Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity

Biochemistry

Volumn 35, Issue 25, 1996, Pages 8166-8171

  Zhang, Fang L ^a   Fu, Hua Wen ^b   Casey, Patrick J ^b   Bishop, W Robert ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (8 CHLORO 5,6 DIHYDRO 11H BENZO[5,6]CYCLOHEPTA[1,2 B]PYRIDIN 11 YLIDENE) 1 (4 PYRIDYLACETYL)PIPERIDINE; CADMIUM; ENZYME INHIBITOR; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; ZINC;

ARTICLE; CATALYSIS; ENZYME INHIBITION; ENZYME RECONSTITUTION; ENZYME SPECIFICITY; ONCOGENE H RAS; PRIORITY JOURNAL;

ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; APOENZYMES; CADMIUM; ENZYME STABILITY; KINETICS; MAGNESIUM; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; RAS PROTEINS; RATS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TRANSFERASES; ZINC;

EID: 0030039165     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi960574+     Document Type: Article

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