The Ras-RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic ras mutants

Science

Volumn 277, Issue 5324, 1997, Pages 333-338

  Scheffzek, Klaus ^a   Ahmadian, Mohammad Reza ^a   Kabsch, Wolfgang ^b   Wiesmüller, Lisa ^a,c   Lautwein, Alfred ^a,d   Schmitz, Frank ^a   Wittinghofer, Alfred ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^c UNIVERSITY OF HAMBURG   (Germany)

^d INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GLUTAMINE; GLYCINE; GLYCOPROTEIN GP 120; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MUTANT PROTEIN; RAS PROTEIN;

ARTICLE; ENZYME ACTIVATION; GENE MUTATION; HYDROPHOBICITY; MOLECULAR INTERACTION; ONCOGENE H RAS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

ALUMINUM COMPOUNDS; AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CELL TRANSFORMATION, NEOPLASTIC; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; FLUORIDES; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEINS; RAS GTPASE-ACTIVATING PROTEINS; RAS PROTEINS; SIGNAL TRANSDUCTION;

EID: 0030772378     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.277.5324.333     Document Type: Article

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79. We thank A. Becker, I. Schlichting, I. Vetter, M. Geyer, A. Scherer, and A. Lavie for helpful discussions, H. Wagner for maintenance of the x-ray facilities at the Max-Planck-Institut für medizinische Forschung Heidelberg, R. Schebaum for secretarial assistance, and K. Holmes for continuous support. Supported by the Peter and Traudl Engelhorn Stiftung (Germany) and the National Neurofibromatosis Foundation (United States) (K.S.). The coordinates have been submitted to the Brookhaven data base. accession number 1WQ1.