Catalysis of GTP hydrolysis by small GTPases at atomic detail by integration of X-ray crystallography, experimental, and theoretical IR spectroscopy

Journal of Biological Chemistry

Volumn 290, Issue 40, 2015, Pages 24079-24090

  Rudack, Till ^a   Jenrich, Sarah ^a   Brucker, Sven ^a   Vetter, Ingrid R ^b   Gerwert, Klaus ^a,c   Kötting, Carsten ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; COORDINATION REACTIONS; CRYSTAL ATOMIC STRUCTURE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; FOURIER TRANSFORM INFRARED SPECTROSCOPY; HYDROGEN BONDS; HYDROLYSIS; MOLECULES; SPACECRAFT INSTRUMENTS;

CATALYTIC CENTER; OPTIMAL POSITIONING; PHOSPHATE GROUP; SPECTRAL DIFFERENCES; STRUCTURAL MODELS; TIME-RESOLVED FT-IR; X RAY STRUCTURE ANALYSIS; X-RAY STRUCTURE;

X RAY CRYSTALLOGRAPHY;

GLUTAMINE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; HYBRID PROTEIN; MAGNESIUM ION; PHOSPHATE; RAN PROTEIN; RAN RANBD1 COMPLEX; RAS PROTEIN; TYROSINE; UNCLASSIFIED DRUG; WATER; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MAGNESIUM; MANGANESE; MEMBRANE PROTEIN; NRAS PROTEIN, HUMAN; PROTEIN BINDING; RANGAP1 PROTEIN, HUMAN;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; HYDROLYSIS; INFRARED SPECTROSCOPY; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SIMULATION; STEREOSPECIFICITY; X RAY CRYSTALLOGRAPHY; CHEMISTRY; ENZYME ACTIVE SITE; HUMAN; INFRARED SPECTROPHOTOMETRY; MOLECULAR DYNAMICS; MUTATION;

CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; GTP PHOSPHOHYDROLASES; GTPASE-ACTIVATING PROTEINS; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROLYSIS; MAGNESIUM; MANGANESE; MEMBRANE PROTEINS; MOLECULAR DYNAMICS SIMULATION; MUTATION; PHOSPHATES; PROTEIN BINDING; SPECTROPHOTOMETRY, INFRARED; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TYROSINE;

EID: 84943302960     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.648071     Document Type: Article

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1. The authors declare no conflict of interest.
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