Conserved charged residues in the leucine-rich repeat domain of the Ran GTPase activating protein are required for Ran binding and GTPase activation

Biochemical Journal

Volumn 343, Issue 3, 1999, Pages 653-662

  Haberland, Jörg ^a   Gerke, Volker ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Arginine finger; Nucleocytoplasmic transport; Protein protein interaction; Small G proteins

Indexed keywords

GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; LEUCINE; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CONSERVED SEQUENCE; GTPASE-ACTIVATING PROTEINS; HUMANS; LEUCINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RECOMBINANT PROTEINS; REPETITIVE SEQUENCES, AMINO ACID; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA;

EID: 0033229912     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3430653     Document Type: Article

References (35)

1. Dingwall, C., Kandels Lewis, S. and Seraphin, B. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 7525-7529
2. Hartmann, E. and Görlich, D. (1995) Trends Cell Biol. 5, 192-193
3. Görlich, D., Dabrowski, M., Bischoff, F. R., Kutay, U., Bork, P., Hartmann, E., Prehn, S. and Izaurralde, E. (1997) J. Cell Biol. 138, 65-80
4. Mattaj, I. W. and Englmeier, L. (1998) Annu. Rev. Biochem. 67, 265-306
5. Pemberton, L. F., Blobel, G. and Rosenblum, J. S. (1998) Curr. Opin. Cell Biol. 10, 392-399
6. Görlich, D. (1998) EMBO J. 17, 2721-2727
7. Melchior, F. and Gerace, L. (1998) Trends Cell Biol. 8, 175-179
8. Dahlberg, J. E. and Lund, E. (1998) Curr. Opin. Cell Biol. 10, 400-408
9. Moore, M. S. (1998) J. Biol. Chem. 273, 22857-22860
10. Saar, S. (1996) Trends Cell Biol. 6, 81-85
11. Melchior, F., Weber, K. and Gerke, V. (1993) Mol. Biol. Cell 4, 569-581
12. Becker, J., Melchior, F., Gerke, V., Bischoff, F. R., Ponstingl, H. and Wittinghofer, A. (1995) J. Biol. Chem. 270, 11860-11865
13. Traglia, H. M., Atkinson, N. S. and Hopper, A. K. (1989) Mol. Cell Biol. 9, 2989-2999
14. DeGregori, J., Russ, A., von Melchner, H., Rayburn, H., Priyaranjan, P., Jenkins, N. A., Copeland, N. G. and Ruley, H. E. (1994) Genes Dev. 8, 265-276
15. Bischoff, F. R., Krebber, H., Kempf, T., Hermes, I. and Ponstingl, H. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 1749-1753
16. Mahajan, R., Delphin, C., Guan, T., Gerace, L. and Melchior, F. (1997) Cell 88, 97-107
17. Matunis, M. J., Coutavas, E. and Blobel, G. (1996) J. Cell Biol. 135, 1457-1470
18. Scheffzek, K., Ahmadian, M. R., Kabsch, W., Wiesmüller, L., Lautwein, A., Schmitz, F. and Wittinghofer, A. (1997) Science 277, 333-338
19. Rittinger, K., Walker, P. A., Eccleston, J. F., Nurmahomed, K., Owen, D., Laue, E., Gamblin, S. J. and Smerdon, S. J. (1997) Nature 388, 693-697
20. Kobe, B. and Deisenhofer, J. (1993) Nature 366, 751-756
21. Haberland, J. and Gerke, V. (1995) FEBS Lett. 357, 173-177
22. Haberland, J., Becker, J. and Gerke, V. (1997) J. Biol. Chem. 272, 24717-24726
23. Lämmli, U. K. (1970) Nature 227, 680-685
24. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
25. Price, S. R., Evans, P. R. and Nagai, K. (1998) Nature 394, 645-650
26. Kobe, B. and Deisenhofer, J. (1995) Nature 374, 183-186
27. Ahmadian, M. R., Hoffmann, U., Goody, R. S. and Wittinghofer, A. (1997) Biochemistry 36, 4535-4541
28. Graham, D. L., Eccleston, J. F. and Lowe, P. N. (1999) Biochemistry 38, 985-991
29. Bischoff, F. R., Klebe, C., Kretschmer, J., Wittinghofer, A. and Ponstingl, H. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 2587-2591
30. Floer, M. and Blobel, G. (1996) J. Biol. Chem. 271, 5313-5316
31. Vetter, I. R., Nowak, C., Nishimoto, T., Kuhlmann, J. and Wittinghofer, A. (1998) Nature 398, 39-46
32. Scheffzek, K., Klebe, C., Fritz-Wolf, K., Kabsch, W. and Wittinghofer, A. (1995) Nature 374, 378-381
33. Scheffzek, K., Ahmadian, M. R. and Wittinghofer, A. (1998) Trends Biochem. Sci. 23, 257-262
34. Goldberg, J. (1999) Cell 96, 893-902
35. Roth, M. G. (1999) Cell 97, 149-152