Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP γ-Phosphate

Journal of Biological Chemistry

Volumn 290, Issue 52, 2015, Pages 31025-31036

  Knihtila, Ryan ^a   Holzapfel, Genevieve ^b   Weiss, Kevin ^c   Meilleur, Flora ^b,c   Mattos, Carla ^a,b  

^a NORTHEASTERN UNIVERSITY   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROLYSIS; NUCLEOTIDES; PROTONATION;

ACTIVE SITE; GTP ANALOGUE; GTP HYDROLYSIS; GTPASES; PROTONATED; PROTONATION STATE;

CRYSTAL STRUCTURE;

GUANOSINE TRIPHOSPHATE; PHOSPHATE; RAS PROTEIN; HRAS PROTEIN, HUMAN; PROTEIN P21;

ARTICLE; CRYSTAL STRUCTURE; HYDROLYSIS; NEUTRON; PH; PRIORITY JOURNAL; PROTON TRANSPORT; ANALOGS AND DERIVATIVES; CATALYSIS; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PROTEIN TERTIARY STRUCTURE;

CATALYSIS; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROLYSIS; NEUTRONS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS P21(RAS);

EID: 84951810234     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.679860     Document Type: Article

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