-
1
-
-
77954273218
-
Keeping p53 in check: a high-stakes balancing act
-
Berger S.L. Keeping p53 in check: a high-stakes balancing act. Cell 2010, 142:17-19.
-
(2010)
Cell
, vol.142
, pp. 17-19
-
-
Berger, S.L.1
-
2
-
-
0032479079
-
Going the distance: a current view of enhancer action
-
Blackwood E.M., Kadonaga J.T. Going the distance: a current view of enhancer action. Science 1998, 281:60-63.
-
(1998)
Science
, vol.281
, pp. 60-63
-
-
Blackwood, E.M.1
Kadonaga, J.T.2
-
3
-
-
34548445454
-
Generation of induced pluripotent stem cells in the absence of drug selection
-
Blelloch R., Venere M., Yen J., Ramalho-Santos M. Generation of induced pluripotent stem cells in the absence of drug selection. Cell Stem Cell 2007, 1:245-247.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 245-247
-
-
Blelloch, R.1
Venere, M.2
Yen, J.3
Ramalho-Santos, M.4
-
4
-
-
4944255743
-
Post-translational modification of p53 in tumorigenesis
-
Bode A.M., Dong Z. Post-translational modification of p53 in tumorigenesis. Nat. Rev. Cancer 2004, 4:793-805.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 793-805
-
-
Bode, A.M.1
Dong, Z.2
-
5
-
-
44649117905
-
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
-
Chen X., Xu H., Yuan P., Fang F., Huss M., Vega V.B., Wong E., Orlov Y.L., Zhang W., Jiang J., et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 2008, 133:1106-1117.
-
(2008)
Cell
, vol.133
, pp. 1106-1117
-
-
Chen, X.1
Xu, H.2
Yuan, P.3
Fang, F.4
Huss, M.5
Vega, V.B.6
Wong, E.7
Orlov, Y.L.8
Zhang, W.9
Jiang, J.10
-
6
-
-
78650758676
-
Histone H3K27ac separates active from poised enhancers and predicts developmental state
-
Creyghton M.P., Cheng A.W., Welstead G.G., Kooistra T., Carey B.W., Steine E.J., Hanna J., Lodato M.A., Frampton G.M., Sharp P.A., et al. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc. Natl. Acad. Sci. USA 2010, 107:21931-21936.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 21931-21936
-
-
Creyghton, M.P.1
Cheng, A.W.2
Welstead, G.G.3
Kooistra, T.4
Carey, B.W.5
Steine, E.J.6
Hanna, J.7
Lodato, M.A.8
Frampton, G.M.9
Sharp, P.A.10
-
7
-
-
0033665287
-
Embryoid bodies: an in vitro model of mouse embryogenesis
-
Desbaillets I., Ziegler U., Groscurth P., Gassmann M. Embryoid bodies: an in vitro model of mouse embryogenesis. Exp. Physiol. 2000, 85:645-651.
-
(2000)
Exp. Physiol.
, vol.85
, pp. 645-651
-
-
Desbaillets, I.1
Ziegler, U.2
Groscurth, P.3
Gassmann, M.4
-
8
-
-
59649105969
-
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb
-
Feng B., Jiang J., Kraus P., Ng J.H., Heng J.C., Chan Y.S., Yaw L.P., Zhang W., Loh Y.H., Han J., et al. Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat. Cell Biol. 2009, 11:197-203.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 197-203
-
-
Feng, B.1
Jiang, J.2
Kraus, P.3
Ng, J.H.4
Heng, J.C.5
Chan, Y.S.6
Yaw, L.P.7
Zhang, W.8
Loh, Y.H.9
Han, J.10
-
9
-
-
33847334699
-
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
-
Heintzman N.D., Stuart R.K., Hon G., Fu Y., Ching C.W., Hawkins R.D., Barrera L.O., Van Calcar S., Qu C., Ching K.A., et al. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat. Genet. 2007, 39:311-318.
-
(2007)
Nat. Genet.
, vol.39
, pp. 311-318
-
-
Heintzman, N.D.1
Stuart, R.K.2
Hon, G.3
Fu, Y.4
Ching, C.W.5
Hawkins, R.D.6
Barrera, L.O.7
Van Calcar, S.8
Qu, C.9
Ching, K.A.10
-
10
-
-
0036479115
-
Transcriptional repression of the anti-apoptotic survivin gene by wild type p53
-
Hoffman W.H., Biade S., Zilfou J.T., Chen J., Murphy M. Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J. Biol. Chem. 2002, 277:3247-3257.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 3247-3257
-
-
Hoffman, W.H.1
Biade, S.2
Zilfou, J.T.3
Chen, J.4
Murphy, M.5
-
11
-
-
33845204856
-
Repression of p53 activity by Smyd2-mediated methylation
-
Huang J., Perez-Burgos L., Placek B.J., Sengupta R., Richter M., Dorsey J.A., Kubicek S., Opravil S., Jenuwein T., Berger S.L. Repression of p53 activity by Smyd2-mediated methylation. Nature 2006, 444:629-632.
-
(2006)
Nature
, vol.444
, pp. 629-632
-
-
Huang, J.1
Perez-Burgos, L.2
Placek, B.J.3
Sengupta, R.4
Richter, M.5
Dorsey, J.A.6
Kubicek, S.7
Opravil, S.8
Jenuwein, T.9
Berger, S.L.10
-
12
-
-
34548513035
-
P53 is regulated by the lysine demethylase LSD1
-
Huang J., Sengupta R., Espejo A.B., Lee M.G., Dorsey J.A., Richter M., Opravil S., Shiekhattar R., Bedford M.T., Jenuwein T., Berger S.L. p53 is regulated by the lysine demethylase LSD1. Nature 2007, 449:105-108.
-
(2007)
Nature
, vol.449
, pp. 105-108
-
-
Huang, J.1
Sengupta, R.2
Espejo, A.B.3
Lee, M.G.4
Dorsey, J.A.5
Richter, M.6
Opravil, S.7
Shiekhattar, R.8
Bedford, M.T.9
Jenuwein, T.10
Berger, S.L.11
-
13
-
-
70350536767
-
A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog
-
Ichida J.K., Blanchard J., Lam K., Son E.Y., Chung J.E., Egli D., Loh K.M., Carter A.C., Di Giorgio F.P., Koszka K., et al. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell 2009, 5:491-503.
-
(2009)
Cell Stem Cell
, vol.5
, pp. 491-503
-
-
Ichida, J.K.1
Blanchard, J.2
Lam, K.3
Son, E.Y.4
Chung, J.E.5
Egli, D.6
Loh, K.M.7
Carter, A.C.8
Di Giorgio, F.P.9
Koszka, K.10
-
14
-
-
0035920197
-
Transcriptional repression by p53 through direct binding to a novel DNA element
-
Johnson R.A., Ince T.A., Scotto K.W. Transcriptional repression by p53 through direct binding to a novel DNA element. J. Biol. Chem. 2001, 276:27716-27720.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 27716-27720
-
-
Johnson, R.A.1
Ince, T.A.2
Scotto, K.W.3
-
15
-
-
77957139539
-
Mediator and cohesin connect gene expression and chromatin architecture
-
Kagey M.H., Newman J.J., Bilodeau S., Zhan Y., Orlando D.A., van Berkum N.L., Ebmeier C.C., Goossens J., Rahl P.B., Levine S.S., et al. Mediator and cohesin connect gene expression and chromatin architecture. Nature 2010, 467:430-435.
-
(2010)
Nature
, vol.467
, pp. 430-435
-
-
Kagey, M.H.1
Newman, J.J.2
Bilodeau, S.3
Zhan, Y.4
Orlando, D.A.5
van Berkum, N.L.6
Ebmeier, C.C.7
Goossens, J.8
Rahl, P.B.9
Levine, S.S.10
-
16
-
-
69349100455
-
Linking the p53 tumour suppressor pathway to somatic cell reprogramming
-
Kawamura T., Suzuki J., Wang Y.V., Menendez S., Morera L.B., Raya A., Wahl G.M., Izpisúa Belmonte J.C. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 2009, 460:1140-1144.
-
(2009)
Nature
, vol.460
, pp. 1140-1144
-
-
Kawamura, T.1
Suzuki, J.2
Wang, Y.V.3
Menendez, S.4
Morera, L.B.5
Raya, A.6
Wahl, G.M.7
Izpisúa Belmonte, J.C.8
-
17
-
-
40749104852
-
An extended transcriptional network for pluripotency of embryonic stem cells
-
Kim J., Chu J., Shen X., Wang J., Orkin S.H. An extended transcriptional network for pluripotency of embryonic stem cells. Cell 2008, 132:1049-1061.
-
(2008)
Cell
, vol.132
, pp. 1049-1061
-
-
Kim, J.1
Chu, J.2
Shen, X.3
Wang, J.4
Orkin, S.H.5
-
18
-
-
77957757417
-
A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs
-
Kim J., Woo A.J., Chu J., Snow J.W., Fujiwara Y., Kim C.G., Cantor A.B., Orkin S.H. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell 2010, 143:313-324.
-
(2010)
Cell
, vol.143
, pp. 313-324
-
-
Kim, J.1
Woo, A.J.2
Chu, J.3
Snow, J.W.4
Fujiwara, Y.5
Kim, C.G.6
Cantor, A.B.7
Orkin, S.H.8
-
19
-
-
65549120715
-
Modes of p53 regulation
-
Kruse J.P., Gu W. Modes of p53 regulation. Cell 2009, 137:609-622.
-
(2009)
Cell
, vol.137
, pp. 609-622
-
-
Kruse, J.P.1
Gu, W.2
-
20
-
-
33646807491
-
Transcriptional regulation by p53: one protein, many possibilities
-
Laptenko O., Prives C. Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ. 2006, 13:951-961.
-
(2006)
Cell Death Differ.
, vol.13
, pp. 951-961
-
-
Laptenko, O.1
Prives, C.2
-
21
-
-
76249102530
-
A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells
-
Lee K.H., Li M., Michalowski A.M., Zhang X., Liao H., Chen L., Xu Y., Wu X., Huang J. A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells. Proc. Natl. Acad. Sci. USA 2010, 107:69-74.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 69-74
-
-
Lee, K.H.1
Li, M.2
Michalowski, A.M.3
Zhang, X.4
Liao, H.5
Chen, L.6
Xu, Y.7
Wu, X.8
Huang, J.9
-
22
-
-
77953598921
-
A new puzzling role of p53 in mouse embryonic stem cells
-
Li M., Huang J. A new puzzling role of p53 in mouse embryonic stem cells. Cell Cycle 2010, 9:1669-1670.
-
(2010)
Cell Cycle
, vol.9
, pp. 1669-1670
-
-
Li, M.1
Huang, J.2
-
23
-
-
13944273471
-
P53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression
-
Lin T., Chao C., Saito S., Mazur S.J., Murphy M.E., Appella E., Xu Y. p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat. Cell Biol. 2005, 7:165-171.
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 165-171
-
-
Lin, T.1
Chao, C.2
Saito, S.3
Mazur, S.J.4
Murphy, M.E.5
Appella, E.6
Xu, Y.7
-
24
-
-
33645381936
-
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
-
Loh Y.H., Wu Q., Chew J.L., Vega V.B., Zhang W., Chen X., Bourque G., George J., Leong B., Liu J., et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 2006, 38:431-440.
-
(2006)
Nat. Genet.
, vol.38
, pp. 431-440
-
-
Loh, Y.H.1
Wu, Q.2
Chew, J.L.3
Vega, V.B.4
Zhang, W.5
Chen, X.6
Bourque, G.7
George, J.8
Leong, B.9
Liu, J.10
-
25
-
-
69349094006
-
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
-
Marión R.M., Strati K., Li H., Murga M., Blanco R., Ortega S., Fernandez-Capetillo O., Serrano M., Blasco M.A. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 2009, 460:1149-1153.
-
(2009)
Nature
, vol.460
, pp. 1149-1153
-
-
Marión, R.M.1
Strati, K.2
Li, H.3
Murga, M.4
Blanco, R.5
Ortega, S.6
Fernandez-Capetillo, O.7
Serrano, M.8
Blasco, M.A.9
-
26
-
-
34547624303
-
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
-
Mikkelsen T.S., Ku M., Jaffe D.B., Issac B., Lieberman E., Giannoukos G., Alvarez P., Brockman W., Kim T.K., Koche R.P., et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 2007, 448:553-560.
-
(2007)
Nature
, vol.448
, pp. 553-560
-
-
Mikkelsen, T.S.1
Ku, M.2
Jaffe, D.B.3
Issac, B.4
Lieberman, E.5
Giannoukos, G.6
Alvarez, P.7
Brockman, W.8
Kim, T.K.9
Koche, R.P.10
-
27
-
-
78651100119
-
Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures
-
Mizuno H., Spike B.T., Wahl G.M., Levine A.J. Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. Proc. Natl. Acad. Sci. USA 2010, 107:22745-22750.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 22745-22750
-
-
Mizuno, H.1
Spike, B.T.2
Wahl, G.M.3
Levine, A.J.4
-
28
-
-
0033215387
-
Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a
-
Murphy M., Ahn J., Walker K.K., Hoffman W.H., Evans R.M., Levine A.J., George D.L. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev. 1999, 13:2490-2501.
-
(1999)
Genes Dev.
, vol.13
, pp. 2490-2501
-
-
Murphy, M.1
Ahn, J.2
Walker, K.K.3
Hoffman, W.H.4
Evans, R.M.5
Levine, A.J.6
George, D.L.7
-
29
-
-
78649644924
-
MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states
-
Neveu P., Kye M.J., Qi S., Buchholz D.E., Clegg D.O., Sahin M., Park I.H., Kim K.S., Daley G.Q., Kornblum H.I., et al. MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states. Cell Stem Cell 2010, 7:671-681.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 671-681
-
-
Neveu, P.1
Kye, M.J.2
Qi, S.3
Buchholz, D.E.4
Clegg, D.O.5
Sahin, M.6
Park, I.H.7
Kim, K.S.8
Daley, G.Q.9
Kornblum, H.I.10
-
30
-
-
0025000915
-
Isolation of embryonic stem (ES) cells in media supplemented with recombinant leukemia inhibitory factor (LIF)
-
Pease S., Braghetta P., Gearing D., Grail D., Williams R.L. Isolation of embryonic stem (ES) cells in media supplemented with recombinant leukemia inhibitory factor (LIF). Dev. Biol. 1990, 141:344-352.
-
(1990)
Dev. Biol.
, vol.141
, pp. 344-352
-
-
Pease, S.1
Braghetta, P.2
Gearing, D.3
Grail, D.4
Williams, R.L.5
-
31
-
-
77951920690
-
C-Myc regulates transcriptional pause release
-
Rahl P.B., Lin C.Y., Seila A.C., Flynn R.A., McCuine S., Burge C.B., Sharp P.A., Young R.A. c-Myc regulates transcriptional pause release. Cell 2010, 141:432-445.
-
(2010)
Cell
, vol.141
, pp. 432-445
-
-
Rahl, P.B.1
Lin, C.Y.2
Seila, A.C.3
Flynn, R.A.4
McCuine, S.5
Burge, C.B.6
Sharp, P.A.7
Young, R.A.8
-
32
-
-
0025950771
-
Mechanism of DNA polymerase alpha inhibition by aphidicolin
-
Sheaff R., Ilsley D., Kuchta R. Mechanism of DNA polymerase alpha inhibition by aphidicolin. Biochemistry 1991, 30:8590-8597.
-
(1991)
Biochemistry
, vol.30
, pp. 8590-8597
-
-
Sheaff, R.1
Ilsley, D.2
Kuchta, R.3
-
33
-
-
34547809957
-
Modulation of p53 function by SET8-mediated methylation at lysine 382
-
Shi X., Kachirskaia I., Yamaguchi H., West L.E., Wen H., Wang E.W., Dutta S., Appella E., Gozani O. Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol. Cell 2007, 27:636-646.
-
(2007)
Mol. Cell
, vol.27
, pp. 636-646
-
-
Shi, X.1
Kachirskaia, I.2
Yamaguchi, H.3
West, L.E.4
Wen, H.5
Wang, E.W.6
Dutta, S.7
Appella, E.8
Gozani, O.9
-
34
-
-
46349094389
-
Characterization of genome-wide p53-binding sites upon stress response
-
Smeenk L., van Heeringen S.J., Koeppel M., van Driel M.A., Bartels S.J., Akkers R.C., Denissov S., Stunnenberg H.G., Lohrum M. Characterization of genome-wide p53-binding sites upon stress response. Nucleic Acids Res. 2008, 36:3639-3654.
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 3639-3654
-
-
Smeenk, L.1
van Heeringen, S.J.2
Koeppel, M.3
van Driel, M.A.4
Bartels, S.J.5
Akkers, R.C.6
Denissov, S.7
Stunnenberg, H.G.8
Lohrum, M.9
-
35
-
-
27344435774
-
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
-
Subramanian A., Tamayo P., Mootha V.K., Mukherjee S., Ebert B.L., Gillette M.A., Paulovich A., Pomeroy S.L., Golub T.R., Lander E.S., Mesirov J.P. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 2005, 102:15545-15550.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 15545-15550
-
-
Subramanian, A.1
Tamayo, P.2
Mootha, V.K.3
Mukherjee, S.4
Ebert, B.L.5
Gillette, M.A.6
Paulovich, A.7
Pomeroy, S.L.8
Golub, T.R.9
Lander, E.S.10
Mesirov, J.P.11
-
36
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
37
-
-
33845270990
-
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
-
Toledo F., Wahl G.M. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat. Rev. Cancer 2006, 6:909-923.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 909-923
-
-
Toledo, F.1
Wahl, G.M.2
-
38
-
-
65349103899
-
Blinded by the Light: The Growing Complexity of p53
-
Vousden K.H., Prives C. Blinded by the Light: The Growing Complexity of p53. Cell 2009, 137:413-431.
-
(2009)
Cell
, vol.137
, pp. 413-431
-
-
Vousden, K.H.1
Prives, C.2
-
39
-
-
79952660821
-
Control of the embryonic stem cell state
-
Young R.A. Control of the embryonic stem cell state. Cell 2011, 144:940-954.
-
(2011)
Cell
, vol.144
, pp. 940-954
-
-
Young, R.A.1
-
40
-
-
36749043230
-
Induced pluripotent stem cell lines derived from human somatic cells
-
Yu J., Vodyanik M.A., Smuga-Otto K., Antosiewicz-Bourget J., Frane J.L., Tian S., Nie J., Jonsdottir G.A., Ruotti V., Stewart R., et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007, 318:1917-1920.
-
(2007)
Science
, vol.318
, pp. 1917-1920
-
-
Yu, J.1
Vodyanik, M.A.2
Smuga-Otto, K.3
Antosiewicz-Bourget, J.4
Frane, J.L.5
Tian, S.6
Nie, J.7
Jonsdottir, G.A.8
Ruotti, V.9
Stewart, R.10
-
41
-
-
77957968414
-
Integrative genome-wide approaches in embryonic stem cell research
-
Zhang X., Huang J. Integrative genome-wide approaches in embryonic stem cell research. Integr Biol (Camb) 2010, 2:510-516.
-
(2010)
Integr Biol (Camb)
, vol.2
, pp. 510-516
-
-
Zhang, X.1
Huang, J.2
-
42
-
-
53849146020
-
Model-based analysis of ChIP-Seq (MACS)
-
Zhang Y., Liu T., Meyer C.A., Eeckhoute J., Johnson D.S., Bernstein B.E., Nusbaum C., Myers R.M., Brown M., Li W., Liu X.S. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 2008, 9:R137.
-
(2008)
Genome Biol.
, vol.9
-
-
Zhang, Y.1
Liu, T.2
Meyer, C.A.3
Eeckhoute, J.4
Johnson, D.S.5
Bernstein, B.E.6
Nusbaum, C.7
Myers, R.M.8
Brown, M.9
Li, W.10
Liu, X.S.11
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