-
1
-
-
0025010979
-
The GTPase superfamily: A conserved switch for diverse cell functions
-
Bourne HR, Sanders DA, McCormick F (1990) The GTPase superfamily: a conserved switch for diverse cell functions. Nature 348(6297):125–132. doi:10.1038/348125a0
-
(1990)
Nature
, vol.348
, Issue.6297
, pp. 125-132
-
-
Bourne, H.R.1
Sanders, D.A.2
McCormick, F.3
-
2
-
-
34249018367
-
GEFs and GAPs: Critical elements in the control of small G proteins
-
Bos JL, Rehmann H, Wittinghofer A (2007) GEFs and GAPs: critical elements in the control of small G proteins. Cell 129(5):865–877
-
(2007)
Cell
, vol.129
, Issue.5
, pp. 865-877
-
-
Bos, J.L.1
Rehmann, H.2
Wittinghofer, A.3
-
3
-
-
3042796979
-
GAP control: Regulating the regulators of small GTPases
-
Bernards A, Settleman J (2004) GAP control: regulating the regulators of small GTPases. Trends Cell Biol 14(7):377–385 doi:10.1016/j. tcb.2004.05.003
-
(2004)
Trends Cell Biol
, vol.14
, Issue.7
, pp. 377-385
-
-
Bernards, A.1
Settleman, J.2
-
4
-
-
84856733759
-
Inhibition and termination of physiological responses by GTPase activating proteins
-
Ligeti E, Welti S, Scheffzek K (2012) Inhibition and termination of physiological responses by GTPase activating proteins. Physiol Rev 92(1):237–272. doi:10.1152/ physrev.00045.2010
-
(2012)
Physiol Rev
, vol.92
, Issue.1
, pp. 237-272
-
-
Ligeti, E.1
Welti, S.2
Scheffzek, K.3
-
6
-
-
28244490259
-
Monitoring the real-time kinetics of the hydrolysis reaction of guanine nucleotide-binding proteins
-
Eberth A, Dvorsky R, Becker CF, Beste A, Goody RS, Ahmadian MR (2005) Monitoring the real-time kinetics of the hydrolysis reaction of guanine nucleotide-binding proteins. Biol Chem 386(11):1105–1114.doi:10.1515/ BC.2005.127
-
(2005)
Biol Chem
, vol.386
, Issue.11
, pp. 1105-1114
-
-
Eberth, A.1
Dvorsky, R.2
Becker, C.F.3
Beste, A.4
Goody, R.S.5
Ahmadian, M.R.6
-
7
-
-
0032127912
-
GTPase-activating proteins: Helping hands to complement an active site
-
Scheffzek K, Ahmadian MR, Wittinghofer A (1998) GTPase-activating proteins: helping hands to complement an active site. Trends Biochem Sci 23(7):257–262
-
(1998)
Trends Biochem Sci
, vol.23
, Issue.7
, pp. 257-262
-
-
Scheffzek, K.1
Ahmadian, M.R.2
Wittinghofer, A.3
-
8
-
-
0026711081
-
Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: The C-terminal domain of GAP is not sufficient for full activity
-
Gideon P, John J, Frech M, Lautwein A, Clark R, Scheffler JE, Wittinghofer A (1992) Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity. Mol Cell Biol 12(5):2050–2056
-
(1992)
Mol Cell Biol
, vol.12
, Issue.5
, pp. 2050-2056
-
-
Gideon, P.1
John, J.2
Frech, M.3
Lautwein, A.4
Clark, R.5
Scheffler, J.E.6
Wittinghofer, A.7
-
9
-
-
84866354687
-
Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts
-
Marshall CB, Meiri D, Smith MJ, Mazhab-Jafari MT, Gasmi-Seabrook GM, Rottapel R, Stambolic V, Ikura M (2012) Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts. Methods 57(4):473–485. doi:10.1016/j.ymeth.2012.06.014
-
(2012)
Methods
, vol.57
, Issue.4
, pp. 473-485
-
-
Marshall, C.B.1
Meiri, D.2
Smith, M.J.3
Mazhab-Jafari, M.T.4
Gasmi-Seabrook, G.M.5
Rottapel, R.6
Stambolic, V.7
Ikura, M.8
-
10
-
-
77949311827
-
Real-time NMR study of three small GTPases reveals that fluorescent 2′(3′)-O-(N-methylanthraniloyl)- tagged nucleotides alter hydrolysis and exchange kinetics
-
Mazhab-Jafari MT, Marshall CB, Smith M, Gasmi-Seabrook GM, Stambolic V, Rottapel R, Neel BG, Ikura M (2010) Real-time NMR study of three small GTPases reveals that fluorescent 2′(3′)-O-(N-methylanthraniloyl)- tagged nucleotides alter hydrolysis and exchange kinetics. J Biol Chem 285(8):5132–5136. doi:10.1074/jbc.C109.064766
-
(2010)
J Biol Chem
, vol.285
, Issue.8
, pp. 5132-5136
-
-
Mazhab-Jafari, M.T.1
Marshall, C.B.2
Smith, M.3
Gasmi-Seabrook, G.M.4
Stambolic, V.5
Rottapel, R.6
Neel, B.G.7
Ikura, M.8
-
11
-
-
0028789134
-
Kinetics of inorganic phosphate release during the interaction of p21ras with the GTPase-activating proteins, p120-GAP and neurofibromin
-
Nixon AE, Brune M, Lowe PN, Webb MR (1995) Kinetics of inorganic phosphate release during the interaction of p21ras with the GTPase-activating proteins, p120-GAP and neurofibromin. Biochemistry 34(47):15592–15598
-
(1995)
Biochemistry
, vol.34
, Issue.47
, pp. 15592-15598
-
-
Nixon, A.E.1
Brune, M.2
Lowe, P.N.3
Webb, M.R.4
-
12
-
-
0028098798
-
Direct, real-time measurement of rapid inorganic phosphate release using a novel fluorescent probe and its application to actomyosin subfragment 1 ATPase
-
Brune M, Hunter JL, Corrie JE, Webb MR (1994) Direct, real-time measurement of rapid inorganic phosphate release using a novel fluorescent probe and its application to actomyosin subfragment 1 ATPase. Biochemistry 33(27): 8262–8271
-
(1994)
Biochemistry
, vol.33
, Issue.27
, pp. 8262-8271
-
-
Brune, M.1
Hunter, J.L.2
Corrie, J.E.3
Webb, M.R.4
-
13
-
-
0026684153
-
A continuous spectrophotometric assay for inorganic phosphate and for measuring phosphate release kinetics in biological systems
-
Webb MR (1992) A continuous spectrophotometric assay for inorganic phosphate and for measuring phosphate release kinetics in biological systems. Proc Natl Acad Sci U S A 89(11):4884–4887
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, Issue.11
, pp. 4884-4887
-
-
Webb, M.R.1
-
14
-
-
0029118307
-
Measurement of intrinsic nucleotide exchange and GTP hydrolysis rates
-
Self AJ, Hall A (1995) Measurement of intrinsic nucleotide exchange and GTP hydrolysis rates. Methods Enzymol 256:67–76
-
(1995)
Methods Enzymol
, vol.256
, pp. 67-76
-
-
Self, A.J.1
Hall, A.2
-
15
-
-
27744509899
-
Real-time in vitro measurement of GTP hydrolysis
-
Shutes A, Der CJ (2005) Real-time in vitro measurement of GTP hydrolysis. Methods 37(2):183–189. doi:10.1016/j.ymeth.2005.05.019
-
(2005)
Methods
, vol.37
, Issue.2
, pp. 183-189
-
-
Shutes, A.1
Der, C.J.2
-
16
-
-
84882408124
-
The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism
-
Mishra AK, Del Campo CM, Collins RE, Roy CR, Lambright DG (2013) The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism. J Biol Chem 288(33):24000–24011. doi:10.1074/jbc.M113.470625
-
(2013)
J Biol Chem
, vol.288
, Issue.33
, pp. 24000-24011
-
-
Mishra, A.K.1
Del Campo, C.M.2
Collins, R.E.3
Roy, C.R.4
Lambright, D.G.5
-
17
-
-
84878709381
-
Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP
-
Yu Q, Hu L, Yao Q, Zhu Y, Dong N, Wang DC, Shao F (2013) Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP. Cell Res 23(6):775–787. doi:10.1038/cr.2013.54
-
(2013)
Cell Res
, vol.23
, Issue.6
, pp. 775-787
-
-
Yu, Q.1
Hu, L.2
Yao, Q.3
Zhu, Y.4
Dong, N.5
Wang, D.C.6
Shao, F.7
-
18
-
-
84863312340
-
RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36
-
Nottingham RM, Pusapati GV, Ganley IG, Barr FA, Lambright DG, Pfeffer SR (2012) RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36. J Biol Chem 287(27):22740–22748. doi:10.1074/jbc.M112.362558
-
(2012)
J Biol Chem
, vol.287
, Issue.27
, pp. 22740-22748
-
-
Nottingham, R.M.1
Pusapati, G.V.2
Ganley, I.G.3
Barr, F.A.4
Lambright, D.G.5
Pfeffer, S.R.6
-
19
-
-
84865693202
-
Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses
-
Dong N, Zhu Y, Lu Q, Hu L, Zheng Y, Shao F (2012) Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses. Cell 150(5):1029–1041. doi:10.1016/j.cell.2012.06.050
-
(2012)
Cell
, vol.150
, Issue.5
, pp. 1029-1041
-
-
Dong, N.1
Zhu, Y.2
Lu, Q.3
Hu, L.4
Zheng, Y.5
Shao, F.6
-
20
-
-
84866302601
-
TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes
-
Davey JR, Humphrey SJ, Junutula JR, Mishra AK, Lambright DG, James DE, Stockli J (2012) TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes. Traffic 13(10):1429–1441. doi:10.1111/j.1600-0854.2012.01397.x
-
(2012)
Traffic
, vol.13
, Issue.10
, pp. 1429-1441
-
-
Davey, J.R.1
Humphrey, S.J.2
Junutula, J.R.3
Mishra, A.K.4
Lambright, D.G.5
James, D.E.6
Stockli, J.7
-
21
-
-
80053000783
-
RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins
-
Nottingham RM, Ganley IG, Barr FA, Lambright DG, Pfeffer SR (2011) RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. J Biol Chem 286(38):33213–33222. doi:10.1074/jbc.M111.261115
-
(2011)
J Biol Chem
, vol.286
, Issue.38
, pp. 33213-33222
-
-
Nottingham, R.M.1
Ganley, I.G.2
Barr, F.A.3
Lambright, D.G.4
Pfeffer, S.R.5
-
22
-
-
77954185159
-
TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in Caenorhabditis elegans
-
Chotard L, Mishra AK, Sylvain MA, Tuck S, Lambright DG, Rocheleau CE (2010) TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in Caenorhabditis elegans. Mol Biol Cell 21(13):2285–2296. doi:10.1091/mbc.E09-11-0947
-
(2010)
Mol Biol Cell
, vol.21
, Issue.13
, pp. 2285-2296
-
-
Chotard, L.1
Mishra, A.K.2
Sylvain, M.A.3
Tuck, S.4
Lambright, D.G.5
Rocheleau, C.E.6
-
23
-
-
36249027095
-
Legionella pneumophila proteins that regulate Rab1 membrane cycling
-
Ingmundson A, Delprato A, Lambright DG, Roy CR (2007) Legionella pneumophila proteins that regulate Rab1 membrane cycling. Nature 450(7168):365–369. doi:10.1038/nature06336
-
(2007)
Nature
, vol.450
, Issue.7168
, pp. 365-369
-
-
Ingmundson, A.1
Delprato, A.2
Lambright, D.G.3
Roy, C.R.4
-
24
-
-
37549004794
-
TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication
-
Sklan EH, Serrano RL, Einav S, Pfeffer SR, Lambright DG, Glenn JS (2007) TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication. J Biol Chem 282(50):36354–36361
-
(2007)
J Biol Chem
, vol.282
, Issue.50
, pp. 36354-36361
-
-
Sklan, E.H.1
Serrano, R.L.2
Einav, S.3
Pfeffer, S.R.4
Lambright, D.G.5
Glenn, J.S.6
-
25
-
-
34848912911
-
An endocytic pathway as a target of tubby for regulation of fat storage
-
Mukhopadhyay A, Pan X, Lambright DG, Tissenbaum HA (2007) An endocytic pathway as a target of tubby for regulation of fat storage. EMBO Rep 8(10):931–938
-
(2007)
EMBO Rep
, vol.8
, Issue.10
, pp. 931-938
-
-
Mukhopadhyay, A.1
Pan, X.2
Lambright, D.G.3
Tissenbaum, H.A.4
-
26
-
-
33746356908
-
TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism
-
Pan X, Eathiraj S, Munson M, Lambright DG (2006) TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism. Nature 442(7100):303–306. doi:10.1038/nature04847
-
(2006)
Nature
, vol.442
, Issue.7100
, pp. 303-306
-
-
Pan, X.1
Eathiraj, S.2
Munson, M.3
Lambright, D.G.4
-
27
-
-
22944444569
-
Structural basis of family-wide Rab GTPase recognition by rabenosyn-5
-
Eathiraj S, Pan X, Ritacco C, Lambright DG (2005) Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature 436(7049):415–419. doi:10.1038/nature03798
-
(2005)
Nature
, vol.436
, Issue.7049
, pp. 415-419
-
-
Eathiraj, S.1
Pan, X.2
Ritacco, C.3
Lambright, D.G.4
-
28
-
-
77954649564
-
Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1)
-
Mishra A, Eathiraj S, Corvera S, Lambright DG (2010) Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Proc Natl Acad Sci U S A 107(24):10866–10871. doi: 10.1073/pnas.1000843107
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.24
, pp. 10866-10871
-
-
Mishra, A.1
Eathiraj, S.2
Corvera, S.3
Lambright, D.G.4
|