-
2
-
-
0142024483
-
Rap1 GTPase: functions, regulation, and malignancy
-
Hattori M., and Minato N. Rap1 GTPase: functions, regulation, and malignancy. J. Biochem. (Tokyo) 134 (2003) 479-484
-
(2003)
J. Biochem. (Tokyo)
, vol.134
, pp. 479-484
-
-
Hattori, M.1
Minato, N.2
-
3
-
-
17044406762
-
Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets
-
Schultess J., Danielewski O., and Smolenski A.P. Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets. Blood 105 (2005) 3185-3192
-
(2005)
Blood
, vol.105
, pp. 3185-3192
-
-
Schultess, J.1
Danielewski, O.2
Smolenski, A.P.3
-
4
-
-
0035797521
-
Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP
-
Pak D.T., Yang S., Rudolph-Correia S., Kim E., and Sheng M. Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron 31 (2001) 289-303
-
(2001)
Neuron
, vol.31
, pp. 289-303
-
-
Pak, D.T.1
Yang, S.2
Rudolph-Correia, S.3
Kim, E.4
Sheng, M.5
-
5
-
-
10744228326
-
Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice
-
Ishida D., Kometani K., Yang H., Kakugawa K., Masuda K., Iwai K., et al. Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. Cancer Cell 4 (2003) 55-65
-
(2003)
Cancer Cell
, vol.4
, pp. 55-65
-
-
Ishida, D.1
Kometani, K.2
Yang, H.3
Kakugawa, K.4
Masuda, K.5
Iwai, K.6
-
6
-
-
0035834649
-
Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras
-
Gao X., Satoh T., Liao Y., Song C., Hu C.D., Kariya Ki K., and Kataoka T. Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras. J. Biol. Chem. 276 (2001) 42219-42225
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 42219-42225
-
-
Gao, X.1
Satoh, T.2
Liao, Y.3
Song, C.4
Hu, C.D.5
Kariya Ki, K.6
Kataoka, T.7
-
7
-
-
0027770784
-
Identification and characterization of the tuberous sclerosis gene on chromosome 16. The European Chromosome 16 Tuberous Sclerosis Consortium
-
Consortium
-
Consortium. Identification and characterization of the tuberous sclerosis gene on chromosome 16. The European Chromosome 16 Tuberous Sclerosis Consortium. Cel 75 (1993) 1305-1315
-
(1993)
Cel
, vol.75
, pp. 1305-1315
-
-
-
8
-
-
0042701991
-
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
Tee A.R., Manning B.D., Roux P.P., Cantley L.C., and Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 13 (2003) 1259-1268
-
(2003)
Curr. Biol.
, vol.13
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
9
-
-
0030772378
-
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants
-
Scheffzek K., Ahmadian M.R., Kabsch W., Wiesmuller L., Lautwein A., Schmitz F., and Wittinghofer A. The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 277 (1997) 333-338
-
(1997)
Science
, vol.277
, pp. 333-338
-
-
Scheffzek, K.1
Ahmadian, M.R.2
Kabsch, W.3
Wiesmuller, L.4
Lautwein, A.5
Schmitz, F.6
Wittinghofer, A.7
-
10
-
-
0028314516
-
Role of glutamine-61 in the hydrolysis of GTP by p21H-ras: an experimental and theoretical study
-
Frech M., Darden T.A., Pedersen L.G., Foley C.K., Charifson P.S., Anderson M.W., and Wittinghofer A. Role of glutamine-61 in the hydrolysis of GTP by p21H-ras: an experimental and theoretical study. Biochemistry 33 (1994) 3237-3244
-
(1994)
Biochemistry
, vol.33
, pp. 3237-3244
-
-
Frech, M.1
Darden, T.A.2
Pedersen, L.G.3
Foley, C.K.4
Charifson, P.S.5
Anderson, M.W.6
Wittinghofer, A.7
-
11
-
-
0025346513
-
Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product
-
Frech M., John J., Pizon V., Chardin P., Tavitian A., Clark R., et al. Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product. Science 249 (1990) 169-171
-
(1990)
Science
, vol.249
, pp. 169-171
-
-
Frech, M.1
John, J.2
Pizon, V.3
Chardin, P.4
Tavitian, A.5
Clark, R.6
-
12
-
-
0026017886
-
The residues of Ras and Rap proteins that determine their GAP specificities
-
Maruta H., Holden J., Sizeland A., and D'Abaco G. The residues of Ras and Rap proteins that determine their GAP specificities. J. Biol. Chem. 266 (1991) 11661-11668
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 11661-11668
-
-
Maruta, H.1
Holden, J.2
Sizeland, A.3
D'Abaco, G.4
-
13
-
-
33746356908
-
TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism
-
Pan X., Eathiraj S., Munson M., and Lambright D.G. TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism. Nature 442 (2006) 303-306
-
(2006)
Nature
, vol.442
, pp. 303-306
-
-
Pan, X.1
Eathiraj, S.2
Munson, M.3
Lambright, D.G.4
-
14
-
-
0037066723
-
Rap-specific GTPase activating protein follows an alternative mechanism
-
Brinkmann T., Daumke O., Herbrand U., Kuhlmann D., Stege P., Ahmadian M.R., and Wittinghofer A. Rap-specific GTPase activating protein follows an alternative mechanism. J. Biol. Chem. 277 (2002) 12525-12531
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 12525-12531
-
-
Brinkmann, T.1
Daumke, O.2
Herbrand, U.3
Kuhlmann, D.4
Stege, P.5
Ahmadian, M.R.6
Wittinghofer, A.7
-
15
-
-
2442669194
-
The GTPase-activating protein Rap1GAP uses a catalytic asparagine
-
Daumke O., Weyand M., Chakrabarti P.P., Vetter I.R., and Wittinghofer A. The GTPase-activating protein Rap1GAP uses a catalytic asparagine. Nature 429 (2004) 197-201
-
(2004)
Nature
, vol.429
, pp. 197-201
-
-
Daumke, O.1
Weyand, M.2
Chakrabarti, P.P.3
Vetter, I.R.4
Wittinghofer, A.5
-
16
-
-
0025310575
-
Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis
-
Pai E.F., Krengel U., Petsko G.A., Goody R.S., Kabsch W., and Wittinghofer A. Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis. EMBO J. 9 (1990) 2351-23519
-
(1990)
EMBO J.
, vol.9
, pp. 2351-23519
-
-
Pai, E.F.1
Krengel, U.2
Petsko, G.A.3
Goody, R.S.4
Kabsch, W.5
Wittinghofer, A.6
-
17
-
-
0022471217
-
Biological and biochemical properties of human rasH genes mutated at codon 61
-
Der C.J., Finkel T., and Cooper G.M. Biological and biochemical properties of human rasH genes mutated at codon 61. Cell 44 (1986) 167-176
-
(1986)
Cell
, vol.44
, pp. 167-176
-
-
Der, C.J.1
Finkel, T.2
Cooper, G.M.3
-
18
-
-
0026711081
-
Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity
-
Gideon P., John J., Frech M., Lautwein A., Clark R., Scheffler J.E., and Wittinghofer A. Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity. Mol. Cell Biol. 12 (1992) 2050-2056
-
(1992)
Mol. Cell Biol.
, vol.12
, pp. 2050-2056
-
-
Gideon, P.1
John, J.2
Frech, M.3
Lautwein, A.4
Clark, R.5
Scheffler, J.E.6
Wittinghofer, A.7
-
19
-
-
0030036699
-
Formation of a transition-state analog of the Ras GTPase reaction by Ras-GDP, tetrafluoroaluminate, and GTPase-activating proteins
-
Mittal R., Ahmadian M.R., Goody R.S., and Wittinghofer A. Formation of a transition-state analog of the Ras GTPase reaction by Ras-GDP, tetrafluoroaluminate, and GTPase-activating proteins. Science 273 (1996) 115-117
-
(1996)
Science
, vol.273
, pp. 115-117
-
-
Mittal, R.1
Ahmadian, M.R.2
Goody, R.S.3
Wittinghofer, A.4
-
20
-
-
0028925947
-
Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins
-
Schweins T., Geyer M., Scheffzek K., Warshel A., Kalbitzer H.R., and Wittinghofer A. Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins. Nature Struct. Biol. 2 (1995) 36-44
-
(1995)
Nature Struct. Biol.
, vol.2
, pp. 36-44
-
-
Schweins, T.1
Geyer, M.2
Scheffzek, K.3
Warshel, A.4
Kalbitzer, H.R.5
Wittinghofer, A.6
-
21
-
-
0036928818
-
Fluorescently labelled guanine nucleotide binding proteins to analyse elementary steps of GAP-catalysed reactions
-
Kraemer A., Brinkmann T., Plettner I., Goody R., and Wittinghofer A. Fluorescently labelled guanine nucleotide binding proteins to analyse elementary steps of GAP-catalysed reactions. J. Mol. Biol. 324 (2002) 763-774
-
(2002)
J. Mol. Biol.
, vol.324
, pp. 763-774
-
-
Kraemer, A.1
Brinkmann, T.2
Plettner, I.3
Goody, R.4
Wittinghofer, A.5
-
22
-
-
0025191377
-
Aluminofluoride and beryllofluoride complexes: a new phosphate analogs in enzymology
-
Chabre M. Aluminofluoride and beryllofluoride complexes: a new phosphate analogs in enzymology. Trends Biochem. Sci. 15 (1990) 6-10
-
(1990)
Trends Biochem. Sci.
, vol.15
, pp. 6-10
-
-
Chabre, M.1
-
23
-
-
0034817799
-
Transition state complexes of the Klebsiella pneumoniae nitrogenase proteins. Spectroscopic properties of aluminium fluoride-stabilized and beryllium fluoride-stabilized MgADP complexes reveal conformational differences of the Fe protein
-
Miller R.W., Eady R.R., Fairhurst S.A., Gormal C.A., and Smith B.E. Transition state complexes of the Klebsiella pneumoniae nitrogenase proteins. Spectroscopic properties of aluminium fluoride-stabilized and beryllium fluoride-stabilized MgADP complexes reveal conformational differences of the Fe protein. Eur. J. Biochem. 268 (2001) 809-818
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 809-818
-
-
Miller, R.W.1
Eady, R.R.2
Fairhurst, S.A.3
Gormal, C.A.4
Smith, B.E.5
-
24
-
-
0019921514
-
Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride
-
Sternweis P.C., and Gilman A.G. Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride. Proc. Natl Acad. Sci. USA 79 (1982) 4888-4891
-
(1982)
Proc. Natl Acad. Sci. USA
, vol.79
, pp. 4888-4891
-
-
Sternweis, P.C.1
Gilman, A.G.2
-
25
-
-
0025297181
-
A novel magnesium-dependent mechanism for the activation of transducin by fluoride
-
Antonny B., Bigay J., and Chabre M. A novel magnesium-dependent mechanism for the activation of transducin by fluoride. FEBS Letters 268 (1990) 277-280
-
(1990)
FEBS Letters
, vol.268
, pp. 277-280
-
-
Antonny, B.1
Bigay, J.2
Chabre, M.3
-
26
-
-
0033539492
-
Magnesium fluoride-dependent binding of small G proteins to their GTPase-activating proteins
-
Graham D.L., Eccleston J.F., Chung C.W., and Lowe P.N. Magnesium fluoride-dependent binding of small G proteins to their GTPase-activating proteins. Biochemistry 38 (1999) 14981-14987
-
(1999)
Biochemistry
, vol.38
, pp. 14981-14987
-
-
Graham, D.L.1
Eccleston, J.F.2
Chung, C.W.3
Lowe, P.N.4
-
28
-
-
0029159959
-
X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP•BeFx and MgADP•AlF4
-
Fisher A.J., Smith C.A., Thoden J.B., Smith R., Sutoh K., Holden H.M., and Rayment I. X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP•BeFx and MgADP•AlF4. Biochemistry 34 (1995) 8960-8972
-
(1995)
Biochemistry
, vol.34
, pp. 8960-8972
-
-
Fisher, A.J.1
Smith, C.A.2
Thoden, J.B.3
Smith, R.4
Sutoh, K.5
Holden, H.M.6
Rayment, I.7
-
29
-
-
0029960235
-
X-ray structure of the magnesium(II).ADP.vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9 Å resolution
-
Smith C.A., and Rayment I. X-ray structure of the magnesium(II).ADP.vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9 Å resolution. Biochemistry 35 (1996) 5404-5417
-
(1996)
Biochemistry
, vol.35
, pp. 5404-5417
-
-
Smith, C.A.1
Rayment, I.2
-
30
-
-
0024795058
-
Characterization of the aluminum and beryllium fluoride species bound to F-actin and microtubules at the site of the gamma-phosphate of the nucleotide
-
Combeau C., and Carlier M.F. Characterization of the aluminum and beryllium fluoride species bound to F-actin and microtubules at the site of the gamma-phosphate of the nucleotide. J. Biol. Chem. 264 (1989) 19017-19021
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 19017-19021
-
-
Combeau, C.1
Carlier, M.F.2
-
32
-
-
2442504897
-
2+-ATPase: changes in catalytic and transport sites during phosphoenzyme hydrolysis
-
2+-ATPase: changes in catalytic and transport sites during phosphoenzyme hydrolysis. J. Biol. Chem. 279 (2004) 14991-14998
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 14991-14998
-
-
Danko, S.1
Yamasaki, K.2
Daiho, T.3
Suzuki, H.4
-
34
-
-
0026779243
-
Characterization of the aluminum and beryllium fluoride species which activate transducin. Analysis of the binding and dissociation kinetics
-
Antonny B., and Chabre M. Characterization of the aluminum and beryllium fluoride species which activate transducin. Analysis of the binding and dissociation kinetics. J. Biol. Chem. 267 (1992) 6710-6718
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 6710-6718
-
-
Antonny, B.1
Chabre, M.2
-
35
-
-
0023951969
-
Stabilization of microtubules by inorganic phosphate and its structural analogues, the fluoride complexes of aluminum and beryllium
-
Carlier M.F., Didry D., Melki R., Chabre M., and Pantaloni D. Stabilization of microtubules by inorganic phosphate and its structural analogues, the fluoride complexes of aluminum and beryllium. Biochemistry 27 (1988) 3555-3559
-
(1988)
Biochemistry
, vol.27
, pp. 3555-3559
-
-
Carlier, M.F.1
Didry, D.2
Melki, R.3
Chabre, M.4
Pantaloni, D.5
-
36
-
-
0031586946
-
Aluminum fluoride associates with the small guanine nucleotide binding proteins
-
Ahmadian M.R., Mittal R., Hall A., and Wittinghofer A. Aluminum fluoride associates with the small guanine nucleotide binding proteins. FEBS Letters 408 (1997) 315-318
-
(1997)
FEBS Letters
, vol.408
, pp. 315-318
-
-
Ahmadian, M.R.1
Mittal, R.2
Hall, A.3
Wittinghofer, A.4
-
37
-
-
0027402928
-
The mechanism of aluminum-independent G-protein activation by fluoride and magnesium. 31P NMR spectroscopy and fluorescence kinetic studies
-
Antonny B., Sukumar M., Bigay J., Chabre M., and Higashijima T. The mechanism of aluminum-independent G-protein activation by fluoride and magnesium. 31P NMR spectroscopy and fluorescence kinetic studies. J. Biol. Chem. 268 (1993) 2393-2402
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 2393-2402
-
-
Antonny, B.1
Sukumar, M.2
Bigay, J.3
Chabre, M.4
Higashijima, T.5
-
38
-
-
0030061189
-
The structural basis of the myosin ATPase activity
-
Rayment I. The structural basis of the myosin ATPase activity. J. Biol. Chem. 271 (1996) 15850-15853
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 15850-15853
-
-
Rayment, I.1
-
39
-
-
0030716497
-
Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue
-
Rittinger K., Walker P.A., Eccleston J.F., Smerdon S.J., and Gamblin S.J. Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue. Nature 389 (1997) 758-762
-
(1997)
Nature
, vol.389
, pp. 758-762
-
-
Rittinger, K.1
Walker, P.A.2
Eccleston, J.F.3
Smerdon, S.J.4
Gamblin, S.J.5
-
40
-
-
0034945818
-
Monitoring the GAP catalyzed H-Ras GTPase reaction at atomic resolution in real time
-
Allin C., Ahmadian M.R., Wittinghofer A., and Gerwert K. Monitoring the GAP catalyzed H-Ras GTPase reaction at atomic resolution in real time. Proc. Natl Acad. Sci. USA 98 (2001) 7754-7759
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 7754-7759
-
-
Allin, C.1
Ahmadian, M.R.2
Wittinghofer, A.3
Gerwert, K.4
-
41
-
-
0031799611
-
Fourier transform infrared photolysis studies of caged compounds
-
Cepus V., Ulbrich C., Allin C., Troullier A., and Gerwert K. Fourier transform infrared photolysis studies of caged compounds. Methods Enzymol. 291 (1998) 223-245
-
(1998)
Methods Enzymol.
, vol.291
, pp. 223-245
-
-
Cepus, V.1
Ulbrich, C.2
Allin, C.3
Troullier, A.4
Gerwert, K.5
-
42
-
-
33749014394
-
A phosphoryl transfer intermediate in the GTPase-reaction of Ras in complex with its GTPase-activating protein
-
Kötting C., Blessenohl M., Suveyzdis Y., Goody R.S., Wittinghofer A., and Gerwert K. A phosphoryl transfer intermediate in the GTPase-reaction of Ras in complex with its GTPase-activating protein. Proc. Natl Acad. Sci. USA 103 (2006) 13911-13916
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 13911-13916
-
-
Kötting, C.1
Blessenohl, M.2
Suveyzdis, Y.3
Goody, R.S.4
Wittinghofer, A.5
Gerwert, K.6
-
43
-
-
8544261164
-
Fourier transform infrared spectroscopy on the Rap.RapGAP reaction, GTPase activation without an arginine finger
-
Chakrabarti P.P., Suveyzdis Y., Wittinghofer A., and Gerwert K. Fourier transform infrared spectroscopy on the Rap.RapGAP reaction, GTPase activation without an arginine finger. J. Biol. Chem. 279 (2004) 46226-46233
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 46226-46233
-
-
Chakrabarti, P.P.1
Suveyzdis, Y.2
Wittinghofer, A.3
Gerwert, K.4
-
44
-
-
0021126650
-
Biological properties of human c-Ha-ras1 genes mutated at codon 12
-
Seeburg P.H., Colby W.W., Capon D.J., Goeddel D.V., and Levinson A.D. Biological properties of human c-Ha-ras1 genes mutated at codon 12. Nature 312 (1984) 71-75
-
(1984)
Nature
, vol.312
, pp. 71-75
-
-
Seeburg, P.H.1
Colby, W.W.2
Capon, D.J.3
Goeddel, D.V.4
Levinson, A.D.5
-
45
-
-
8844221289
-
The power of vanadate in crystallographic investigations of phosphoryl transfer enzymes
-
Davies D.R., and Hol W.G. The power of vanadate in crystallographic investigations of phosphoryl transfer enzymes. FEBS Letters 577 (2004) 315-321
-
(2004)
FEBS Letters
, vol.577
, pp. 315-321
-
-
Davies, D.R.1
Hol, W.G.2
-
46
-
-
0037033983
-
RanGAP mediates GTP hydrolysis without an arginine finger
-
Seewald M.J., Korner C., Wittinghofer A., and Vetter I.R. RanGAP mediates GTP hydrolysis without an arginine finger. Nature 415 (2002) 662-666
-
(2002)
Nature
, vol.415
, pp. 662-666
-
-
Seewald, M.J.1
Korner, C.2
Wittinghofer, A.3
Vetter, I.R.4
-
47
-
-
0029781354
-
Ras-catalyzed hydrolysis of GTP: a new perspective from model studies
-
Maegley K.A., Admiraal S.J., and Herschlag D. Ras-catalyzed hydrolysis of GTP: a new perspective from model studies. Proc. Natl Acad. Sci. USA 93 (1996) 8160-8166
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 8160-8166
-
-
Maegley, K.A.1
Admiraal, S.J.2
Herschlag, D.3
-
48
-
-
0038054300
-
Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP
-
Ahmadian M.R., Kiel C., Stege P., and Scheffzek K. Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP. J. Mol. Biol. 329 (2003) 699-710
-
(2003)
J. Mol. Biol.
, vol.329
, pp. 699-710
-
-
Ahmadian, M.R.1
Kiel, C.2
Stege, P.3
Scheffzek, K.4
-
49
-
-
0027765499
-
Kinetics of interaction between normal and proline 12 Ras and the GTPase-activating proteins, p120-GAP and neurofibromin. The significance of the intrinsic GTPase rate in determining the transforming ability of ras
-
Eccleston J.F., Moore K.J., Morgan L., Skinner R.H., and Lowe P.N. Kinetics of interaction between normal and proline 12 Ras and the GTPase-activating proteins, p120-GAP and neurofibromin. The significance of the intrinsic GTPase rate in determining the transforming ability of ras. J. Biol. Chem. 268 (1993) 27012-27019
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 27012-27019
-
-
Eccleston, J.F.1
Moore, K.J.2
Morgan, L.3
Skinner, R.H.4
Lowe, P.N.5
-
50
-
-
0027297116
-
Mechanism of GTP hydrolysis by p21N-ras catalyzed by GAP: studies with a fluorescent GTP analogue
-
Moore K.J., Webb M.R., and Eccleston J.F. Mechanism of GTP hydrolysis by p21N-ras catalyzed by GAP: studies with a fluorescent GTP analogue. Biochemistry 32 (1993) 7451-7459
-
(1993)
Biochemistry
, vol.32
, pp. 7451-7459
-
-
Moore, K.J.1
Webb, M.R.2
Eccleston, J.F.3
-
51
-
-
0028789134
-
Kinetics of inorganic phosphate release during the interaction of p21ras with the GTPase-activating proteins, p120-GAP and neurofibromin
-
Nixon A.E., Brune M., Lowe P.N., and Webb M.R. Kinetics of inorganic phosphate release during the interaction of p21ras with the GTPase-activating proteins, p120-GAP and neurofibromin. Biochemistry 34 (1995) 15592-15598
-
(1995)
Biochemistry
, vol.34
, pp. 15592-15598
-
-
Nixon, A.E.1
Brune, M.2
Lowe, P.N.3
Webb, M.R.4
-
52
-
-
0026349335
-
Is there a rate-limiting step before GTP cleavage by H-ras p21?
-
Rensland H., Lautwein A., Wittinghofer A., and Goody R.S. Is there a rate-limiting step before GTP cleavage by H-ras p21?. Biochemistry 30 (1991) 11181-11185
-
(1991)
Biochemistry
, vol.30
, pp. 11181-11185
-
-
Rensland, H.1
Lautwein, A.2
Wittinghofer, A.3
Goody, R.S.4
-
53
-
-
0037013143
-
The conformational plasticity of protein kinases
-
Huse M., and Kuriyan J. The conformational plasticity of protein kinases. Cell 109 (2002) 275-282
-
(2002)
Cell
, vol.109
, pp. 275-282
-
-
Huse, M.1
Kuriyan, J.2
-
54
-
-
16344395751
-
ATP hydrolysis in the betaTP and betaDP catalytic sites of F1-ATPase
-
Dittrich M., Hayashi S., and Schulten K. ATP hydrolysis in the betaTP and betaDP catalytic sites of F1-ATPase. Biophys. J. 87 (2004) 2954-2967
-
(2004)
Biophys. J.
, vol.87
, pp. 2954-2967
-
-
Dittrich, M.1
Hayashi, S.2
Schulten, K.3
-
55
-
-
33745520400
-
Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element
-
Scrima A., and Wittinghofer A. Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element. EMBO J. 25 (2006) 2940-2951
-
(2006)
EMBO J.
, vol.25
, pp. 2940-2951
-
-
Scrima, A.1
Wittinghofer, A.2
-
56
-
-
0022727887
-
Expression of p21 proteins in Escherichia coli and stereochemistry of the nucleotide-binding site
-
Tucker J., Sczakiel G., Feuerstein J., John J., Goody R.S., and Wittinghofer A. Expression of p21 proteins in Escherichia coli and stereochemistry of the nucleotide-binding site. EMBO J. 5 (1986) 1351-1358
-
(1986)
EMBO J.
, vol.5
, pp. 1351-1358
-
-
Tucker, J.1
Sczakiel, G.2
Feuerstein, J.3
John, J.4
Goody, R.S.5
Wittinghofer, A.6
-
57
-
-
2442678744
-
Purification, crystallization and preliminary structural characterization of human Rap1GAP
-
Daumke O., Wittinghofer A., and Weyand M. Purification, crystallization and preliminary structural characterization of human Rap1GAP. Acta Crystallog. sect. D 60 (2004) 752-754
-
(2004)
Acta Crystallog. sect. D
, vol.60
, pp. 752-754
-
-
Daumke, O.1
Wittinghofer, A.2
Weyand, M.3
-
58
-
-
0023687515
-
Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction
-
John J., Frech M., and Wittinghofer A. Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction. J. Biol. Chem. 263 (1988) 11792-11799
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 11792-11799
-
-
John, J.1
Frech, M.2
Wittinghofer, A.3
-
59
-
-
0029112918
-
Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements
-
Lenzen C., Cool R.H., and Wittinghofer A. Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements. Methods Enzymol. 255 (1995) 95-109
-
(1995)
Methods Enzymol.
, vol.255
, pp. 95-109
-
-
Lenzen, C.1
Cool, R.H.2
Wittinghofer, A.3
-
60
-
-
0025953405
-
Use of vanadate as protein-phosphotyrosine phosphatase inhibitor
-
Gordon J.A. Use of vanadate as protein-phosphotyrosine phosphatase inhibitor. Methods Enzymol. 201 (1991) 477-482
-
(1991)
Methods Enzymol.
, vol.201
, pp. 477-482
-
-
Gordon, J.A.1
-
61
-
-
0030907953
-
New photoactivated protecting groups. 6. p-hydroxyphenacyl: a phototrigger for chemical and biochemical probes
-
Park C.-H.G., and R.S. New photoactivated protecting groups. 6. p-hydroxyphenacyl: a phototrigger for chemical and biochemical probes. J. Am. Chem. Soc. 119 (1997) 2453-2463
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 2453-2463
-
-
Park, C.-H.G.1
-
62
-
-
33845279305
-
Photolabile 1-(2-nitrophenyl)ethyl phosphate esters of adenine nucleotide analogs. Synthesis and mechanism of photolysis
-
Walker J., Reid G.P., McCray J.A., and Trentham D.R. Photolabile 1-(2-nitrophenyl)ethyl phosphate esters of adenine nucleotide analogs. Synthesis and mechanism of photolysis. J. Am. Chem. Soc. 110 (1988) 7170-7177
-
(1988)
J. Am. Chem. Soc.
, vol.110
, pp. 7170-7177
-
-
Walker, J.1
Reid, G.P.2
McCray, J.A.3
Trentham, D.R.4
-
63
-
-
0025629995
-
Simultaneous monitoring of light-induced changes in protein side-group protonation, chromophore isomerization, and backbone motion of bacteriorhodopsin by time-resolved Fourier-transform infrared spectroscopy
-
Gerwert K., Souvignier G., and Hess B. Simultaneous monitoring of light-induced changes in protein side-group protonation, chromophore isomerization, and backbone motion of bacteriorhodopsin by time-resolved Fourier-transform infrared spectroscopy. Proc. Natl Acad. Sci. USA 87 (1990) 9774-9778
-
(1990)
Proc. Natl Acad. Sci. USA
, vol.87
, pp. 9774-9778
-
-
Gerwert, K.1
Souvignier, G.2
Hess, B.3
-
64
-
-
0027429642
-
A model-independent approach to assigning bacteriorhodopsin's intramolecular reactions to photocycle intermediates
-
Hessling B., Souvignier G., and Gerwert K. A model-independent approach to assigning bacteriorhodopsin's intramolecular reactions to photocycle intermediates. Biophys. J. 65 (1993) 1929-1941
-
(1993)
Biophys. J.
, vol.65
, pp. 1929-1941
-
-
Hessling, B.1
Souvignier, G.2
Gerwert, K.3
|