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Volumn 7, Issue 2, 2016, Pages 114-125

Microglia communication: Parallels between aging and Alzheimer's disease

Author keywords

aging; Alzheimer's disease; microglia; neuroinflammation

Indexed keywords

COMPLEMENT FACTOR; CYTOKINE;

EID: 84964727728     PISSN: None     EISSN: 17591961     Source Type: Journal    
DOI: 10.1111/cen3.12307     Document Type: Review
Times cited : (62)

References (106)
  • 1
    • 67650966680 scopus 로고    scopus 로고
    • Microglial physiology: Unique stimuli, specialized responses
    • Ransohoff RM, Perry VH,. Microglial physiology: unique stimuli, specialized responses. Annu Rev Immunol. 2009; 27: 119-45.
    • (2009) Annu Rev Immunol , vol.27 , pp. 119-145
    • Ransohoff, R.M.1    Perry, V.H.2
  • 2
    • 84875940314 scopus 로고    scopus 로고
    • Factors regulating microglia activation
    • Kierdorf K, Prinz M,. Factors regulating microglia activation. Front Cell Neurosci. 2013; 7: 44.
    • (2013) Front Cell Neurosci , vol.7 , pp. 44
    • Kierdorf, K.1    Prinz, M.2
  • 3
    • 84951284076 scopus 로고    scopus 로고
    • The development and maintenance of resident macrophages
    • Perdiguero EG, Geissmann F,. The development and maintenance of resident macrophages. Nat Immunol. 2015; 17: 2-8.
    • (2015) Nat Immunol , vol.17 , pp. 2-8
    • Perdiguero, E.G.1    Geissmann, F.2
  • 4
    • 77957328867 scopus 로고    scopus 로고
    • Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis
    • Sierra A, Encinas JM, Deudero JJ, et al., Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell. 2010; 7: 483-95.
    • (2010) Cell Stem Cell , vol.7 , pp. 483-495
    • Sierra, A.1    Encinas, J.M.2    Deudero, J.J.3
  • 5
    • 84875870356 scopus 로고    scopus 로고
    • Microglia: Actively surveying and shaping neuronal circuit structure and function
    • Wake H, Moorhouse AJ, Miyamoto A, Nabekura J,. Microglia: actively surveying and shaping neuronal circuit structure and function. Trends Neurosci. 2013; 36: 209-17.
    • (2013) Trends Neurosci , vol.36 , pp. 209-217
    • Wake, H.1    Moorhouse, A.J.2    Miyamoto, A.3    Nabekura, J.4
  • 6
    • 84894574217 scopus 로고    scopus 로고
    • Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
    • Parkhurst CN, Yang G, Ninan I, et al., Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. 2013; 155: 1596-609.
    • (2013) Cell , vol.155 , pp. 1596-1609
    • Parkhurst, C.N.1    Yang, G.2    Ninan, I.3
  • 7
    • 84904009117 scopus 로고    scopus 로고
    • Sublime microglia: Expanding roles for the guardians of the CNS
    • Salter MW, Beggs S,. Sublime microglia: expanding roles for the guardians of the CNS. Cell. 2014; 158: 15-24.
    • (2014) Cell , vol.158 , pp. 15-24
    • Salter, M.W.1    Beggs, S.2
  • 8
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A, Kirchhoff F, Helmchen F,. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science. 2005; 308: 1314-8.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 9
    • 22244464662 scopus 로고    scopus 로고
    • ATP mediates rapid microglial response to local brain injury in vivo
    • Davalos D, Grutzendler J, Yang G, et al., ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci. 2005; 8: 752-8.
    • (2005) Nat Neurosci , vol.8 , pp. 752-758
    • Davalos, D.1    Grutzendler, J.2    Yang, G.3
  • 10
    • 84897954445 scopus 로고    scopus 로고
    • Microglial dysfunction in brain aging and Alzheimer's disease
    • Mosher KI, Wyss-Coray T,. Microglial dysfunction in brain aging and Alzheimer's disease. Biochem Pharmacol. 2014; 88: 594-604.
    • (2014) Biochem Pharmacol , vol.88 , pp. 594-604
    • Mosher, K.I.1    Wyss-Coray, T.2
  • 11
    • 84861989218 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced interleukin (IL)-4 receptor-alpha expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice
    • Fenn AM, Henry CJ, Huang Y, Dugan A, Godbout JP,. Lipopolysaccharide-induced interleukin (IL)-4 receptor-alpha expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice. Brain Behav Immun. 2012; 26: 766-77.
    • (2012) Brain Behav Immun , vol.26 , pp. 766-777
    • Fenn, A.M.1    Henry, C.J.2    Huang, Y.3    Dugan, A.4    Godbout, J.P.5
  • 12
    • 84880513276 scopus 로고    scopus 로고
    • Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice
    • Crain JM, Nikodemova M, Watters JJ,. Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice. J Neurosci Res. 2013; 91: 1143-51.
    • (2013) J Neurosci Res , vol.91 , pp. 1143-1151
    • Crain, J.M.1    Nikodemova, M.2    Watters, J.J.3
  • 13
    • 0032916578 scopus 로고    scopus 로고
    • Increased interleukin-6 expression by microglia from brain of aged mice
    • Ye SM, Johnson RW,. Increased interleukin-6 expression by microglia from brain of aged mice. J Neuroimmunol. 1999; 93: 139-48.
    • (1999) J Neuroimmunol , vol.93 , pp. 139-148
    • Ye, S.M.1    Johnson, R.W.2
  • 14
    • 33846980461 scopus 로고    scopus 로고
    • Microglia derived from aging mice exhibit an altered inflammatory profile
    • Sierra A, Gottfried-Blackmore AC, McEwen BS, Bulloch K,. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia. 2007; 55: 412-24.
    • (2007) Glia , vol.55 , pp. 412-424
    • Sierra, A.1    Gottfried-Blackmore, A.C.2    McEwen, B.S.3    Bulloch, K.4
  • 15
    • 84920937355 scopus 로고    scopus 로고
    • SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1beta
    • Cho SH, Chen JA, Sayed F, et al., SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1beta. J Neurosci. 2015; 35: 807-18.
    • (2015) J Neurosci , vol.35 , pp. 807-818
    • Cho, S.H.1    Chen, J.A.2    Sayed, F.3
  • 16
    • 84911991625 scopus 로고    scopus 로고
    • Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction
    • Orre M, Kamphuis W, Osborn LM, et al., Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction. Neurobiol Aging. 2014; 35: 2746-60.
    • (2014) Neurobiol Aging , vol.35 , pp. 2746-2760
    • Orre, M.1    Kamphuis, W.2    Osborn, L.M.3
  • 17
    • 67349251479 scopus 로고    scopus 로고
    • Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta
    • Michelucci A, Heurtaux T, Grandbarbe L, Morga E, Heuschling P,. Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: effects of oligomeric and fibrillar amyloid-beta. J Neuroimmunol. 2009; 210: 3-12.
    • (2009) J Neuroimmunol , vol.210 , pp. 3-12
    • Michelucci, A.1    Heurtaux, T.2    Grandbarbe, L.3    Morga, E.4    Heuschling, P.5
  • 18
    • 0033982028 scopus 로고    scopus 로고
    • Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia
    • Yates SL, Burgess LH, Kocsis-Angle J, et al., Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia. J Neurochem. 2000; 74: 1017-25.
    • (2000) J Neurochem , vol.74 , pp. 1017-1025
    • Yates, S.L.1    Burgess, L.H.2    Kocsis-Angle, J.3
  • 20
    • 84885173894 scopus 로고    scopus 로고
    • Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice
    • Orre M, Kamphuis W, Osborn LM, et al., Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice. Neurobiol Aging. 2014; 35: 1-14.
    • (2014) Neurobiol Aging , vol.35 , pp. 1-14
    • Orre, M.1    Kamphuis, W.2    Osborn, L.M.3
  • 21
    • 85018223217 scopus 로고    scopus 로고
    • Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: A co-expression meta-analysis
    • Holtman IR, Raj DD, Miller JA, et al., Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis. Acta Neuropathol Commun. 2015; 3: 31.
    • (2015) Acta Neuropathol Commun , vol.3 , pp. 31
    • Holtman, I.R.1    Raj, D.D.2    Miller, J.A.3
  • 22
    • 84959110290 scopus 로고    scopus 로고
    • Microglial brain region-dependent diversity and selective regional sensitivities to aging
    • Grabert K, Michoel T, Karavolos MH, et al., Microglial brain region-dependent diversity and selective regional sensitivities to aging. Nat Neurosci. 2016; 19: 504-16.
    • (2016) Nat Neurosci , vol.19 , pp. 504-516
    • Grabert, K.1    Michoel, T.2    Karavolos, M.H.3
  • 23
    • 84897976299 scopus 로고    scopus 로고
    • Microglial priming in neurodegenerative disease
    • Perry VH, Holmes C,. Microglial priming in neurodegenerative disease. Nat Rev Neurol. 2014; 10: 217-24.
    • (2014) Nat Rev Neurol , vol.10 , pp. 217-224
    • Perry, V.H.1    Holmes, C.2
  • 24
    • 84888324248 scopus 로고    scopus 로고
    • The microglial sensome revealed by direct RNA sequencing
    • Hickman SE, Kingery ND, Ohsumi TK, et al., The microglial sensome revealed by direct RNA sequencing. Nat Neurosci. 2013; 16: 1896-905.
    • (2013) Nat Neurosci , vol.16 , pp. 1896-1905
    • Hickman, S.E.1    Kingery, N.D.2    Ohsumi, T.K.3
  • 25
    • 0029926153 scopus 로고    scopus 로고
    • Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2
    • Molina H, Holers VM, Li B, et al., Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. Proc Natl Acad Sci U S A. 1996; 93: 3357-61.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 3357-3361
    • Molina, H.1    Holers, V.M.2    Li, B.3
  • 26
    • 77955883153 scopus 로고    scopus 로고
    • Complement: A key system for immune surveillance and homeostasis
    • Ricklin D, Hajishengallis G, Yang K, Lambris JD,. Complement: a key system for immune surveillance and homeostasis. Nat Immunol. 2010; 11: 785-97.
    • (2010) Nat Immunol , vol.11 , pp. 785-797
    • Ricklin, D.1    Hajishengallis, G.2    Yang, K.3    Lambris, J.D.4
  • 27
    • 36849076770 scopus 로고    scopus 로고
    • The classical complement cascade mediates CNS synapse elimination
    • Stevens B, Allen NJ, Vazquez LE, et al., The classical complement cascade mediates CNS synapse elimination. Cell. 2007; 131: 1164-78.
    • (2007) Cell , vol.131 , pp. 1164-1178
    • Stevens, B.1    Allen, N.J.2    Vazquez, L.E.3
  • 28
    • 0032710620 scopus 로고    scopus 로고
    • Cytokines associated with amyloid plaques in Alzheimer's disease brain stimulate human glial and neuronal cell cultures to secrete early complement proteins, but not C1-inhibitor
    • Veerhuis R, Janssen I, De Groot CJ, Van Muiswinkel FL, Hack CE, Eikelenboom P,. Cytokines associated with amyloid plaques in Alzheimer's disease brain stimulate human glial and neuronal cell cultures to secrete early complement proteins, but not C1-inhibitor. Exp Neurol. 1999; 160: 289-99.
    • (1999) Exp Neurol , vol.160 , pp. 289-299
    • Veerhuis, R.1    Janssen, I.2    De Groot, C.J.3    Van Muiswinkel, F.L.4    Hack, C.E.5    Eikelenboom, P.6
  • 29
    • 79951708091 scopus 로고    scopus 로고
    • Histological and direct evidence for the role of complement in the neuroinflammation of AD
    • Veerhuis R,. Histological and direct evidence for the role of complement in the neuroinflammation of AD. Curr Alzheimer Res. 2011; 8: 34-58.
    • (2011) Curr Alzheimer Res , vol.8 , pp. 34-58
    • Veerhuis, R.1
  • 31
    • 33748780095 scopus 로고    scopus 로고
    • Role of complement in neurodegeneration and neuroinflammation
    • Bonifati DM, Kishore U,. Role of complement in neurodegeneration and neuroinflammation. Mol Immunol. 2007; 44: 999-1010.
    • (2007) Mol Immunol , vol.44 , pp. 999-1010
    • Bonifati, D.M.1    Kishore, U.2
  • 32
    • 71049194870 scopus 로고    scopus 로고
    • Expression of complement system components during aging and amyloid deposition in APP transgenic mice
    • Reichwald J, Danner S, Wiederhold KH, Staufenbiel M,. Expression of complement system components during aging and amyloid deposition in APP transgenic mice. J Neuroinflammation. 2009; 6: 35.
    • (2009) J Neuroinflammation , vol.6 , pp. 35
    • Reichwald, J.1    Danner, S.2    Wiederhold, K.H.3    Staufenbiel, M.4
  • 33
    • 84862809855 scopus 로고    scopus 로고
    • Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Abeta by microglia
    • Fu H, Liu B, Frost JL, et al., Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Abeta by microglia. Glia. 2012; 60: 993-1003.
    • (2012) Glia , vol.60 , pp. 993-1003
    • Fu, H.1    Liu, B.2    Frost, J.L.3
  • 34
    • 84865199264 scopus 로고    scopus 로고
    • Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: A microarray study
    • Cribbs DH, Berchtold NC, Perreau V, et al., Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study. J Neuroinflammation. 2012; 9: 179.
    • (2012) J Neuroinflammation , vol.9 , pp. 179
    • Cribbs, D.H.1    Berchtold, N.C.2    Perreau, V.3
  • 35
    • 84872067877 scopus 로고    scopus 로고
    • C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity
    • Benoit ME, Hernandez MX, Dinh ML, Benavente F, Vasquez O, Tenner AJ,. C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity. J Biol Chem. 2013; 288: 654-65.
    • (2013) J Biol Chem , vol.288 , pp. 654-665
    • Benoit, M.E.1    Hernandez, M.X.2    Dinh, M.L.3    Benavente, F.4    Vasquez, O.5    Tenner, A.J.6
  • 36
    • 0026447529 scopus 로고
    • Complement activation by beta-amyloid in Alzheimer disease
    • Rogers J, Cooper NR, Webster S, et al., Complement activation by beta-amyloid in Alzheimer disease. Proc Natl Acad Sci U S A. 1992; 89: 10016-20.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 10016-10020
    • Rogers, J.1    Cooper, N.R.2    Webster, S.3
  • 37
    • 0028178458 scopus 로고
    • Beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain
    • Jiang H, Burdick D, Glabe CG, Cotman CW, Tenner AJ,. Beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. J Immunol. 1994; 152: 5050-9.
    • (1994) J Immunol , vol.152 , pp. 5050-5059
    • Jiang, H.1    Burdick, D.2    Glabe, C.G.3    Cotman, C.W.4    Tenner, A.J.5
  • 38
    • 0035877077 scopus 로고    scopus 로고
    • Complement activation by neurofibrillary tangles in Alzheimer's disease
    • Shen Y, Lue L, Yang L, et al., Complement activation by neurofibrillary tangles in Alzheimer's disease. Neurosci Lett. 2001; 305: 165-8.
    • (2001) Neurosci Lett , vol.305 , pp. 165-168
    • Shen, Y.1    Lue, L.2    Yang, L.3
  • 39
    • 78549264026 scopus 로고    scopus 로고
    • Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
    • Lambert JC, Heath S, Even G, et al., Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet. 2009; 41: 1094-9.
    • (2009) Nat Genet , vol.41 , pp. 1094-1099
    • Lambert, J.C.1    Heath, S.2    Even, G.3
  • 40
    • 84881490625 scopus 로고    scopus 로고
    • A dramatic increase of C1q protein in the CNS during normal aging
    • Stephan AH, Madison DV, Mateos JM, et al., A dramatic increase of C1q protein in the CNS during normal aging. J Neurosci. 2013; 33: 13460-74.
    • (2013) J Neurosci , vol.33 , pp. 13460-13474
    • Stephan, A.H.1    Madison, D.V.2    Mateos, J.M.3
  • 42
    • 39749162770 scopus 로고    scopus 로고
    • The role of exosomes in the processing of proteins associated with neurodegenerative diseases
    • Vella LJ, Sharples RA, Nisbet RM, Cappai R, Hill AF,. The role of exosomes in the processing of proteins associated with neurodegenerative diseases. Eur Biophys J. 2008; 37: 323-32.
    • (2008) Eur Biophys J , vol.37 , pp. 323-332
    • Vella, L.J.1    Sharples, R.A.2    Nisbet, R.M.3    Cappai, R.4    Hill, A.F.5
  • 43
    • 84929269782 scopus 로고    scopus 로고
    • Extracellular vesicles-Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases
    • Coleman BM, Hill AF,. Extracellular vesicles-Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases. Semin Cell Dev Biol. 2015; 40: 89-96.
    • (2015) Semin Cell Dev Biol , vol.40 , pp. 89-96
    • Coleman, B.M.1    Hill, A.F.2
  • 44
    • 33746593662 scopus 로고    scopus 로고
    • Alzheimer's disease beta-amyloid peptides are released in association with exosomes
    • Rajendran L, Honsho M, Zahn TR, et al., Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc Natl Acad Sci U S A. 2006; 103: 11172-7.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 11172-11177
    • Rajendran, L.1    Honsho, M.2    Zahn, T.R.3
  • 45
    • 84899968840 scopus 로고    scopus 로고
    • Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease
    • Dinkins MB, Dasgupta S, Wang G, Zhu G, Bieberich E,. Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease. Neurobiol Aging. 2014; 35: 1792-800.
    • (2014) Neurobiol Aging , vol.35 , pp. 1792-1800
    • Dinkins, M.B.1    Dasgupta, S.2    Wang, G.3    Zhu, G.4    Bieberich, E.5
  • 46
    • 84880950361 scopus 로고    scopus 로고
    • Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication
    • Fruhbeis C, Frohlich D, Kuo WP, et al., Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS Biol. 2013; 11: e1001604.
    • (2013) PLoS Biol , vol.11 , pp. e1001604
    • Fruhbeis, C.1    Frohlich, D.2    Kuo, W.P.3
  • 47
    • 84859499570 scopus 로고    scopus 로고
    • Sphingolipid-modulated exosome secretion promotes clearance of amyloid-beta by microglia
    • Yuyama K, Sun H, Mitsutake S, Igarashi Y,. Sphingolipid-modulated exosome secretion promotes clearance of amyloid-beta by microglia. J Biol Chem. 2012; 287: 10977-89.
    • (2012) J Biol Chem , vol.287 , pp. 10977-10989
    • Yuyama, K.1    Sun, H.2    Mitsutake, S.3    Igarashi, Y.4
  • 48
    • 84945474523 scopus 로고    scopus 로고
    • Depletion of microglia and inhibition of exosome synthesis halt tau propagation
    • Asai H, Ikezu S, Tsunoda S, et al., Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015; 18: 1584-93.
    • (2015) Nat Neurosci , vol.18 , pp. 1584-1593
    • Asai, H.1    Ikezu, S.2    Tsunoda, S.3
  • 49
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • Thery C, Ostrowski M, Segura E,. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. 2009; 9: 581-93.
    • (2009) Nat Rev Immunol , vol.9 , pp. 581-593
    • Thery, C.1    Ostrowski, M.2    Segura, E.3
  • 50
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: Exosomes, microvesicles, and friends
    • Raposo G, Stoorvogel W,. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013; 200: 373-83.
    • (2013) J Cell Biol , vol.200 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 51
    • 23444448020 scopus 로고    scopus 로고
    • Proteomic analysis of microglia-derived exosomes: Metabolic role of the aminopeptidase CD13 in neuropeptide catabolism
    • Potolicchio I, Carven GJ, Xu X, et al., Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism. J Immunol. 2005; 175: 2237-43.
    • (2005) J Immunol , vol.175 , pp. 2237-2243
    • Potolicchio, I.1    Carven, G.J.2    Xu, X.3
  • 52
    • 67349114201 scopus 로고    scopus 로고
    • Acid sphingomyelinase activity triggers microparticle release from glial cells
    • Bianco F, Perrotta C, Novellino L, et al., Acid sphingomyelinase activity triggers microparticle release from glial cells. EMBO J. 2009; 28: 1043-54.
    • (2009) EMBO J , vol.28 , pp. 1043-1054
    • Bianco, F.1    Perrotta, C.2    Novellino, L.3
  • 53
    • 84939260061 scopus 로고    scopus 로고
    • Extracellular vesicles from neural stem cells transfer IFN-gamma via Ifngr1 to activate Stat1 signaling in target cells
    • Cossetti C, Iraci N, Mercer TR, et al., Extracellular vesicles from neural stem cells transfer IFN-gamma via Ifngr1 to activate Stat1 signaling in target cells. Mol Cell. 2014; 56: 193-204.
    • (2014) Mol Cell , vol.56 , pp. 193-204
    • Cossetti, C.1    Iraci, N.2    Mercer, T.R.3
  • 54
    • 84876927914 scopus 로고    scopus 로고
    • Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development
    • Kucharzewska P, Christianson HC, Welch JE, et al., Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proc Natl Acad Sci U S A. 2013; 110: 7312-7.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 7312-7317
    • Kucharzewska, P.1    Christianson, H.C.2    Welch, J.E.3
  • 55
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kreutzberg GW,. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996; 19: 312-8.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 56
    • 0016261856 scopus 로고
    • Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: An electron microscope study
    • Vaughan DW, Peters A,. Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: an electron microscope study. J Neurocytol. 1974; 3: 405-29.
    • (1974) J Neurocytol , vol.3 , pp. 405-429
    • Vaughan, D.W.1    Peters, A.2
  • 58
    • 84856756074 scopus 로고    scopus 로고
    • Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices
    • Tremblay ME, Zettel ML, Ison JR, Allen PD, Majewska AK,. Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices. Glia. 2012; 60: 541-58.
    • (2012) Glia , vol.60 , pp. 541-558
    • Tremblay, M.E.1    Zettel, M.L.2    Ison, J.R.3    Allen, P.D.4    Majewska, A.K.5
  • 59
    • 84879092634 scopus 로고    scopus 로고
    • The microglial activation state regulates migration and roles of matrix-dissolving enzymes for invasion
    • Lively S, Schlichter LC,. The microglial activation state regulates migration and roles of matrix-dissolving enzymes for invasion. J Neuroinflammation. 2013; 10: 75.
    • (2013) J Neuroinflammation , vol.10 , pp. 75
    • Lively, S.1    Schlichter, L.C.2
  • 60
    • 0037377947 scopus 로고    scopus 로고
    • The extracellular matrix and cytokines regulate microglial integrin expression and activation
    • Milner R, Campbell IL,. The extracellular matrix and cytokines regulate microglial integrin expression and activation. J Immunol. 2003; 170: 3850-8.
    • (2003) J Immunol , vol.170 , pp. 3850-3858
    • Milner, R.1    Campbell, I.L.2
  • 61
    • 78349296382 scopus 로고    scopus 로고
    • WNT signaling in activated microglia is proinflammatory
    • Halleskog C, Mulder J, Dahlstrom J, et al., WNT signaling in activated microglia is proinflammatory. Glia. 2011; 59: 119-31.
    • (2011) Glia , vol.59 , pp. 119-131
    • Halleskog, C.1    Mulder, J.2    Dahlstrom, J.3
  • 62
    • 46749087854 scopus 로고    scopus 로고
    • Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice
    • Maier M, Peng Y, Jiang L, Seabrook TJ, Carroll MC, Lemere CA,. Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice. J Neurosci. 2008; 28: 6333-41.
    • (2008) J Neurosci , vol.28 , pp. 6333-6341
    • Maier, M.1    Peng, Y.2    Jiang, L.3    Seabrook, T.J.4    Carroll, M.C.5    Lemere, C.A.6
  • 63
    • 45949106077 scopus 로고    scopus 로고
    • Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease
    • Richard KL, Filali M, Prefontaine P, Rivest S,. Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease. J Neurosci. 2008; 28: 5784-93.
    • (2008) J Neurosci , vol.28 , pp. 5784-5793
    • Richard, K.L.1    Filali, M.2    Prefontaine, P.3    Rivest, S.4
  • 64
    • 84858762160 scopus 로고    scopus 로고
    • Crosstalk between complement and toll-like receptors
    • Song WC,. Crosstalk between complement and toll-like receptors. Toxicol Pathol. 2012; 40: 174-82.
    • (2012) Toxicol Pathol , vol.40 , pp. 174-182
    • Song, W.C.1
  • 65
    • 20444364844 scopus 로고    scopus 로고
    • Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective
    • Butovsky O, Talpalar AE, Ben-Yaakov K, Schwartz M,. Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective. Mol Cell Neurosci. 2005; 29: 381-93.
    • (2005) Mol Cell Neurosci , vol.29 , pp. 381-393
    • Butovsky, O.1    Talpalar, A.E.2    Ben-Yaakov, K.3    Schwartz, M.4
  • 66
    • 0024436506 scopus 로고
    • Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
    • Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe D,. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J Neuroimmunol. 1989; 24: 173-82.
    • (1989) J Neuroimmunol , vol.24 , pp. 173-182
    • Itagaki, S.1    McGeer, P.L.2    Akiyama, H.3    Zhu, S.4    Selkoe, D.5
  • 67
    • 84904957734 scopus 로고    scopus 로고
    • Accelerated microglial pathology is associated with Abeta plaques in mouse models of Alzheimer's disease
    • Baron R, Babcock AA, Nemirovsky A, Finsen B, Monsonego A,. Accelerated microglial pathology is associated with Abeta plaques in mouse models of Alzheimer's disease. Aging Cell. 2014; 13: 584-95.
    • (2014) Aging Cell , vol.13 , pp. 584-595
    • Baron, R.1    Babcock, A.A.2    Nemirovsky, A.3    Finsen, B.4    Monsonego, A.5
  • 69
    • 33845259342 scopus 로고    scopus 로고
    • The P2Y12 receptor regulates microglial activation by extracellular nucleotides
    • Haynes SE, Hollopeter G, Yang G, et al., The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci. 2006; 9: 1512-9.
    • (2006) Nat Neurosci , vol.9 , pp. 1512-1519
    • Haynes, S.E.1    Hollopeter, G.2    Yang, G.3
  • 70
  • 71
    • 84869192542 scopus 로고    scopus 로고
    • Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors
    • Koizumi S, Ohsawa K, Inoue K, Kohsaka S,. Purinergic receptors in microglia: functional modal shifts of microglia mediated by P2 and P1 receptors. Glia. 2013; 61: 47-54.
    • (2013) Glia , vol.61 , pp. 47-54
    • Koizumi, S.1    Ohsawa, K.2    Inoue, K.3    Kohsaka, S.4
  • 72
    • 84876006819 scopus 로고    scopus 로고
    • Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology
    • Krabbe G, Halle A, Matyash V, et al., Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology. PLoS ONE. 2013; 8: e60921.
    • (2013) PLoS ONE , vol.8 , pp. e60921
    • Krabbe, G.1    Halle, A.2    Matyash, V.3
  • 73
    • 58149401811 scopus 로고    scopus 로고
    • Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice
    • Koenigsknecht-Talboo J, Meyer-Luehmann M, Parsadanian M, et al., Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice. J Neurosci. 2008; 28: 14156-64.
    • (2008) J Neurosci , vol.28 , pp. 14156-14164
    • Koenigsknecht-Talboo, J.1    Meyer-Luehmann, M.2    Parsadanian, M.3
  • 74
    • 84937113148 scopus 로고    scopus 로고
    • Microglia constitute a barrier that prevents neurotoxic protofibrillar Abeta42 hotspots around plaques
    • Condello C, Yuan P, Schain A, Grutzendler J,. Microglia constitute a barrier that prevents neurotoxic protofibrillar Abeta42 hotspots around plaques. Nat Commun. 2015; 6: 6176.
    • (2015) Nat Commun , vol.6 , pp. 6176
    • Condello, C.1    Yuan, P.2    Schain, A.3    Grutzendler, J.4
  • 75
    • 38349116263 scopus 로고    scopus 로고
    • Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice
    • Xu H, Chen M, Manivannan A, Lois N, Forrester JV,. Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice. Aging Cell. 2008; 7: 58-68.
    • (2008) Aging Cell , vol.7 , pp. 58-68
    • Xu, H.1    Chen, M.2    Manivannan, A.3    Lois, N.4    Forrester, J.V.5
  • 76
    • 84864670735 scopus 로고    scopus 로고
    • The role of microglial mtDNA damage in age-dependent prolonged LPS-induced sickness behavior
    • Nakanishi H, Hayashi Y, Wu Z,. The role of microglial mtDNA damage in age-dependent prolonged LPS-induced sickness behavior. Neuron Glia Biol. 2011; 7: 17-23.
    • (2011) Neuron Glia Biol , vol.7 , pp. 17-23
    • Nakanishi, H.1    Hayashi, Y.2    Wu, Z.3
  • 77
    • 84870515243 scopus 로고    scopus 로고
    • A2E accumulation influences retinal microglial activation and complement regulation
    • Ma W, Coon S, Zhao L, Fariss RN, Wong WT,. A2E accumulation influences retinal microglial activation and complement regulation. Neurobiol Aging. 2013; 34: 943-60.
    • (2013) Neurobiol Aging , vol.34 , pp. 943-960
    • Ma, W.1    Coon, S.2    Zhao, L.3    Fariss, R.N.4    Wong, W.T.5
  • 78
    • 84879881897 scopus 로고    scopus 로고
    • Gene expression changes in aging retinal microglia: Relationship to microglial support functions and regulation of activation
    • Ma W, Cojocaru R, Gotoh N, et al., Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation. Neurobiol Aging. 2013; 34: 2310-21.
    • (2013) Neurobiol Aging , vol.34 , pp. 2310-2321
    • Ma, W.1    Cojocaru, R.2    Gotoh, N.3
  • 79
    • 84888198684 scopus 로고    scopus 로고
    • Phagocyte dysfunction, tissue aging and degeneration
    • Li W,. Phagocyte dysfunction, tissue aging and degeneration. Ageing Res Rev. 2013; 12: 1005-12.
    • (2013) Ageing Res Rev , vol.12 , pp. 1005-1012
    • Li, W.1
  • 80
    • 84929264999 scopus 로고    scopus 로고
    • Age- and location-related changes in microglial function
    • Ritzel RM, Patel AR, Pan S, et al., Age- and location-related changes in microglial function. Neurobiol Aging. 2015; 36: 2153-63.
    • (2015) Neurobiol Aging , vol.36 , pp. 2153-2163
    • Ritzel, R.M.1    Patel, A.R.2    Pan, S.3
  • 81
    • 79960744467 scopus 로고    scopus 로고
    • Microglia demonstrate age-dependent interaction with amyloid-beta fibrils
    • Floden AM, Combs CK,. Microglia demonstrate age-dependent interaction with amyloid-beta fibrils. J Alzheimers Dis. 2011; 25: 279-93.
    • (2011) J Alzheimers Dis , vol.25 , pp. 279-293
    • Floden, A.M.1    Combs, C.K.2
  • 82
    • 42949175211 scopus 로고    scopus 로고
    • Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance
    • Bolmont T, Haiss F, Eicke D, et al., Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance. J Neurosci. 2008; 28: 4283-92.
    • (2008) J Neurosci , vol.28 , pp. 4283-4292
    • Bolmont, T.1    Haiss, F.2    Eicke, D.3
  • 83
    • 29244439038 scopus 로고    scopus 로고
    • Neural plasticity in the ageing brain
    • Burke SN, Barnes CA,. Neural plasticity in the ageing brain. Nat Rev Neurosci. 2006; 7: 30-40.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 30-40
    • Burke, S.N.1    Barnes, C.A.2
  • 85
    • 80052633284 scopus 로고    scopus 로고
    • Synaptic pruning by microglia is necessary for normal brain development
    • Paolicelli RC, Bolasco G, Pagani F, et al., Synaptic pruning by microglia is necessary for normal brain development. Science. 2011; 333: 1456-8.
    • (2011) Science , vol.333 , pp. 1456-1458
    • Paolicelli, R.C.1    Bolasco, G.2    Pagani, F.3
  • 86
    • 84861427387 scopus 로고    scopus 로고
    • Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
    • Schafer DP, Lehrman EK, Kautzman AG, et al., Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron. 2012; 74: 691-705.
    • (2012) Neuron , vol.74 , pp. 691-705
    • Schafer, D.P.1    Lehrman, E.K.2    Kautzman, A.G.3
  • 88
    • 10644224469 scopus 로고    scopus 로고
    • Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse
    • Roumier A, Bechade C, Poncer JC, et al., Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse. J Neurosci. 2004; 24: 11421-8.
    • (2004) J Neurosci , vol.24 , pp. 11421-11428
    • Roumier, A.1    Bechade, C.2    Poncer, J.C.3
  • 89
    • 80755168022 scopus 로고    scopus 로고
    • CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity
    • Rogers JT, Morganti JM, Bachstetter AD, et al., CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity. J Neurosci. 2011; 31: 16241-50.
    • (2011) J Neurosci , vol.31 , pp. 16241-16250
    • Rogers, J.T.1    Morganti, J.M.2    Bachstetter, A.D.3
  • 90
    • 33750480549 scopus 로고    scopus 로고
    • The age-related attenuation in long-term potentiation is associated with microglial activation
    • Griffin R, Nally R, Nolan Y, McCartney Y, Linden J, Lynch MA,. The age-related attenuation in long-term potentiation is associated with microglial activation. J Neurochem. 2006; 99: 1263-72.
    • (2006) J Neurochem , vol.99 , pp. 1263-1272
    • Griffin, R.1    Nally, R.2    Nolan, Y.3    McCartney, Y.4    Linden, J.5    Lynch, M.A.6
  • 91
    • 84861993323 scopus 로고    scopus 로고
    • CD200 fusion protein decreases microglial activation in the hippocampus of aged rats
    • Cox FF, Carney D, Miller AM, Lynch MA,. CD200 fusion protein decreases microglial activation in the hippocampus of aged rats. Brain Behav Immun. 2012; 26: 789-96.
    • (2012) Brain Behav Immun , vol.26 , pp. 789-796
    • Cox, F.F.1    Carney, D.2    Miller, A.M.3    Lynch, M.A.4
  • 92
    • 84929921146 scopus 로고    scopus 로고
    • Immune attack: The role of inflammation in Alzheimer disease
    • Heppner FL, Ransohoff RM, Becher B,. Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci. 2015; 16: 358-72.
    • (2015) Nat Rev Neurosci , vol.16 , pp. 358-372
    • Heppner, F.L.1    Ransohoff, R.M.2    Becher, B.3
  • 93
    • 84873087532 scopus 로고    scopus 로고
    • NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
    • Heneka MT, Kummer MP, Stutz A, et al., NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. 2013; 493: 674-8.
    • (2013) Nature , vol.493 , pp. 674-678
    • Heneka, M.T.1    Kummer, M.P.2    Stutz, A.3
  • 94
    • 84872057940 scopus 로고    scopus 로고
    • TREM2 variants in Alzheimer's disease
    • Guerreiro R, Wojtas A, Bras J, et al., TREM2 variants in Alzheimer's disease. N Engl J Med. 2013; 368: 117-27.
    • (2013) N Engl J Med , vol.368 , pp. 117-127
    • Guerreiro, R.1    Wojtas, A.2    Bras, J.3
  • 95
    • 84872088087 scopus 로고    scopus 로고
    • Variant of TREM2 associated with the risk of Alzheimer's disease
    • Jonsson T, Stefansson H, Steinberg S, et al., Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med. 2013; 368: 107-16.
    • (2013) N Engl J Med , vol.368 , pp. 107-116
    • Jonsson, T.1    Stefansson, H.2    Steinberg, S.3
  • 96
    • 84891706947 scopus 로고    scopus 로고
    • CD33 Alzheimer's disease locus: Altered monocyte function and amyloid biology
    • Bradshaw EM, Chibnik LB, Keenan BT, et al., CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology. Nat Neurosci. 2013; 16: 848-50.
    • (2013) Nat Neurosci , vol.16 , pp. 848-850
    • Bradshaw, E.M.1    Chibnik, L.B.2    Keenan, B.T.3
  • 97
    • 84876907931 scopus 로고    scopus 로고
    • Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease
    • Zhang B, Gaiteri C, Bodea LG, et al., Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell. 2013; 153: 707-20.
    • (2013) Cell , vol.153 , pp. 707-720
    • Zhang, B.1    Gaiteri, C.2    Bodea, L.G.3
  • 98
    • 84945443544 scopus 로고    scopus 로고
    • CD33 modulates TREM2: Convergence of Alzheimer loci
    • Chan G, White CC, Winn PA, et al., CD33 modulates TREM2: convergence of Alzheimer loci. Nat Neurosci. 2015; 18: 1556-8.
    • (2015) Nat Neurosci , vol.18 , pp. 1556-1558
    • Chan, G.1    White, C.C.2    Winn, P.A.3
  • 99
    • 84940094599 scopus 로고    scopus 로고
    • DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response
    • Zhong L, Chen XF, Zhang ZL, et al., DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response. J Biol Chem. 2015; 290: 15866-77.
    • (2015) J Biol Chem , vol.290 , pp. 15866-15877
    • Zhong, L.1    Chen, X.F.2    Zhang, Z.L.3
  • 100
    • 84942133629 scopus 로고    scopus 로고
    • Complement C3-deficient mice fail to display age-related hippocampal decline
    • Shi Q, Colodner KJ, Matousek SB, et al., Complement C3-deficient mice fail to display age-related hippocampal decline. J Neurosci. 2015; 35: 13029-42.
    • (2015) J Neurosci , vol.35 , pp. 13029-13042
    • Shi, Q.1    Colodner, K.J.2    Matousek, S.B.3
  • 101
    • 3242766671 scopus 로고    scopus 로고
    • Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease
    • Fonseca MI, Zhou J, Botto M, Tenner AJ,. Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease. J Neurosci. 2004; 24: 6457-65.
    • (2004) J Neurosci , vol.24 , pp. 6457-6465
    • Fonseca, M.I.1    Zhou, J.2    Botto, M.3    Tenner, A.J.4
  • 102
    • 84962418507 scopus 로고    scopus 로고
    • Complement and microglia mediate early synapse loss in Alzheimer mouse models
    • pii: aad8373
    • Hong S, Beja-Glasser VF, Nfonoyim BM, et al., Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science. 2016; pii: aad8373.
    • (2016) Science
    • Hong, S.1    Beja-Glasser, V.F.2    Nfonoyim, B.M.3
  • 103
    • 84923076793 scopus 로고    scopus 로고
    • Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia
    • Bahrini I, Song JH, Diez D, Hanayama R,. Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia. Sci Rep. 2015; 5: 7989.
    • (2015) Sci Rep , vol.5 , pp. 7989
    • Bahrini, I.1    Song, J.H.2    Diez, D.3    Hanayama, R.4
  • 104
    • 80052714655 scopus 로고    scopus 로고
    • CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease
    • Cho SH, Sun B, Zhou Y, et al., CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease. J Biol Chem. 2011; 286: 32713-22.
    • (2011) J Biol Chem , vol.286 , pp. 32713-32722
    • Cho, S.H.1    Sun, B.2    Zhou, Y.3
  • 106
    • 84920405563 scopus 로고    scopus 로고
    • Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models
    • Johansson JU, Woodling NS, Wang Q, et al., Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models. J Clin Invest. 2015; 125: 350-64.
    • (2015) J Clin Invest , vol.125 , pp. 350-364
    • Johansson, J.U.1    Woodling, N.S.2    Wang, Q.3


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