Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 38, 2012, Pages 15295-15300

  Rudack, Till ^a   Xia, Fei ^b   Schlitter, Jürgen ^a   Koẗting, Carsten ^a   Gerwert, Klaus ^a,b  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b MAX PLANCK INSTITUTE   (Germany)

Author keywords

Enzyme catalysis; Free energy of activation; Reaction mechanism

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATE; OXYGEN; PHOSPHATE; RAS PROTEIN; WATER;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; INFRARED SPECTROSCOPY; MOLECULAR MECHANICS; NUCLEOPHILICITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; PROTON TRANSPORT; QUANTUM MECHANICS; SIMULATION; STRUCTURE ANALYSIS; X RAY;

CATALYSIS; COMPUTER SIMULATION; GTPASE-ACTIVATING PROTEINS; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROLYSIS; LIGANDS; MAGNESIUM; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; OXYGEN; PHOSPHATES; PROTEIN CONFORMATION; PROTONS; RAS PROTEINS; SPECTROPHOTOMETRY, INFRARED; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; THERMODYNAMICS; X-RAYS;

EID: 84866534653     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1204333109     Document Type: Article

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