MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells

Cell

Volumn 137, Issue 4, 2009, Pages 647-658

  Xu, Na ^a   Papagiannakopoulos, Thales ^a   Pan, Guangjin ^b   Thomson, James A ^b   Kosik, Kenneth S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

RNA; STEMCELL

Indexed keywords

KRUPPEL LIKE FACTOR 4; MICRORNA; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR SOX2;

ARTICLE; CELL DIFFERENTIATION; CELL RENEWAL; CONTROLLED STUDY; EMBRYONIC STEM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROMOTER REGION;

EID: 67349149082     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2009.02.038     Document Type: Article

References (48)

1. Avilion A.A., Nicolis S.K., Pevny L.H., Perez L., Vivian N., and Lovell-Badge R. Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev. 17 (2003) 126-140
2. Baek D., Villen J., Shin C., Camargo F.D., Gygi S.P., and Bartel D.P. The impact of microRNAs on protein output. Nature 455 (2008) 64-71
3. Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116 (2004) 281-297
4. Benetti R., Gonzalo S., Jaco I., Munoz P., Gonzalez S., Schoeftner S., Murchison E., Andl T., Chen T., Klatt P., et al. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat. Struct. Mol. Biol. 15 (2008) 998
5. Boyer L.A., Lee T.I., Cole M.F., Johnstone S.E., Levine S.S., Zucker J.P., Guenther M.G., Kumar R.M., Murray H.L., Jenner R.G., et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122 (2005) 947-956
6. Farh K.K., Grimson A., Jan C., Lewis B.P., Johnston W.K., Lim L.P., Burge C.B., and Bartel D.P. The widespread impact of mammalian microRNAs on mRNA repression and evolution. Science 310 (2005) 1817-1821
7. Fong H., Hohenstein K.A., and Donovan P.J. Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. Stem Cells 26 (2008) 1931-1938
8. Griffiths-Jones S., Grocock R.J., van Dongen S., Bateman A., and Enright A.J. miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 34 (2006) D140-D144
9. Gropp M., and Reubinoff B. Lentiviral vector-mediated gene delivery into human embryonic stem cells. Methods Enzymol. 420 (2006) 64-81
10. Houbaviy H.B., Murray M.F., and Sharp P.A. Embryonic stem cell-specific microRNAs. Dev. Cell 5 (2003) 351-358
11. Ivey K.N., Muth A., Arnold J., King F.W., Yeh R.F., Fish J.E., Hsiao E.C., Schwartz R.J., Conklin B.R., Bernstein H.S., and Srivastava D. MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell 2 (2008) 219-229
12. Jaenisch R., and Young R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 132 (2008) 567-582
13. Jiang J., Chan Y.S., Loh Y.H., Cai J., Tong G.Q., Lim C.A., Robson P., Zhong S., and Ng H.H. A core Klf circuitry regulates self-renewal of embryonic stem cells. Nat. Cell Biol. 10 (2008) 353-360
14. Kanellopoulou C., Muljo S.A., Kung A.L., Ganesan S., Drapkin R., Jenuwein T., Livingston D.M., and Rajewsky K. Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev. 19 (2005) 489-501
15. Kopp J.L., Ormsbee B.D., Desler M., and Rizzino A. Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cells. Stem Cells 26 (2008) 903-911
16. Kye M.J., Liu T., Levy S.F., Xu N.L., Groves B.B., Bonneau R., Lao K., and Kosik K.S. Somatodendritic microRNAs identified by laser capture and multiplex RT-PCR. RNA 13 (2007) 1224-1234
17. Lagos-Quintana M., Rauhut R., Lendeckel W., and Tuschl T. Identification of novel genes coding for small expressed RNAs. Science 294 (2001) 853-858
18. Landgraf P., Rusu M., Sheridan R., Sewer A., Iovino N., Aravin A., Pfeffer S., Rice A., Kamphorst A.O., Landthaler M., et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129 (2007) 1401-1414
19. Laurent L.C., Chen J., Ulitsky I., Mueller F.J., Lu C., Shamir R., Fan J.B., and Loring J.F. Comprehensive microRNA profiling reveals a unique human embryonic stem cell signature dominated by a single seed sequence. Stem Cells 26 (2008) 1506-1516
20. Lewis B.P., Shih I.H., Jones-Rhoades M.W., Bartel D.P., and Burge C.B. Prediction of mammalian microRNA targets. Cell 115 (2003) 787-798
21. Lewis B.P., Burge C.B., and Bartel D.P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120 (2005) 15-20
22. Marson A., Levine S.S., Cole M.F., Frampton G.M., Brambrink T., Johnstone S., Guenther M.G., Johnston W.K., Wernig M., Newman J., et al. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 134 (2008) 521-533
23. Michael M.Z., O'Conner S.M., van Holst Pellekaan N.G., Young G.P., and James R.J. Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol. Cancer Res. 1 (2003) 882-891
24. Mineno J., Okamoto S., Ando T., Sato M., Chono H., Izu H., Takayama M., Asada K., Mirochnitchenko O., Inouye M., and Kato I. The expression profile of microRNAs in mouse embryos. Nucleic Acids Res. 34 (2006) 1765-1771
25. Morin R.D., O'Connor M.D., Griffith M., Kuchenbauer F., Delaney A., Prabhu A.L., Zhao Y., McDonald H., Zeng T., Hirst M., et al. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res. 18 (2008) 610-621
26. Murchison E.P., Partridge J.F., Tam O.H., Cheloufi S., and Hannon G.J. Characterization of Dicer-deficient murine embryonic stem cells. Proc. Natl. Acad. Sci. USA 102 (2005) 12135-12140
27. Nakagawa M., Koyanagi M., Tanabe K., Takahashi K., Ichisaka T., Aoi T., Okita K., Mochiduki Y., Takizawa N., and Yamanaka S. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat. Biotechnol. 26 (2008) 101-106
28. Nakatake Y., Fukui N., Iwamatsu Y., Masui S., Takahashi K., Yagi R., Yagi K., Miyazaki J., Matoba R., Ko M.S., and Niwa H. Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells. Mol. Cell. Biol. 26 (2006) 7772-7782
29. Niwa H., Miyazaki J., and Smith A.G. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24 (2000) 372-376
30. Park I.H., Zhao R., West J.A., Yabuuchi A., Huo H., Ince T.A., Lerou P.H., Lensch M.W., and Daley G.Q. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 451 (2008) 141-146
31. Pei D. Regulation of pluripotency and reprogramming by transcription factors. J. Biol. Chem. 284 (2008) 3365-3369
32. Rodda D.J., Chew J.L., Lim L.H., Loh Y.H., Wang B., Ng H.H., and Robson P. Transcriptional regulation of nanog by OCT4 and SOX2. J. Biol. Chem. 280 (2005) 24731-24737
33. Scholer H.R., Dressler G.R., Balling R., Rohdewohld H., and Gruss P. Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J. 9 (1990) 2185-2195
34. Sinkkonen L., Hugenschmidt T., Berninger P., Gaidatzis D., Mohn F., Artus-Revel C.G., Zavolan M., Svoboda P., and Filipowicz W. MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells. Nat. Struct. Mol. Biol. 15 (2008) 259-267
35. Stefani G., and Slack F.J. Small non-coding RNAs in animal development. Nat. Rev. Mol. Cell Biol. 9 (2008) 219-230
36. Suh M.R., Lee Y., Kim J.Y., Kim S.K., Moon S.H., Lee J.Y., Cha K.Y., Chung H.M., Yoon H.S., Moon S.Y., et al. Human embryonic stem cells express a unique set of microRNAs. Dev. Biol. 270 (2004) 488-498
37. Takahashi K., and Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126 (2006) 663-676
38. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., and Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131 (2007) 861-872
39. Tay Y., Zhang J., Thomson A.M., Lim B., and Rigoutsos I. MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature 455 (2008) 1124-1128
40. Tay Y.M., Tam W.L., Ang Y.S., Gaughwin P.M., Yang H., Wang W., Liu R., George J., Ng H.H., Perera R.J., et al. MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1. Stem Cells 26 (2008) 17-29
41. Thomson J.A., Itskovitz-Eldor J., Shapiro S.S., Waknitz M.A., Swiergiel J.J., Marshall V.S., and Jones J.M. Embryonic stem cell lines derived from human blastocysts. Science 282 (1998) 1145-1147
42. Wang Y., Medvid R., Melton C., Jaenisch R., and Blelloch R. DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat. Genet. 39 (2007) 380-385
43. Wang Y., Keys D.N., Au-Young J.K., and Chen C. MicroRNAs in embryonic stem cells. J. Cell. Physiol. 218 (2008) 251-255
44. Wernig M., Meissner A., Foreman R., Brambrink T., Ku M., Hochedlinger K., Bernstein B.E., and Jaenisch R. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448 (2007) 318-324
45. Xu R.H., Chen X., Li D.S., Li R., Addicks G.C., Glennon C., Zwaka T.P., and Thomson J.A. BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat. Biotechnol. 20 (2002) 1261-1264
46. Yi R., Poy M.N., Stoffel M., and Fuchs E. A skin microRNA promotes differentiation by repressing 'stemness'. Nature 452 (2008) 225-229
47. Yu J., Vodyanik M.A., Smuga-Otto K., Antosiewicz-Bourget J., Frane J.L., Tian S., Nie J., Jonsdottir G.A., Ruotti V., Stewart R., et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 318 (2007) 1917-1920
48. Zaehres H., Lensch M.W., Daheron L., Stewart S.A., Itskovitz-Eldor J., and Daley G.Q. High-efficiency RNA interference in human embryonic stem cells. Stem Cells 23 (2005) 299-305