 로고
    • Krüppel-Like Transcription Factor 4 Contributes to Maintenance of Telomerase Activity in Stem Cells
    • 20629177
    • C.-W.Wong, P.S.Hou, S.F.Tseng, C.L.Chien, K.J.Wu, H.F.Chen, H.N.Ho, S.Kyo, S.C.Teng. Krüppel-Like Transcription Factor 4 Contributes to Maintenance of Telomerase Activity in Stem Cells. Stem Cells 2010; 28:1510-17; PMID:20629177; http://dx.doi.org/10.1002/stem.477
    • (2010) Stem Cells , vol.28 , pp. 1510-1517
    • Wong, C.-W.1    Hou, P.S.2    Tseng, S.F.3    Chien, C.L.4    Wu, K.J.5    Chen, H.F.6    Ho, H.N.7    Kyo, S.8    Teng, S.C.9
  • 67
    • 84866551580 scopus 로고    scopus 로고
    • Human telomerase reverse transcriptase (hTERT) is a novel target of the Wnt/β-catenin pathway in human cancer
    • 22854964
    • Y.Zhang, L.Toh, P.Lau, X.Wang. Human telomerase reverse transcriptase (hTERT) is a novel target of the Wnt/β-catenin pathway in human cancer. Journal of Biological Chemistry 2012; 287:32494-511; PMID:22854964; http://dx.doi.org/10.1074/jbc.M112.368282
    • (2012) Journal of Biological Chemistry , vol.287 , pp. 32494-32511
    • Zhang, Y.1    Toh, L.2    Lau, P.3    Wang, X.4
  • 68
  • 69
    • 30144440248 scopus 로고    scopus 로고
    • The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene
    • 16244670
    • B.D.Rowland, R.Bernards, D.S.Peeper. The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat Cell Biol 2005; 7:1074-82; PMID:16244670; http://dx.doi.org/10.1038/ncb1314
    • (2005) Nat Cell Biol , vol.7 , pp. 1074-1082
    • Rowland, B.D.1    Bernards, R.2    Peeper, D.S.3
  • 70
    • 33747195353 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
    • 16904174
    • K.Takahashi, S.Yamanaka. Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors. Cell 126:663-76; PMID:16904174; http://dx.doi.org/10.1016/j.cell.2006.07.024
    • Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 71
    • 37549008674 scopus 로고    scopus 로고
    • c-Myc Is Dispensable for Direct Reprogramming of Mouse Fibroblasts
    • 18371415
    • M.Wernig, A.Meissner, J.P.Cassady, R.Jaenisch. c-Myc Is Dispensable for Direct Reprogramming of Mouse Fibroblasts. Cell Stem Cell 2:10-12; PMID:18371415; http://dx.doi.org/10.1016/j.stem.2007.12.001
    • Cell Stem Cell , vol.2 , pp. 10-12
    • Wernig, M.1    Meissner, A.2    Cassady, J.P.3    Jaenisch, R.4
  • 73
    • 2642610318 scopus 로고    scopus 로고
    • Myc activates telomerase
    • 9637678
    • J.Wang, L.Y.Xie, S.Allan, D.Beach, G.J.Hannon. Myc activates telomerase. Gen Dev 1998; 12:1769-74; PMID:9637678; http://dx.doi.org/10.1101/gad.12.12.1769
    • (1998) Gen Dev , vol.12 , pp. 1769-1774
    • Wang, J.1    Xie, L.Y.2    Allan, S.3    Beach, D.4    Hannon, G.J.5
  • 74
    • 69249107379 scopus 로고    scopus 로고
    • Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog
    • 19544440
    • P.Y.Bourillot, I.Aksoy, V.Schreiber, F.Wianny, H.Schulz, O.Hummel, N.Hubner, P.Savatier. Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog. Stem Cells 2009; 27:1760-71; PMID:19544440; http://dx.doi.org/10.1002/stem.110
    • (2009) Stem Cells , vol.27 , pp. 1760-1771
    • Bourillot, P.Y.1    Aksoy, I.2    Schreiber, V.3    Wianny, F.4    Schulz, H.5    Hummel, O.6    Hubner, N.7    Savatier, P.8
  • 75
    • 67349149082 scopus 로고    scopus 로고
    • MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells
    • 19409607
    • N.Xu, T.Papagiannakopoulos, G.Pan, J.A.Thomson, K.S.Kosik. MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells. Cell 137:647-58; PMID:19409607; http://dx.doi.org/10.1016/j.cell.2009.02.038
    • Cell , vol.137 , pp. 647-658
    • Xu, N.1    Papagiannakopoulos, T.2    Pan, G.3    Thomson, J.A.4    Kosik, K.S.5
  • 76
    • 1942437469 scopus 로고    scopus 로고
    • Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice
    • 15079066
    • N.Erdmann, Y.Liu, L.Harrington. Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice. Proc Natl Acad Sci of the United States of America 2004; 101:6080-5; PMID:15079066; http://dx.doi.org/10.1073/pnas.0401580101
    • (2004) Proc Natl Acad Sci of the United States of America , vol.101 , pp. 6080-6085
    • Erdmann, N.1    Liu, Y.2    Harrington, L.3
  • 77
    • 0030931491 scopus 로고    scopus 로고
    • Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
    • 9335332
    • M.A.Blasco, H.W.Lee, M.P.Hande, E.Samper, P.M.Lansdorp, R.A.DePinho, C.W.Greider. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997; 91:25-34; PMID:9335332; http://dx.doi.org/10.1016/S0092-8674(01)80006-4
    • (1997) Cell , vol.91 , pp. 25-34
    • Blasco, M.A.1    Lee, H.W.2    Hande, M.P.3    Samper, E.4    Lansdorp, P.M.5    DePinho, R.A.6    Greider, C.W.7
  • 78
    • 84915764260 scopus 로고    scopus 로고
    • Telomere Elongation and Naive Pluripotent Stem Cells Achieved from Telomerase Haplo-Insufficient Cells by Somatic Cell Nuclear Transfer
    • 25464850
    • L.-Y.Sung, W.F.Chang, Q.Zhang, C.C.Liu, J.Y.Liou, C.C.Chang, H.Ou-Yang, R.Guo, H.Fu, W.T.Cheng, et al. Telomere Elongation and Naive Pluripotent Stem Cells Achieved from Telomerase Haplo-Insufficient Cells by Somatic Cell Nuclear Transfer. Cell reports 2014; 9:1603-9; PMID:25464850; http://dx.doi.org/10.1016/j.celrep.2014.10.052
    • (2014) Cell reports , vol.9 , pp. 1603-1609
    • Sung, L.-Y.1    Chang, W.F.2    Zhang, Q.3    Liu, C.C.4    Liou, J.Y.5    Chang, C.C.6    Ou-Yang, H.7    Guo, R.8    Fu, H.9    Cheng, W.T.10
  • 79
    • 59649105969 scopus 로고    scopus 로고
    • Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb
    • 19136965
    • B.Feng, J.Jiang, P.Kraus, J.H.Ng, J.C.Heng, Y.S.Chan, L.P.Yaw, W.Zhang, Y.H.Loh, J.Han, et al. Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol 2009; 11:197-203; PMID:19136965; http://dx.doi.org/10.1038/ncb1827
    • (2009) Nat Cell Biol , vol.11 , pp. 197-203
    • Feng, B.1    Jiang, J.2    Kraus, P.3    Ng, J.H.4    Heng, J.C.5    Chan, Y.S.6    Yaw, L.P.7    Zhang, W.8    Loh, Y.H.9    Han, J.10
  • 81
    • 84862777719 scopus 로고    scopus 로고
    • Distinct Regulatory Mechanisms and Functions for p53-Activated and p53-Repressed DNA Damage Response Genes in Embryonic Stem Cells
    • 22387025
    • M.Li, Y.He, W.Dubois, X.Wu, J.Shi, J.Huang. Distinct Regulatory Mechanisms and Functions for p53-Activated and p53-Repressed DNA Damage Response Genes in Embryonic Stem Cells. Molecular Cell 2012; 46:30-42; PMID:22387025; http://dx.doi.org/10.1016/j.molcel.2012.01.020
    • (2012) Molecular Cell , vol.46 , pp. 30-42
    • Li, M.1    He, Y.2    Dubois, W.3    Wu, X.4    Shi, J.5    Huang, J.6
  • 82
    • 77149135754 scopus 로고    scopus 로고
    • A unique interplay between Rap1 and E-cadherin in the endocytic pathway regulates self-renewal of human embryonic stem cells
    • 20039365
    • L.Li, S.Wang, A.Jezierski, L.Moalim-Nour, K.Mohib, R.J.Parks, S.F.Retta, L.Wang. A unique interplay between Rap1 and E-cadherin in the endocytic pathway regulates self-renewal of human embryonic stem cells. Stem Cells 2010; 28:247-57; PMID:20039365; http://dx.doi.org/10.1002/stem.532
    • (2010) Stem Cells , vol.28 , pp. 247-257
    • Li, L.1    Wang, S.2    Jezierski, A.3    Moalim-Nour, L.4    Mohib, K.5    Parks, R.J.6    Retta, S.F.7    Wang, L.8
  • 84
    • 49249111098 scopus 로고    scopus 로고
    • A key role for telomerase reverse transcriptase unit in modulating human embryonic stem cell proliferation, cell cycle dynamics, and in vitro differentiation
    • 18203676
    • C.Yang, S.Przyborski, M.J.Cooke, X.Zhang, R.Stewart, G.Anyfantis, S.P.Atkinson, G.Saretzki, L.Armstrong, et al. A key role for telomerase reverse transcriptase unit in modulating human embryonic stem cell proliferation, cell cycle dynamics, and in vitro differentiation. Stem Cells 2008; 26:850-63; PMID:18203676; http://dx.doi.org/10.1634/stemcells.2007-0677
    • (2008) Stem Cells , vol.26 , pp. 850-863
    • Yang, C.1    Przyborski, S.2    Cooke, M.J.3    Zhang, X.4    Stewart, R.5    Anyfantis, G.6    Atkinson, S.P.7    Saretzki, G.8    Armstrong, L.9
  • 86
    • 84906886498 scopus 로고    scopus 로고
    • Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation
    • 25128433
    • A.N.Sexton, S.G.Regalado, C.S.Lai, G.J.Cost, C.M.O'Neil, F.D.Urnov, P.D.Gregory, R.Jaenisch, K.Collins, D.Hockemeyer. Genetic and molecular identification of three human TPP1 functions in telomerase action:recruitment, activation, and homeostasis set point regulation. Gen Dev 2014; 28:1885-99; PMID:25128433; http://dx.doi.org/10.1101/gad.246819.114
    • (2014) Gen Dev , vol.28 , pp. 1885-1899
    • Sexton, A.N.1    Regalado, S.G.2    Lai, C.S.3    Cost, G.J.4    O'Neil, C.M.5    Urnov, F.D.6    Gregory, P.D.7    Jaenisch, R.8    Collins, K.9    Hockemeyer, D.10
  • 87
    • 38949156672 scopus 로고    scopus 로고
    • TERT Promotes Epithelial Proliferation through Transcriptional Control of a Myc- and Wnt-Related Developmental Program
    • 18208333
    • J.Choi, L.K.Southworth, K.Y.Sarin, A.S.Venteicher, W.Ma, W.Chang, P.Cheung, S.Jun, M.K.Artandi, N.Shah, et al. TERT Promotes Epithelial Proliferation through Transcriptional Control of a Myc- and Wnt-Related Developmental Program. PLoS Genet 2008; 4:e10; PMID:18208333; http://dx.doi.org/10.1371/journal.pgen.0040010
    • (2008) PLoS Genet , vol.4 , pp. e10
    • Choi, J.1    Southworth, L.K.2    Sarin, K.Y.3    Venteicher, A.S.4    Ma, W.5    Chang, W.6    Cheung, P.7    Jun, S.8    Artandi, M.K.9    Shah, N.10
  • 88
    • 46749152214 scopus 로고    scopus 로고
    • Actions of human telomerase beyond telomeres
    • 18574498
    • Y.Cong, J.W.Shay. Actions of human telomerase beyond telomeres. Cell Res 2008; 18:725-32; PMID:18574498; http://dx.doi.org/10.1038/cr.2008.74
    • (2008) Cell Res , vol.18 , pp. 725-732
    • Cong, Y.1    Shay, J.W.2
  • 89
    • 48249112529 scopus 로고    scopus 로고
    • A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere length in mice
    • B.-W.Gu, M.Bessler, P.J.Mason. A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere length in mice. Proc Natl Acad Sci 2008; 105:10173-8; PMID:18626023; http://dx.doi.org/10.1073/pnas.0803559105
    • (2008) Proc Natl Acad Sci , vol.105 , pp. 10173-10178
    • Gu, B.-W.1    Bessler, M.2    Mason, P.J.3
  • 90
    • 23944516520 scopus 로고    scopus 로고
    • Conditional telomerase induction causes proliferation of hair follicle stem cells
    • 16107853
    • K.Y.Sarin. Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature 2005; 436:1048-52; PMID:16107853; http://dx.doi.org/10.1038/nature03836
    • (2005) Nature , vol.436 , pp. 1048-1052
    • Sarin, K.Y.1
  • 92
    • 0038056347 scopus 로고    scopus 로고
    • Telomerase modulates expression of growth-controlling genes and enhances cell proliferation
    • 12717449
    • L.L.Smith, H.A.Coller, J.M.Roberts. Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat Cell Biol 2003; 5:474-9; PMID:12717449; http://dx.doi.org/10.1038/ncb985
    • (2003) Nat Cell Biol , vol.5 , pp. 474-479
    • Smith, L.L.1    Coller, H.A.2    Roberts, J.M.3
  • 93
    • 23844540299 scopus 로고    scopus 로고
    • Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior
    • 16037417
    • I.Flores, M.L.Cayuela, M.A.Blasco. Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior. Science 2005; 309:1253-6; PMID:16037417; http://dx.doi.org/10.1126/science.1115025
    • (2005) Science , vol.309 , pp. 1253-1256
    • Flores, I.1    Cayuela, M.L.2    Blasco, M.A.3
  • 94
    • 79952017845 scopus 로고    scopus 로고
    • Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
    • P.Martínez, M.A.Blasco. Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat Rev Cancer 2011; 11:161-76; PMID:21346783; http://dx.doi.org/10.1038/nrc3025
    • (2011) Nat Rev Cancer , vol.11 , pp. 161-176
    • Martínez, P.1    Blasco, M.A.2
  • 95
    • 0036674425 scopus 로고    scopus 로고
    • Telomerase beyond telomeres
    • 12154355
    • M.A.Blasco. Telomerase beyond telomeres. Nat Rev Cancer 2002; 2:627-33; PMID:12154355; http://dx.doi.org/10.1038/nrc862
    • (2002) Nat Rev Cancer , vol.2 , pp. 627-633
    • Blasco, M.A.1
  • 96
    • 84872251777 scopus 로고    scopus 로고
    • Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis
    • C.Singhapol, D.Pal, R.Czapiewski, M.Porika, G.Nelson, G.C.Saretzki. Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis. PLoS ONE 2013; 8:9; PMID:23326372; http://dx.doi.org/10.1371/journal.pone.0052989
    • (2013) PLoS ONE , vol.8 , pp. 9
    • Singhapol, C.1    Pal, D.2    Czapiewski, R.3    Porika, M.4    Nelson, G.5    Saretzki, G.C.6
  • 97
    • 78651386195 scopus 로고    scopus 로고
    • hTERT Overexpression Alleviates Intracellular ROS Production, Improves Mitochondrial Function, and Inhibits ROS-Mediated Apoptosis in Cancer Cells
    • 21071633
    • I.R.Indran, M.P.Hande, S.Pervaiz. hTERT Overexpression Alleviates Intracellular ROS Production, Improves Mitochondrial Function, and Inhibits ROS-Mediated Apoptosis in Cancer Cells. Cancer Res 2011; 71:266-76; PMID:21071633; http://dx.doi.org/10.1158/0008-5472.CAN-10-1588
    • (2011) Cancer Res , vol.71 , pp. 266-276
    • Indran, I.R.1    Hande, M.P.2    Pervaiz, S.3
  • 99
    • 84872221670 scopus 로고    scopus 로고
    • ES micro-environment enhances stemness and inhibits apoptosis in human limbal stem cells via the maintenance of telomerase activity
    • 23326460
    • Z.Liu, P.Wan, H.Duan, J.Zhou, B.Tan, Y.Liu, Q.Zhou, C.Zhou, Z.Huang, B.Tian, et al. ES micro-environment enhances stemness and inhibits apoptosis in human limbal stem cells via the maintenance of telomerase activity. PLoS ONE 2013; 8:e53576; PMID:23326460; http://dx.doi.org/10.1371/journal.pone.0053576
    • (2013) PLoS ONE , vol.8 , pp. e53576
    • Liu, Z.1    Wan, P.2    Duan, H.3    Zhou, J.4    Tan, B.5    Liu, Y.6    Zhou, Q.7    Zhou, C.8    Huang, Z.9    Tian, B.10
  • 100
    • 84855574766 scopus 로고    scopus 로고
    • Human telomerase represses ROS-dependent cellular responses to Tumor Necrosis Factor-α without affecting NF-κB activation
    • 22108091
    • M.Mattiussi, G.Tilman, S.Lenglez, A.Decottignies. Human telomerase represses ROS-dependent cellular responses to Tumor Necrosis Factor-α without affecting NF-κB activation. Cellular Signalling 2012; 24:708-17; PMID:22108091; http://dx.doi.org/10.1016/j.cellsig.2011.11.004
    • (2012) Cellular Signalling , vol.24 , pp. 708-717
    • Mattiussi, M.1    Tilman, G.2    Lenglez, S.3    Decottignies, A.4
  • 101
    • 84901987354 scopus 로고    scopus 로고
    • Telomerase as a “stemness” enzyme
    • 24829107
    • F.Kong, C.Zheng, D.Xu. Telomerase as a “stemness” enzyme. Science China Life Sciences 2014; 57:564-70; PMID:24829107; http://dx.doi.org/10.1007/s11427-014-4666-6
    • (2014) Science China Life Sciences , vol.57 , pp. 564-570
    • Kong, F.1    Zheng, C.2    Xu, D.3
  • 109
    • 77954222814 scopus 로고    scopus 로고
    • Chromatin regulation by Brg1 underlies heart muscle development and disease
    • 20596014
    • C.T.Hang, J.Yang, P.Han, H.L.Cheng, C.Shang, E.Ashley, B.Zhou, C.P.Chang. Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature 2010; 466:62-67; PMID:20596014; http://dx.doi.org/10.1038/nature09130
    • (2010) Nature , vol.466 , pp. 62-67
    • Hang, C.T.1    Yang, J.2    Han, P.3    Cheng, H.L.4    Shang, C.5    Ashley, E.6    Zhou, B.7    Chang, C.P.8
  • 110
    • 41649084825 scopus 로고    scopus 로고
    • The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development
    • 18094026
    • C.T.Griffin, J.Brennan, T.Magnuson. The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development. Development 2008; 135:493-500; PMID:18094026; http://dx.doi.org/10.1242/dev.010090
    • (2008) Development , vol.135 , pp. 493-500
    • Griffin, C.T.1    Brennan, J.2    Magnuson, T.3
  • 111
    • 13444263724 scopus 로고    scopus 로고
    • The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD
    • 15576411
    • S.Seo, G.A.Richardson, K.L.Kroll. The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD. Development 2005; 132:105-15; PMID:15576411; http://dx.doi.org/10.1242/dev.01548
    • (2005) Development , vol.132 , pp. 105-115
    • Seo, S.1    Richardson, G.A.2    Kroll, K.L.3
  • 113
    • 33745619776 scopus 로고    scopus 로고
    • Maternal BRG1 regulates zygotic genome activation in the mouse
    • 16818606
    • S.J.Bultman, T.C.Gebuhr, H.Pan, P.Svoboda, R.M.Schultz, T.Magnuson. Maternal BRG1 regulates zygotic genome activation in the mouse. Gen Dev 2006; 20:1744-54; PMID:16818606; http://dx.doi.org/10.1101/gad.1435106
    • (2006) Gen Dev , vol.20 , pp. 1744-1754
    • Bultman, S.J.1    Gebuhr, T.C.2    Pan, H.3    Svoboda, P.4    Schultz, R.M.5    Magnuson, T.6
  • 114
    • 84891427530 scopus 로고    scopus 로고
    • An investigation of the effects of the core protein telomerase reverse transcriptase on wnt signaling in breast Cancer cells
    • 24216762
    • I.Listerman, F.S.Gazzaniga, E.H.Blackburn. An investigation of the effects of the core protein telomerase reverse transcriptase on wnt signaling in breast Cancer cells. Mol Cell Biol 2014; 34:280-9; PMID:24216762; http://dx.doi.org/10.1128/MCB.00844-13
    • (2014) Mol Cell Biol , vol.34 , pp. 280-289
    • Listerman, I.1    Gazzaniga, F.S.2    Blackburn, E.H.3
  • 115
    • 84883743387 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase promotes epithelial–mesenchymal transition and stem cell-like traits in cancer cells
    • 23045275
    • Z.Liu, Q.Li, K.Li, L.Chen, W.Li, M.Hou, T.Liu, J.Yang, C.Lindvall, M.Björkholm, et al. Telomerase reverse transcriptase promotes epithelial–mesenchymal transition and stem cell-like traits in cancer cells. Oncogene 2013; 32:4203-13; PMID:23045275; http://dx.doi.org/10.1038/onc.2012.441
    • (2013) Oncogene , vol.32 , pp. 4203-4213
    • Liu, Z.1    Li, Q.2    Li, K.3    Chen, L.4    Li, W.5    Hou, M.6    Liu, T.7    Yang, J.8    Lindvall, C.9    Björkholm, M.10
  • 116
    • 0032891720 scopus 로고    scopus 로고
    • E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation
    • 10085258
    • S.Orsulic, O.Huber, H.Aberle, S.Arnold, R.Kemler. E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation. J Cell Sci 1999; 112 (Pt 8), 1237-45; PMID:10085258
    • (1999) J Cell Sci , vol.112 , pp. 1237-1245
    • Orsulic, S.1    Huber, O.2    Aberle, H.3    Arnold, S.4    Kemler, R.5
  • 117
    • 84880330190 scopus 로고    scopus 로고
    • Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT–MET mechanism for optimal reprogramming
    • 23708003
    • X.Liu, H.Sun, J.Qi, L.Wang, S.He, J.Liu, C.Feng, C.Chen, W.Li, Y.Guo, et al. Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT–MET mechanism for optimal reprogramming. Nat Cell Biol 2013; 15:829-38; PMID:23708003; http://dx.doi.org/10.1038/ncb2765
    • (2013) Nat Cell Biol , vol.15 , pp. 829-838
    • Liu, X.1    Sun, H.2    Qi, J.3    Wang, L.4    He, S.5    Liu, J.6    Feng, C.7    Chen, C.8    Li, W.9    Guo, Y.10
  • 118
    • 84860751699 scopus 로고    scopus 로고
    • Telomeres and Mitochondria in the Aging Heart
    • 22539756
    • J.Moslehi, R.A.DePinho, E.Sahin. Telomeres and Mitochondria in the Aging Heart. Circulation Res 2012; 110:1226-37; PMID:22539756; http://dx.doi.org/10.1161/CIRCRESAHA.111.246868
    • (2012) Circulation Res , vol.110 , pp. 1226-1237
    • Moslehi, J.1    DePinho, R.A.2    Sahin, E.3
  • 119
    • 84911477017 scopus 로고    scopus 로고
    • Extra-telomeric functions of human telomerase: cancer, mitochondria and oxidative stress
    • 24975608
    • G.Saretzki. Extra-telomeric functions of human telomerase:cancer, mitochondria and oxidative stress. Curr Pharmaceutical Design 2014; 20:6386-403; PMID:24975608; http://dx.doi.org/10.2174/1381612820666140630095606
    • (2014) Curr Pharmaceutical Design , vol.20 , pp. 6386-6403
    • Saretzki, G.1
  • 120
    • 0023283102 scopus 로고
    • A novel endoribonuclease cleaves at a priming site of mouse mitochondrial DNA replication
    • 3582365
    • D.D.Chang, D.A.Clayton. A novel endoribonuclease cleaves at a priming site of mouse mitochondrial DNA replication. The EMBO Journal 1987; 6:409-17; PMID:3582365
    • (1987) The EMBO Journal , vol.6 , pp. 409-417
    • Chang, D.D.1    Clayton, D.A.2
  • 121
    • 80054781000 scopus 로고    scopus 로고
    • RMRP Is a Non-Coding RNA Essential for Early Murine Development
    • 22039455
    • J.Rosenbluh, D.Nijhawan, Z.Chen, K.K.Wong, K.Masutomi, W.C.Hahn. RMRP Is a Non-Coding RNA Essential for Early Murine Development. PLoS ONE 2011; 6:e26270; PMID:22039455; http://dx.doi.org/10.1371/journal.pone.0026270
    • (2011) PLoS ONE , vol.6 , pp. e26270
    • Rosenbluh, J.1    Nijhawan, D.2    Chen, Z.3    Wong, K.K.4    Masutomi, K.5    Hahn, W.C.6
  • 122
    • 84877323295 scopus 로고    scopus 로고
    • Off-Target Effect of Endogenous siRNA Derived from RMRP in Human Cells
    • 23629666
    • Y.Maida, S.Kyo, T.Lassmann, Y.Hayashizaki, K.Masutomi. Off-Target Effect of Endogenous siRNA Derived from RMRP in Human Cells. Int J Mol Sci 2013; 14:9305-18; PMID:23629666; http://dx.doi.org/10.3390/ijms14059305
    • (2013) Int J Mol Sci , vol.14 , pp. 9305-9318
    • Maida, Y.1    Kyo, S.2    Lassmann, T.3    Hayashizaki, Y.4    Masutomi, K.5
  • 123
    • 84913591488 scopus 로고    scopus 로고
    • Silencing of TERT decreases levels of miR-1, miR-21, miR-29a and miR-208a in cardiomyocytes
    • 25156787
    • T.I.Drevytska, V.S.Nagibin, V.L.Gurianova, V.R.Kedlyan, A.A.Moibenko, V.E.Dosenko. Silencing of TERT decreases levels of miR-1, miR-21, miR-29a and miR-208a in cardiomyocytes. Cell Biochem Funct 2014; 32:565-70; PMID:25156787; http://dx.doi.org/10.1002/cbf.3051
    • (2014) Cell Biochem Funct , vol.32 , pp. 565-570
    • Drevytska, T.I.1    Nagibin, V.S.2    Gurianova, V.L.3    Kedlyan, V.R.4    Moibenko, A.A.5    Dosenko, V.E.6
  • 124
    • 79958053622 scopus 로고    scopus 로고
    • Phenotypes in mTERT(+)/(−) and mTERT(−)/(−) mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase
    • 21464209
    • M.A.Strong, S.L.Vidal-Cardenas, B.Karim, H.Yu, N.Guo, C.W.Greider. Phenotypes in mTERT(+)/(−) and mTERT(−)/(−) mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase. Mol Cell Biol 2011; 31:2369-79; PMID:21464209; http://dx.doi.org/10.1128/MCB.05312-11
    • (2011) Mol Cell Biol , vol.31 , pp. 2369-2379
    • Strong, M.A.1    Vidal-Cardenas, S.L.2    Karim, B.3    Yu, H.4    Guo, N.5    Greider, C.W.6
  • 125
    • 0035584117 scopus 로고    scopus 로고
    • Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells
    • 11726691
    • X.Yi, J.W.Shay, W.E.Wright. Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells. Nucleic Acids Res 2001; 29:4818-25; PMID:11726691; http://dx.doi.org/10.1093/nar/29.23.4818
    • (2001) Nucleic Acids Res , vol.29 , pp. 4818-4825
    • Yi, X.1    Shay, J.W.2    Wright, W.E.3
  • 126
    • 0031230933 scopus 로고    scopus 로고
    • Developmental regulation of telomerase activity in human fetal tissues during gestation
    • 9358002
    • G.A.Ulaner, L.C.Giudice. Developmental regulation of telomerase activity in human fetal tissues during gestation. Mol Hum Reprod 1997; 3:769-73; PMID:9358002; http://dx.doi.org/10.1093/molehr/3.9.769
    • (1997) Mol Hum Reprod , vol.3 , pp. 769-773
    • Ulaner, G.A.1    Giudice, L.C.2
  • 127
    • 0032530136 scopus 로고    scopus 로고
    • Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts
    • 9751630
    • G.A.Ulaner, J.F.Hu, T.H.Vu, L.C.Giudice, A.R.Hoffman. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res 1998; 58:4168-72; PMID:9751630
    • (1998) Cancer Res , vol.58 , pp. 4168-4172
    • Ulaner, G.A.1    Hu, J.F.2    Vu, T.H.3    Giudice, L.C.4    Hoffman, A.R.5
  • 128
    • 0035283896 scopus 로고    scopus 로고
    • Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development
    • G.A.Ulaner, J.-F.Hu, T.H.Vu, L.C.Giudice, A.R.Hoffman. Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development. Int J Cancer 2001; 91:644-9; PMID:11267974; http://dx.doi.org/10.1002/1097-0215(200002)9999:9999%3c::AID-IJC1103%3e3.0.CO;2-V
    • (2001) Int J Cancer , vol.91 , pp. 644-649
    • Ulaner, G.A.1    Hu, J.-F.2    Vu, T.H.3    Giudice, L.C.4    Hoffman, A.R.5
  • 129
    • 0034847607 scopus 로고    scopus 로고
    • Alternatively spliced variant deleting exons 7 and 8 of the human telomerase reverse transcriptase gene is dominantly expressed in the uterus
    • 11517292
    • Y.Yokoyama, X.Wan, Y.Takahashi, A.Shinohara, T.Tamaya. Alternatively spliced variant deleting exons 7 and 8 of the human telomerase reverse transcriptase gene is dominantly expressed in the uterus. Mol Hum Reprod 2001; 7:853-7; PMID:11517292; http://dx.doi.org/10.1093/molehr/7.9.853
    • (2001) Mol Hum Reprod , vol.7 , pp. 853-857
    • Yokoyama, Y.1    Wan, X.2    Takahashi, Y.3    Shinohara, A.4    Tamaya, T.5
  • 130
    • 0035252410 scopus 로고    scopus 로고
    • Alternative splicing: increasing diversity in the proteomic world
    • 11173120
    • B.R.Graveley. Alternative splicing:increasing diversity in the proteomic world. Trends Genet 2001; 17:100-7; PMID:11173120; http://dx.doi.org/10.1016/S0168-9525(00)02176-4
    • (2001) Trends Genet , vol.17 , pp. 100-107
    • Graveley, B.R.1
  • 131
    • 0030681073 scopus 로고    scopus 로고
    • Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types
    • 9328464
    • A.Kilian, D.D.Bowtell, H.E.Abud, G.R.Hime, D.J.Venter, P.K.Keese, E.L.Duncan, R.R.Reddel, R.A.Jefferson. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum Mol Genet 1997; 6:2011-9; PMID:9328464; http://dx.doi.org/10.1093/hmg/6.12.2011
    • (1997) Hum Mol Genet , vol.6 , pp. 2011-2019
    • Kilian, A.1    Bowtell, D.D.2    Abud, H.E.3    Hime, G.R.4    Venter, D.J.5    Keese, P.K.6    Duncan, E.L.7    Reddel, R.R.8    Jefferson, R.A.9
  • 132
    • 0038239507 scopus 로고    scopus 로고
    • Expression profile of a gamma-deletion variant of the human telomerase reverse transcriptase gene
    • 12869302
    • H.Hisatomi, K.Ohyashiki, J.H.Ohyashiki, K.Nagao, T.Kanamaru, H.Hirata, N.Hibi, Y.Tsukada. Expression profile of a gamma-deletion variant of the human telomerase reverse transcriptase gene. Neoplasia 2003; 5:193-7; PMID:12869302; http://dx.doi.org/10.1016/S1476-5586(03)80051-9
    • (2003) Neoplasia , vol.5 , pp. 193-197
    • Hisatomi, H.1    Ohyashiki, K.2    Ohyashiki, J.H.3    Nagao, K.4    Kanamaru, T.5    Hirata, H.6    Hibi, N.7    Tsukada, Y.8
  • 133
    • 33748675710 scopus 로고    scopus 로고
    • Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues
    • S.Sæbøe-Larssen, E.Fossberg, G.Gaudernack. Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT):analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues. BMC Mol Biol 2006; 7:26; PMID:16939641
    • (2006) BMC Mol Biol , vol.7 , pp. 26
    • Sæbøe-Larssen, S.1    Fossberg, E.2    Gaudernack, G.3
  • 134
    • 84868139453 scopus 로고    scopus 로고
    • Exclusion of exon 2 is a common mRNA splice variant of primate telomerase reverse transcriptases
    • 23110161
    • J.B.Withers, T.Ashvetiya, K.L.Beemon. Exclusion of exon 2 is a common mRNA splice variant of primate telomerase reverse transcriptases. PLoS One 2012; 7:e48016; PMID:23110161; http://dx.doi.org/10.1371/journal.pone.0048016
    • (2012) PLoS One , vol.7 , pp. e48016
    • Withers, J.B.1    Ashvetiya, T.2    Beemon, K.L.3
  • 135
    • 0033577876 scopus 로고    scopus 로고
    • Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)
    • 10333526
    • M.Wick, D.Zubov, G.Hagen. Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT). Gene 1999; 232:97-106; PMID:10333526; http://dx.doi.org/10.1016/S0378-1119(99)00108-0
    • (1999) Gene , vol.232 , pp. 97-106
    • Wick, M.1    Zubov, D.2    Hagen, G.3
  • 136
    • 84876994472 scopus 로고    scopus 로고
    • Regulation of Telomerase Alternative Splicing: A Target for Chemotherapy
    • 23562158
    • S.Wong Mandy, L.Chen, C.Foster, R.Kainthla, J.W.Shay, W.E.Wright. Regulation of Telomerase Alternative Splicing:A Target for Chemotherapy. Cell Rep 2013; 3:1028-35; PMID:23562158; http://dx.doi.org/10.1016/j.celrep.2013.03.011
    • (2013) Cell Rep , vol.3 , pp. 1028-1035
    • Wong Mandy, S.1    Chen, L.2    Foster, C.3    Kainthla, R.4    Shay, J.W.5    Wright, W.E.6
  • 137
    • 0034523665 scopus 로고    scopus 로고
    • An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity
    • 11191110
    • X.Yi, D.M.White, D.L.Aisner, J.A.Baur, W.E.Wright, J.W.Shay. An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity. Neoplasia 2000; 2:433-40; PMID:11191110; http://dx.doi.org/10.1038/sj.neo.7900113
    • (2000) Neoplasia , vol.2 , pp. 433-440
    • Yi, X.1    White, D.M.2    Aisner, D.L.3    Baur, J.A.4    Wright, W.E.5    Shay, J.W.6
  • 138
    • 77949904260 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors
    • 19859661
    • P.Nicholson, H.Yepiskoposyan, S.Metze, R.Zamudio Orozco, N.Kleinschmidt, O.Mühlemann. Nonsense-mediated mRNA decay in human cells:mechanistic insights, functions beyond quality control and the double-life of NMD factors. Cell Mol Life Sci 2010; 67:677-700; PMID:19859661; http://dx.doi.org/10.1007/s00018-009-0177-1
    • (2010) Cell Mol Life Sci , vol.67 , pp. 677-700
    • Nicholson, P.1    Yepiskoposyan, H.2    Metze, S.3    Zamudio Orozco, R.4    Kleinschmidt, N.5    Mühlemann, O.6
  • 139
    • 13844272923 scopus 로고    scopus 로고
    • Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage
    • 15569357
    • J.H.Santos, J.N.Meyer, M.Skorvaga, L.A.Annab, B.Van Houten,. Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. Aging Cell 2004; 3:399-411; PMID:15569357; http://dx.doi.org/10.1111/j.1474-9728.2004.00124.x
    • (2004) Aging Cell , vol.3 , pp. 399-411
    • Santos, J.H.1    Meyer, J.N.2    Skorvaga, M.3    Annab, L.A.4    Van Houten, B.5
  • 140
    • 84864966476 scopus 로고    scopus 로고
    • Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation
    • 22366458
    • J.Chung, P.Khadka, I.K.Chung. Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation. J Cell Sci 2012; 125:2684-97; PMID:22366458; http://dx.doi.org/10.1242/jcs.099267
    • (2012) J Cell Sci , vol.125 , pp. 2684-2697
    • Chung, J.1    Khadka, P.2    Chung, I.K.3
  • 141
    • 0033948026 scopus 로고    scopus 로고
    • Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase
    • 10866675
    • J.Xia, Y.Peng, I.S.Mian, N.F.Lue. Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase. Mol Cell Biol 2000; 20:5196-207; PMID:10866675; http://dx.doi.org/10.1128/MCB.20.14.5196-5207.2000
    • (2000) Mol Cell Biol , vol.20 , pp. 5196-5207
    • Xia, J.1    Peng, Y.2    Mian, I.S.3    Lue, N.F.4
  • 142
    • 0033526838 scopus 로고    scopus 로고
    • Hypoxia up-regulates telomerase activity via mitogen-activated protein kinase signaling in human solid tumor cells
    • 10403776
    • H.Seimiya, M.Tanji, T.Oh-hara, A.Tomida, I.Naasani, T.Tsuruo. Hypoxia up-regulates telomerase activity via mitogen-activated protein kinase signaling in human solid tumor cells. Biochem Biophys Res Commun 1999; 260:365-70; PMID:10403776; http://dx.doi.org/10.1006/bbrc.1999.0910
    • (1999) Biochem Biophys Res Commun , vol.260 , pp. 365-370
    • Seimiya, H.1    Tanji, M.2    Oh-hara, T.3    Tomida, A.4    Naasani, I.5    Tsuruo, T.6
  • 143
    • 0038721199 scopus 로고    scopus 로고
    • Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707
    • 12808100
    • J.Haendeler, J.Hoffmann, R.P.Brandes, A.M.Zeiher, S.Dimmeler. Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707. Mol Cell Biol 2003; 23:4598-610; PMID:12808100; http://dx.doi.org/10.1128/MCB.23.13.4598-4610.2003
    • (2003) Mol Cell Biol , vol.23 , pp. 4598-4610
    • Haendeler, J.1    Hoffmann, J.2    Brandes, R.P.3    Zeiher, A.M.4    Dimmeler, S.5
  • 144
    • 0037040990 scopus 로고    scopus 로고
    • Two independent regions of human telomerase reverse transcriptase are important for its oligomerization and telomerase activity
    • 11751869
    • K.Arai, K.Masutomi, S.Khurts, S.Kaneko, K.Kobayashi, S.Murakami. Two independent regions of human telomerase reverse transcriptase are important for its oligomerization and telomerase activity. J Biol Chem 2002; 277:8538-44; PMID:11751869; http://dx.doi.org/10.1074/jbc.M111068200
    • (2002) J Biol Chem , vol.277 , pp. 8538-8544
    • Arai, K.1    Masutomi, K.2    Khurts, S.3    Kaneko, S.4    Kobayashi, K.5    Murakami, S.6
  • 145
    • 57749107715 scopus 로고    scopus 로고
    • Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase
    • 18829466
    • S.Jakob, P.Schroeder, M.Lukosz, N.Büchner, I.Spyridopoulos, J.Altschmied, J.Haendeler. Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase. J Biol Chem 2008; 283:33155-61; PMID:18829466; http://dx.doi.org/10.1074/jbc.M805138200
    • (2008) J Biol Chem , vol.283 , pp. 33155-33161
    • Jakob, S.1    Schroeder, P.2    Lukosz, M.3    Büchner, N.4    Spyridopoulos, I.5    Altschmied, J.6    Haendeler, J.7
  • 146
    • 33845965382 scopus 로고    scopus 로고
    • Real-time RT-PCR quantification of human telomerase reverse transcriptase splice variants in tumor cell lines and non-small cell lung cancer
    • 17130181
    • E.Mavrogiannou, A.Strati, A.Stathopoulou, E.G.Tsaroucha, L.Kaklamanis, E.S.Lianidou. Real-time RT-PCR quantification of human telomerase reverse transcriptase splice variants in tumor cell lines and non-small cell lung cancer. Clin Chem 2007; 53:53-61; PMID:17130181; http://dx.doi.org/10.1373/clinchem.2006.073015
    • (2007) Clin Chem , vol.53 , pp. 53-61
    • Mavrogiannou, E.1    Strati, A.2    Stathopoulou, A.3    Tsaroucha, E.G.4    Kaklamanis, L.5    Lianidou, E.S.6
  • 147
    • 54249156408 scopus 로고    scopus 로고
    • Quantification of hTERT splice variants in melanoma by SYBR green real-time polymerase chain reaction indicates a negative regulatory role for the beta deletion variant
    • 18813352
    • L.F.Lincz, L.M.Mudge, F.E.Scorgie, J.A.Sakoff, C.S.Hamilton, M.Seldon. Quantification of hTERT splice variants in melanoma by SYBR green real-time polymerase chain reaction indicates a negative regulatory role for the beta deletion variant. Neoplasia 2008; 10:1131-7; PMID:18813352; http://dx.doi.org/10.1593/neo.08644
    • (2008) Neoplasia , vol.10 , pp. 1131-1137
    • Lincz, L.F.1    Mudge, L.M.2    Scorgie, F.E.3    Sakoff, J.A.4    Hamilton, C.S.5    Seldon, M.6
  • 148
    • 20344380433 scopus 로고    scopus 로고
    • Quantitative relationship between functionally active telomerase and major telomerase components (hTERT and hTR) in acute leukaemia cells
    • 15827550
    • J.H.Ohyashiki, H.Hisatomi, K.Nagao, S.Honda, T.Takaku, Y.Zhang, G.Sashida, K.Ohyashiki. Quantitative relationship between functionally active telomerase and major telomerase components (hTERT and hTR) in acute leukaemia cells. Br J Cancer 2005; 92:1942-7; PMID:15827550; http://dx.doi.org/10.1038/sj.bjc.6602546
    • (2005) Br J Cancer , vol.92 , pp. 1942-1947
    • Ohyashiki, J.H.1    Hisatomi, H.2    Nagao, K.3    Honda, S.4    Takaku, T.5    Zhang, Y.6    Sashida, G.7    Ohyashiki, K.8
  • 149
    • 0034989980 scopus 로고    scopus 로고
    • Possible regulation of telomerase activity by transcription and alternative splicing of telomerase reverse transcriptase in human melanoma
    • 11407973
    • R.Villa, C.D.Porta, M.Folini, M.G.Daidone, N.Zaffaroni. Possible regulation of telomerase activity by transcription and alternative splicing of telomerase reverse transcriptase in human melanoma. J Invest Dermatol 2001; 116:867-73; PMID:11407973; http://dx.doi.org/10.1046/j.1523-1747.2001.01343.x
    • (2001) J Invest Dermatol , vol.116 , pp. 867-873
    • Villa, R.1    Porta, C.D.2    Folini, M.3    Daidone, M.G.4    Zaffaroni, N.5
  • 150
    • 84862503099 scopus 로고    scopus 로고
    • Quantification of alternative splicing variants of human telomerase reverse transcriptase and correlations with telomerase activity in lung cancer
    • 22723897
    • Y.Liu, B.Q.Wu, H.H.Zhong, X.X.Tian, W.G.Fang. Quantification of alternative splicing variants of human telomerase reverse transcriptase and correlations with telomerase activity in lung cancer. PLoS One 2012; 7:e38868; PMID:22723897; http://dx.doi.org/10.1371/journal.pone.0038868
    • (2012) PLoS One , vol.7 , pp. e38868
    • Liu, Y.1    Wu, B.Q.2    Zhong, H.H.3    Tian, X.X.4    Fang, W.G.5
  • 151
    • 77951219259 scopus 로고    scopus 로고
    • Changes of telomerase activity by alternative splicing of full-length and beta variants of hTERT in breast cancer patients
    • 20225759
    • S.Y.Rha, H.C.Jeung, K.H.Park, J.J.Kim, H.C.Chung. Changes of telomerase activity by alternative splicing of full-length and beta variants of hTERT in breast cancer patients. Oncol Res 2009; 18:213-20; PMID:20225759; http://dx.doi.org/10.3727/096504009X12596189659123
    • (2009) Oncol Res , vol.18 , pp. 213-220
    • Rha, S.Y.1    Jeung, H.C.2    Park, K.H.3    Kim, J.J.4    Chung, H.C.5
  • 152
    • 0034352944 scopus 로고    scopus 로고
    • The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity
    • 11191109
    • L.M.Colgin, C.Wilkinson, A.Englezou, A.Kilian, M.O.Robinson, R.R.Reddel. The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity. Neoplasia 2000; 2:426-32; PMID:11191109; http://dx.doi.org/10.1038/sj.neo.7900112
    • (2000) Neoplasia , vol.2 , pp. 426-432
    • Colgin, L.M.1    Wilkinson, C.2    Englezou, A.3    Kilian, A.4    Robinson, M.O.5    Reddel, R.R.6
  • 153
    • 34147095342 scopus 로고    scopus 로고
    • Protein composition of catalytically active human telomerase from immortal cells
    • 17395830
    • S.B.Cohen, M.E.Graham, G.O.Lovrecz, N.Bache, P.J.Robinson, R.R.Reddel. Protein composition of catalytically active human telomerase from immortal cells. Science 2007; 315:1850-3; PMID:17395830; http://dx.doi.org/10.1126/science.1138596
    • (2007) Science , vol.315 , pp. 1850-1853
    • Cohen, S.B.1    Graham, M.E.2    Lovrecz, G.O.3    Bache, N.4    Robinson, P.J.5    Reddel, R.R.6
  • 154
    • 0033049185 scopus 로고    scopus 로고
    • Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels
    • 10330139
    • X.Yi, V.M.Tesmer, I.Savre-Train, J.W.Shay, W.E.Wright. Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels. Mol Cell Biol 1999; 19:3989-97; PMID:10330139; http://dx.doi.org/10.1128/MCB.19.6.3989
    • (1999) Mol Cell Biol , vol.19 , pp. 3989-3997
    • Yi, X.1    Tesmer, V.M.2    Savre-Train, I.3    Shay, J.W.4    Wright, W.E.5
  • 155
    • 84055207463 scopus 로고    scopus 로고
    • Separation of telomerase functions by reverse genetics
    • 21949400
    • S.Mukherjee, E.J.Firpo, Y.Wang, J.M.Roberts. Separation of telomerase functions by reverse genetics. Proc Natl Acad Sci U S A 2011; 108:E1363-71; PMID:21949400; http://dx.doi.org/10.1073/pnas.1112414108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. E1363-E1371
    • Mukherjee, S.1    Firpo, E.J.2    Wang, Y.3    Roberts, J.M.4
  • 156
    • 33744745014 scopus 로고    scopus 로고
    • Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis
    • 16613901
    • J.H.Santos, J.N.Meyer, B.Van Houten. Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. Hum Mol Genet 2006; 15:1757-68; PMID:16613901; http://dx.doi.org/10.1093/hmg/ddl098
    • (2006) Hum Mol Genet , vol.15 , pp. 1757-1768
    • Santos, J.H.1    Meyer, J.N.2    Van Houten, B.3
  • 157
    • 77953362149 scopus 로고    scopus 로고
    • Downregulation of mitochondrial telomerase reverse transcriptase induced by H2O2 is Src kinase dependent
    • 20211239
    • N.Buchner, T.C.Zschauer, M.Lukosz, J.Altschmied, J.Haendeler. Downregulation of mitochondrial telomerase reverse transcriptase induced by H2O2 is Src kinase dependent. Exp Gerontol 2010; 45:558-62; PMID:20211239; http://dx.doi.org/10.1016/j.exger.2010.03.003
    • (2010) Exp Gerontol , vol.45 , pp. 558-562
    • Buchner, N.1    Zschauer, T.C.2    Lukosz, M.3    Altschmied, J.4    Haendeler, J.5
  • 159
    • 0037087550 scopus 로고    scopus 로고
    • Dual regulation of telomerase activity through c-Myc-dependent inhibition and alternative splicing of hTERT
    • 11884529
    • A.Cerezo, H.Kalthoff, M.Schuermann, B.Schafer, P.Boukamp. Dual regulation of telomerase activity through c-Myc-dependent inhibition and alternative splicing of hTERT. J Cell Sci 2002; 115:1305-12; PMID:11884529
    • (2002) J Cell Sci , vol.115 , pp. 1305-1312
    • Cerezo, A.1    Kalthoff, H.2    Schuermann, M.3    Schafer, B.4    Boukamp, P.5
  • 160
    • 30044436210 scopus 로고    scopus 로고
    • Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms
    • 16170363
    • C.J.Anderson, S.F.Hoare, M.Ashcroft, A.E.Bilsland, W.N.Keith. Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms. Oncogene 2006; 25:61-9; PMID:16170363
    • (2006) Oncogene , vol.25 , pp. 61-69
    • Anderson, C.J.1    Hoare, S.F.2    Ashcroft, M.3    Bilsland, A.E.4    Keith, W.N.5
  • 161
    • 75149117810 scopus 로고    scopus 로고
    • Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions
    • 19755485
    • C.E.Forristal, K.L.Wright, N.A.Hanley, R.O.Oreffo, F.D.Houghton. Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions. Reproduction 2010; 139:85-97; PMID:19755485; http://dx.doi.org/10.1530/REP-09-0300
    • (2010) Reproduction , vol.139 , pp. 85-97
    • Forristal, C.E.1    Wright, K.L.2    Hanley, N.A.3    Oreffo, R.O.4    Houghton, F.D.5
  • 162
    • 77956295358 scopus 로고    scopus 로고
    • Telomere lengths in human oocytes, cleavage stage embryos and blastocysts
    • 20573647
    • S.Turner, H.P.Wong, J.Rai, G.M.Hartshorne. Telomere lengths in human oocytes, cleavage stage embryos and blastocysts. Molecular Human Reproduction 2010; 16:685-694; PMID:20573647; http://dx.doi.org/10.1093/molehr/gaq048
    • (2010) Molecular Human Reproduction , vol.16 , pp. 685-694
    • Turner, S.1    Wong, H.P.2    Rai, J.3    Hartshorne, G.M.4


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