Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 37, 2011, Pages 15207-15212

  Varela, Elisa ^a   Schneider, Ralph P ^a   Ortega, Sagrario ^a   Blasco, Maria A ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

Author keywords

Embryo; Nanog; Oct4; Sox2

Indexed keywords

TELOMERIC REPEAT BINDING FACTOR 1;

ANIMAL CELL; ARTICLE; BLASTOCYST; DYNAMICS; EMBRYO; EMBRYONIC STEM CELL; EPIGENETICS; IN VITRO STUDY; IN VIVO STUDY; INNER CELL MASS; MORULA; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; STEM CELL EXPANSION; TELOMERE;

ANIMALS; BLASTOCYST; CELL AGGREGATION; CELL LINE; CELL PROLIFERATION; CELL SEPARATION; EMBRYONIC STEM CELLS; HETEROCHROMATIN; MICE; MICE, INBRED C57BL; OCTAMER TRANSCRIPTION FACTOR-3; TELOMERE; TELOMERIC REPEAT BINDING PROTEIN 1;

MURINAE;

EID: 80053082069     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1105414108     Document Type: Article

References (52)

1. Albert M, Peters AH (2009) Genetic and epigenetic control of early mouse development. Curr Opin Genet Dev 19(2):113-121.
2. Mattout A, Meshorer E (2010) Chromatin plasticity and genome organization in pluripotent embryonic stem cells. Curr Opin Cell Biol 22:334-341.
3. Shay JW, Wright WE (2010) Telomeres and telomerase in normal and cancer stem cells. FEBS Lett 584:3819-3825.
4. Evans MJ, Kaufman MH (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292(5819):154-156. (Pubitemid 11050741)
5. Marion RM, et al. (2009) Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells. Cell Stem Cell 4(2):141-154.
6. Flores I, et al. (2008) The longest telomeres: A general signature of adult stem cell compartments. Genes Dev 22:654-667. (Pubitemid 351342437)
7. Flores I, Blasco MA (2009) A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres. PLoS ONE 4:e4934.
8. Wright DL, et al. (2001) Characterization of telomerase activity in the human oocyte and preimplantation embryo. Mol Hum Reprod 7:947-955. (Pubitemid 32952176)
9. Aoi T, et al. (2008) Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science 321:699-702.
10. Maherali N, et al. (2007) Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 1(1):55-70.
11. Nakagawa M, et al. (2008) Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol 26(1):101-106.
12. Okita K, Ichisaka T, Yamanaka S (2007) Generation of germline-competent induced pluripotent stem cells. Nature 448:313-317. (Pubitemid 47080336)
13. Stadtfeld M, Maherali N, Breault DT, Hochedlinger K (2008) Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell 2:230-240.
14. Takahashi K, et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-872. (Pubitemid 350138099)
15. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676. (Pubitemid 44233629)
16. Wernig M, et al. (2007) In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448:318-324. (Pubitemid 47080337)
17. Betts DH, King WA (1999) Telomerase activity and telomere detection during early bovine development. Dev Genet 25:397-403.
18. Blasco MA, Funk W, Villeponteau B, Greider CW (1995) Functional characterization and developmental regulation of mouse telomerase RNA. Science 269:1267-1270.
19. Liu L, et al. (2007) Telomere lengthening early in development. Nat Cell Biol 9: 1436-1441. (Pubitemid 350201757)
20. Mantell LL, Greider CW (1994) Telomerase activity in germline and embryonic cells of Xenopus. EMBO J 13:3211-3217. (Pubitemid 24213473)
21. Xu J, Yang X (2001) Telomerase activity in early bovine embryos derived from parthenogenetic activation and nuclear transfer. Biol Reprod 64:770-774. (Pubitemid 32174046)
22. Blasco MA (2007) The epigenetic regulation of mammalian telomeres. Nat Rev Genet 8:299-309. (Pubitemid 46439289)
23. Jaco I, Canela A, Vera E, Blasco MA (2008) Centromere mitotic recombination in mammalian cells. J Cell Biol 181:885-892. (Pubitemid 351846822)
24. McIlrath J, et al. (2001) Telomere length abnormalities in mammalian radiosensitive cells. Cancer Res 61:912-915. (Pubitemid 32174402)
25. Schaetzlein S, et al. (2004) Telomere length is reset during early mammalian embryogenesis. Proc Natl Acad Sci USA 101:8034-8038. (Pubitemid 38698049)
26. Benetti R, et al. (2008) A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol 15(3):268-279. (Pubitemid 351654050)
27. García-Cao M, O'Sullivan R, Peters AH, Jenuwein T, Blasco MA (2004) Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet 36(1):94-99. (Pubitemid 38056214)
28. Gonzalo S, et al. (2006) DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol 8:416-424.
29. Vera E, Canela A, Fraga MF, Esteller M, Blasco MA (2008) Epigenetic regulation of telomeres in human cancer. Oncogene 27:6817-6833.
30. Smith KP, Luong MX, Stein GS (2009) Pluripotency: Toward a gold standard for human ES and iPS cells. J Cell Physiol 220(1):21-29.
31. Orkin SH, et al. (2008) The transcriptional network controlling pluripotency in ES cells. Cold Spring Harb Symp Quant Biol 73:195-202.
32. Mitsui K, et al. (2003) The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113:631-642. (Pubitemid 36694188)
33. Liu N, et al. (2008) Identification of genes regulated by nanog which is involved in ES cells pluripotency and early differentiation. J Cell Biochem 104:2348-2362.
34. Kuroda T, Tada M (2006) Molecular network of transcriptional factors controlling pluripotency of ES cells. (Translated from Japanese) Seikagaku 78(2):137-141.
35. Dong WZ, Shen WZ, Hua JL, Dou ZY (2007) Study on pluripotency and cultivation of ES-like cells derived from male germ stem cells of bovine fetuses. (Translated from Chinese) Sheng Wu Gong Cheng Xue Bao 23:751-755.
36. Chambers I, et al. (2003) Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113:643-655. (Pubitemid 36694189)
37. De Lange T (2005) Shelterin: The protein complex that shapes and safeguards human telomeres. Genes Dev 19:2100-2110.
38. Blasco MA (2007) Telomere length, stem cells and aging. Nat Chem Biol 3:640-649. (Pubitemid 47417712)
39. Blasco MA (2005) Telomeres and human disease: Ageing, cancer and beyond. Nat Rev Genet 6:611-622. (Pubitemid 41044298)
40. Tejera AM, et al. (2010) TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice. Dev Cell 18: 775-789.
41. Karlseder J, et al. (2003) Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol Cell Biol 23:6533-6541. (Pubitemid 37075764)
42. Martínez P, et al. (2009) Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes Dev 23:2060-2075.
43. Ancelin K, et al. (2002) Targeting assay to study the cis functions of human telomeric proteins: Evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol Cell Biol 22:3474-3487. (Pubitemid 34453986)
44. Smogorzewska A, et al. (2000) Control of human telomere length by TRF1 and TRF2. Mol Cell Biol 20:1659-1668. (Pubitemid 30100185)
45. Van Steensel B, De Lange T (1997) Control of telomere length by the human telomeric protein TRF1. Nature 385:740-743. (Pubitemid 27098097)
46. Muñoz P, et al. (2009) TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis. Mol Cell Biol 29:1608-1625.
47. Avilion AA, et al. (2003) Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev 17(6):126-140. (Pubitemid 36062514)
48. Nichols J, et al. (1998) Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95:379-391. (Pubitemid 28507326)
49. Niwa H, Miyazaki J, Smith AG (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24:372-376. (Pubitemid 30187435)
50. Muñoz P, Blanco R, Flores JM, Blasco MA (2005) XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. Nat Genet 37:1063-1071. (Pubitemid 41486658)
51. Samper E, Flores JM, Blasco MA (2001) Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres. EMBO Rep 2:800-807. (Pubitemid 32982748)
52. Zijlmans JM, et al. (1997) Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc Natl Acad Sci USA 94:7423-7428. (Pubitemid 27345331)