Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue

Journal of Biological Chemistry

Volumn 273, Issue 16, 1998, Pages 9656-9666

  Ihara, Kentaro ^a   Muraguchi, Sachiko ^a   Kato, Masato ^a   Shimizu, Toshiyuki ^a   Shirakawa, Masahiro ^a   Kuroda, Shinya ^a,b   Kaibuchi, Kozo ^a   Hakoshima, Toshio ^a  

^a NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATASE;

AMINO ACID SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; GENE INSERTION; GENE SWITCHING; HYDROGEN BOND; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BINDING SITES; CLONING, MOLECULAR; COMPUTER SIMULATION; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; RHOA GTP-BINDING PROTEIN; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 0032540249     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.16.9656     Document Type: Article

References (71)

1. Yamamoto, K., Kondo, J., Hishida, T., Teranishi, Y., and Takai, Y. (1988) J. Biol. Chem. 263, 9926-9932
2. Morii, N., Sekine, A., Ohashi, Y., Nakao, K., Imura, H., Fujiwara, M., and Narumiya, S. (1988) J. Biol. Chem. 263, 12420-12426
3. Madaule, P., and Axel, R. (1985) Cell 41, 31-40
4. Simon, M. (1996) Trends Biochem. Sci. 21, 178-181
5. Machesky, L. M., and Hall, A. (1996) Trends Cell Biol. 6, 304-310
6. Narumiya, S. (1996) J. Biochem. 120, 215-228
7. Takai, Y., Sasaki, T., Tanaka, K., and Nakanishi, H. (1995) Trends. Biochem. Sci. 20, 227-231
8. Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okada, K., Iwamatsu, A., and Kaibuchi, K. (1996) Science 273, 245-248
9. Matsui, T., Amano, M., Yamamoto, T., Chihara, K., Fukuta, Y., Nakafuku, M., Ito, M., Nakano, T., Okawa, K., Iwamatsu, A., and Kaibuchi, K. (1996) EMBO J. 15, 2208-2216
10. Amano, M., Ito, M., Kimura, K., Fukata, Y., Chihara, K., Nakano, T., Matsuura, Y., and Kaibuchi, K. (1996) J. Biol. Chem. 271, 20246-20249
11. Amano, M., Chihara, K., Kimura, K., Fukata, Y., Nakamura, N., Matsuura, Y., and Kaibuchi, K. (1997) Science 275, 1308-1311
12. Tan, J. L., Ravid, S., and Spudich, J. A. (1992) Annu. Rev. Biochem. 61, 721-759
13. Leung, T., Chen, X. Q., Manser, E., and Lim, L. (1996) Mol. Cell. Biol. 16, 5313-5327
14. Ishizaki, T., Maekawa, M., Fujisawa, K., Okawa, K., Iwamatsu, A., Fujita, A., Watanabe, N., Saito, Y., Kakizuka, A., Morii, N., and Narumiya, S. (1996) EMBO J. 15, 1885-1893
15. Amano, M., Mukai, H., Ono, Y., Chihara, K., Matsui, T., Hamajima, Y., Okawa, K., Iwamatsu, A., and Kaibuchi, K. (1996) Science 271, 648-650
16. Watanabe, G., Saito, Y., Madaule, P., Ishizaki, T., Fujisawa, K., Morii, N., Mukai, H., Ono, Y., Kakizuka, A., and Narumiya, S. (1996) Science 271, 645-648
17. Reid, T., Furuyashiki, T., Ishizaki, T., Watanabe, G., Watanabe, N., Fujisawa, K., Morii, N., Madaule, P., and Narumiya, S. (1996) J. Biol. Chem. 271, 13556-13560
18. Madaule, P., Furuyashiki, T., Reid, T., Ishizaki, T., Watanabe, G., Morii, N., and Narumiya, S. (1995) FEBS Lett. 377, 243-248
19. Ren, X.-D., Bokoch, G. M., Traynor-Kaplan, A., Jenkins, G. H., Anderson, R. A., and Schwartz, M. A. (1996) Mol. Biol. Cell 7, 435-442
20. Watanabe, N., Madaule, P., Reid, T., Ishizaki, T., Watanabe, G., Kakizuka, A., Saito, Y., Nakao, K., Jockusch, B. M., and Narumiya, S. (1997) EMBO J. 16, 3044-3056
21. Fujisawa, K., Fujita, A., Ishizaki, T., Saito, Y., and Narumiya, S. (1996) J. Biol. Chem. 271, 23022-23028
22. Manser, E., Leung, T., Salihuddin, H., Tan, L., and Lim, L. (1993) Nature 363, 364-367
23. Manser, E., Leung, T., Salihuddin, H., Zhao, Z. S., and Lim, L. (1994) Nature 367, 40-46
24. Fabian, J. R., Vojtek, A. B., Cooper, J. A., and Morrison, D. K. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 5982-5986
25. Aktories, K. (1997) Trends Microbiol. 5, 282-287
26. Navara, J. (1994) Acta Crystallogr. Sec. A 50, 157-163
27. Brunger, A. T., Kuriyan, J., and Karplus, M., (1990) Acta Crystallogr. Sec. A 46, 585-593
28. Cowtan, K., and Main, P. (1996) Acta Crystallogr. Sec. D 52, 43-48
29. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. Sec. A 47, 110-119
30. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
31. Milburn, M. V., Tong, L., de Vos, A. M., Brunger, A., Yamaizumi, Z., Nishimura, S., and Kim, S. H. (1990) Science 247, 939-945
32. Pai, E. F., Krengel, U., Petsko, G. A., Goody, R. S., Kabsch, W., and Wittinghofer, A. (1990) EMBO J. 9, 2351-2359
33. Amor, J. C., Harrison, D. H., Kahn, R. A., and Ringe, D. (1994) Nature 372, 704-708
34. Scheffzek, K., Klebe, C., Fritz-Wolf, K., Kabsch, W., and Wittinghofer, A. (1995) Nature 374, 378-381
35. Nassar, N., Horn, G., Herrmann, C., Scherer, A., McCormick, F., and Wittinghofer, A. (1995) Nature 375, 554-560
36. Hirshberg, M., Stockley, R. W., Dodson, G., and Webb, M. R. (1997) Nat. Struct. Biol. 4, 147-152
37. Krengel, U., Schlichting, L., Scherer, A., Schumann, R., Frech, M., John, J., Kabsch, W., Pai, E. F., and Wittinghofer, A. (1990) Cell 62, 539-548
38. Wei, Y., Zhang, Y., Derewenda, U., Liu, X., Minor, W., Nakamoto, R. K., Somlyo, A. V., Somlyo, A. P., and Derewenda, Z. S. (1997) Nat. Struct. Biol. 4, 699-703
39. Tong, L., de Vos, A. M., Milburn, M. V., and Kim, S. H. (1991) J. Mol. Biol. 217, 503-516
40. Schlichting, I., Almo, S., Rapp, G., Wilson, K., Petratos, K., Lentfer, A., Wittinghofer, A., Kabsch, W., Pai, E. F., Petsko, G. A., and Goody, R. S. (1990) Nature 345, 309-315
41. Lambright, D. G., Noel, J. P., Hamm, H. E., and Sigler, P. B. (1994) Nature 369, 621-628
42. Der, C. J., Finkel, T., and Cooper, G. M. (1986) Cell 44, 167-176
43. Marshall, M. S. (1993) Trends Biochem. Sci. 18, 250-254
44. Noel, J. P., Hamm, H. E., and Sigler, P. B. (1993) Nature 366, 654-663
45. Coleman, D. E., Berghuis, A. M., Lee, E., Linder, M. E., Gilman, A. G., and Sprang, S. R. (1994) Science 265, 1405-1412
46. Berchtold, H., Reshetnikova, L., Reiser, C. O. A., Schirmer, N. K., Sprinzl, M., and Hillgenfeld, R. (1993) Nature 365, 126-132
47. Sekine, A., Fujiwara, M., and Narumiya, S. (1989) J. Biol. Chem. 264, 8602-8605
48. Morii, N., Kawano, K., Sekine, A., Yamada, T., and Narumiya S. (1991) J. Biol. Chem. 266, 7646-7650
49. Chong, L. D., Traynor-Kaplan, A., Bokoch, G. M., and Schwartz, M. A. (1994) Cell 79, 507-513
50. Just, I., Mohr, C., Schallehn, G., Menard, L., Didsbury, J. R., Vandekerckhove, J., van Damme, J., and Aktories, K. (1992) J. Biol. Chem. 267, 10274-10280
51. Just, I., Richter, H. P., Prepens, U., von Eichel-Streiber C., and Aktories, K. (1994) J. Cell Sci. 107, 1653-1659
52. Just, I., Selzer, J., Wilm, M., von Eichel-Streiber, C., Mann, M., and Aktories, K. (1995) Nature 375, 500-503
53. Schmidt, G., Sehr, P., Wilm, M., Selzer, J., Mann, M., and Aktories, K. (1997) Nature 387, 725-729
54. Flatau, G., Lemichez, E., Gauthier, M., Chardin, P., Paris, S., Florentini, C., and Boquet, P. (1997) Nature 387, 729-733
55. Mixon, M. B., Lee, E., Coleman, D. E., Berghuis, A. M., Gilman, A. G., and Sprang, S. R. (1995) Science 270, 954-960
56. Cherfils, J., Menetrey, J., Le Bras, G., Le Bras, G., Janoueix-Lerosey, I., de Gunzburg, J., Garel, J.-R., and Auzat, I. (1997) EMBO J. 16, 5582-5591
57. Self, A. J., Paterson, H. F., and Hall A. (1993) Oncogene 8, 655-661
58. Nassar, N., Horn, G., Herrmann, C., Scherer, A., McCormick, F., and Wittinghofer, A. (1996) Nat. Struct. Biol. 3, 723-729
59. Freeman, J. L., Abo, A., and Lambeth, J. D. (1996) J. Biol. Chem. 271, 19794-19801
60. Cerione, R. A., and Zheng, Y. (1996) Curr. Biol. 8, 216-222
61. Zheng, Y., Olson, M. F., Hall, A., Cerione, R. A., and Toksoz, D. (1995) J. Biol. Chem. 270, 9031-9034
62. Habets, G. G., Scholtes, E. H., Zuydgeest, D., van der Kammen, R. A., Stam, J. C., Berns, A., and Collard, J. G. (1994) Cell 77, 537-549
63. Hart, M. J., Eva, A., Evans, T., Aaronson, S. A., and Cerione, R. A. (1991) Nature 354, 311-314
64. Li, R., and Zheng, Y. (1997) J. Biol. Chem. 272, 4671-4679
65. Kaibuchi, K., Mizuno, T., Fujioka, H., Yamamoto, T., Kishi, K., Fukumoto, Y., Hori, Y., and Takai, Y. (1991) Mol. Cell. Biol. 11, 2873-2880
66. Yaku, H., Sasaki, T., and Takai, Y. (1994) Biochem. Biophys. Res. Commun. 198, 811-817
67. Kikuchi, A., Kuroda, S., Sasaki, T., Kotani, K., Hirata, K., Katayama, M., and Takai, Y. (1992) J. Biol. Chem. 267, 14611-14615
68. Araki, S., Kikuchi, A., Hata, Y., Isomura, M., and Takai, Y. (1990) J. Biol. Chem. 265, 13007-13015
69. Gosser, Y. Q., Nomanbhoy, T. K., Aghazadeh, B., Manor, D., Combs, C., Cerione, R. A., and Rosen, M. K. (1997) Nature 387, 814-819
70. Keep, N. H., Barnes, M., Barsukov, I., Badii, R., Lian, L. Y., Segal, A. W., Moody, P. C., and Roberts, G. C. (1997) Structure (Lond.) 5, 623-633
71. Rittinger, K., Walker, P. A., Eccleston, J. F., Nurmahomed, K., Owen, D., Laue, E., Gamblin, S. J., and Smerdon, S. J. (1997) Nature 388, 693-697