Invited review: Small GTPases and their GAPs

Biopolymers

Volumn 105, Issue 8, 2016, Pages 431-448

  Mishra, Ashwini K ^a   Lambright, David G ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

GAP; GTPase; hydrolysis; mechanism; structure

Indexed keywords

CHEMICAL ACTIVATION; MECHANISMS; NUCLEOTIDES; PROTEINS; STRUCTURE (COMPOSITION);

CATALYTIC ACCELERATION; CONFORMATIONAL SWITCHES; GTPASE; GTPASE-ACTIVATING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HYDROLYTIC REACTIONS; NUCLEOTIDE EXCHANGE; REACTION MECHANISM;

HYDROLYSIS;

ARF PROTEIN; ARGININE; CALCIUM DERIVATIVE; GLUCOSE TRANSPORTER; GLUTAMINE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RAB PROTEIN; RHEB PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATE;

AUTOREGULATION; CANCER INHIBITION; CATALYSIS; CHEMICAL REACTION KINETICS; CHEMICAL STRUCTURE; COMPUTER MODEL; DOORS SYNDROME; ENTEROPATHOGENIC ESCHERICHIA COLI; ENZYME REGULATION; FAMILIAL DISEASE; HUMAN; HYDROLYSIS; LEGIONELLA PNEUMOPHILA; NEUROLOGIC DISEASE; NONHUMAN; PROTEIN DOMAIN; PROTEIN LOCALIZATION; REACTION ANALYSIS; RETINITIS PIGMENTOSA; REVIEW; SHIGELLA FLEXNERI; TUBEROUS SCLEROSIS; ANIMAL; CELL CYCLE; METABOLISM; PHYSIOLOGY;

ANIMALS; CATALYSIS; CELL CYCLE; GTP PHOSPHOHYDROLASES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROLYSIS;

EID: 84969584491     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.22833     Document Type: Review

References (189)

1. Kamerlin, S. C.,;, Sharma, P. K.,;, Prasad, R. B.,;, Warshel, A., Q Rev Biophys 2013, 46, 1-132.
2. Lassila, J. K.,;, Zalatan, J. G.,;, Herschlag, D., Annu Rev Biochem 2011, 80, 669-702.
3. Westheimer, F. H., Science 1987, 235, 1173-1178.
4. Bourne, H. R.,;, Sanders, D. A.,;, McCormick, F., Nature 1991, 349, 117-127.
5. Feuerstein, J.,;, Goody, R. S.,;, Wittinghofer, A., J Biol Chem 1987, 262, 8455-8458.
6. John, J.,;, Rensland, H.,;, Schlichting, I.,;, Vetter, I.,;, Borasio, G. D.,;, Goody, R. S.,;, Wittinghofer, A., J Biol Chem 1993, 268, 923-929.
7. John, J.,;, Sohmen, R.,;, Feuerstein, J.,;, Linke, R.,;, Wittinghofer, A.,;, Goody, R. S., Biochemistry 1990, 29, 6058-6065.
8. Traut, T. W., Mol Cell Biochem 1994, 140, 1-22.
9. Ahmadian, M. R.,;, Stege, P.,;, Scheffzek, K.,;, Wittinghofer, A., Nat Struct Biol 1997, 4, 686-689.
10. Wittinghofer, A.,;, Vetter, I. R., Annu Rev Biochem 2011, 80, 943-971.
11. Barr, F.,;, Lambright, D. G., Curr Opin Cell Biol 2010, 22, 461-470.
12. DerMardirossian, C.,;, Bokoch, G. M., Trends Cell Biol 2005, 15, 356-363.
13. Bos, J. L.,;, Rehmann, H.,;, Wittinghofer, A., Cell 2007, 129, 865-877.
14. Carvalho, A. T.,;, Szeler, K.,;, Vavitsas, K.,;, Aqvist, J.,;, Kamerlin, S. C., Arch Biochem Biophys 2015, 582, 80-90.
15. Cherfils, J.,;, Zeghouf, M., Physiol Rev 2013, 93, 269-309.
16. Goody, R. S.,;, Rak, A.,;, Alexandrov, K., Cell Mol Life Sci 2005, 62, 1657-1670.
17. Jaffe, A. B.,;, Hall, A., Annu Rev Cell Dev Biol 2005, 21, 247-269.
18. Kotting, C.,;, Gerwert, K., Biol Chem 2015, 396, 131-144.
19. Ligeti, E.,;, Welti, S.,;, Scheffzek, K., Physiol Rev 2012, 92, 237-272.
20. Loirand, G.,;, Sauzeau, V.,;, Pacaud, P., Physiol Rev 2013, 93, 1659-1720.
21. Mizuno-Yamasaki, E.,;, Rivera-Molina, F.,;, Novick, P., Annu Rev Biochem 2012, 81, 637-659.
22. Vetter, I. R.,;, Wittinghofer, A., Science 2001, 294, 1299-1304.
23. Casey, P. J.,;, Solski, P. A.,;, Der, C. J.,;, Buss, J. E., Proc Natl Acad Sci USA 1989, 86, 8323-8327.
24. Farnsworth, C. C.,;, Kawata, M.,;, Yoshida, Y.,;, Takai, Y.,;, Gelb, M. H.,;, Glomset, J. A., Proc Natl Acad Sci USA 1991, 88, 6196-6200.
25. Hancock, J. F.,;, Magee, A. I.,;, Childs, J. E.,;, Marshall, C., J. Cell 1989, 57, 1167-1177.
26. Resh, M. D., Curr Biol 2013, 23, R431-R435.
27. Zhang, F. L.,;, Fu, H. W.,;, Casey, P. J.,;, Bishop, W. R., Biochemistry 1996, 35, 8166-8171.
28. Pfeffer, S. R., Biochem Soc Trans 2012, 40, 1373-1377.
29. Kahn, R. A.,;, Goddard, C.,;, Newkirk, M., J Biol Chem 1988, 263, 8282-8287.
30. Haun, R. S.,;, Tsai, S. C.,;, Adamik, R.,;, Moss, J.,;, Vaughan, M., J Biol Chem 1993, 268, 7064-7068.
31. Gillingham, A. K.,;, Munro, S., Annu Rev Cell Dev Biol 2007, 23, 579-611.
32. Lin, C. Y.,;, Huang, P. H.,;, Liao, W. L.,;, Cheng, H. J.,;, Huang, C. F.,;, Kuo, J. C.,;, Patton, W. A.,;, Massenburg, D.,;, Moss, J.,;, Lee, F. J., J Biol Chem 2000, 275, 37815-37823.
33. Lu, L.,;, Horstmann, H.,;, Ng, C.,;, Hong, W., J Cell Sci 2001, 114, 4543-4555.
34. Lin, C. Y.,;, Li, C. C.,;, Huang, P. H.,;, Lee, F. J., J Cell Sci 2002, 115, 4433-4445.
35. Wright, M. H.,;, Heal, W. P.,;, Mann, D. J.,;, Tate, E. W., J Chem Biol 2010, 3, 19-35.
36. Kapoor, S.,;, Fansa, E. K.,;, Mobitz, S.,;, Ismail, S. A.,;, Winter, R.,;, Wittinghofer, A.,;, Weise, K., Biophys J 2015, 109, 1619-1629.
37. Behnia, R.,;, Panic, B.,;, Whyte, J. R.,;, Munro, S., Nat Cell Biol 2004, 6, 405-413.
38. Setty, S. R.,;, Strochlic, T. I.,;, Tong, A. H.,;, Boone, C.,;, Burd, C. G., Nat Cell Biol 2004, 6, 414-419.
39. Hofmann, I.,;, Munro, S., J Cell Sci 2006, 119, 1494-1503.
40. Lee, M. C.,;, Orci, L.,;, Hamamoto, S.,;, Futai, E.,;, Ravazzola, M.,;, Schekman, R., Cell 2005, 122, 605-617.
41. Jin, H.,;, White, S. R.,;, Shida, T.,;, Schulz, S.,;, Aguiar, M.,;, Gygi, S. P.,;, Bazan, J. F.,;, Nachury, M. V., Cell 2010, 141, 1208-1219.
42. Milburn, M. V.,;, Tong, L.,;, deVos, A. M.,;, Brunger, A.,;, Yamaizumi, Z.,;, Nishimura, S.,;, Kim, S. H., Science 1990, 247, 939-945.
43. Pai, E. F.,;, Kabsch, W.,;, Krengel, U.,;, Holmes, K. C.,;, John, J.,;, Wittinghofer, A., Nature 1989, 341, 209-214.
44. Schlichting, I.,;, Almo, S. C.,;, Rapp, G.,;, Wilson, K.,;, Petratos, K.,;, Lentfer, A.,;, Wittinghofer, A.,;, Kabsch, W.,;, Pai, E. F.,;, Petsko, G. A., Nature 1990, 345, 309-315.
45. Eathiraj, S.,;, Pan, X.,;, Ritacco, C.,;, Lambright, D. G., Nature 2005, 436, 415-419.
46. Goldberg, J., Cell 1998, 95, 237-248.
47. Ihara, K.,;, Muraguchi, S.,;, Kato, M.,;, Shimizu, T.,;, Shirakawa, M.,;, Kuroda, S.,;, Kaibuchi, K.,;, Hakoshima, T., J Biol Chem 1998, 273, 9656-9666.
48. Merithew, E.,;, Hatherly, S.,;, Dumas, J. J.,;, Lawe, D. C.,;, Heller-Harrison, R.,;, Lambright, D. G., J Biol Chem 2001, 276, 13982-13988.
49. Stroupe, C.,;, Brunger, A. T., J Mol Biol 2000, 304, 585-598.
50. Pylayeva-Gupta, Y.,;, Grabocka, E.,;, Bar-Sagi, D., Nat Rev Cancer 2011, 11, 761-774.
51. Seeburg, P. H.,;, Colby, W. W.,;, Capon, D. J.,;, Goeddel, D. V.,;, Levinson, A. D., Nature 1984, 312, 71-75.
52. Franken, S. M.,;, Scheidig, A. J.,;, Krengel, U.,;, Rensland, H.,;, Lautwein, A.,;, Geyer, M.,;, Scheffzek, K.,;, Goody, R. S.,;, Kalbitzer, H. R.,;, Pai, E. F,. Biochemistry 1993, 32, 8411-8420.
53. Ahmadian, M. R.,;, Zor, T.,;, Vogt, D.,;, Kabsch, W.,;, Selinger, Z.,;, Wittinghofer, A.,;, Scheffzek, K., Proc Natl Acad Sci USA 1999, 96, 7065-7070.
54. Li, L., Crit Rev Oral Biol Med 2003, 14, 100-114.
55. Bigay, J.,;, Deterre, P.,;, Pfister, C.,;, Chabre, M., EMBO J 1987, 6, 2907-2913.
56. Gremer, L.,;, Gilsbach, B.,;, Ahmadian, M. R.,;, Wittinghofer, A., Biol Chem 2008, 389, 1163-1171.
57. Coleman, D. E.,;, Berghuis, A. M.,;, Lee, E.,;, Linder, M. E.,;, Gilman, A. G.,;, Sprang, S. R., Science 1994, 265, 1405-1412.
58. Sondek, J.,;, Lambright, D. G.,;, Noel, J. P.,;, Hamm, H. E.,;, Sigler, P. B., Nature 1994, 372, 276-279.
59. Dong, N.,;, Zhu, Y.,;, Lu, Q.,;, Hu, L.,;, Zheng, Y.,;, Shao, F., Cell 2012, 150, 1029-1041.
60. Gavriljuk, K.,;, Gazdag, E. M.,;, Itzen, A.,;, Kotting, C.,;, Goody, R. S.,;, Gerwert, K., Proc Natl Acad Sci USA 2012, 109, 21348-21353.
61. Mishra, A. K.,;, Lambright, D. G., Methods Mol Biol 2015, 1298, 47-60.
62. Pan, X.,;, Eathiraj, S.,;, Munson, M.,;, Lambright, D. G., Nature 2006, 442, 303-306.
63. Rittinger, K.,;, Walker, P. A.,;, Eccleston, J. F.,;, Smerdon, S. J.,;, Gamblin, S., J. Nature 1997, 389, 758-762.
64. Scheffzek, K.,;, Ahmadian, M. R.,;, Kabsch, W.,;, Wiesmuller, L.,;, Lautwein, A.,;, Schmitz, F.,;, Wittinghofer, A., Science 1997, 277, 333-338.
65. Veltel, S.,;, Gasper, R.,;, Eisenacher, E.,;, Wittinghofer, A., Nat Struct Mol Biol 2008, 15, 373-380.
66. Yu, Q.,;, Hu, L.,;, Yao, Q.,;, Zhu, Y.,;, Dong, N.,;, Wang, D. C.,;, Shao, F., Cell Res 2013, 23, 775-787.
67. Issartel, J. P.,;, Dupuis, A.,;, Lunardi, J.,;, Vignais, P. V., Biochemistry 1991, 30, 4726-4733.
68. Carlier, M. F.,;, Didry, D.,;, Simon, C.,;, Pantaloni, D., Biochemistry 1989, 28, 1783-1791.
69. Graham, D. L.,;, Lowe, P. N.,;, Grime, G. W.,;, Marsh, M.,;, Rittinger, K.,;, Smerdon, S. J.,;, Gamblin, S. J.,;, Eccleston, J. F., Chem Biol 2002, 9, 375-381.
70. Grigorenko, B. L.,;, Nemukhin, A. V.,;, Cachau, R. E.,;, Topol, I. A.,;, Burt, S. K., J Mol Model 2005, 11, 503-508.
71. Howlett, A. C.,;, Sternweis, P. C.,;, Macik, B. A.,;, Van Arsdale, P. M.,;, Gilman, A. G., J Biol Chem 1979, 254, 2287-2295.
72. Mittal, R.,;, Ahmadian, M. R.,;, Goody, R. S.,;, Wittinghofer, A., Science 1996, 273, 115-117.
73. Hoffman, G. R.,;, Nassar, N.,;, Oswald, R. E.,;, Cerione, R. A., J Biol Chem 1998, 273, 4392-4399.
74. Diaz, J. F.,;, Sillen, A.,;, Engelborghs, Y., J Biol Chem 1997, 272, 23138-23143.
75. Zhu, G.,;, Liu, J.,;, Terzyan, S.,;, Zhai, P.,;, Li, G.,;, Zhang, X. C., J Biol Chem 2003, 278, 2452-2460.
76. Rudack, T.,;, Jenrich, S.,;, Brucker, S.,;, Vetter, I. R.,;, Gerwert, K.,;, Kotting, C., J Biol Chem 2015, 290, 24079-24090.
77. Khrenova, M. G.,;, Grigorenko, B. L.,;, Kolomeisky, A. B.,;, Nemukhin, A. V., J Phys Chem B 2015, 119, 12838-12845.
78. Allin, C.,;, Ahmadian, M. R.,;, Wittinghofer, A.,;, Gerwert, K., Proc Natl Acad Sci USA 2001, 98, 7754-7759.
79. Du, X.,;, Frei, H.,;, Kim, S. H., J Biol Chem 2000, 275, 8492-8500.
80. Wittinghofer, A., Trends Biochem Sci 2006, 31, 20-23.
81. Frech, M.,;, Darden, T. A.,;, Pedersen, L. G.,;, Foley, C. K.,;, Charifson, P. S.,;, Anderson, M. W.,;, Wittinghofer, A., Biochemistry 1994, 33, 3237-3244.
82. Aqvist, J.,;, Kolmodin, K.,;, Florian, J.,;, Warshel, A., Chem Biol 1999, 6, R71-R80.
83. Prasad, B.,;, Plotnikov, R.,;, Lameira, N. V.,;, Warshel, J. A.,; Proc Natl Acad Sci USA 2013, 110, 20509-20514.
84. Klahn, M.,;, Rosta, E.,;, Warshel, A., J Am Chem Soc 2006, 128, 15310-15323.
85. Langen, R.,;, Schweins, T.,;, Warshel, A., Biochemistry 1992, 31, 8691-8696.
86. Schweins, T.,;, Geyer, M.,;, Scheffzek, K.,;, Warshel, A.,;, Kalbitzer, H. R.,;, Wittinghofer, A., Nat Struct Biol 1995, 2, 36-44.
87. Grigorenko, B. L.,;, Nemukhin, A. V.,;, Shadrina, M. S.,;, Topol, I. A.,;, Burt, S. K., Proteins 2007, 66, 456-466.
88. Rudack, T.,;, Xia, F.,;, Schlitter, J.,;, Kotting, C.,;, Gerwert, K., Proc Natl Acad Sci USA 2012, 109, 15295-15300.
89. Spoerner, M.,;, Nuehs, A.,;, Ganser, P.,;, Herrmann, C.,;, Wittinghofer, A.,;, Kalbitzer, H. R., Biochemistry 2005, 44, 2225-2236.
90. Knihtila, R.,;, Holzapfel, G.,;, Weiss, K.,;, Meilleur, F.,;, Mattos, C., J Biol Chem 2015, 290, 31025-31036.
91. Muller, M. P.,;, Peters, H.,;, Blumer, J.,;, Blankenfeldt, W.,;, Goody, R. S.,;, Itzen, A., Science 2010, 329, 946-949.
92. Buhrman, G.,;, Holzapfel, G.,;, Fetics, S.,;, Mattos, C., Proc Natl Acad Sci USA 2010, 107, 4931-4936.
93. Holzapfel, G.,;, Buhrman, G.,;, Mattos, C., Biochemistry 2012, 51, 6114-6126.
94. Kotting, C.,;, Gerwert, K., FEBS Lett 2013, 587, 2025-2027.
95. Kotting, C.,;, Blessenohl, M.,;, Suveyzdis, Y.,;, Goody, R. S.,;, Wittinghofer, A.,;, Gerwert, K., Proc Natl Acad Sci USA 2006, 103, 13911-13916.
96. Xia, F.,;, Rudack, T.,;, Cui, Q.,;, Kotting, C.,;, Gerwert, K., J Am Chem Soc 2012, 134, 20041-20044.
97. Chakrabarti, P. P.,;, Daumke, O.,;, Suveyzdis, Y.,;, Kotting, C.,;, Gerwert, K.,;, Wittinghofer, A., J Mol Biol 2007, 367, 983-995.
98. Brucker, S.,;, Gerwert, K.,;, Kotting, C., J Mol Biol 2010, 401, 1-6.
99. Goldberg, J., Cell 1999, 96, 893-902.
100. Rittinger, K.,;, Taylor, W. R.,;, Smerdon, S. J.,;, Gamblin, S., J. Nature 1998, 392, 448-449.
101. Rittinger, K.,;, Walker, P. A.,;, Eccleston, J. F.,;, Nurmahomed, K.,;, Owen, D.,;, Laue, E.,;, Gamblin, S. J.,;, Smerdon, S., J. Nature 1997, 388, 693-697.
102. Nassar, N.,;, Hoffman, G. R.,;, Manor, D.,;, Clardy, J. C.,;, Cerione, R. A., Nat Struct Biol 1998, 5, 1047-1052.
103. Ismail, S. A.,;, Vetter, I. R.,;, Sot, B.,;, Wittinghofer, A., Cell 2010, 141, 812-821.
104. Seewald, M. J.,;, Korner, C.,;, Wittinghofer, A.,;, Vetter, I. R., Nature 2002, 415, 662-666.
105. Slep, K. C.,;, Kercher, M. A.,;, He, W.,;, Cowan, C. W.,;, Wensel, T. G.,;, Sigler, P. B., Nature 2001, 409, 1071-1077.
106. Tesmer, J. J.,;, Berman, D. M.,;, Gilman, A. G.,;, Sprang, S. R., Cell 1997, 89, 251-261.
107. Haberland, J.,;, Gerke, V., Biochem J 1999, 343(Part 3), 653-662.
108. Hillig, R. C.,;, Renault, L.,;, Vetter, I. R.,;, Drell, T.,;, Wittinghofer, A.,;, Becker, J., Mol Cell 1999, 3, 781-791.
109. Brinkmann, T.,;, Daumke, O.,;, Herbrand, U.,;, Kuhlmann, D.,;, Stege, P.,;, Ahmadian, M. R.,;, Wittinghofer, A., J Biol Chem 2002, 277, 12525-12531.
110. Daumke, O.,;, Weyand, M.,;, Chakrabarti, P. P.,;, Vetter, I. R.,;, Wittinghofer, A., Nature 2004, 429, 197-201.
111. Scrima, A.,;, Thomas, C.,;, Deaconescu, D.,;, Wittinghofer, A., EMBO J 2008, 27, 1145-1153.
112. Chakrabarti, P. P.,;, Suveyzdis, Y.,;, Wittinghofer, A.,;, Gerwert, K., J Biol Chem 2004, 279, 46226-46233.
113. Aqvist, J.,;, Kamerlin, S. C., Biochemistry 2015, 54, 546-556.
114. Bi, X.,;, Corpina, R. A.,;, Goldberg, J., Nature 2002, 419, 271-277.
115. Mishra, R.,;, Gara, S. K.,;, Mishra, S.,;, Prakash, B., Proteins 2005, 59, 332-338.
116. Rafay, A.,;, Majumdar, S.,;, Prakash, B., FEBS Open Bio 2012, 2, 173-177.
117. Scrima, A.,;, Wittinghofer, A., EMBO J 2006, 25, 2940-2951.
118. Anand, B.,;, Majumdar, S.,;, Prakash, B., Biochemistry 2013, 52, 1122-1130.
119. Pereira-Leal, J. B.,;, Seabra, M. C., J Mol Biol 2000, 301, 1077-1087.
120. Pereira-Leal, J. B.,;, Seabra, M. C., J Mol Biol 2001, 313, 889-901.
121. Brighouse, A.,;, Dacks, J. B.,;, Field, M. C., Cell Mol Life Sci 2010, 67, 3449-3465.
122. Elias, M.,;, Brighouse, A.,;, Gabernet-Castello, C.,;, Field, M. C.,;, Dacks, J. B., J Cell Sci 2012, 125, 2500-2508.
123. Gabernet-Castello, C.,;, O'Reilly, A. J.,;, Dacks, J. B.,;, Field, M. C., Mol Biol Cell 2013, 24, 1574-1583.
124. Albert, S.,;, Will, E.,;, Gallwitz, D., EMBO J 1999, 18, 5216-5225.
125. Du, L. L.,;, Collins, R. N.,;, Novick, P. J., J Biol Chem 1998, 273, 3253-3256.
126. Du, L. L.,;, Novick, P., Mol Biol Cell 2001, 12, 1215-1226.
127. Strom, M.,;, Vollmer, P.,;, Tan, T. J.,;, Gallwitz, D., Nature 1993, 361, 736-739.
128. Rak, A.,;, Fedorov, R.,;, Alexandrov, K.,;, Albert, S.,;, Goody, R. S.,;, Gallwitz, D.,;, Scheidig, A., J. EMBO J 2000, 19, 5105-5113.
129. Nottingham, R. M.,;, Ganley, I. G.,;, Barr, F. A.,;, Lambright, D. G.,;, Pfeffer, S. R., J Biol Chem 2011, 286, 33213-33222.
130. Ingmundson, A.,;, Delprato, A.,;, Lambright, D. G.,;, Roy, C. R., Nature 2007, 450, 365-369.
131. Mishra, A. K.,;, Del Campo, C. M.,;, Collins, R. E.,;, Roy, C. R.,;, Lambright, D. G., J Biol Chem 2013, 288, 24000-24011.
132. Muller, M. P.,;, Shkumatov, A. V.,;, Oesterlin, L. K.,;, Schoebel, S.,;, Goody, P. R.,;, Goody, R. S.,;, Itzen, A., J Biol Chem 2012, 287, 35036-35046.
133. Gazdag, E. M.,;, Streller, A.,;, Haneburger, I.,;, Hilbi, H.,;, Vetter, I. R.,;, Goody, R. S.,;, Itzen, A., EMBO Rep 2013, 14, 199-205.
134. Canagarajah, B.,;, Leskow, F. C.,;, Ho, J. Y.,;, Mischak, H.,;, Saidi, L. F.,;, Kazanietz, M. G.,;, Hurley, J. H., Cell 2004, 119, 407-418.
135. Moskwa, P.,;, Paclet, M. H.,;, Dagher, M. C.,;, Ligeti, E., J Biol Chem 2005, 280, 6716-6720.
136. Sirokmany, G.,;, Szidonya, L.,;, Kaldi, K.,;, Gaborik, Z.,;, Ligeti, E.,;, Geiszt, M., J Biol Chem 2006, 281, 6096-6105.
137. Bustos, R. I.,;, Forget, M. A.,;, Settleman, J. E.,;, Hansen, S. H., Curr Biol 2008, 18, 1606-1611.
138. Yamada, T.,;, Sakisaka, T.,;, Hisata, S.,;, Baba, T.,;, Takai, Y., J Biol Chem 2005, 280, 33026-33034.
139. Kam, J. L.,;, Miura, K.,;, Jackson, T. R.,;, Gruschus, J.,;, Roller, P.,;, Stauffer, S.,;, Clark, J.,;, Aneja, R.,;, Randazzo, P. A., J Biol Chem 2000, 275, 9653-9663.
140. Luo, R.,;, Miller Jenkins, L. M.,;, Randazzo, P. A.,;, Gruschus, J., Cell Signal 2008, 20, 1968-1977.
141. Jian, X.,;, Tang, W. K.,;, Zhai, P.,;, Roy, N. S.,;, Luo, R.,;, Gruschus, J. M.,;, Yohe, M. E.,;, Chen, P. W.,;, Li, Y.,;, Byrd, R. A.,;, Xia, D.,;, Randazzo, P. A., Structure 2015, 23, 1977-1988.
142. Bigay, J.,;, Gounon, P.,;, Robineau, S.,;, Antonny, B., Nature 2003, 426, 563-566.
143. Bigay, J.,;, Casella, J. F.,;, Drin, G.,;, Mesmin, B.,;, Antonny, B., EMBO J 2005, 24, 2244-2253.
144. Rivera-Molina, F. E.,;, Novick, P., J. Proc Natl Acad Sci USA 2009, 106, 14408-14413.
145. Miinea, C. P.,;, Sano, H.,;, Kane, S.,;, Sano, E.,;, Fukuda, M.,;, Peranen, J.,;, Lane, W. S.,;, Lienhard, G. E., Biochem J 2005, 391, 87-93.
146. Kane, S.,;, Sano, H.,;, Liu, S. C.,;, Asara, J. M.,;, Lane, W. S.,;, Garner, C. C.,;, Lienhard, G. E. J., Biol Chem 2002, 277, 22115-22118.
147. Sano, H.,;, Eguez, L.,;, Teruel, M. N.,;, Fukuda, M.,;, Chuang, T. D.,;, Chavez, J. A.,;, Lienhard, G. E.,;, McGraw, T. E., Cell Metab 2007, 5, 293-303.
148. Machner, M. P.,;, Isberg, R. R., Dev Cell 2006, 11, 47-56.
149. Murata, T.,;, Delprato, A.,;, Ingmundson, A.,;, Toomre, D. K.,;, Lambright, D. G.,;, Roy, C. R., Nat Cell Biol 2006, 8, 971-977.
150. Brombacher, E.,;, Urwyler, S.,;, Ragaz, C.,;, Weber, S. S.,;, Kami, K.,;, Overduin, M.,;, Hilbi, H., J Biol Chem 2009, 284, 4846-4856.
151. Schoebel, S.,;, Oesterlin, L. K.,;, Blankenfeldt, W.,;, Goody, R. S.,;, Itzen, A., Mol Cell 2009, 36, 1060-1072.
152. Suh, H. Y.,;, Lee, D. W.,;, Lee, K. H.,;, Ku, B.,;, Choi, S. J.,;, Woo, J. S.,;, Kim, Y. G.,;, Oh, B. H., EMBO J 2010, 29, 496-504.
153. Zhu, Y.,;, Hu, L.,;, Zhou, Y.,;, Yao, Q.,;, Liu, L.,;, Shao, F., Proc Natl Acad Sci USA 2010, 107, 4699-4704.
154. Tan, Y.,;, Luo, Z. Q., Nature 2011, 475, 506-509.
155. Cheng, W.,;, Yin, K.,;, Lu, D.,;, Li, B.,;, Zhu, D.,;, Chen, Y.,;, Zhang, H.,;, Xu, S.,;, Chai, J.,;, Gu, L., PLoS Pathog 2012, 8, e1002528.
156. Schoebel, S.,;, Cichy, A. L.,;, Goody, R. S.,;, Itzen, A., Proc Natl Acad Sci USA 2011, 108, 17945-17950.
157. Neunuebel, M. R.,;, Mohammadi, S.,;, Jarnik, M.,;, Machner, M. P., J Bacteriol 2012, 194, 1389-1400.
158. Hutagalung, A. H.,;, Novick, P., J. Physiol Rev 2011, 91, 119-149.
159. Lu, S.,;, Jang, H.,;, Muratcioglu, S.,;, Gursoy, A.,;, Keskin, O.,;, Nussinov, R.,;, Zhang, J., Chem Rev 2016, Jan 27. [Epub ahead of print].
160. Maertens, O.,;, Cichowski, K., Adv Biol Regul 2014, 55, 1-14.
161. Stenmark, H., Nat Rev Mol Cell Biol 2009, 10, 513-525.
162. Cichowski, K.,;, Jacks, T., Cell 2001, 104, 593-604.
163. Manning, B. D.,;, Cantley, L. C., Trends Biochem Sci 2003, 28, 573-576.
164. Dibble, C. C.,;, Elis, W.,;, Menon, S.,;, Qin, W.,;, Klekota, J.,;, Asara, J. M.,;, Finan, P. M.,;, Kwiatkowski, D. J.,;, Murphy, L. O.,;, Manning, B. D., Mol Cell 2012, 47, 535-546.
165. Evans, R. J.,;, Schwarz, N.,;, Nagel-Wolfrum, K.,;, Wolfrum, U.,;, Hardcastle, A. J.,;, Cheetham, M. E., Hum Mol Genet 2010, 19, 1358-1367.
166. Schwarz, N.,;, Hardcastle, A. J.,;, Cheetham, M. E., Vis Res 2012, 75, 2-4.
167. Corbett, M. A.,;, Bahlo, M.,;, Jolly, L.,;, Afawi, Z.,;, Gardner, A. E.,;, Oliver, K. L.,;, Tan, S.,;, Coffey, A.,;, Mulley, J. C.,;, Dibbens, L. M.,;, Simri, W.,;, Shalata, A.,;, Kivity, S.,;, Jackson, G. D.,;, Berkovic, S. F.,;, Gecz, J., Am J Hum Genet 2010, 87, 371-375.
168. Falace, A.,;, Filipello, F.,;, La Padula, V.,;, Vanni, N.,;, Madia, F.,;, De Pietri Tonelli, D.,;, de Falco, F. A.,;, Striano, P.,;, Dagna Bricarelli, F.,;, Minetti, C.,;, Benfenati, F.,;, Fassio, A.,;, Zara, F., Am J Hum Genet 2010, 87, 365-370.
169. Azaiez, H.,;, Booth, K. T.,;, Bu, F.,;, Huygen, P.,;, Shibata, S. B.,;, Shearer, A. E.,;, Kolbe, D.,;, Meyer, N.,;, Black-Ziegelbein, E. A.,;, Smith, R., J. Hum Mutat 2014, 35, 819-823.
170. Rehman, A. U.,;, Santos-Cortez, R. L.,;, Morell, R. J.,;, Drummond, M. C.,;, Ito, T.,;, Lee, K.,;, Khan, A. A.,;, Basra, M. A.,;, Wasif, N.,;, Ayub, M.,;, Ali, R. A.,;, Raza, S. I.,;, University of Washington Center for Mendelian, G.,;, Nickerson, D. A.,;, Shendure, J.,;, Bamshad, M.,;, Riazuddin, S.,;, Billington, N.,;, Khan, S. N.,;, Friedman, P. L.,;, Griffith, A. J.,;, Ahmad, W.,;, Riazuddin, S.,;, Leal, S. M.,;, Friedman, T. B., Am J Hum Genet 2014, 94, 144-152.
171. Zhang, L.,;, Hu, L.,;, Chai, Y.,;, Pang, X.,;, Yang, T.,;, Wu, H., Hum Mutat 2014, 35, 814-818.
172. Falace, A.,;, Buhler, E.,;, Fadda, M.,;, Watrin, F.,;, Lippiello, P.,;, Pallesi-Pocachard, E.,;, Baldelli, P.,;, Benfenati, F.,;, Zara, F.,;, Represa, A.,;, Fassio, A.,;, Cardoso, C., Proc Natl Acad Sci USA 2014, 111, 2337-2342.
173. Fukui, K.,;, Sasaki, T.,;, Imazumi, K.,;, Matsuura, Y.,;, Nakanishi, H.,;, Takai, Y., J Biol Chem 1997, 272, 4655-4658.
174. Nagano, F.,;, Sasaki, T.,;, Fukui, K.,;, Asakura, T.,;, Imazumi, K.,;, Takai, Y., J Biol Chem 1998, 273, 24781-24785.
175. Aligianis, I. A.,;, Johnson, C. A.,;, Gissen, P.,;, Chen, D.,;, Hampshire, D.,;, Hoffmann, K.,;, Maina, E. N.,;, Morgan, N. V.,;, Tee, L.,;, Morton, J.,;, Ainsworth, J. R.,;, Horn, D.,;, Rosser, E.,;, Cole, T. R.,;, Stolte-Dijkstra, I.,;, Fieggen, K.,;, Clayton-Smith, J.,;, Megarbane, A.,;, Shield, J. P.,;, Newbury-Ecob, R.,;, Dobyns, W. B.,;, Graham, J. M.,;;, Kjaer, K. W.,;, Warburg, M.,;, Bond, J.,;, Trembath, R. C.,;, Harris, L. W.,;, Takai, Y.,;, Mundlos, S.,;, Tannahill, D.,;, Woods, C. G.,;, Maher, E. R., Nat Genet 2005, 37, 221-223.
176. Aligianis, I. A.,;, Morgan, N. V.,;, Mione, M.,;, Johnson, C. A.,;, Rosser, E.,;, Hennekam, R. C.,;, Adams, G.,;, Trembath, R. C.,;, Pilz, D. T.,;, Stoodley, N.,;, Moore, A. T.,;, Wilson, S.,;, Maher, E. R., Am J Hum Genet 2006, 78, 702-707.
177. Fu, Y.,;, Galan, J. E., Nature 1999, 401, 293-297.
178. Hardt, W. D.,;, Chen, L. M.,;, Schuebel, K. E.,;, Bustelo, X. R.,;, Galan, J. E., Cell 1998, 93, 815-826.
179. Stebbins, C. E.,;, Galan, J. E., Mol Cell 2000, 6, 1449-1460.
180. Evdokimov, A. G.,;, Tropea, J. E.,;, Routzahn, K. M.,;, Waugh, D. S., Protein Sci 2002, 11, 401-408.
181. Wurtele, M.,;, Wolf, E.,;, Pederson, K. J.,;, Buchwald, G.,;, Ahmadian, M. R.,;, Barbieri, J. T.,;, Wittinghofer, A., Nat Struct Biol 2001, 8, 23-26.
182. Dey, S.,;, Datta, S., FEBS J 2014, 281, 1267-1280.
183. Litvak, Y.,;, Selinger, Z., J Bacteriol 2007, 189, 2558-2560.
184. Peyroche, A.,;, Antonny, B.,;, Robineau, S.,;, Acker, J.,;, Cherfils, J.,;, Jackson, C. L., Mol Cell 1999, 3, 275-285.
185. Zeghouf, M.,;, Guibert, B.,;, Zeeh, J. C.,;, Cherfils, J., Biochem Soc Trans 2005, 33, 1265-1268.
186. Hafner, M.,;, Schmitz, A.,;, Grune, I.,;, Srivatsan, S. G.,;, Paul, B.,;, Kolanus, W.,;, Quast, T.,;, Kremmer, E.,;, Bauer, I.,;, Famulok, M., Nature 2006, 444, 941-944.
187. Reardon, S., Nature 2015, 527, 146-147.
188. Platt, R. J.,;, Chen, S.,;, Zhou, Y.,;, Yim, M. J.,;, Swiech, L.,;, Kempton, H. R.,;, Dahlman, J. E.,;, Parnas, O.,;, Eisenhaure, T. M.,;, Jovanovic, M.,;, Graham, D. B.,;, Jhunjhunwala, S.,;, Heidenreich, M.,;, Xavier, R. J.,;, Langer, R.,;, Anderson, D. G.,;, Hacohen, N.,;, Regev, A.,;, Feng, G.,;, Sharp, P. A.,;, Zhang, F., Cell 2014, 159, 440-455.
189. Heller, H.,;, Schaefer, M.,;, Schulten, K., J Phys Chem 1993, 97, 8343-8360.